A Supplemental computer-assisted intervention to prevent early reading difficulties in spanish learners: a randomised controlled trial

Difficulties implementing effective instruction for at-risk students arise from two challenges: evidence-based knowledge transfer and lack of economic resources. Computer-assisted programs can offer a suitable solution, providing quality instruction with low cost resources. Thirty first grade students with learning difficulties were identified and paired on at least four pretest reading measures (reading efficiency of monosyllabic and disyllabic items, words, pseudowords, and texts). Each pair was assigned to two different intervention programs: a computer-assisted instructional program (CAP) focused on developing phonological route versus to the Spanish public school assistance services (AS). Computer-assisted instruction consisted of four individual 12-15 minute sessions per week focused on syllable decoding plus a collective comprehension session per week of 1 hour. CAP was delivered by university students. The assistance services typically consisted of one hour per week, individually or in small groups, delivered by trained teachers. Both programs were applied during eleven weeks. 9 of 15 subjects from the AS condition showed resistance to treatment, while only 5 of 15 subjects were treatment resisters on the CAP condition.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Stereotype Development in Andalusian Children

Los psicólogos sociales manifiestan un profundo interés por las relaciones intergrupales. Sin embargo, hay pocas publicaciones relacionadas con los aspectos evolutivos que explican los mecanismos psicológicos implicados en la construcción de la identidad grupal y cultural. Nuestra investigación ha pretendido estudiar cómo evoluciona la autocategorización de los niños andaluces. También hemos evaluado el grado en que la identificación de los niños como andaluces, españoles y europeos cambia con la edad. Al mismo tiempo, nos interesaba conocer cómo los niños andaluces evalúan a diferentes grupos (franceses, italianos, ingleses, alemanes, españoles, catalanes y andaluces). Igualmente, hemos analizado la relación entre la autocategorización y la evaluación de esos grupos. Los resultados muestran que el desarrollo y adquisición de la identidad nacional está influida tanto por los aspectos cognoscitivos (indicados por la edad) como por las relaciones entre las comunidades de España y las relaciones entre España y otros países. La peculiaridad de los andaluces como grupo es que asumen la identidad como español y como andaluz desde una edad muy temprana. El favoritismo endogrupal es un fenómeno extendido a todas las edades, de ahí que los niños andaluces tengan un estereotipo más negativo de los exogrupos.Social psychologists have shown a profound interest in intergroup relationships, but there are very few papers focusing on the developmental aspects that explain the psychological mechanisms involved in the construction of group and cultural identity. Our research aims to explore how the self-categorization of Andalusian children evolves. We tried to assess the degree to which they self-identify as Andalusian, Spanish, and European, and how this identification changes with age. We were also interested in the affective evaluation of different groups (French, Italian, English, German, Spanish, Catalonian, and Andalusian) made by Andalusian children. Furthermore, we analyzed the relationship between selfcategorization and the evaluation of these groups. Results show that the development of national (autonomous community) identity in these children is influenced by their cognitive development, as well as by the relationships among the regional communities of Spain and the relationships between Spain and other countries. The peculiarity of Andalusians as a group is that they assume both identities: Spanish and Andalusian, from a very early age. In-group favoritism is an extended phenomenon at all ages, and Andalusian children have a negative stereotype of the other Spanish groups and other European communities

Fiabilidad y validez de la versión española del "Childhood Executive Functioning Inventory" (CHEXI)

Background: The Childhood Executive Functioning Inventory (CHEXI) was designed to identify EF deficits in daily life contexts. The aim of the present study was to validate the Spanish version of the CHEXI in 4-5-year-old children. Method: Parents’ ratings of the CHEXI and laboratory tests of EF were investigated in two large samples of 445 children aged 4 years (196 girls, 249 boys) and 459 children aged 5 years (208 girls, 251 boys). CHEXI ratings were collected again after one-year. Results: The two-factor structure of the CHEXI (i.e., Working Memory and Inhibition) was replicated, showing high internal consistency and temporal stability. The 4-year-olds were reported to have higher EF deficits than 5-year-olds have. Boys were rated as having higher EF deficits than girls were. However, gender differences were not significant contrasting performance on EF tasks. Finally, associations between CHEXI ratings and EF tests were weak, suggesting that EF tests and EF ratings capture different aspects of EF. Conclusions: The Spanish CHEXI provides a suitable instrument to assess EF in 4-5-year-old children.Contexto: El Childhood Executive Functioning Inventory (CHEXI) se diseñó para detectar déficit de Funciones Ejecutivas (FE) en contextos de la vida diaria. El propósito del presente estudio era validar la versión española del CHEXI para niños de 4 y 5 años. Método: Se obtuvieron las valoraciones de los padres y las puntuaciones en test de laboratorio en una muestra de 445 niños de 4 años (196 niñas, 249niños) y otra de 459 niños de 5 años (208 niñas, 251 niños). Un año más tarde se volvieron a recoger las valoraciones de los padres en CHEXI. Resultados: Se replicó la estructura de dos factores de CHEXI (Memoria de Trabajo e Inhibición), obteniendo una alta consistencia interna y estabilidad temporal. Los niños de 4 años eran valorados con mayor déficit en FE que los niños de 5 años. Los niños alcanzaban puntuaciones más elevadas de déficit de FE. Sin embargo, no aparecieron diferencias significativas de género en las pruebas conductuales. Finalmente, se encontró una baja asociación entre las valoraciones de CHEXI y las puntuaciones de las pruebas conductuales. Este resultado sugiere que los inventarios y las medidas conductuales evalúan diferentes aspectos de las FE. Conclusiones: La versión española de CHEXI ofrece un instrumento válido para evaluar las FE en niños de 4 y 5 años

Complex network modelling of EEG band coupling in dyslexia: An exploratory analysis of auditory processing and diagnosis

Complex network analysis has an increasing relevance in the study of neurological disorders, enhancing the knowledge of brain’s structural and functional organization. Network structure and efficiency reveal different brain states along with different ways of processing the informa- tion. This work is structured around the exploratory analysis of the brain processes involved in low-level auditory processing. A complex network analysis was performed on the basis of brain coupling obtained from electroencephalography (EEG) data, while different auditory stim- uli were presented to the subjects. This coupling is inferred from the Phase-Amplitude coupling (PAC) from different EEG electrodes to explore differences between control and dyslexic sub- jects. Coupling data allows the construction of a graph, and then, graph theory is used to study the characteristics of the complex networks throughout time for control and dyslexic subjects. This results in a set of metrics including clustering coefficient, path length and small-worldness. From this, different characteristics linked to the temporal evolution of networks and coupling are pointed out for dyslexics. Our study revealed patterns related to Dyslexia as losing the small- world topology. Finally, these graph-based features are used to classify between control and dyslexic subjects by means of a Support Vector Machine (SVM).This work was supported by projects PGC2018-098813-B-C32 (Spanish “Ministerio de Cien- cia, Innovación y Universidades”), UMA20-FEDERJA-086 (Consejería de econnomía y conocimiento, Junta de Andalucía) and by European Regional Development Funds (ERDF). We gratefully ac- knowledge the support of NVIDIA Corporation with the donation of one of the GPUs used for this research. Work by F.J.M.M. was supported by the MICINN “Juan de la Cierva - Incorpo- ración” Fellowship. We also thank the Leeduca research group and Junta de Andalucía for the data supplied and the support. Funding for open access charge: Universidad de Málaga / CBU

Dyslexia Diagnosis by EEG Temporal and Spectral Descriptors: An Anomaly Detection Approach.

Diagnosis of learning difficulties is a challenging goal. There are huge number of factors involved in the evaluation procedure that present high variance among the population with the same difficulty. Diagnosis is usually performed by scoring subjects according to results obtained in different neuropsychological (performance-based) tests specifically designed to this end. One of the most frequent disorders is developmental dyslexia (DD), a specific difficulty in the acquisition of reading skills not related to mental age or inadequate schooling. Its prevalence is estimated between 5% and 12% of the population. Traditional tests for DD diagnosis aim to measure different behavioral variables involved in the reading process. In this paper, we propose a diagnostic method not based on behavioral variables but on involuntary neurophysiological responses to different auditory stimuli. The experiments performed use electroencephalography (EEG) signals to analyze the temporal behavior and the spectral content of the signal acquired from each electrode to extract relevant (temporal and spectral) features. Moreover, the relationship of the features extracted among electrodes allows to infer a connectivity-like model showing brain areas that process auditory stimuli in a synchronized way. Then an anomaly detection system based on the reconstruction residuals of an autoencoder using these features has been proposed. Hence, classification is performed by the proposed system based on the differences in the resulting connectivity models that have demonstrated to be a useful tool for differential diagnosis of DD as well as a method to step towards gaining a better knowledge of the brain processes involved in DD.This work was partly supported by the MINECO/FEDER under PGC2018-098813-B-C31, PGC2018-098813-B-C32 and PSI2015-65848-R projects. We gratefully acknowledge the support of NVIDIA Corporation with the donation of one of the GPUs used for this research. Work by F.J.M.M. was supported by the MICINN “Juan de la Cierva - Formaci´on” Fellowship. We also thank the Leeduca research group and Junta de Andaluc´ıa for the data supplied and the support

Evaluación de estudiantes universitarios con dificultades lectoras

Se ha diseñado una batería de pruebas para evaluar la habilidad lectora de estudiantes universitarios. Se ha evaluado una muestra de 145 participantes. Una vez analizados los resultados se han realizado análisis estadísticos para seleccionar las pruebas que obtienen un mejor porcentaje de aciertos en la identificación de estudiantes con dificultades lectoras.Se está desarrollando un procedimiento para identificar a estudiantes universitarios con dificultades lectora. Se presenta el material inicial y los resultados preliminares.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. PIE-211 Proyecto Innovación Educativa - UM

Distance learning during the COVID-19 pandemic for children with ADHD and/or ASD: a European multi-center study examining the role of executive function deficits and age

BackgroundOne of the COVID-19 pandemic consequences that has affected families the most is school lockdowns. Some studies have shown that distance learning has been especially challenging for families with a child with neurodevelopmental disorders such as ADHD or ASD. However, previous studies have not taken the heterogeneity of these disorders into account. The aim of the present study was therefore to investigate differences between families with a child with ADHD, ASD, or both conditions, and to examine the role of underlying deficits in executive functioning (EF) in both children and parents in relation to negative and positive effects of distance learning.MethodsSurvey data assessing both negative and positive experiences of distance learning were collected from parents with a child aged 5–19 years in seven Western European countries: the UK, Germany, Spain, Sweden, the Netherlands, Italy, and Belgium. Altogether, the study included 1010 families with a child with ADHD and/or ASD and an equally large comparison group of families with a child without mental health problems. We included measures of three different types of negative effects (i.e., effects on the child, effects on the parent, and lack of support from school) and positive effects on the family.ResultsResults confirmed that families with a child with ADHD, ASD or a combination of ADHD and ASD showed higher levels of both negative and positive effects of distance learning than the comparison group. However, few differences were found between the clinical groups. Group differences were more pronounced for older compared to younger children. Regarding the role of both ADHD/ASD diagnosis and EF deficits, primarily children’s EF deficits contributed to high levels of negative effects. Parent EF deficits did not contribute significantly beyond the influence of child EF deficits. Families of children with ADHD/ASD without EF deficits experienced the highest levels of positive effects.ConclusionsSchool closings during COVID-19 have a major impact on children with EF problems, including children with neurodevelopmental disorders. The present study emphasizes that schools should not focus primarily on whether a student has a neurodevelopmental disorder, but rather provide support based on the student’s individual profile of underlying neuropsychological deficits

Parental experiences of homeschooling during the COVID-19 pandemic: differences between seven European countries and between children with and without mental health conditions

The aim of the present study was to examine parental experiences of homeschooling during the COVID-19 pandemic in families with or without a child with a mental health condition across Europe. The study included 6720 parents recruited through schools, patient organizations and social media platforms (2002 parents with a child with a mental health condition and 4718 without) from seven European countries: The United Kingdom (n=508), Sweden (n=1436), Spain (n=1491), Belgium (n=508), the Netherlands (n=324), Germany (n=1662) and Italy (n=794). Many parents reported negative effects of homeschooling for themselves and their child, and many found homeschooling to be of poor quality, with insufficient support from schools. In most countries, contact with teachers was limited, leaving parents with primary responsibility for managing homeschooling. Parents also reported increased levels of stress, worry, social isolation, and domestic conflict. A small number of parents reported increased parental alcohol/drug use. Some differences were found between countries and some negative experiences were more common in families with a child with a mental health condition. However, differences between countries and between families with and without a mental health condition were generally small, indicating that many parents across countries reported negative experiences. Some parents also reported positive experiences of homeschooling. The adverse effects of homeschooling will likely have a long-term impact and contribute to increased inequalities. Given that school closures may be less effective than other interventions, policymakers need to carefully consider the negative consequences of homeschooling during additional waves of the COVID-19 pandemic and future pandemics

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research