Development of Non-Proprietary Ultra-High Performance Concrete Mixtures

The development of non-proprietary Ultra-High Performance Concrete (UHPC) is one way to reduce the initial cost of construction. However, workability is a major issue for which such mixtures are not practical in field conditions. Ultra-high performance cannot be achieved in field conditions if the concrete is not placed, finished, and compacted properly during placement. In this research, six UHPC mixtures were developed (three with steel fibers and three without fibers) using materials which are readily available on the local marketplace with water-to-cementitious materials ratios ranging between 0.17 to 0.30. The workability was determined using standard ASTM flow table apparatus, and specimens were prepared to determine compressive strength, splitting tensile strength, and permeable porosity. Flow table test exhibited flow values greater than 250 mm. Such high workability of the mixtures was achieved by optimizing the silica fume content and water reducing admixture dosage. These mixtures exhibited compressive strengths greater than 120 MPa and splitting tensile strengths greater than 5.10 MPa in both ambient and elevated curing temperatures. Results indicated that UHPC can be produced with a water-to-cementitious materials ratio as high as 0.30. Steel fibers helped to increase splitting tensile strength due to fiber-matrix interactions. Very low permeable porosity (1.7-16.7%) was observed which indicates superior durability due to the significant reduction of ingress of deleterious ions

Obesity, unhappiness, and the challenge of affluence : theory and evidence

Is affluence a good thing? The book "The Challenge of Affluence" by Avner Offer (2006) argues that economic prosperity weakens self-control and undermines human well-being. Consistent with a pessimistic view, we show that psychological distress has been rising through time in modern Great Britain. Taking over-eating as an example, our data reveal that half the British population view themselves as overweight, and that happiness and mental health are worse among fatter people in Britain and Germany. Comparisons also matter. We discuss problems of inference and argue that longitudinal data are needed. We suggest a theory of obesity imitation where utility depends on relative weight

(Discrete) Almansi Type Decompositions: An umbral calculus framework based on osp(1∣2)\mathfrak{osp}(1|2) symmetries

We introduce the umbral calculus formalism for hypercomplex variables starting from the fact that the algebra of multivariate polynomials \BR[\underline{x}] shall be described in terms of the generators of the Weyl-Heisenberg algebra. The extension of \BR[\underline{x}] to the algebra of Clifford-valued polynomials $\mathcal{P}$ gives rise to an algebra of Clifford-valued operators whose canonical generators are isomorphic to the orthosymplectic Lie algebra $\mathfrak{osp}(1|2)$. This extension provides an effective framework in continuity and discreteness that allow us to establish an alternative formulation of Almansi decomposition in Clifford analysis (c.f. \cite{Ryan90,MR02,MAGU}) that corresponds to a meaningful generalization of Fischer decomposition for the subspaces $\ker (D')^k$. We will discuss afterwards how the symmetries of \mathfrak{sl}_2(\BR) (even part of $\mathfrak{osp}(1|2)$) are ubiquitous on the recent approach of \textsc{Render} (c.f. \cite{Render08}), showing that they can be interpreted in terms of the method of separation of variables for the Hamiltonian operator in quantum mechanics.Comment: Improved version of the Technical Report arXiv:0901.4691v1; accepted for publication @ Math. Meth. Appl. Sci http://www.mat.uc.pt/preprints/ps/p1054.pdf (Preliminary Report December 2010

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer

The underpinnings of STAT3 hyperphosphorylation resulting in enhanced signaling and cancer progression are incompletely understood. Loss-of-function mutations of enzymes that dephosphorylate STAT3, such as receptor protein tyrosine phosphatases, which are encoded by the PTPR gene family, represent a plausible mechanism of STAT3 hyperactivation. We analyzed whole exome sequencing (n = 374) and reverse-phase protein array data (n = 212) from head and neck squamous cell carcinomas (HNSCCs). PTPR mutations are most common and are associated with significantly increased phospho-STAT3 expression in HNSCC tumors. Expression of receptor-like protein tyrosine phosphatase T (PTPRT) mutant proteins induces STAT3 phosphorylation and cell survival, consistent with a “driver” phenotype. Computational modeling reveals functional consequences of PTPRT mutations on phospho-tyrosine–substrate interactions. A high mutation rate (30%) of PTPRs was found in HNSCC and 14 other solid tumors, suggesting that PTPR alterations, in particular PTPRT mutations, may define a subset of patients where STAT3 pathway inhibitors hold particular promise as effective therapeutic agents.Fil: Lui, Vivian Wai Yan. University of Pittsburgh; Estados UnidosFil: Peyser, Noah D.. University of Pittsburgh; Estados UnidosFil: Ng, Patrick Kwok-Shing. University Of Texas Md Anderson Cancer Center;Fil: Hritz, Jozef. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados Unidos. Masaryk University; República ChecaFil: Zeng, Yan. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Lu, Yiling. University Of Texas Md Anderson Cancer Center;Fil: Li, Hua. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Wang, Lin. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Gilbert, Breean R.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: General, Ignacio. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Bahar, Ivet. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Ju, Zhenlin. University Of Texas Md Anderson Cancer Center;Fil: Wang, Zhenghe. Case Western Reserve University; Estados UnidosFil: Pendleton, Kelsey P.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Xiao, Xiao. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Du, Yu. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Vries, John K.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Hammerman, Peter S.. Harvard Medical School; Estados UnidosFil: Garraway, Levi A.. Harvard Medical School; Estados UnidosFil: Mills, Gordon B.. University Of Texas Md Anderson Cancer Center;Fil: Johnson, Daniel E.. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Grandis, Jennifer R.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados Unido

Transition Between Ground State and Metastable States in Classical 2D Atoms

Structural and static properties of a classical two-dimensional (2D) system consisting of a finite number of charged particles which are laterally confined by a parabolic potential are investigated by Monte Carlo (MC) simulations and the Newton optimization technique. This system is the classical analog of the well-known quantum dot problem. The energies and configurations of the ground and all metastable states are obtained. In order to investigate the barriers and the transitions between the ground and all metastable states we first locate the saddle points between them, then by walking downhill from the saddle point to the different minima, we find the path in configurational space from the ground state to the metastable states, from which the geometric properties of the energy landscape are obtained. The sensitivity of the ground-state configuration on the functional form of the inter-particle interaction and on the confinement potential is also investigated

Empowering Reentrant Projections from V5 to V1 Boosts Sensitivity to Motion

Evidence from macaques [1] and humans [2, 3] has shown that back projections from extrastriate areas to the primary visual area (V1) determine whether visual awareness will arise. For example, reentrant projections from the visual motion area (V5) to V1 are considered to be critical for awareness of motion [2, 3]. If these projections are also instrumental to functional processing of moving stimuli [4–8], then increasing synaptic efficacy in V5-V1 connections should induce functionally relevant short-term plastic changes, resulting in enhanced perception of visual motion. Using transcranial magnetic stimulation (TMS), we applied a novel cortico-cortical paired associative stimulation (ccPAS) protocol to transiently enhance visual motion sensitivity and demonstrate both the functional relevance of V5-V1 reentrant projections to motion perception and their plasticity. Specifically, we found that ccPAS aimed at strengthening reentrant connectivity from V5 to V1 (but not in the opposite direction) enhanced the human ability to perceive coherent visual motion. This perceptual enhancement followed the temporal profile of Hebbian plasticity [9–18] and was observed only when an optimal timing of 20 ms between TMS pulses [2, 3, 5, 6] was used, not when TMS pulses were delivered synchronously. Thus, plastic change is critically dependent on both the direction and timing of connectivity; if either of these requirements was not met, perceptual enhancement did not take place. We therefore provide novel causal evidence that V5-V1 back projections, instrumental to motion perception, are functionally malleable. These findings have implications for theoretical models of visual awareness and for the rehabilitation of visual deficits