118 research outputs found
Baryon-Baryon Interactions
After a short survey of some topics of interest in the study of baryon-baryon
scattering, the recent Nijmegen energy dependent partial wave analysis (PWA) of
the nucleon-nucleon data is reviewed. In this PWA the energy range for both pp
and np is now 0 < Tlab < 350 MeV and a chi^2_{d.o.f.}=1.08 was reached. The
implications for the pion-nucleon coupling constants are discussed. Comments
are made with respect to recent discussions around this coupling constant in
the literature. In the second part, we briefly sketch the picture of the baryon
in several, more or less QCD-based, quark-models that have been rather
prominent in the literature. Inspired by these pictures we constructed a new
soft-core model for the nucleon-nucleon interaction and present the first
results of this model in a chi^2 -fit to the new multi-energy Nijmegen PWA.
With this new model we succeeded in narrowing the gap between theory and
experiment at low energies. For the energies Tlab = 25-320 MeV we reached a
record low chi^2_{p.d.p.} = 1.16. We finish the paper with some conclusions and
an outlook describing the extension of the new model to baryon-baryon
scattering.Comment: 12 pages LaTeX and one postscript figure included. Invited talk
presented at the XIVth European Conference of Few-Body Problems in Physics,
Amsterdam, August 23-28, 199
SU(3) Predictions for Weak Decays of Doubly Heavy Baryons -- including SU(3) breaking terms
We find expressions for the weak decay amplitudes of baryons containing two b
quarks (or one b and one c quark -- many relationship are the same) in terms of
unknown reduced matrix elements. This project was originally motivated by the
request of the FNAL Run II b Physics Workshop organizers for a guide to
experimentalists in their search for as yet unobserved hadrons. We include an
analysis of linear SU(3) breaking terms in addition to relationships generated
by unbroken SU(3) symmetry, and relate these to expressions in terms of the
complete set of possible reduced matrix elements.Comment: 49 page
Baryons as non-topological chiral solitons
The present review gives a survey of recent developments and applications of
the Nambu--Jona-Lasinio model with and quark flavors for the
structure of baryons. The model is an effective chiral quark theory which
incorporates the SU(N)SU(N)U(1) approximate
symmetry of Quantum chromodynamics. The approach describes the spontaneous
chiral symmetry breaking and dynamical quark mass generation. Mesons appear as
quark-antiquark excitations and baryons arise as non-topological solitons with
three valence quarks and a polarized Dirac sea. For the evaluation of the
baryon properties the present review concentrates on the non-linear
Nambu--Jona-Lasinio model with quark and Goldstone degrees of freedom which is
identical to the Chiral quark soliton model obtained from the instanton liquid
model of the QCD vacuum. In this non-linear model, a wide variety of
observables of baryons of the octet and decuplet is considered. These include,
in particular, electromagnetic, axial, pseudoscalar and pion nucleon form
factors and the related static properties like magnetic moments, radii and
coupling constants of the nucleon as well as the mass splittings and
electromagnetic form factors of hyperons. Predictions are given for the strange
form factors, the scalar form factor and the tensor charge of the nucleon.Comment: 104 pages, 27 figures as uuencoded and compressed postscript files ,
hardcopy available upon request; Prog.Part.Nucl.Phys. 37 (1996) (in print
Controlled ultraviolet (UV) photoinitiated fabrication of monolithic porous layer open tubular (monoPLOT) capillary columns for chromatographic applications
An automated column fabrication technique that is based on a ultraviolet (UV) light-emitting diode (LED) array oven, and provides precisely controlled "in-capillary" ultraviolet (UV) initiated polymerization at 365 nm, is presented for the production of open tubular monolithic porous polymer layer capillary (monoPLOT) columns of varying length, inner diameter (ID), and porous layer thickness. The developed approach allows the preparation of columns of varying length, because of an automated capillary delivery approach, with precisely controlled and uniform layer thickness and monolith morphology, from controlled UV power and exposure time. The relationships between direct exposure times, intensity, and layer thickness were determined, as were the effects of capillary delivery rate (indirect exposure rate), and multiple exposures on the layer thickness and axial distribution. Layer thickness measurements were taken by scanning electron microscopy (SEM), with the longitudinal homogeneity of the stationary phase confirmed using scanning capacitively coupled contactless conductivity detection (sC(4)D). The new automated UV polymerization technique presented in this work allows the fabrication of monoPLOT columns with a very high column-to-column production reproducibility, displaying a longitudinal phase thickness variation within ±0.8% RSD (relative standard deviation)
Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants
BACKGROUND: In 2003, severe acute respiratory syndrome coronavirus (SARS-CoV) was identified as the etiological agent of severe acute respiratory syndrome, a disease characterized by severe pneumonia that sometimes results in death. SARS-CoV is a zoonotic virus that crossed the species barrier, most likely originating from bats or from other species including civets, raccoon dogs, domestic cats, swine, and rodents. A SARS-CoV vaccine should confer long-term protection, especially in vulnerable senescent populations, against both the 2003 epidemic strains and zoonotic strains that may yet emerge from animal reservoirs. We report the comprehensive investigation of SARS vaccine efficacy in young and senescent mice following homologous and heterologous challenge. METHODS AND FINDINGS: Using Venezuelan equine encephalitis virus replicon particles (VRP) expressing the 2003 epidemic Urbani SARS-CoV strain spike (S) glycoprotein (VRP-S) or the nucleocapsid (N) protein from the same strain (VRP-N), we demonstrate that VRP-S, but not VRP-N vaccines provide complete short- and long-term protection against homologous strain challenge in young and senescent mice. To test VRP vaccine efficacy against a heterologous SARS-CoV, we used phylogenetic analyses, synthetic biology, and reverse genetics to construct a chimeric virus (icGDO3-S) encoding a synthetic S glycoprotein gene of the most genetically divergent human strain, GDO3, which clusters among the zoonotic SARS-CoV. icGD03-S replicated efficiently in human airway epithelial cells and in the lungs of young and senescent mice, and was highly resistant to neutralization with antisera directed against the Urbani strain. Although VRP-S vaccines provided complete short-term protection against heterologous icGD03-S challenge in young mice, only limited protection was seen in vaccinated senescent animals. VRP-N vaccines not only failed to protect from homologous or heterologous challenge, but resulted in enhanced immunopathology with eosinophilic infiltrates within the lungs of SARS-CoV–challenged mice. VRP-N–induced pathology presented at day 4, peaked around day 7, and persisted through day 14, and was likely mediated by cellular immune responses. CONCLUSIONS: This study identifies gaps and challenges in vaccine design for controlling future SARS-CoV zoonosis, especially in vulnerable elderly populations. The availability of a SARS-CoV virus bearing heterologous S glycoproteins provides a robust challenge inoculum for evaluating vaccine efficacy against zoonotic strains, the most likely source of future outbreaks
The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation
Respiratory syncytial virus (RSV) is an important cause of acute respiratory disease in infants, immunocompromised subjects and the elderly. However, it is unclear why most primary RSV infections are associated with relatively mild symptoms, whereas some result in severe lower respiratory tract infections and bronchiolitis. Since RSV hospitalization has been associated with respiratory bacterial co-infections, we have tested if bacterial Toll-like receptor (TLR) agonists influence RSVA2- GFP infection in human primary cells or cell lines. The synthetic bacterial lipopeptide Pam3-Cys-Ser-Lys4 (Pam3CSK4), the prototype ligand for the heterodimeric TLR1/TLR2 complex, enhanced RSV infection in primary epithelial, myeloid and lymphoid cells. Surprisingly, enhancement was optimal when lipopeptides and virus were added simultaneously, whereas addition of Pam3CSK4 immediately after infection had no effect. We have identified two structurally related lipopeptides without TLR-signaling capacity that also modulate RSV infection, whereas Pam3CSK4-reminiscent TLR1/2 agonists did not, and conclude that modulation of infection is independent of TLR activation. A similar TLR-independent enhancement of infection could also be demonstrated for wild-type RSV strains, and for HIV-1, measles virus and human metapneumovirus. We show that the effect of Pam3CSK4 is primarily mediated by enhanced binding of RSV to its target cells. The Npalmitoylated cystein
A reduction in CD90 (THY-1) expression results in increased differentiation of mesenchymal stromal cells
Controlled Ultraviolet (UV) Photoinitiated Fabrication of Monolithic Porous Layer Open Tubular (monoPLOT) Capillary Columns for Chromatographic Applications
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
Meeting abstrac
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