44 research outputs found
Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life.
- Publication venue
- Health Sciences Research Commons
- Publication date
- 01/04/2018
- Field of study
Human respiratory conditions are largely influenced by the individual\u27s sex resulting in overall higher risk for males. Sex-based respiratory differences are present at birth suggesting a strong genetic component. Our objective was to characterize early life sex-based genomic signatures determined by variable X-chromosome methylation in the airways. We compared male versus female genome-wide DNA methylation in nasal airway samples from newborns and infants aged 1-6 months (N = 12). We analyzed methylation signals across CpG sites mapped to each X-linked gene using an unsupervised classifier (principal components) followed by an internal evaluation and an exhaustive cross-validation. Results were validated in an independent population of children (N = 72) following the same algorithm. X-linked genes with significant sex-based differential methylation in the nasal airway of infants represented only about 50% of the unique protein coding transcripts. X-linked genes without significant sex-based differential methylation included genes with evidence of escaping X-inactivation and female-biased airway expression. These genes showed similar methylation patterns in males and females suggesting unbalanced X-chromosome dosage. In conclusion, we identified that the human airways have already sex-based DNA methylation signatures at birth. These early airway epigenomic marks may determine sex-based respiratory phenotypes and overall predisposition to develop respiratory disorders later in life
Coping with climatic extremes: Dietary fat content decreased the thermal resilience of barramundi (Lates calcarifer)
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/04/2019
- Field of study
Aquatic organisms, including important cultured species, are forced to contend with acute changes in water temperature as the frequency and intensity of extreme weather events worsen. Acute temperature spikes are likely to threaten aquaculture species, but dietary intervention may play an important protective role. Increasing the concentration of macronutrients, for example dietary fat content, may improve the thermal resilience of aquaculture species, however, this remains unexplored. To evaluate this hypothesis, we used two commercially available diets (20% versus 10% crude fat) to examine if dietary fat content improves the growth performance of juvenile barramundi (Lates calcarifer) while increasing their resilience to acute thermal stress. Fish were fed their assigned diets for 28-days before assessing the upper thermal tolerance (CTMAX) and the thermal sensitivity of swimming performance (UCRIT) and metabolism. We found that feeding fish a high fat diet resulted in heavier fish, but did not affect the thermal sensitivity of swimming performance or metabolism over an 18 °C temperature range (from 20 to 38 °C). Thermal tolerance was compromised in fish fed the high fat diet by 0.48 °C, showing significantly lower CTMAX. Together, these results suggest that while a high fat diet increases juvenile L. calcarifer growth, it does not benefit physiological performance across a range of relevant water temperatures and may even reduce fish tolerance of extreme water temperatures. These data may have implications for aquaculture production in a warming world, where episodic extremes of temperature are likely to become more frequent
An Indo-Pacific coral spawning database.
- Author
- Abrego D
- Alvarez-Noriega M
- Babcock RC
- Baird AH
- Barbosa MB
- Bauman AG
- Bonito V
- Bouwmeester J
- Burt J
- Cabaitan PC
- Chang C-F
- Chavanich S
- Chen C-J
- Chen CA
- Chen W-J
- Chung F-C
- Connolly SR
- Cumbo VR
- Dornelas M
- Doropoulos C
- Edwards AJ
- Eyal G
- Eyal-Shaham L
- Fadli N
- Figueiredo J
- Flot J-F
- Gan S-H
- Gomez E
- Graham EM
- Grinblat M
- Guest JR
- Gutiérrez-Isaza N
- Harii S
- Harrison PL
- Hatta M
- Ho NAJ
- Hoarau G
- Hoogenboom M
- Howells EJ
- Iguchi A
- Isomura N
- Jamodiong EA
- Jandang S
- Keyse J
- Kitanobo S
- Kongjandtre N
- Kuo C-Y
- Ligson C
- Lin C-H
- Low J
- Loya Y
- Maboloc EA
- Madin JS
- Mera H
- Mezaki T
- Min C
- Morita M
- Moya A
- Neo S-H
- Nitschke MR
- Nojima S
- Nozawa Y
- Piromvaragorn S
- Plathong S
- Puill-Stephan E
- Quigley K
- Ramirez-Portilla C
- Ricardo G
- Sakai K
- Sampayo E
- Shlesinger T
- Sikim L
- Simpson C
- Sims CA
- Sinniger F
- Spiji DA
- Tabalanza T
- Tan C-H
- Terraneo TI
- Torda G
- True J
- Tun K
- Vicentuan K
- Viyakarn V
- Waheed Z
- Ward S
- Willis B
- Woods RM
- Woolsey ES
- Yamamoto HH
- Yusuf S
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 12/01/2022
- Field of study
The discovery of multi-species synchronous spawning of scleractinian corals on the Great Barrier Reef in the 1980s stimulated an extraordinary effort to document spawning times in other parts of the globe. Unfortunately, most of these data remain unpublished which limits our understanding of regional and global reproductive patterns. The Coral Spawning Database (CSD) collates much of these disparate data into a single place. The CSD includes 6178 observations (3085 of which were unpublished) of the time or day of spawning for over 300 scleractinian species in 61 genera from 101 sites in the Indo-Pacific. The goal of the CSD is to provide open access to coral spawning data to accelerate our understanding of coral reproductive biology and to provide a baseline against which to evaluate any future changes in reproductive phenology
Asymptomatic internal carotid artery stenosis and cerebrovascular risk stratification
- Author
- Abbott AL
- Adovasio R
- Aloi T
- Alò FP
- Ambrosio G
- Andreadis EA
- Andreev A
- Andreozzi GM
- Arosio E
- Arrigucci S
- Aston S
- Barkauskas E
- Barros D'Sa AA
- Batchvarova V
- Belardi P
- Bell P
- Biasi GM
- Bicchi M
- Blinc A
- Bobelyn M
- Bornstein NM
- Bosone D
- Bouchier-Hayes D
- Brannigan P
- Cairols MA
- Camporese G
- Cao PG
- Cappeli R
- Carboni GP
- Cardaiolli G
- Catalano M
- Chambers B
- Cicilioni CG
- Clement D
- Coccheri S
- Conforti M
- Conti E
- De Rango P
- De Rango P
- Dennis MS
- Diamantopoulos E
- Dickinson A
- Dimakakos PB
- Doré CJ
- Dramov A
- Eikelboom B
- Entz L
- Faintuch JM
- Fernandes e Fernandes J
- Ferrari-Bardile
- Finocchi C
- Fitzgerald DE
- Fitzgerald P
- Fletcher J
- Forconi S
- Galanis P
- Gallai V
- Geoffredo C
- Geroulakos G
- Geroulakos G
- Giannoukas A
- Goetzmann M
- Gomez-Isaza LF
- Gorgoyannis G
- Graf M
- Griffin M
- Gronholdt ML
- Guarini P
- Hardy S
- Harris P
- Hottermans C
- Iosa G
- Kakkos S
- Kakkos S
- Kakkos SK
- Katsamouris A
- Kotsis T
- Krzanowski
- Krzanowski M
- Kyriacou E
- Labropoulos N
- Ladurner G
- Leal-Monedero J
- Lee BB
- Levison R
- Liapis C
- Liasis N
- Liboni W
- Mannarino E
- Matticari S
- McCollum P
- Micieli G
- Middleton L
- Minar E
- Mingazzini P
- Moggi L
- Moonen Taylor PR
- Morris TP
- Naylor R
- Negreira J
- Nenci G
- Nicolaides A
- Nicolaides AN
- Norgren L
- Novelli GP
- Novo S
- O'Shaunnersy A
- Olinic D
- Paaske W
- Pagliara V
- Pagnan A
- Pantziaris M
- Pauletto P
- Pavanelli E
- Pedro L
- Pettina G
- Polivka J
- Poredos P
- Pratesi C
- Pujia A
- Radicchia S
- Raso A
- Ribbe E
- Rispoli P
- Robinson T
- Rodriguez G
- Rosfors S
- Rudofsky G
- Sabetai M
- Sadzot B
- Salerno M
- Scarpelli P
- Schroeder T
- Sevcik P
- Simoni G
- Simoni G
- Spartera C
- Sprynger M
- Tantillo R
- Tegos T
- Thomas D
- Thomas DJ
- Tovar-Pardo A
- Tyllis T
- Valaikiené J
- Vaudo G
- Vayssairat M
- Ventura M
- Verlato F
- Videcnik V
- Walker MG
- Wilkinson AR
- Willfort A
- Ziani B
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2010
- Field of study
Background The purpose of this study was to determine the cerebrovascular risk stratification potential of baseline degree of stenosis, clinical features, and ultrasonic plaque characteristics in patients with asymptomatic internal carotid artery (ICA) stenosis. Methods This was a prospective, multicenter, cohort study of patients undergoing medical intervention for vascular disease. Hazard ratios for ICA stenosis, clinical features, and plaque texture features associated with ipsilateral cerebrovascular or retinal ischemic (CORI) events were calculated using proportional hazards models. Results A total of 1121 patients with 50% to 99% asymptomatic ICA stenosis in relation to the bulb (European Carotid Surgery Trial [ECST] method) were followed-up for 6 to 96 months (mean, 48). A total of 130 ipsilateral CORI events occurred. Severity of stenosis, age, systolic blood pressure, increased serum creatinine, smoking history of more than 10 pack-years, history of contralateral transient ischemic attacks (TIAs) or stroke, low grayscale median (GSM), increased plaque area, plaque types 1, 2, and 3, and the presence of discrete white areas (DWAs) without acoustic shadowing were associated with increased risk. Receiver operating characteristic (ROC) curves were constructed for predicted risk versus observed CORI events as a measure of model validity. The areas under the ROC curves for a model of stenosis alone, a model of stenosis combined with clinical features and a model of stenosis combined with clinical, and plaque features were 0.59 (95% confidence interval [CI] 0.54-0.64), 0.66 (0.62-0.72), and 0.82 (0.78-0.86), respectively. In the last model, stenosis, history of contralateral TIAs or stroke, GSM, plaque area, and DWAs were independent predictors of ipsilateral CORI events. Combinations of these could stratify patients into different levels of risk for ipsilateral CORI and stroke, with predicted risk close to observed risk. Of the 923 patients with <70% stenosis, the predicted cumulative 5-year stroke rate was <5% in 495, 5% to 9.9% in 202, 10% to 19.9% in 142, and <20% in 84 patients. Conclusion Cerebrovascular risk stratification is possible using a combination of clinical and ultrasonic plaque features. These findings need to be validated in additional prospective studies of patients receiving optimal medical intervention alone. Copyright © 2010 by the Society for Vascular Surgery
The size of juxtaluminal hypoechoic area in ultrasound images of asymptomatic carotid plaques predicts the occurrence of stroke
- Author
- A. Andreev
- A. Blinc
- A. Dickinson
- A. Dramov
- A. Ferrari-Bardile
- A. Giannoukas
- A. Katsamouris
- A. Nicolaides
- A. Pagnan
- A. Pujia
- A. Raso
- A. Tovar-Pardo
- A. Willfort
- A.A.B. Barros D&apos
- A.M. O&apos
- A.N. Nicolaides
- A.R. Wilkinson
- B. Chambers
- B. Eikelboom
- B. Sadzot
- B. Ziani
- B.B. Lee
- C. Finocchi
- C. Geoffredo
- C. Hottermans
- C. Liapis
- C. Pratesi
- C. Spartera
- C.G. Cicilioni
- D. Bosone
- D. Bouchier-Hayes
- D. Clement
- D. Olinic
- D. Thomas
- D.E. Fitzgerald
- D.J. Thomas
- E. Arosio
- E. Barkauskas
- E. Conti
- E. Diamantopoulos
- E. Kyriacou
- E. Mannarino
- E. Minar
- E. Pavanelli
- E. Ribbe
- E.A. Andreadis
- F. Verlato
- F.P. Alo
- G. Ambrosio
- G. Camporese
- G. Cardaiolli
- G. Geroulakos
- G. Geroulakos
- G. Gorgoyannis
- G. Iosa
- G. Ladurner
- G. Micieli
- G. Nenci
- G. Pettina
- G. Rodriguez
- G. Rudofsky
- G. Simoni
- G. Simoni
- G. Vaudo
- G.C. Makris
- G.M. Andreozzi
- G.M. Biasi
- G.P. Carboni
- G.P. Novelli
- J. Fernandes E Fernandes
- J. Fletcher
- J. Leal-Monedero
- J. Negreira
- J. Polivka
- J. Valaikiene
- J.M. Faintuch
- L. Entz
- L. Middleton
- L. Moggi
- L. Norgren
- L. Pedro
- L.F. Gomez-Isaza
- M. Bicchi
- M. Bobelyn
- M. Catalano
- M. Conforti
- M. Goetzmann
- M. Graf
- M. Krzanowski
- M. Moonen
- M. Pantziaris
- M. Salerno
- M. Sprynger
- M. Vayssairat
- M. Ventura
- M.A. Cairols
- M.B. Griffin
- M.G. Walker
- M.L. Gronholdt
- M.M. Sabetai
- M.S.J. Dennis
- N. Liasis
- N.M. Bornstein
- P. Belardi
- P. Bell
- P. Brannigan
- P. Derango
- P. Derango
- P. Fitzgerald
- P. Galanis
- P. Guarini
- P. Harris
- P. Mccollum
- P. Mingazzini
- P. Pauletto
- P. Poredos
- P. Rispoli
- P. Scarpelli
- P. Sevcik
- P.B. Dimakakos
- P.G. Cao
- P.R. Taylor
- R. Adovasio
- R. Cappeli
- R. Levison
- R. Tantillo
- S. Arrigucci
- S. Aston
- S. Coccheri
- S. Forconi
- S. Hardy
- S. Kakkos
- S. Kakkos
- S. Matticari
- S. Novo
- S. Radicchia
- S. Rosfors
- S.K. Kakkos
- T. Aloi
- T. Kotsis
- T. Robinson
- T. Schroeder
- T. Tegos
- T. Tyllis
- V. Batchvarova
- V. Gallai
- V. Pagliara
- V. Videcnik
- W. Liboni
- W. Paaske
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Objective: To test the hypothesis that the size of a juxtaluminal black (hypoechoic) area (JBA) in ultrasound images of asymptomatic carotid artery plaques predicts future ipsilateral ischemic stroke. Methods: A JBA was defined as an area of pixels with a grayscale value <25 adjacent to the lumen without a visible echogenic cap after image normalization. The size of a JBA was measured in the carotid plaque images of 1121 patients with asymptomatic carotid stenosis 50% to 99% in relation to the bulb (Asymptomatic Carotid Stenosis and Risk of Stroke study); the patients were followed for up to 8 years. Results: The JBA had a linear association with future stroke rate. The area under the receiver-operating characteristic curve was 0.816. Using Kaplan-Meier curves, the mean annual stroke rate was 0.4% in 706 patients with a JBA <4 mm 2, 1.4% in 171 patients with a JBA 4 to 8 mm2, 3.2% in 46 patients with a JBA 8 to 10 mm2, and 5% in 198 patients with a JBA >10 mm2 (P <.001). In a Cox model with ipsilateral ischemic events (amaurosis fugax, transient ischemic attack [TIA], or stroke) as the dependent variable, the JBA (<4 mm2, 4-8 mm2, >8 mm2) was still significant after adjusting for other plaque features known to be associated with increased risk, including stenosis, grayscale median, presence of discrete white areas without acoustic shadowing indicating neovascularization, plaque area, and history of contralateral TIA or stroke. Plaque area and grayscale median were not significant. Using the significant variables (stenosis, discrete white areas without acoustic shadowing, JBA, and history of contralateral TIA or stroke), this model predicted the annual risk of stroke for each patient (range, 0.1%-10.0%). The average annual stroke risk was <1% in 734 patients, 1% to 1.9% in 94 patients, 2% to 3.9% in 134 patients, 4% to 5.9% in 125 patients, and 6% to 10% in 34 patients. Conclusions: The size of a JBA is linearly related to the risk of stroke and can be used in risk stratification models. These findings need to be confirmed in future prospective studies or in the medical arm of randomized controlled studies in the presence of optimal medical therapy. In the meantime, the JBA may be used to select asymptomatic patients at high stroke risk for carotid endarterectomy and spare patients at low risk from an unnecessary operation
An Indo-Pacifc coral spawning database
- Author
- Abrego David
- Alvera-Noriega Mariana
- Babcock Russel C
- Baird Andrew H
- Barbosa Miguel B
- Bauman Andrew G
- Bonito Victor
- Bouwmeester Jessica
- Burt John
- Cabaitan Patrick C
- Chang Ching-Fong
- Chavanich Suchana
- Chen Chaolun A
- Chen Chieh-Jhen
- Chen Wei-Jen
- Chung Fung-Chen
- Connolly Sean R
- Cumbo Vivian R
- Dornelas Maria
- Doropoulos Christopher
- Edwards Alasdair J
- Eyal Gal
- Eyal-Shaham Lee
- Fadli Nur
- Figueiredo Joana
- Flot Jean-François
- Gan Sze-Hoon
- Gomez Elizabeth
- Graham Erin M
- Grinblat Mila
- Guest James R
- Gutiérrez-Isaza Nataly
- Harii Saki
- Harrison Peter L
- Hatta Masayuki
- Ho Nina Ann Jin
- Hoarau Gaetan
- Hoogenboom Mia
- Howells Emily J
- Iguchi Akira
- Isomura Naoko
- Jamodiong Emmeline A
- Jandang Suppakarn
- Keyse Jude
- Kitanobo Seiya
- Kongjandtre Narinratana
- Kuo Chao-Yang
- Ligson Charlon
- Lin Che-Hung
- Low Jeffrey
- Loya Yossi
- Maboloc Elizaldy A
- Madin Joshua S
- Mera Hanaka
- Mezaki Takuma
- Min Choo
- Morita Masaya
- Moya Aurelie
- Neo Su-Hwei
- Nitschke Matthew R
- Nojima Satoshi
- Nozawa Yoko
- Piromvaragorn Srisakul
- Plathong Sakanan
- Puill-Stephan Eneour
- Quigley Kate
- Ramirez-Portilla Catalina
- Ricardo Gerard
- Sakai Kazuhiko
- Sampayo Eugenia
- Shlesinger Tom
- Sikim Leony
- Simpson Chris
- Sims Carrie A
- Sinniger Frederic
- Spiji Davies A
- Tabalanza Tracy
- Tan Chung-Hong
- Terraneo Tullia I
- Torda Gergely
- True James
- Tun Karenne
- Vicentuan Kareen
- Viyakarn Voranop
- Waheed Zarinah
- Ward Selina
- Willis Bette
- Woods Rachael M
- Woolsey Erika S
- Yamamoto Hiromi H
- Yusuf Syafyudin
- Publication venue
- NSUWorks
- Publication date
- 29/01/2021
- Field of study
The discovery of multi-species synchronous spawning of scleractinian corals on the Great Barrier Reef in the 1980s stimulated an extraordinary effort to document spawning times in other parts of the globe. Unfortunately, most of these data remain unpublished which limits our understanding of regional and global reproductive patterns. The Coral Spawning Database (CSD) collates much of these disparate data into a single place. The CSD includes 6178 observations (3085 of which were unpublished) of the time or day of spawning for over 300 scleractinian species in 61 genera from 101 sites in the Indo-Pacific. The goal of the CSD is to provide open access to coral spawning data to accelerate our understanding of coral reproductive biology and to provide a baseline against which to evaluate any future changes in reproductive phenology
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
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- A Yacoub M.
- A. Adam M.
- A. Nassar M.
- A. Nemer A.
- Aahlin E. K.
- Ab Rahim M. F.
- Abad Gurumeta A.
- Abad-Motos A.
- Abang Jamari D. Z. H.
- Abantanga F.
- Abarca S.
- Abazid E.
- Abbas A.
- Abbas K.
- Abbas M. M.
- Abbasy J.
- Abbosh A.
- Abd B.
- Abd Karim M. F. S.
- Abd Wahab H. H.
- Abdalei A.
- Abdalla Ahmed Elkamel A.
- Abdallah A.
- AbdAllah M. S. M.
- Abdel Malik A. B.
- Abdelhady Mousa H.
- Abdelhady S.
- Abdelhakim A.
- Abdelkader M.
- Abdelkawy S.
- Abdelkhalek M.
- Abdellatif E.
- Abdelmaksoud Tawakel N.
- Abdelmohsen N.
- Abdelmotaleb I.
- Abdelrazek A.
- Abdelsalam I.
- Abdelshakour M.
- Abdelwahed A. M.
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- Abdou A. O.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
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- Publication venue
- Oxford University Press (OUP)
- Publication date
- 01/07/2023
- Field of study
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
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- Shiwani Haaris
- Shmukler Daniel
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- Shrestha Rashmit
- Siboe Mark
- Sica Giuseppe
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- Singer Georg
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- Slavchev Mihail
- Sleem Adham
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- Smith A.
- Smolle-Juettner Freyja-Maria
- Sodhai Vivek
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- Suer Muhammed Salih
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- Sultania Mahesh
- Sundarraju Shalini
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- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
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- Yassin Abubaker
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- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries