The mechanisms underlying grammatical gender selection in language production: a meta-analysis of the gender congruency effect

Grammatical gender retrieval during language production has been largely addressed through the picture-word interference (PWI) paradigm, with the aim of capturing the so-called gender congruency effect (GCE). In the PWI paradigm, participants name target pictures while ignoring superimposed written distractor nouns. The GCE shows faster responses when target and distractor nouns share the same gender than when gender differs. Yet, the locus of this effect is not clear: it might be either due to the selection of a determiner or due to the selection of a gender node at the lemma level, which may be primed or delayed by competition. Importantly, many of those who argue that the GCE is not a genuine effect of gender conclude that gender is a feature that is retrieved automatically. Such a claim is controversial since the PWI paradigm has been seen as too complex and perhaps not sensitive enough to capture small effects. Besides, for Romance languages, mixed results draw a complex picture with effects occurring mainly in the opposite direction, i.e., a gender incongruency effect (GIE). In the present study, we conducted a meta-analysis of the 18 studies that have addressed this issue. The results confirm the existence of the GCE as a determiner effect in Germanic/Slavic languages, while little support is found for the GIE in Romance languages. Nevertheless, we argue that the absence of gender effects in Germanic and Slavic languages within the PWI paradigm cannot be taken as evidence of an absence of priming/competition during gender selection and thus as evidence of an automatic selection of gender. Parametric replication of previous studies, especially those featuring bound morphemes, together with the use of other measuring techniques such as event related potentials are suggested as a way forwardThis work was supported by the Government of Spain, Spanish Ministry of Education and Vocational Training, through the Training program for Academic Staff (Ayudas para la Formación del Profesorado Universitario, FPU [FPU16/06983]); the Spanish Ministry of Science and Innovation [research project PID2019-110583GB-I00]; the Galician Government [grant for research groups ED431B 2019/2020]; and the Foundation for Science and Technology of Portugal [IF / 00784/2013 / CP1158 / CT0013]. Finally, the study has also been partially supported by the FCT and the Portuguese Ministry of Science, Technology and Higher Education through national funds and co-financed by FEDER- European Regional Development Fund through COMPETE2020 under the PT2020 Partnership Agreement [POCI-01-0145- FEDER-007653]S

What a transparent Romance language with a Germanic gender-determiner mapping tells us about gender retrieval: Insights from European Portuguese

The study of the representation and processing of grammatical gender during language production has encountered mixed results regarding which conditions must be met to observe gender effects and whether these reflect the selection of gender values or competition between elements of agreement. The answer seems to depend on the number of determiners associated with each gender and on the language being explored. The present study aims to assess this issue through three picture-word interference tasks in European Portuguese. This is a transparent Romance language featuring a one-to-one gender-determiner mapping system similar to opaque Germanic languages. Conditions of gender in/congruency between targets and distractors were considered, along with gender transparency and agreement. We observed a gender congruency effect restricted to noun phrases. Importantly, the effect was modulated by transparency, which seems relevant regardless of agreement. To explain the results, we adapted the Dual-Route Model of language comprehension to productionThis work was supported by the Government of Spain, Ministry of Education and Vocational Training, through the Training program for Academic Staff (Ayudas para la Formación del Profesorado Universitario, FPU [FPU16/06983]); the Spanish Ministry of Science and Innovation [research project PID2019-110583GB-I00]; the Galician Government [grant for research groups ED431B 2022/2019]; and the Foundation for Science and Technology of Portugal [IF / 00784/2013 / CP1158 / CT0013]. Finally, the study has also been partially supported by the FCT and the Portuguese Ministry of Science, Technology and Higher Education through national funds and co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement [POCI-01-0145- FEDER-007653]S

Serão os sinónimos e as traduções processados de forma semelhante na mente bilingue?

Dissertação de mestrado integrado em PsicologiaAccording to the Multilink model (Dijkstra et al., 2018), words from the first (L1) and second (L2) language share a common store and their access is non-selective. Thus, the presentation of a target-word activates in parallel lexical candidates from both languages that share with it orthographic, phonological, and semantic overlap. The degree of words’ activation not only depends on the form and semantic overlap but also on their resting level of activation (i.e., words that are more used, usually L1 words, have a higher resting level of activation). Since translations and synonyms share meaning, they are seen as qualitatively similar lexical representations and so might be subject to a similar processing if their frequency levels are matched. The aim of the present study was to test the tenets of the Multilink model regarding the representation and processing of synonyms and translations by using a masked priming lexical decision task (LDT). Twenty-two unbalanced highly proficient bilinguals of European Portuguese and English were recruited for the task. In the LDT, English target words could be preceded either by synonyms or their corresponding unrelated English control prime words. One month later, the target words were preceded by their non-cognate European Portuguese translations or their corresponding unrelated European Portuguese control prime words. The order of the presentation was counterbalanced. Results showed no significant priming effects for synonyms nor translations.De acordo com o modelo Multilink (Dijkstra et al., 2018), as palavras de primeira (L1) e segunda (L2) língua partilham um armazenamento comum e o seu acesso é não-seletivo. Desta forma, a apresentação de uma palavra-alvo ativa, em paralelo, candidatos léxicos de ambas as línguas que partilham sobreposição ortográfica, fonológica e semântica com o alvo. O grau de ativação de palavras depende da forma, sobreposição ortográfica e semântica, bem como do seu nível de ativação em repouso (i.e., palavras usadas com mais frequência, usualmente palavras de L1, têm um maior nível de ativação em repouso). Dado que as traduções e sinónimos partilham significado, podem ser vistas como representações léxicas qualitativamente semelhantes e, portanto, sujeitas a um processamento similar se os níveis de frequência forem comparáveis. O presente estudo objetivou testar as assunções do modelo Multilink (Dijkstra et al., 2018) relativamente à representação e processamento dos sinónimos e traduções recorrendo a uma tarefa de decisão lexical com priming mascarado (TDL). Vinte e dois bilingues proficientes de Português Europeu e Inglês foram recrutados para a tarefa. Na TDL, palavras-alvo Inglesas eram precedidas pelo seu sinónimo ou por uma palavra Inglesa de controlo não relacionada. Após um mês, as palavras-alvo eram precedidas pela sua tradução em Português Europeu ou por uma palavra Portuguesa de controlo não relacionada. A ordem de apresentação dos primes foi contra balanceada. Os resultados não mostraram quaisquer efeitos significativos de priming para sinónimo ou traduções

Apparence et performance aux limites de la vision spatiale

La perception visuelle humaine est généralement étudiée en mesurant la performance. Cependant, cette mesure ne permet d'obtenir que des informations limitées sur la manière dont un stimulus est apparu aux observateurs. L'objectif général de cette thèse était de mieux comprendre comment les stimuli apparaissent aux observateurs aux limites de la vision spatiale. Pour l'étude 1, une interface interactive à grille carrée a été développée pour saisir l'apparence des stimuli en permettant aux observateurs de sélectionner des carrés sur les grilles pour obtenir des "espaces d'apparence" (c.-à-d. comment les ensembles de stimuli se présentent) des cibles présentées. L'apparence des symboles des cibles (optotypes) a été étudiée en dessous, au niveau et au-dessus de la limite de résolution visuelle des observateurs. Les résultats ont montré que les représentations sur les grilles variaient selon les observateurs, les cibles et les tailles, et ont révélé des erreurs caractéristiques jusqu'alors inconnues pour les cibles présentées autour de la limite de résolution visuelle. Dans l'étude 2, des tâches typiques de choix alternatif forcé ont été utilisées pour étudier l'apparence. L'expérience 2.1 visait à déterminer si l'apparence des cibles était partagée entre les observateurs. Les résultats n'ont montré aucune preuve de partage des espaces d'apparence au seuil et en dessous du seuil. L'expérience 2.2 a examiné la force de la relation entre les cibles physiques et leur apparence chez les participants. Lorsqu'on leur présentait une cible déjà vue, les participants déclaraient plus souvent que la forme initiale (canonique) de la cible correspondait le mieux à la cible qu'à n'importe quelle représentation de la cible précédemment capturée, ce qui indique que les relations entre les cibles et leur apparence déclarée peuvent être fortement modulées par d'autres facteurs, tels que les biais de déclaration des cibles canoniques. L'expérience 2.3 visait à déterminer si les observateurs identifiaient une cible en fonction de leurs propres représentations correspondantes (antérieures) de la cible. Les résultats ont montré qu'en présence de choix de réponses très distincts, la correspondance entre la cible et l'apparence était forte. Dans l'ensemble, cette thèse a permis de mettre au point un nouvel outil de capture de l'apparence et de l'appliquer à l'étude de la vision spatiale. Le travail actuel a révélé comment les stimuli apparaissent aux observateurs à la limite de la résolution visuelle et que l'apparence de la cible rapportée est fortement modulée par d'autres facteurs lorsque les catégories de réponses sont limitées. Les travaux futurs porteront sur l'utilisation de l'interface des grilles pour saisir l'apparence des stimuli en cas de dysfonctionnement visuel, sur l'étude de la cohérence de l'apparence dans d'autres conditions d'observation (par exemple, dans la périphérie visuelle), ainsi que sur l'utilisation de l'ophtalmoscopie laser à balayage par optique adaptative (AOSLO) pour démêler l'impact des aberrations optiques de l'œil des autres limitations neuronales possibles sur l'apparence des stimuli.Human visual perception is usually investigated by measuring performance. However, when measuring performance, only limited information on how a stimulus appeared to the observers is obtained. The general aim of this dissertation was to better understand how stimuli appear to observers at the limits of spatial vision. For Study 1, an interactive square-grid interface was developed to capture the appearance of stimuli by letting observers select squares on the grids to obtain ‘appearance spaces' (i.e., how sets of stimuli looked like) of the presented targets. The appearance of target symbols (optotypes) was investigated below, at and above observers' visual resolution limit. Results showed how depictions on the grids varied between observers, targets, and sizes, and revealed characteristic errors that were previously unknown for targets presented around the visual resolution limit. In Study 2, typical alternative-forced-choice tasks were used to investigate appearance. Experiment 2.1 investigated whether target appearance was shared across observers. Results showed no evidence for shared appearance spaces at and below threshold. Experiment 2.2 examined the strength of the relation between physical targets and their appearance within participants. When presented with a previously seen target, the initial (canonical) target shape was reported as the best target match more often than any of their previously captured target depictions, indicating that relations between targets and their reported appearance may be strongly modulated by other factors, such as biases to report canonical targets. Experiment 2.3 explored whether observers identify a target given their own corresponding (previous) target depictions. Results showed that given highly distinct response options, the mapping of target and appearance was strong. Taken together, in this dissertation a new tool to capture appearance has been developed and applied to investigate spatial vision. The current work has revealed how stimuli appear to observers at the visual resolution limit and that reported target appearance is strongly modulated by other factors when response categories are limited. Future work will focus on using the grids interface to capture the appearance of stimuli in cases of visual dysfunction; probing the consistency of appearance in other viewing conditions (e.g., in the visual periphery); as well as using adaptive optics scanning laser ophthalmoscopy (AOSLO) to disentangle the impact of the optical aberrations of the eye from other possible neural limitations on stimulus' appearance

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

7th drug hypersensitivity meeting: part one

Table of contents Oral Abstracts O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir Pirmohamed O2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture? Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel Yerly O3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivity Rebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, David Koelle, Abha Chopra, Craig Rive, Alec Redwood, Susana Restrepo, Austin Bracey, Jing Yuan, Silvana Gaudieri, Mary Carrington, David Haas, Simon Mallal, Elizabeth Phillips O4 Do we need to measure total ige for the interpretation of analytical results of ImmunoCAP dnd 3gAllergy specific IgE? Douwe De Boer, Paul Menheere, Chris Nieuwhof, Judith Bons O5 Neutrophil activation in systemic anaphylaxis: results from the multicentric NASA study Friederike Jonsson, Luc De Chaisemartin, Vanessa Granger, Caitlin Gillis, Aurelie Gouel, Catherine Neukirch, Fadia Dib, Pascale Roland Nicaise, Dan Longrois, Florence Tubach, Sylvie Martin, Pierre Bruhns, NASA Study Group O6 Purpuric drug eruptions due to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for non-small-cell lung cancer (NSCLC): a clinic-pathological study of 32 cases Kai-Lung Chen, Shu-Ling Liao, Yi-Shuan Sheen, Yung-Tsu Cho, Che-Wen Yang, Jau-Yu Liau, Chia-Yu Chu Poster presentations: Poster Walk 1—Anaphylaxis (P01–P09) P1 Anaphylactic reactions during anaesthesia and the perioperative period Rita Aguiar, Anabela Lopes, Natália Fernandes, Leonor Viegas, M. A. Pereira-Barbosa P2 Anaphylaxis to chlorhexidine: is there a cross-reactivity to alexidine? Antonia Bünter, Nisha Gupta, Tatjana Pecaric Petkovic, Nicole Wirth, Werner J. Pichler, Oliver Hausmann P3 Cefotaxime-induced severe anaphylaxis in a neonate Mehtap Yazicioglu, Pinar G. Ozdemir, Gokce Ciplak, Ozkan Kaya P4 Clinical features and diagnosis of anaphylaxis resulting from exposure to chlorhexidine Peter John Cooke P5 Drug-induced anaphylaxis: five-year single-center survey Inês Mota, Ângela Gaspar, Filipe Benito-Garcia, Marta Chambel, Mário Morais-Almeida P6 Intraoperative severe anaphylactic reaction due to patent blue v dye Luis Marques, Eva Alcoceba, Silvia Lara P7 Kounis syndrome in the setting of anaphylaxis to diclofenac Leonor Carneiro-Leão, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas P8 Perioperative anaphylaxis audit: Royal Melbourne Hospital Katherine Nicholls, William Lay, Olivia Smith, Christine Collins, Gary Unglik, Kymble Spriggs, Priscilla Auyeung, Jeremy McComish, Jo A. Douglass P9 Recurrent peri-operative anaphylaxis: a perfect storm Jonny G. Peter, Paul Potter Poster Walk 2: DH regions and patient groups (P10–P19) P10 A rare presentation of amoxicillin allergy in a young child Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas P11 Adverse drug reactions in children: antibiotics or virus? Ana Sofia Moreira, Carmo Abreu, Eva Gomes P12 Allergic reactions in invasive medical procedures Bárbara Kong Cardoso, Elza Tomaz, Sara Correia, Filipe Inácio P13 Antibiotic allergy in children: room for improvement Annabelle Arnold, Natasha Bear, Kristina Rueter, Grace Gong, Michael O’Sullivan, Saravanan Muthusamy, Valerie Noble, Michaela Lucas P14 Drug hypersensitivity reactions in children and results of diagnostic evaluation Neringa Buterleviciute, Odilija Rudzeviciene P15 Nonimmediate cutaneous drug reactions in children: are skin tests required? Ana Sofia Moreira, Carmo Abreu, Eva Gomes P16 Pediatric patients with a history of penicillin allergy and a positive penicillin skin test may not be at an increased risk for multiple drug allergies Sara May, Thanai Pongdee, Miguel Park P17 Proved hypersensitivity to drugs according data of Vilnius University Hospital Santariskiu Klinikos Linas Griguola, Arturas Vinikovas, Simona Kašinskaite, Violeta Kvedariene P18 Self-reported prevalence of drug hypersensitivity reactions among students in Celal Bayar University, Turkey Ayse Aktas, Suheyla Rahman, Huseyin Elbi, Beyhan Cengiz Ozyurt P19 Severe drug hypersensitivity reactions in pediatric age Ozlem Cavkaytar, Betul Karaatmaca, Pinar Gur Cetinkaya, Saliha Esenboga, Umit M. Sahiner, Bulent E. Sekerel, Ozge Soyer Poster Walk 3: Desensitisation (P20–P28) P20 A protocol for desensitisation to valaciclovir Celia Zubrinich, Bianca Tong, Mittal Patel, Michelle Giles, Robyn O’Hehir, Robert Puy P21 A rare case of desensitization to modafinil Josefina Cernadas, Luís Amaral, Fabrícia Carolino P22 A sixteen-day desensitization protocol in delayed type hypersensitivity reactions to oral drugs Semra Demir, Asli Gelincik, Muge Olgac, Raif Caskun, Derya Unal, Bahauddin Colakoglu, Suna Buyukozturk P23 Desensitization to intravenous etoposide using a 12 and a 13-step protocol. Two cases report Olga Vega Matute, Amalia Bernad, Gabriel Gastaminza, Roselle Madamba, Carlos Lacasa, M. J. Goikoetxea, Carmen D’Amelio, Jose Rifón, Nicolas Martínez, Marta Ferrer P24 Drug desensitisation in oncology: the experience of an immunoallergology department for 5 years Carmelita Ribeiro, Emília Faria, Cristina Frutuoso, Anabela Barros, Rosário Lebre, Alice Pego, Ana Todo Bom P25 Filgrastim anaphylaxis: a successful desensitization protocol Luis Amaral, Josefina Cernadas P26 Galsulfase hypersensitivity and desensitization of a mucopolysaccharidosis VI patient Luis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Ana Maria Martins, Dirceu Solé P27 Rapid drug desensitization with biologicals: one-center experience with four biologicals Sevim Bavbek, Resat Kendirlinan, Pamir Çerçi, Seda Tutluer, Sadan Soyyigit, Zeynep Çelebi Sözener, Ömür Aydin, Reyhan Gümüsburun P28 Successful desensitization to a high dose of methotrexate in a delayed type hypersensitivity reaction Josefina Cernadas, Leonor Carneiro-Leão, Fabrícia Carolino, Marta Almeida Poster Walk 4: SJS (P29–P38) P29 Assessment of impact of infection on drug-induced severe cutaneous adverse reactions and rhabdomyolysis using the Japanese adverse drug event report database Kimie Sai, Takuya Imatoh, Ryosuke Nakamura, Chisato Fukazawa, Yasushi Hinomura, Yoshiro Saito P30 Characterization of erythema multiforme and severe cutaneous adverse reactions hospitalizations Bernardo Sousa-Pinto, Cláudia Correia, Lídia Gomes, Sara Gil-Mata, Luís Araújo, Luís Delgado P31 Effects of infection on incidence/severity of SJS/TEN and myopathy in Japanese cases analyzed by voluntary case reports Ryosuke Nakamura, Kimie Sai, Takuya Imatoh, Yoshimi Okamoto-Uchida, Koji Kajinami, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito P32 Efficacy of tumor necrosis factor—a antagonists in Stevens–Johnson syndrome and toxic epidermal necrolysis: a randomized controlled trial and immunosuppressive effects evaluation Chuang-Wei Wang, Shih-Chi Su, Shuen-Iu Hung, Hsin-Chun Ho, Chih-Hsun Yang, Wen-Hung Chung P33 Evolution of drug causality in Stevens–Johnson syndrome and toxic epidermal necrolysis in Europe: analysis of 10 years RegiSCAR-Study Maren Paulmann, Ariane Dunant, Maja Mockenhaupt, Peggy Sekula, Martin Schumacher, Sylvia Kardaun, Luigi Naldi, Teresa Bellón, Daniel Creamer, Cynthia Haddad, Bruno Sassolas, Bénédicte Lebrun-Vignes, Laurence Valeyrie-Allanore, Jean-Claude Roujeau P34 Long-term sequelae in patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: a 5-year analysis Maren Paulmann, Carmen Kremmler, Peggy Sekula, Laurence Valeyrie-Allanore, Luigi Naldi, Sylvia Kardaun, Maja Mockenhaupt P35 Major emotional complications and decreased health related quality of life among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis Roni P. Dodiuk-Gad, Cristina Olteanu, Anthony Feinstein, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear P36 Retrospective analysis of Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients: treatment and outcome Naoko Takamura, Yumiko Yamane, Setsuko Matsukura, Kazuko Nakamura, Yuko Watanabe, Yukie Yamaguchi, Takeshi Kambara, Zenro Ikezawa, Michiko Aihara P37 Severe physical complications among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis Roni P. Dodiuk-Gad, Cristina Olteanu, Rena Hashimoto, Hall Chew, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear P38 Stevens–Johnson syndrome/toxic epidermal necrolysis combined with haemophagocytic lymphohistiocytosis: a case report Brittany Knezevic, Una Nic Ionmhain, Allison Barraclough, Michaela Lucas, Matthew Anstey Poster Walk 5: Other organs/unexpected immune reactions (P39–P47) P39 A case report of patient with anti-tuberculosis drug-related severe liver failure Toru Usui, Xiaoli Meng, John Farrell, Paul Whitaker, John Watson, Neil French, Kevin Park, Dean Naisbitt P40 Acute interstitial nephritis induced by ibuprofen Ana Castro Neves, Susana Cadinha, Ana Moreira, J. P. Moreira Da Silva P41 Cetuximab induced acneiform rash—two case reports Daniela Ledic Drvar, Sandra Jerkovic Gulin, Suzana Ljubojevic Hadzavdic, Romana Ceovic P42 Enteropathy associated with losartan Ana Montoro De Francisco, Talía De Vicente Jiménez, Amelia García Luque, Natalia Rosado David, José Mª Mateos Galván P43 Granuloma annulare after therapy with canakinumab Razvigor Darlenski P44 Hypersensitivity eosinophilic myocarditis or acute coronary syndrome? Case report Dario Gulin, Jozica Sikic, Jasna Cerkez Habek, Sandra Jerkovic Gulin, Edvard Galic P45 Piperacillin-induced immune haemolytic anaemia: a severe and frequent complication of antibiotic treatment in patients with cystic fibrosis Philip Specht, Doris Staab, Beate Mayer, Jobst Roehmel P46 Progesterone triggered pemphigus foliaceus: case report Sandra Jerkovic Gulin, Caius Solovan, Anca Chiriac P47 Ramipril: triggered generalized pustular psoriasis Paola Djurinec, Kresimir Kostovic, Mirna Bradamante, Sandra Jerkovic Gulin, Romana Ceovic Poster Walk 6: NSAIDs (P48–P56) P48 Aspirin desensitization in cardiovascular disease—Portuguese experience Jose Pedro Almeida, Joana Caiado, Elisa Pedro, Pedro Canas Da Silva, Manuel Pereira Barbosa P49 Asthma and/or rhinitis to NSAIDs with good tolerance to ASA Gador Bogas, Natalia Blanca-López, Diana Pérez-Alzate, Inmaculada Doña, José Augusto Agúndez, Elena García-Martín, José Antonio Cornejo-García, Cristobalina Mayorga, María José Torres, Gabriela Canto, Miguel Blanca P50 Clinical characteristics of 196 patients with non-steroidal anti-inflammatory drug (NSAIDs) hypersensitivity Sengül Aksakal, Aytül Zerrin Sin, Zeynep Peker Koç, Fatma Düsünür Günsen, Ömür Ardeniz, Emine Nihal Mete Gökmen, Okan Gülbahar, Ali Kokuludag P51 Development of immediate hypersensitivity to several NSAIDs maintaining good tolerance to ASA Natalia Pérez-Sánchez, Natalia Blanca-López, Diana Pérez-Alzate, Gador Bogas, Inmaculada Doña, María Salas, María José Torres, Miguel Blanca, Gabriela Canto P52 Diagnosis of hypersensitivity reactions to paracetamol in a large series of cases Inmaculada Doña, Maria Salas, Francisca Gomez, Natalia Blanca-Lopez, Diana Perez-Alzate, Gador Bogas, Esther Barrionuevo, Maria Jose Torres, Inmaculada Andreu, Miguel Ángel Miranda, Gabriela Canto, Miguel Blanca P53 Hypersensitivity to paracetamol according to the new classification of hypersensitivity to NSAIDs Gabija Didžiokaite, Olesia Gaidej, Simona Kašinskaite, Violeta Kvedariene P54 Ibuprofen and other aryl propionic derivates can induce immediate selective hypersensitivity responses Diana Perez-Alzate, Natalia Blanca-López, Maria Isabel Garcimartin, Inmaculada Doña, Maria Luisa Somoza, Cristobalina Mayorga, Maria Jose Torres, Gador Bojas, Jose Antonio Cornejo-Garcia, Maria Gabriela Canto, Miguel Blanca P55 Subjects developing immediate responses to several NSAIDs can be selective with good tolerance to ASA Natalia Blanca-Lopez, Diana Pérez-Alzate, Francisco Javier Ruano Perez, Inmaculada Doña, Maria Luisa Somoza, Inmaculada Andreu, Miguel Angel Miranda, Cristobalina Mayorga, Maria Jose Torres, Jose Antonio Cornejo-Garcia, Miguel Blanca, Maria Gabriela Canto P56 Utility of low-dose oral aspirin challenges for diagnosis of aspirin exacerbated respiratory disease Elina Jerschow, Teresa Pelletier, Zhen Ren, Golda Hudes, Marek Sanak, Esperanza Morales, Victor Schuster, Simon D. Spivack, David Rosenstreich Poster Walk 7: NSAID 2 (P57–P65) P57 Alternate regulation of cyclooxygenase-2 (COX-2) MRNA expression may predispose patients to aspirin-induced exacerbations Renato Erzen, Mira Silar, Nissera Bajrovic, Matija Rijavec, Mihaela Zidarn, Peter Korosec P58 Anaphylaxis to diclofenac: what about the underlying mechanism? Leonor Carneiro-Leão, Fabrícia Carolino, Luís Amaral, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas P59 COX-2 inhibitors: are they always a safe alternative in hypersensitivity to nonsteroidal anti-inflammatory drugs? Luis Amaral, Fabricia Carolino, Eunice Castro, Josefina Cernadas P60 Management of patients with history of NSAIDs reactions prior to coronary angioplasty Mona Al-Ahmad, Tito Rodriguez P61 Oral drug challenge with non-steroidal anti-inflammatory drug under spirometric control: clinical series of 110 patients João Pedro Azevedo, Emília Faria, Beatriz Tavares, Frederico Regateiro, Ana Todo-Bom P62 Prevalence and incidence of analgesic hypersensitivity reactions in Colombia Pablo Andrés Miranda, Bautista De La Cruz Hoyos P63 Recent endoscopic sinus surgery lessens reactions during aspirin challenge in patients with aspirin exacerbated respiratory disease Teresa Pelletier, Waleed Abuzeid, Nadeem Akbar, Marc Gibber, Marvin Fried, Weiguo Han, Taha Keskin, Robert Tamayev, Golda Hudes, Simon D. Spivack, David Rosenstreich, Elina Jerschow P64 Safe use of imidazole salycilate in a case of multiple NSAIDs induced urticaria-angioedema Elisa Boni, Marina Russello, Marina Mauro P65 Selective hypersensitivity reactions to ibuprofen—seven years experience Marta Ferreira Neto Poster Walk 8: Epidemiological methods (P66–P72) P66 Allopurinol hypersensitivity: a 7-year review Lise Brosseron, Daniela Malheiro, Susana Cadinha, Patrícia Barreira, J. P. Moreira Da Silva P67 Antibiotic allergy labelling is associated with increased hospital readmission rates in Australia Brittany Knezevic, Dustin Sprigg, Michelle Trevenen, Jason Seet, Jason Trubiano, William Smith, Yogesh Jeelall, Sandra Vale, Richard Loh, Andrew Mclean-Tooke, Michaela Lucas P68 Experts’ opinions on severe cutaneous adverse drug reactions-report of a survey from the 9th international congress on cutaneous adverse drug reactions 2015 Roni P. Dodiuk-Gad, Cristina Olteanu, Wen-Hung Chung, Neil H. Shear P69 HLA-A*31-positive AGEP with carbamazepine use and other severe cutaneous adverse drug reactions (SCARs) detected by electronic medical records screening Sabine Müller, Ursula Amstutz, Lukas Jörg, Nikhil Yawalkar, Stephan Krähenbühl P70 Patients with suspected drug allergy: a specific psychological profile? Eunice Dias-Castro, Ana Leblanc, Laura Ribeiro, Josefina R. Cernadas P71 Use of an electronic device and a computerized mathematic algorithm to detect the allergic drug reactions through the analysis of heart rate variability Arantza Vega, Raquel Gutierrez Rivas, Ana Alonso, Juan Maria Beitia, Belén Mateo, Remedios Cárdenas, Juan Jesus Garcia-Dominguez P72 Variation in ERAP influences risk for HLA-B*57:01 positive abacavir hypersensitivity Rebecca Pavlos, Kaija Strautins, Ian James, Simon Mallal, Alec Redwood, Elizabeth Phillips Poster Walk 9: DRESS/AGEP (P73–P81) P73 A clinical case of DRESS syndrome in a child after administration of amoxicillin-clavulanic acid Rita Aguiar, Anabela Lopes, Ana Neves, Maria Do Céu Machado, M. A. Pereira-Barbosa P74 Acute generalized exanthematous pustulosis (AGEP) induced by mesalazine, reliable and oftenly used drug to treat inflammatory bowel disease Ceyda Tunakan Dalgiç, Emine Nihal Mete Gökmen, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Ali Kokuludag, Aytül Zerrin Sin P75 Changes of blood plasmacytoid dendritic cells, myeloid dendritic cells, and basophils during the acute stage of drug reaction with eosinophilia and systemic symptoms (DRESS) and other drug eruptions Shao-Hsuan Hsu, Yung-Tsu Cho, Che-Wen Yang, Kai-Lung Chen, Chia-Yu Chu P76 Characterization of isoniazid/rifampicin-specific t-cell responses in patients with DRESS syndrome Young-Min Ye, Gyu-Young Hur, Hae-Sim Park, Seung-Hyun Kim P77 DRESS syndrome secondary to sulfasalazine with delayed TEN: a case presentation Syed Ali, Michaela Lucas, Peter N. Hollingsworth, Andrew P. C. Mclean-Tooke P78 Drug rash with eosinophilia and systemic symptoms (DRESS) features according to the culprit drug Zohra Chadly, Nadia Ben Fredj, Karim Aouam, Haifa Ben Romdhane, Naceur A. Boughattas, Amel Chaabane P79 Drug reaction with eosinophilia and systemic symptoms induced by allopurinol: not always easy to diagnose Marina Lluncor Salazar, Beatriz Pola, Ana Fiandor, Teresa Bellón, Elena Ramírez, Javier Domínguez Ortega, Santiago Quirce, Rosario Cabañas P80 Drug reaction with eosinophilia and systemic symptoms syndrome induced by two drugs simultaneously: a case report Krasimira Baynova, Marina Labella, Manuel Prados P81 The drug reaction with eosinophilia and systemic symptoms (DRESS) induced by the second-line antituberculosis drugs and Epstein–Barr virus infection Agne Ramonaite, Ieva Bajoriuniene, Brigita Sitkauskiene, Raimundas Sakalauskas Poster Walk 10: Miscellaneous drug hypersensitivity (P82–P91) P82 A case of cycloserine-induced lichenoid drug eruption confirmed with a lymphocatye transformation test Jae-Woo Kwon, Shinyoung Park P83 Allergic reaction to topical eye drops: 5 years’ retrospective study in a drug allergy unit Diana Silva, Leonor Carneiro Leão, Fabricia Carolino, Eunice Castro, Josefina Cernadas P84 Allergy to heparins Diana Perez-Alzate, Natalia Blanca-López, Maria Luisa Somoza Alvarez, Maria Garcimartin, Maria Vazquez De La Torre, Francisco Javier Ruano Pérez, Elisa Haroun, Gabriela Canto Diez P85 Allopurinol-induced adverse drug reactions Katinka Ónodi-Nagy, Ágnes Kinyó, Lajos Kemény, Zsuzsanna Bata-Csörgo P86 Analysis of a population with immediate hypersensitivity to corticosteroids: an 11 year review Joana Sofia Pita, Emília Faria, Rosa Anita Fernandes, Ana Moura, Nuno Sousa, Carmelita Ribeiro, Carlos Loureiro, Ana Todo Bom P87 Anaphylaxis against mivacurium in a 12-months old boy at first-time exposure Wolfgang Pfützner P88 Antihistamine-exacerbated chronic spontaneous urticaria: a paradox? Nadine Marrouche, Clive Grattan P89 Anti-osteoporotic agents-induced cutaneous adverse drug reactions in Asians Yu-En Chen, Chun-Bing Chen, Wen-Hung Chung, Yu-