A survey of the facilities of twenty-seven philanthropic day nurseries and nursery schools in Boston

Thesis (M.A.)--Boston University, 1948. This item was digitized by the Internet Archive

Predicting and Manipulating Cardiac Drug Inactivation by the Human Gut Bacterium Eggerthella lenta

Despite numerous examples of the effects of the human gastrointestinal microbiome on drug efficacy and toxicity, there is often an incomplete understanding of the underlying mechanisms. Here, we dissect the inactivation of the cardiac drug digoxin by the gut Actinobacterium Eggerthella lenta. Transcriptional profiling, comparative genomics, and culture-based assays revealed a cytochrome-encoding operon up-regulated by digoxin, inhibited by arginine, absent in nonmetabolizing E. lenta strains, and predictive of digoxin inactivation by the human gut microbiome. Pharmacokinetic studies using gnotobiotic mice revealed that dietary protein reduces the in vivo microbial metabolism of digoxin, with significant changes to drug concentration in the serum and urine. These results emphasize the importance of viewing pharmacology from the perspective of both our human and microbial genomes.Chemistry and Chemical Biolog

Chilean trade 1880-1930: A comment on the sources for the Age of Exports

This research note discusses the accuracy of the main sources used to study the foreign sector during the export-led growth process in Chile. Chilean foreign trade statistics are available for the period under analysis (1850-1930) and offered a good overview of products exported and imported. Bilateral trade data are also available providing information of exports and imports by origin and destiny. Although more research is needed on trade prices, we conclude that Chilean statistics are reliable and provide a way for understanding the export-led growth in Chile and the trade performance of the Chilean partners

Citizenship or repression? Coca, eradication and development in the Andes

For over two decades the US has funded repressive forced coca eradication in Peru, Colombia and Bolivia to reduce the illegal cocaine trade. These policies have never met their stated goals and have generated violence and poverty. In 2006 Bolivia definitively broke with the US anti-narcotics model, replacing the militarized eradication of coca crops with a community-based coca control strategy. The program substantially reduced the coca crop while simultaneously respecting human rights and allowing farmers to diversify their livelihoods. This article outlines the elements of the Bolivian initiative that ensure its continued successful functioning. It explores to what extent this model can be translated to other Andean contexts

Failure to launch: cost of living and living standards in Peru during the 19th century

Based on a variety of archival sources, this paper presents estimations for cost of living and living standards for Lima, Peru during the 19th century. During this century Peru experienced deep swings in economic activity marked by the independence wars, the War of the Pacific, and a commodity boom. These new series show that a sizable inflationary period during the guano age had dampening effects on the living standards of the popular class. While living standards peaked by mid 1850s, GDP per capita did not do so until two decades later. These results suggest that the guano bonanza failed to lift working-class living standards above subsistence levels. Even though living standards climbed steadily, almost reaching those of England, all these gains were lost by the end of the century.Basado en diversas fuentes primarias, este artículo presenta estimaciones de costo de vida y estándares de vida para Lima, Perú durante el siglo XIX. Durante esta centuria este país sufrió profundos vaivenes en la actividad económica debido a las guerras de la independencia, la guerra del Pacífico y a un auge monoexportador. Estas series delinean un importante proceso inflacionario durante la era del guano que tuvo efectos adversos en los estándares de vida de la clase popular. Mientras que los estándares de vida llegaron a su punto máximo en los mediados de la década de los 50, el PIB per cápita lo hizo dos décadas más tarde. Estos resultados sugieren que la bonanza del guano no logró mejorar el bienestar económico de la clase popular de manera sustentable. A pesar de alcanzar niveles cercanos al inglés, estos beneficios se evaporaron al fin de siglo

The rise of drug dealing in the life of the North American street gang

Historical gang literature traditionally perceived street gangs as boisterous outfits occasionally engaged in delinquency. In recent decades however, street gang behavior has come to be seen ever more as encroaching upon criminality, primarily due to its involvement in drug supply. This article aims to provide a brief historical review as to how the practice of drug supply entered into the life of the street gang, with specific emphasis on The War on Drugs in the 1970s and the rise of the crack cocaine economy in the 1980s

HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation

Purpose of review Despite HIV therapy advances, average life expectancy in HIV-infected individuals on effective treatment is significantly decreased relative to uninfected persons, largely because of increased incidence of inflammation-related diseases, such as cardiovascular disease and renal dysfunction. The enteric microbial community could potentially cause this inflammation, as HIV-driven destruction of gastrointestinal CD4+ T cells may disturb the microbiota–mucosal immune system balance, disrupting the stable gut microbiome and leading to further deleterious host outcomes. Recent findings Varied enteric microbiome changes have been reported during HIV infection, but unifying patterns have emerged. Community diversity is decreased, similar to pathologies such as inflammatory bowel disease, obesity, and Clostridium difficile infection. Many taxa frequently enriched in HIV-infected individuals, such as Enterobacteriaceae and Erysipelotrichaceae, have pathogenic potential, whereas depleted taxa, such as Bacteroidaceae and Ruminococcaceae, are more linked with anti-inflammatory properties and maintenance of gut homeostasis. The gut viral community in HIV has been found to contain a greater abundance of pathogenesis-associated Adenoviridae and Anelloviridae. These bacterial and viral changes correlate with increased systemic inflammatory markers, such as serum sCD14, sCD163, and IL-6. Summary Enteric microbial community changes may contribute to chronic HIV pathogenesis, but more investigation is necessary, especially in the developing world population with the greatest HIV burden (Video, Supplemental Digital Content 1, which includes the authors’ summary of the importance of the work)

Becoming coca: A materiality approach to a commodity chain analysis of hoja de coca in Colombia

Coca is a controversial plant, existing on the boundary between legality and illegality. This study aims at providing an analytical technique for discussing the problematic of coca in Colombia. Using new theoretical propositions in human geography, a more‐than‐human approach is adopted to encounter coca holistically. The results are a narrative account of coca's social life as experienced by the researcher following its network of non‐cocaine derivatives. An analytical section invokes the Foucauldian dispositif to the drug trade and utilizes concepts of informed materials and technological zones to describe coca outside a political economy discourse. The research finds that coca's dynamic materiality complicates it as a commodity and that these conventional approaches do not fully encapsulate this complexity. By grappling with the messiness of coca's materiality, this paper reveals the multiplicity and interplay of coca's definitions, which lie at the heart of many conflicts