2,087 research outputs found
Industrial Involvement in Information System Education: Lessons Learned from a Software Quality Course
As Information System (IS) development is closely related to industry and real-world applications, industrial involvement is a critical element in IS education. This paper studies one typical IS course - a Software Quality course, and reflects our experience with involving a mix of industrial experts in building a practical IS course that would increase students’ competences in critical thinking about the consequences of the design and quality engineering decisions that they are making during software development. In the course design, the industrial experts are involved in lecturing, hands-on-exercise seminars and final student evaluation. We find that students are showing active course participation with our designed industrial involvement. Furthermore, we summarize lessons learned from the industry involvement, as well as the reflections on the value perceived by the industrial experts involved in the IS education
CopAS: A Big Data Forensic Analytics System
With the advancing digitization of our society, network security has become
one of the critical concerns for most organizations. In this paper, we present
CopAS, a system targeted at Big Data forensics analysis, allowing network
operators to comfortably analyze and correlate large amounts of network data to
get insights about potentially malicious and suspicious events. We demonstrate
the practical usage of CopAS for insider threat detection on a publicly
available PCAP dataset and show how the system can be used to detect insiders
hiding their malicious activity in the large amounts of networking data streams
generated during the daily activities of an organization
Bridge deck flutter derivatives: efficient numerical evaluation exploiting their interdependence
Increasing the efficiency in the process to numerically compute the flutter derivatives of bridge deck sections is desirable to advance the application of CFD based aerodynamic design in industrial projects. In this article, a 2D unsteady Reynolds-averaged Navier-Stokes (URANS) approach adopting Menter׳s SST k-ω turbulence model is employed for computing the flutter derivatives and the static aerodynamic characteristics of two well known examples: a rectangular cylinder showing a completely reattached flow and the generic G1 section representative of streamlined deck sections. The analytical relationships between flutter derivatives reported in the literature are applied with the purpose of halving the number of required numerical simulations for computing the flutter derivatives. The solver of choice has been the open source code OpenFOAM. It has been found that the proposed methodology offers results which agree well with the experimental data and the accuracy of the estimated flutter derivatives is similar to the results reported in the literature where the complete set of numerical simulations has been performed for both heave and pitch degrees of freedom
Evolutionary dynamic optimisation of airport security lane schedules
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Reducing costs whilst maintaining passenger satisfaction is an important problem for airports. One area this can be applied is the security lane checks at the airport. However, reducing costs through reducing lane openings typically increases queue length and hence passenger dissatisfaction. This paper demonstrates that evolutionary methods can be used to optimise airport security lane schedules such that passenger dissatisfaction and staffing costs can be minimised. However, it is shown that these schedules typically over-fit the forecasts of passenger arrivals at security such that in actuality significant passenger delays can occur with deviations from the forecast. Consequently, this paper further demonstrates that dynamic evolutionary re-optimisation of these schedules can significantly mitigate this over-fitting problem with much reduced passenger delays
Transport Through Andreev Bound States in a Graphene Quantum Dot
Andreev reflection-where an electron in a normal metal backscatters off a
superconductor into a hole-forms the basis of low energy transport through
superconducting junctions. Andreev reflection in confined regions gives rise to
discrete Andreev bound states (ABS), which can carry a supercurrent and have
recently been proposed as the basis of qubits [1-3]. Although signatures of
Andreev reflection and bound states in conductance have been widely reported
[4], it has been difficult to directly probe individual ABS. Here, we report
transport measurements of sharp, gate-tunable ABS formed in a
superconductor-quantum dot (QD)-normal system, which incorporates graphene. The
QD exists in the graphene under the superconducting contact, due to a
work-function mismatch [5, 6]. The ABS form when the discrete QD levels are
proximity coupled to the superconducting contact. Due to the low density of
states of graphene and the sensitivity of the QD levels to an applied gate
voltage, the ABS spectra are narrow, can be tuned to zero energy via gate
voltage, and show a striking pattern in transport measurements.Comment: 25 Pages, included SO
Role of IL-28B and inosine triphosphatase polymorphisms in efficacy and safety of Peg-Interferon and ribavirin in chronic hepatitis C compensated cirrhosis with and without oesophageal varices.
Genetic factors can influence the outcome of antiviral therapy in chronic hepatitis C (HCV). We evaluated the role of interleukin-28B single nucleotide polymorphisms (SNPs) and inosine triphosphatase (ITPA) gene variants in HCV cirrhosis treated with Peg-Interferon and ribavirin. A prospective cohort of 233 patients with compensated cirrhosis received 1-1.5 μg/kg/week of Peg-Interferon alpha-2b plus 1000-1200 mg/day of RBV for 48 weeks. A sustained virologic response (SVR) was achieved in 27% of patients. On multivariate logistic analysis, the absence of oesophageal varices (OR 3.64 CI 95% 1.27-10.44 P = 0.016), infection with genotype 2 or 3 (OR 4.06, CI 95% 1.08-15.26, P = 0.038), C/C alleles of rs12979860 SNP (OR 7.04, CI 95% 2.40-20.72, P < 0.001) and rapid virologic response (RVR) (OR 78.29, CI 95% 16.07-381.29, P < 0.001) were independently associated with SVR. Patients who experienced post-treatment relapse received lower total doses of Peg-Interferon (52.0 ± 15.8 μg/kg vs 65.7 ± 13.3 μg/kg, P < 0.001) and lower total dose of RBV (3829 ± 1210 mg vs 4709 ± 954 mg, P < 0.001) than patients who achieved an SVR. ITPA variants predictive of high ITPase activity were associated with reduction of haemoglobin ≥3 g/dL in the first 4 weeks (P < 0.001), and with reduction of haemoglobin <10 g/dL (P = 0.03) on treatment. In conclusion, combination therapy with Peg-Interferon and RBV in patients with HCV cirrhosis must be guided by virus genotype, severity of portal hypertension, favourable IL-28B polymorphisms and ITPA variants, and RVR on treatment
(6R)-2-tert-Butyl-6-[(4R,5S)-3-isopropyl-4-methyl-5-phenyloxazolidin-2-yl]phenol
In the title compound, C23H31NO2, the lone pair on the nitrogen atom is oriented to facilitate intramolecular hydrogen bonding with the hydroxy group residing on the phenyl substituent. The five-membered ring adopts an envelope confornmation with the O atom at the flap. The absolute stereochemistry was verified by measurement of optical activity using a digital polarimeter
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