The disruption of proteostasis in neurodegenerative diseases

Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio

Heterogeneous Beliefs and Asset Price Dynamics: A Survey of Recent Evidence

This paper reviews the empirical literature on heterogeneous beliefs and asset price dynamics that challenges the traditional rational agent framework. Emphasis is given to the validation and estimation of (dynamic) heterogeneous agent models that have their roots in the agent-based literature. Heterogeneous agent models per- form well in describing, explaining, and often forecasting asset markets dynamics, such as equities, foreign exchange, credit, housing, derivatives, and commodities. Our survey suggests that heterogeneous agent models have the ability to produce important stylised facts observed in nancial time series and to replicate important episodes of nancial turmoil.publishedVersio