Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0

The step by step assembly process from preribosome in the nucleus to translation-competent 60S ribosome subunit in the cytoplasm is revealed (also see Kemmler et al. in this issue)

Young stars and brown dwarfs surrounding Alnilam (eps Ori) and Mintaka (del Ori)

Aims: We look for new regions for the search of substellar objects. Methods: Two circular areas, 45 arcmin-radius each, centred on the young massive star systems Alnilam and Mintaka in the Orion Belt, have been explored. The regions are very young (less than 10 Ma), have low extinction, and are neighbours to sigma Orionis (~3 Ma), a young open cluster very rich in brown dwarfs and planetary-mass objects. We have used Virtual Observatory tools, the astro-photometric Tycho-2, DENIS and 2MASS catalogues, 10 control fields at similar galactic latitudes, and X-ray, mid-infrared and spectroscopic data from the literature. Results: We have compiled exhaustive lists of known young stars and new candidate members in the Ori OB1b association, and of fore- and background sources. A total of 136 stars display features of extreme youth, like early spectral types, lithium in absorption, or mid-infrared flux excess. Other two young brown dwarf and 289 star candidates have been identified from an optical/near-infrared colour-magnitude diagram. We list additional 74 known objects that might belong to the association. This catalogue can serve as an input for characterisation of the stellar and high-mass substellar populations in the Orion Belt. Finally, we have investigated the surface densities and radial distributions of young objects surrounding Alnilam and Mintaka, and compared them with those in the sigma Orionis cluster. We report a new open cluster centred on Mintaka. Conclusions: Both regions can be analogs to the sigma Orionis cluster, but more massive, more extended, slightly older, and less radially concentrated.Comment: Accepted for publication in A&A. It will be published on line in Sect. 14 (Catalogs and data). Tables in Appendix A will soon be available at the CD

Global variations in diabetes mellitus based on fasting glucose and haemogloblin A1c

Fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) are both used to diagnose diabetes, but may identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening had elevated FPG, HbA1c, or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardised proportion of diabetes that was previously undiagnosed, and detected in survey screening, ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the agestandardised proportion who had elevated levels of both FPG and HbA1c was 29-39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global gap in diabetes diagnosis and surveillance.peer-reviewe

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20–27) for women and 18% (16–21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings

Diminishing benefits of urban living for children and adolescents’ growth and development

AbstractOptimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was &lt;1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.</jats:p

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining https://researchonline.ljmu.ac.uk/images/research_banner_face_lab_290.jpgunderweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity

Análisis del patrón de comercio entre Corea del Sur y Venezuela, 2000-2017

Corea del Sur y Venezuela tienen una larga historia de relaciones económicas, políticas y sociales. En este sentido, el presente capítulo tiene como objetivo analizar las características del comercio entre estos dos países durante el período 2000- 2017. Para este fin se estiman índices de comercio exterior. El análisis empírico del comercio entre los dos países se lleva a cabo identificando el flujo comercial y construyendo los siguientes índices: a) Índice de ventaja comparativa revelada, b) Índice de similitud, y c) Índice de intensidad comercial de Krugman. Los resultados muestran la posibilidad de comercio complementario entre ambas economías, debido a las altas diferencias entre las industrias coreana y venezolana.South Korea and Venezuela have a long history of economic, political and social relations. In this regard, this chapter aims to analyze the characteristics of trade between these two countries during the period 2001-2017. To this end, foreign trade indices are estimated. Empirical analysis of trade between the two countries is carried out by identifying trade flows and constructing the following indices: a) Revealed Comparative Advantage Index, b) Similarity Index, and c) Krugman Trade Intensity Index. The results show the possibility of complementary trade between the two economies, due to the high differences between Korean and Venezuelan industries.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001753768https://orcid.org/0000-0003-3660-8299https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000003164alberto.hurtadob@campusucc.edu.c

Corea del Sur-América Latina: Relación comercial e inversión

Teniendo en cuenta el acercamiento económico, cultural, de inversión y de ayuda humanitaria de Corea del Sur con los países latinoamericanos, y reconociendo la importancia de los vínculos entre economías con base en relaciones comerciales y de inversión externa como aspecto fundamental para comprender la dinámica del crecimiento de los países. El presente libro tiene por objetivo analizar la relación comercial y de inversión entre Corea del Sur y América Latina. Para ello se desarrollan ocho capítulos donde se analizan las relaciones actuales y se reconocen los vínculos sostenibles entre el país asiático y la región latinoamericana. En este sentido, la conexión comercial y de inversión entre Corea del Sur y América Latina representa paz, futuro y opción de desarrollo con igualdad.Taking into account the economic, cultural, investment and humanitarian rapprochement of South Korea with the Latin American countries, and recognizing the importance of the links between economies based on trade and external investment relations as a fundamental aspect of understanding the dynamics of growth of countries. This book aims to analyze the trade and investment relationship between South Korea and Latin America. To this end, eight chapters are developed to analyze current relations and recognizing sustainable links between the Asian country and the Latin American region. In this sense, the trade and investment connection between South Korea and Latin America represents peace, future and option of development with equality.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001753768https://orcid.org/0000-0003-3660-8299https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000003164alberto.hurtadob@campusucc.edu.c