Increased fluid flow activity in shallow sediments at the 3 km Long Hugin Fracture in the central North Sea

The North Sea hosts a wide variety of seafloor seeps that may be important for transfer of chemical species, such as methane, from the Earth's interior to its exterior. Here we provide geochemical and geophysical evidence for fluid flow within shallow sediments at the recently discovered, 3-km long Hugin Fracture in the Central North Sea. Although venting of gas bubbles was not observed, concentrations of dissolved methane were significantly elevated (up to six-times background values) in the water column at various locations above the fracture, and microbial mats that form in the presence of methane were observed at the seafloor. Seismic amplitude anomalies revealed a bright spot at a fault bend that may be the source of the water column methane. Sediment porewaters recovered in close proximity to the Hugin Fracture indicate the presence of fluids from two different shallow (<500m) sources: (i) a reduced fluid characterized by elevated methane concentrations and/or high levels of dissolved sulfide (up to 6 mmol L−1), and (ii) a low-chlorinity fluid (Cl ∼305 mmol L−1) that has low levels of dissolved methane and/or sulfide. The area of the seafloor affected by the presence of methane-enriched fluids is similar to the footprint of seepage from other morphological features in the North Sea

Successful and unsuccessful approaches to imaging carcinoids: Comparison of a radiolabelled tryptophan hydroxylase inhibitor with a tracer of biogenic amine uptake and storage, and a somatostatin analogue

A mouse mastocytoma model was used to determine the biodistribution and tumour uptake of four radiopharmaceuticals developed to target the serotonin synthetic pathway in carcinoid tumours. Three of the compounds were competitive inhibitors of the rate-limiting enzyme of serotonin synthesis, tryptophan hydroxylase. Radiolabelled iodo- dl -phenylalanine (iodine-131 PIPA) was found to have the highest uptake and tumourto-liver ratio. Four patients with known carcinoid tumours were then injected with 0.5 mCi 131 I-PIPA and imaged at 1, 4, 24 and 48 h post-injection. The radiopharmaceutical, however, failed to localize in the known tumour sites. This result was in contrast to the authors' experience of 131 I- and 123 I-MIBG imaging of carcinoid tumours. Seven patients with known metastatic carcinoid tumours, two patients with symptoms of recurrence following tumour resection, one patient with completely resected disease, and two patients with a flushing syndrome of uncertain aetiology were studied with 131 I-MIBG. Three of the seven patients with known metastatic disease had positive 131 I-MIBG scans. Both patients with clinical evidence of recurrent disease had negative scans, as did the patient who was considered to have had complete resection of her primary tumour. The two patients with idiopathic flushing syndrome also had negative scans. Among seven patients imaged with 123 I-MIBG there were four true-negative scans and one falsenegative, the latter in a patient with biochemical and CT evidence of recurrence. In a seventh patient with distant metastases there was variable uptake in some of the lesions. Four patients were studied with indium-111 penetetreodide. Two patients with metastatic carcinoid disease had positive scans, although hepatic metastases were not seen in one. Another two with idiopathic flushing syndrome had normal studies. The literature suggests that up 50% of carcinoid tumour cases are detected with 131 I-MIBG, compared to a sensitivity of 87% reported with somatostatin receptor imaging using 111 In-pentetreotide. The experience with 123 I-MIBG is much less extensive. The mechanisms of carcinoid tumour localization for each of the three classes of radiotracers are discussed and contrasted to their varying sensitivities. The relative success of 131 I-MIBG and 111 In-pentetreotide relative to 131 I-PIPA may be related to the fact that 131 I-MIBG is actively taken up and stored by the enterochromaffin cells of the tumours and 111 In-pentetreotide binds to cell surface receptors, whereas 131 I-PIPA binds to tryptophan hydroxylase, which may be present in quantities too small to permit tumours to be imaged.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46840/1/259_2005_Article_BF01731835.pd

CARMENES: high-resolution spectra and precise radial velocities in the red and infrared

SPIE Astronomical Telescopes + Instrumentation (2018, Austin, Texas, United States

Orbital forcing of glacial/interglacial variations in chemical weathering and silicon cycling within the upper White Nile basin, East Africa: Stable-isotope and biomarker evidence from Lakes Victoria and Edward

On Quaternary time scales, the global biogeochemical cycle of silicon is interlocked with the carbon cycle through biotic enhancement of silicate weathering and uptake of dissolved silica by vascular plants and aquatic microalgae (notably diatoms, for which Si is an essential nutrient). Large tropical river systems dominate the export of Si from the continents to the oceans. Here, we investigate variations in Si cycling in the upper White Nile basin over the last 15 ka, using sediment cores from Lakes Victoria and Edward. Coupled measurements of stable O and Si isotopes on diatom separates were used to reconstruct past changes in lake hydrology and Si cycling, while the abundances of lipid biomarkers characteristic of terrestrial/emergent higher plants, submerged/floating aquatic macrophytes and freshwater algae document past ecosystem changes. During the late-glacial to mid-Holocene, 15–5.5 ka BP, orbital forcing greatly enhanced monsoon rainfall, forest cover and chemical weathering. Riverine inputs of dissolved silica from the lake catchments exceeded aquatic demand and may also have had lower Si-isotope values. Since 5.5 ka BP, increasingly dry climates and more open vegetation, reinforced by the spread of agricultural cropland over the last 3–4 ka, have reduced dissolved silica inputs into the lakes. Centennial-to millennial-scale dry episodes are also evident in the isotopic records and merit further investigation