Synthèse CIRED 2015 Rapport sur le Congrès International des Réseaux Electriques de Distribution

International audienceUne synthèse globale de la conférence CIRED 2015 fait par des doctorants de plusieurs écoles

The Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode

Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even more degraded than those of closely related Rickettsia species, Wolbachia has retained more intact metabolic pathways. The ability to provide riboflavin, flavin adenine dinucleotide, heme, and nucleotides is likely to be Wolbachia's principal contribution to the mutualistic relationship, whereas the host nematode likely supplies amino acids required for Wolbachia growth. Genome comparison of the Wolbachia endosymbiont of B. malayi (wBm) with the Wolbachia endosymbiont of Drosophila melanogaster (wMel) shows that they share similar metabolic trends, although their genomes show a high degree of genome shuffling. In contrast to wMel, wBm contains no prophage and has a reduced level of repeated DNA. Both Wolbachia have lost a considerable number of membrane biogenesis genes that apparently make them unable to synthesize lipid A, the usual component of proteobacterial membranes. However, differences in their peptidoglycan structures may reflect the mutualistic lifestyle of wBm in contrast to the parasitic lifestyle of wMel. The smaller genome size of wBm, relative to wMel, may reflect the loss of genes required for infecting host cells and avoiding host defense systems. Analysis of this first sequenced endosymbiont genome from a filarial nematode provides insight into endosymbiont evolution and additionally provides new potential targets for elimination of cutaneous and lymphatic human filarial disease

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) has heterogeneous clinical and biological behavior. Whole-genome and -exome sequencing has contributed to the characterization of the mutational spectrum of the disease, but the underlying transcriptional profile is still poorly understood. We have performed deep RNA sequencing in different subpopulations of normal B-lymphocytes and CLL cells from a cohort of 98 patients, and characterized the CLL transcriptional landscape with unprecedented resolution. We detected thousands of transcriptional elements differentially expressed between the CLL and normal B cells, including protein-coding genes, noncoding RNAs, and pseudogenes. Transposable elements are globally derepressed in CLL cells. In addition, two thousand genes-most of which are not differentially expressed-exhibit CLL-specific splicing patterns. Genes involved in metabolic pathways showed higher expression in CLL, while genes related to spliceosome, proteasome, and ribosome were among the most down-regulated in CLL. Clustering of the CLL samples according to RNA-seq derived gene expression levels unveiled two robust molecular subgroups, C1 and C2. C1/C2 subgroups and the mutational status of the immunoglobulin heavy variable (IGHV) region were the only independent variables in predicting time to treatment in a multivariate analysis with main clinico-biological features. This subdivision was validated in an independent cohort of patients monitored through DNA microarrays. Further analysis shows that B-cell receptor (BCR) activation in the microenvironment of the lymph node may be at the origin of the C1/C2 differences

SELNET clinical practice guidelines for bone sarcoma

Bone sarcoma are infrequent diseases, representing < 0.2% of all adult neoplasms. A multidisciplinary management within reference centers for sarcoma, with discussion of the diagnostic and therapeutic strategies within an expert multidisciplinary tumour board, is essential for these patients, given its heterogeneity and low frequency. This approach leads to an improvement in patient's outcome, as demonstrated in several studies. The Sarcoma European Latin-American Network (SELNET), aims to improve clinical outcome in sarcoma care, with a special focus in Latin-American countries. These Clinical Practice Guidelines (CPG) have been developed and agreed by a multidisciplinary expert group (including medical and radiation oncologist, surgical oncologist, orthopaedic surgeons, radiologist, pathologist, molecular biologist and representatives of patients advocacy groups) of the SELNET consortium, and are conceived to provide the standard approach to diagnosis, treatment and follow-up of bone sarcoma patients in the Latin-American context

Evaluation of the impact of Smart Grid on planning practices with distributed generation and flexible loads

Les réseaux intelligents, ou Smart Grids, résultent de la combinaison des réseaux électriques et des nouvelles technologies de l'information et de la communication. Ils s'accompagnent de changements de paradigmes comme l'insertion importante de production décentralisée et le développement de nouveaux modes de consommation, comme les véhicules électriques et les « consom'acteurs ». Des contraintes apparaissent ainsi sur des réseaux vieillissants et non dimensionnés pour ces nouveaux usages. Cette thèse étudie l'impact des nouveaux paradigmes sur les techniques de planification des réseaux électriques de distribution. Un premier outil utilisant un algorithme de recuit simulé adapté et des méthodes issues de la théorie des graphes a été développé pour dimensionner les réseaux à moindre coût, selon les règles usuelles de planification. Dans un second temps, une méthodologie combinant une approche de type Monte Carlo et la construction de profils annuels de charge a été proposée pour analyser l'impact de la production décentralisée et des véhicules électriques dans un contexte soumis à des incertitudes. La troisième étape du travail a été de mettre en place des fonctions avancées de conduite comme alternative aux solutions de renforcement, très coûteuses. Un regard particulier est porté sur les stratégies d'effacement. Enfin, une nouvelle planification opérationnelle combinant les précédents outils développés a été créée afin d'évoluer vers une planification des réseaux intelligents.The Smart Grids are the combination of electrical networks and new information and communication technologies. They deal with a change of paradigms that are the insertion of distributed generation and the development of new forms of consumption, such as electric vehicles and prosumers. These changes induce many constraints on networks both aging and historically not sized for this context. This thesis studies the impact of these paradigms on the rules for electrical distribution networks planning. A first tool using an adapted simulated annealing algorithm and methods from graph theory was developed to size the networks at low cost, according to the usual rules for planning. Secondly, a methodology combining a Monte Carlo approach and the construction of annual load profiles was proposed to analyze the impact of distributed generation and electric vehicles in an environment subject to uncertainties. The third stage of the work was to implement advanced distribution automations as an alternative to reinforcement, which is very expensive. This part is focused on demand side management. Finally, a new operational planning combining the previous developed tools was created to move towards the planning of the Smart Grids

Évaluation de l’impact du Smart Grid sur les pratiques de planification en cas d’insertion de production décentralisée et de charges flexibles

The Smart Grids are the combination of electrical networks and new information and communication technologies. They deal with a change of paradigms that are the insertion of distributed generation and the development of new forms of consumption, such as electric vehicles and prosumers. These changes induce many constraints on networks both aging and historically not sized for this context. This thesis studies the impact of these paradigms on the rules for electrical distribution networks planning. A first tool using an adapted simulated annealing algorithm and methods from graph theory was developed to size the networks at low cost, according to the usual rules for planning. Secondly, a methodology combining a Monte Carlo approach and the construction of annual load profiles was proposed to analyze the impact of distributed generation and electric vehicles in an environment subject to uncertainties. The third stage of the work was to implement advanced distribution automations as an alternative to reinforcement, which is very expensive. This part is focused on demand side management. Finally, a new operational planning combining the previous developed tools was created to move towards the planning of the Smart Grids.Les réseaux intelligents, ou Smart Grids, résultent de la combinaison des réseaux électriques et des nouvelles technologies de l'information et de la communication. Ils s'accompagnent de changements de paradigmes comme l'insertion importante de production décentralisée et le développement de nouveaux modes de consommation, comme les véhicules électriques et les « consom'acteurs ». Des contraintes apparaissent ainsi sur des réseaux vieillissants et non dimensionnés pour ces nouveaux usages. Cette thèse étudie l'impact des nouveaux paradigmes sur les techniques de planification des réseaux électriques de distribution. Un premier outil utilisant un algorithme de recuit simulé adapté et des méthodes issues de la théorie des graphes a été développé pour dimensionner les réseaux à moindre coût, selon les règles usuelles de planification. Dans un second temps, une méthodologie combinant une approche de type Monte Carlo et la construction de profils annuels de charge a été proposée pour analyser l'impact de la production décentralisée et des véhicules électriques dans un contexte soumis à des incertitudes. La troisième étape du travail a été de mettre en place des fonctions avancées de conduite comme alternative aux solutions de renforcement, très coûteuses. Un regard particulier est porté sur les stratégies d'effacement. Enfin, une nouvelle planification opérationnelle combinant les précédents outils développés a été créée afin d'évoluer vers une planification des réseaux intelligents

Stochastic integration of demand response and reconfiguration in distribution network expansion planning

International audienc

Stochastic integration of demand response and reconfiguration in distribution network expansion planning

International audienc