Cruise tourism in Lisbon - Cruise tourism activity and its impact on the city

Field lab: Touris

City, space and place in the digital age : an analysis of how technology shapes our everyday experience of space in cities : a case-study analysis of a coworking space : second home Lisbon

The aim of this dissertation is the analysis of how technology shapes our everyday experience of space in cities. Focusing on a new urban typology, the coworking space, it looks towards emerging practices, and new patterns of behaviour, shaped or mediated by technology. Current literature projects an increasingly greater impact of technology on society, ranging from the very concept of ‘smart cities’ to the manner in which personal devices seamlessly integrate into our lives. In order to access this impact, the current work relied on the case-study analysis of a coworking space – Second Home Lisbon – which stands out in the local context for its unique spatiality and strong cultural programme. After the elaboration of the theoretical framework, documental analysis provided a complete recognition of the object, and finally, in situ observational research was undertaken for a month, and a members’ survey was conducted. For the observational research process, a grid of analysis was developed, consisting of several categories: privacy, community, mobility, communication, cooperation, and legacy patterns. It was argued that all these categories have a spatial underpinning and, in addition to informing on a specific layer of the object, they also constitute relevant dimensions of everyday life, which have potentially been affected by technology. As a conclusion, this work highlights the contradiction between the apparent dematerializing of work and the growing number of spaces for working, asserting the importance of place, still. Furthermore, it considers that technology has affected the way we experience space, and that is seen on the coworking space on both a macro or external level, in the conceptual co-construction of the narratives of the coworking space and, on a micro or internal level, in the manner in which people perceive and appropriate the space

Quando a Universidade era o Liceu: Sociedade, Política e Elites em Évora durante a I República

O presente estudo pretende contribuir para o conhecimento do meio social eborense no período da I Republica. O nosso intuito é colocar em destaque a acção pública das elites políticas e intelectuais cuja trajectória de vida as relacionou com a cidade e as suas instituições ao longo do período considerado. Embora a cronologia enunciada se inclua no logo interregno do ensino universitário em Évora, a nossa perspectiva analítica pretende dar relevo ao tópico da relação entre as instituições ligadas ao ensino, o Liceu em particular, e a dinâmica social e política da cidade. A prossecução deste objectivo desdobra-se nas seguintes etapas analíticas. Primeiro, efectua-se uma síntese sobre os traços essenciais da formação social no Sul de Portugal no período em estudo. Depois, procede-se a uma caracterização da cidade do ponto de vista do seu perfil de estratificação social e principais sectores de actividade económica. Em seguida, procuram captar-se as linhas de continuidade e/ou de ruptura em relação à composição social das mencionadas elites, quer em relação ao final da Monarquia Constitucional quer em relação ao início do Estado Novo. Finalmente, partindo do perfil biográfico de algumas das personalidades marcantes do período, reflecte-se sobre o significado de uma instituição como o Liceu para o processo de estruturação das elites políticas e diferenciação social em Évora

Is the Financial Report Quality Important in the Default Prediction? SME Portuguese Construction Sector Evidence

This work analyses whether financial information quality is relevant to explaining firms’ probability of default. A financial default prediction model for SMEs (Small and Medium Enterprises) is presented, which includes not only traditional measures but also financial reporting quality (FRQ) measures. FRQ influences the decision-making due to its impact on financial information, which has repercussions on the accounting ratios’ informativeness. A panel data of 1560 Portuguese SMEs in the construction sector, from 2012 to 2018, is analysed. First, firms are classified as default or compliant using an ex-ante criterion which allows us to identify signs of financial constraints in advance. Then, the stepwise method is employed to identify which variables are more relevant to explain the default probability. Results show that FRQ measures, namely accruals quality and timeliness, impact firms’ defaulting, supporting their relevance in predicting financial difficulties. Finally, using a logit approach, the accuracy of the model increased when FRQ variables were included. Results are confirmed using “new age” classifiers, namely the random forest methodology. This work is not only relevant to the extant financial distress literature but has also relevant implications for practice since stakeholders can understand the impact of financial reporting quality to prevent additional risks.info:eu-repo/semantics/publishedVersio

Emerging biomarkers and targeted therapies in feline mammary carcinoma

Research Areas: Veterinary SciencesABSTRACT - : Feline mammary carcinoma (FMC) is a common aggressive malignancy with a low survival rate that lacks viable therapeutic options beyond mastectomy. Recently, increasing efforts have been made to understand the molecular mechanisms underlying FMC development, using the knowledge gained from studies on human breast cancer to discover new diagnostic and prognostic biomarkers, thus reinforcing the utility of the cat as a cancer model. In this article, we review the current knowledge on FMC pathogenesis, biomarkers, and prognosis factors and offer new insights into novel therapeutic options for HER2-positive and triple-negative FMC subtypes.info:eu-repo/semantics/publishedVersio

URTICÁRIA DE CONTACTO INDUZIDA POR FÁRMACOS

Contact dermatitis includes any inflammatory skin reaction due to direct or indirect skin contact with noxious agents. The main clinical expression is eczema and other delayed reactions, but immediate reactions, namely contact urticaria, can also occur. Contact urticaria has a broad range of clinical manifestations. The limited form is restricted to the area of contact between the allergen and the skin or mucosa, but more severe presentations include generalized urticaria lesions, angioedema and even anaphylaxis. All topical drugs can theoretically precipitate contact urticaria. The culprit may be either the active compound or the excipients, and the mechanisms of the immediate reactions can be both immune-mediated (IgE-dependent) and non-immune-mediated. The authors present an overview of the different drugs reported to induce contact urticaria, emphasizing the specific contexts of mucosal exposure and contact urticaria induced by drugs in occupational settings.A dermatite de contacto inclui qualquer reação inflamatória da pele, secundária a contato direto ou indireto entre esta e agentes agressores. A expressão clínica mais comum é o eczema, ou outros padrões resultantes de reações retardadas, mas reações imediatas como a urticária de contacto podem também ocorrer. O espectro de manifestações clínicas por urticária de contacto é amplo. Na sua forma mais limitada, manifesta-se por urticária localizada à área de contacto entre o alergénio e a pele ou mucosa, e nos casos de apresentações mais exuberantes, podem surgir lesões urticariformes generalizadas, angioedema, ou mesmo anafilaxia. Em teoria, todos os fármacos tópicos podem ser responsáveis por urticária de contacto, e vários fármacos foram já descritos como indutores. As moléculas implicadas podem ser os princípios ativos ou os excipientes, por via de mecanismos imunológicos ou não. Os autores apresentam uma revisão dos diferentes fármacos descritos na urticária de contacto, dando enfâse à urticária de contacto das mucosas e em contexto profissional

Why ophthalmology? Analysis of the motivating factors influencing the choice of ophthalmology as a career among different generations in Brazil

OBJECTIVES: The increasing demand for medical specialties with flexible working hours has been associated with the important role of quality of life as a determining factor when choosing a career in medicine, which might change the motivations for pursuing a career in ophthalmology. We aim to identify the main determinants of ophthalmology as a career choice as well as the reasons that motivated previous generations to follow this path. METHODS: Responses to self-administered online questionnaires were analyzed. RESULTS: A total of 225 responses were analyzed, including those of baby boomers (21), generation X (48), generation Y (131) and generation Z (25). Although the main reasons for choosing ophthalmology as a career are the same for all the generations in this study (flexible working hours, self-satisfaction from helping people improve their vision and the possibility of performing surgical procedures), some reasons for this career choice are more important to the younger generations (short-term results and short procedures), and some are more important to the older generations (the influence of an ophthalmologist in the family). CONCLUSION: The main reasons for choosing ophthalmology as a career are essentially

Estratégias de ensino da estereoquímica: Abordagens a aprendizagem de estudantes pré-universitários e universitários

Inexistent

Drug-Induced Photosensitivity

A fotossensibilidade induzida por fármacos traduz uma resposta cutânea anormal à luz em indivíduos expostos a um fármaco, os quais, na sua ausência, tolerariam o mesmo grau de fotoexposição. Pode ocorrer como uma reação aguda ou retardada, assumindo características clínicas polimórficas que variam desde a queimadura solar exagerada até aspectos de fotoonicólise, pseudo- -porfíria, pigmentação, eczema agudo e lúpus eritematoso cutâneo. Os autores descrevem os fármacos mais frequentemente envolvidos neste tipo de reações e as formas clínicas mais frequentes e discutem o possível contributo destes fármacos na potenciação da fotocarcinogénese. O reconhecimento d estes padrões clínicos de fotossensibilidade e dos fármacos responsáveis é fundamental para a evicção do fármaco causal e consequente melhoria ou resolução da reação de fotossensibilidade.Drug-induced photosensitivity is an abnormal skin reaction to light in individuals exposed to a drug, whom, in the absence of the culprit drug, would tolerate the same amount of light exposure. It can present as an acute or delayed clinical picture, with polymorphic features ranging from an exaggerate sunburn to acute eczema, photoonycholysis, pseudo-porphyria, pigmentation or cutaneous lupus erythematosus. The authors describe the drugs involved in these photosensitivity reactions and their main clinical pictures and discuss the possibility that these drugs can enhance photocarcinogenesis. Clinical recognition of these clinical patterns is of outmost importance in order to avoid the culprit drug and consequently improve or resolve photosensitivity

Avaliação empírica do risco de mercado: expected shortfall vs value-at-risk

Tese de mestrado em Matemática Financeira, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2017O risco financeiro tem influenciado cada vez mais as decisões tomadas pelas instituições financeiras. Como tal, o preço de um ativo influencia os mercados financeiros, o que atinge diretamente as ações das instituições financeiras, uma vez que estas correm um risco, dado o investimento efetuado previamente. Neste seguimento, as instituições financeiras têm implementado algumas estratégias de prevenção e de gestão do risco, tais como o Value-at-Risk (VaR) e o Expected Shortfall (ES). O Value-at-Risk é um método de risco bastante utilizado pelas instituições financeiras. Contudo, a desvantagem deste método, ao não ser uma medida de risco coerente, propiciou a procura de um método alternativo, o Expected Shortfall, por parte das instituições financeiras. Embora, o Expected Shortfall tenha surgido para colmatar as lacunas do Value-at-Risk, este método também apresenta as suas desvantagens, pois é considerado uma medida não eliciável, segundo Roccioletti (2016) e Osmundsen (2016). Embora não seja relevante para o backtesting de acordo com Acerbi e Szekely (2014). Atualmente, ambos os métodos são utilizados para a avaliação do risco de mercado. Nesta dissertação apresenta-se uma análise de como são aplicadas, em séries financeiras, as várias formas de implementação do Value-at-Risk e do Expected Shortfall associado ao principal índice bolsista de Portugal, o PSI20. Recorreu-se a modelos paramétricos e não-paramétricos: o modelo com distribuição Normal e o modelo com distribuição e T-student, e o modelo Kernel, respetivamente. E, foi, também, utilizado o modelo GARCH com distribuição Normal. Por fim, foram aplicadas e analisadas metodologias de backtesting: o teste de Kupiec (1995) e o teste de Christoffersen (1998), para a avaliação dos diferentes modelos de previsão do Value-at-Risk e, ainda, os testes 1 e 2 desenvolvidos por Acerbi e Szekely (2014) para a previsão do Expected Shortfall. Para a série financeira em estudo conclui-se que o modelo paramétrico com distribuição Normal determina o melhor desempenho na previsão do risco, relativamente ao método Expected Shortfall.The financial risk has increasingly affect the decisions taken by financial institutions. As such, the price of an asset affects the financial markets, which directly affects the actions of financial institutions, since these are at risk, given an investiment made previously. Following this, financial institutions have implemented some risk prevention and risk management strategies, such as Value-at-Risk (VaR) and Expected Shortfall (ES). Value-at-Risk is a risk method widely used by financial institutions. However, the disadvantage of this method, not being a coherent measure, led to search for an alternative method, the Expected Shortall, by financial institutions. Although, Expected Shortfall has emerged to rectify the gaps of Value-at-Risk, this method also has its drawbacks, is it considered a non-elicitable measure, according to Roccioletti (2016) and Osmundsen (2016). Although it is not relevant for backtesting according to Acerbi e Szekely (2014). Currently, both methods are used for market risk evaluation. This dissertation present an analysis of how several forms of implementation of Value-at-Risk and Expected Shortfall associated with the main stock index of Portugal, the PSI20, are applied to financial series. We used parametric and non-parametric models: the model with Normal distribution and the model with T-student distribution, and the Kernel model, respectively. And , the GARCH model with Normal distribution was also used. Finally, we applied and analyzed backtesting methodologies: the Kupiec (1995) test and the Christoffersen (1998) test, for the evaluation of different Value-at-Risk forecasting models, as well as the tests 1 e 2 developed by Acerbi e Szekely (2014) for the Expected Shortfall forecasting. For the financial serie under study we conclude that the parametric model with Normal distribution determines the best performance in the risk forecast, in relation to the Expected Shorfall method