379 research outputs found
On a Tree and a Path with no Geometric Simultaneous Embedding
Two graphs and admit a geometric simultaneous
embedding if there exists a set of points P and a bijection M: P -> V that
induce planar straight-line embeddings both for and for . While it
is known that two caterpillars always admit a geometric simultaneous embedding
and that two trees not always admit one, the question about a tree and a path
is still open and is often regarded as the most prominent open problem in this
area. We answer this question in the negative by providing a counterexample.
Additionally, since the counterexample uses disjoint edge sets for the two
graphs, we also negatively answer another open question, that is, whether it is
possible to simultaneously embed two edge-disjoint trees. As a final result, we
study the same problem when some constraints on the tree are imposed. Namely,
we show that a tree of depth 2 and a path always admit a geometric simultaneous
embedding. In fact, such a strong constraint is not so far from closing the gap
with the instances not admitting any solution, as the tree used in our
counterexample has depth 4.Comment: 42 pages, 33 figure
Pattern densities in fluid dimer models
In this paper, we introduce a family of observables for the dimer model on a
bi-periodic bipartite planar graph, called pattern density fields. We study the
scaling limit of these objects for liquid and gaseous Gibbs measures of the
dimer model, and prove that they converge to a linear combination of a
derivative of the Gaussian massless free field and an independent white noise.Comment: 38 pages, 3 figure
Convexity in partial cubes: the hull number
We prove that the combinatorial optimization problem of determining the hull
number of a partial cube is NP-complete. This makes partial cubes the minimal
graph class for which NP-completeness of this problem is known and improves
some earlier results in the literature.
On the other hand we provide a polynomial-time algorithm to determine the
hull number of planar partial cube quadrangulations.
Instances of the hull number problem for partial cubes described include
poset dimension and hitting sets for interiors of curves in the plane.
To obtain the above results, we investigate convexity in partial cubes and
characterize these graphs in terms of their lattice of convex subgraphs,
improving a theorem of Handa. Furthermore we provide a topological
representation theorem for planar partial cubes, generalizing a result of
Fukuda and Handa about rank three oriented matroids.Comment: 19 pages, 4 figure
A radium assay technique using hydrous titanium oxide adsorbent for the Sudbury Neutrino Observatory
As photodisintegration of deuterons mimics the disintegration of deuterons by
neutrinos, the accurate measurement of the radioactivity from thorium and
uranium decay chains in the heavy water in the Sudbury Neutrino Observatory
(SNO) is essential for the determination of the total solar neutrino flux. A
radium assay technique of the required sensitivity is described that uses
hydrous titanium oxide adsorbent on a filtration membrane together with a
beta-alpha delayed coincidence counting system. For a 200 tonne assay the
detection limit for 232Th is a concentration of 3 x 10^(-16) g Th/g water and
for 238U of 3 x 10^(-16) g U/g water. Results of assays of both the heavy and
light water carried out during the first two years of data collection of SNO
are presented.Comment: 12 pages, 4 figure
Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-ÎČ
Increasing evidence suggests that kynurenine pathway (KP) dyshomeostasis may promote disease progression in dementia. Studies in Alzheimer's disease (AD) patients confirm KP dyshomeostasis in plasma and cerebrospinal fluid (CSF) which correlates with amyloid-ÎČ and tau pathology. Herein, we performed the first comprehensive study assessing baseline levels of KP metabolites in participants enrolling in the Australian Imaging Biomarkers Flagship Study of Aging. Our purpose was to test the hypothesis that changes in KP metabolites may be biomarkers of dementia processes that are largely silent. We used a cross-sectional analytical approach to assess non-progressors (N = 73); cognitively normal (CN) or mild cognitive impairment (MCI) participants at baseline and throughout the study, and progressors (N = 166); CN or MCI at baseline but progressing to either MCI or AD during the study. Significant KP changes in progressors included increased 3-hydroxyanthranilic acid (3-HAA) and 3-hydroxyanthranilic acid/anthranilic acid (3-HAA/AA) ratio, the latter having the largest effect on the odds of an individual being a progressor (OR 35.3; 95% CI between 14 and 104). 3-HAA levels were hence surprisingly bi-phasic, high in progressors but low in non-progressors or participants who had already transitioned to MCI or dementia. This is a new, unexpected and interesting result, as most studies of the KP in neurodegenerative disease show reduced 3-HAA/AA ratio after diagnosis. The neuroprotective metabolite picolinic acid was also significantly decreased while the neurotoxic metabolite 3-hydroxykynurenine increased in progressors. These results were significant even after adjustment for confounders. Considering the magnitude of the OR to predict change in cognition, it is important that these findings are replicated in other populations. Independent validation of our findings may confirm the utility of 3-HAA/AA ratio to predict change in cognition leading to dementia in clinical settings
Alzheimerâs disease cerebrospinal fluid biomarkers are not influenced by gravity drip or aspiration extraction methodology
Introduction: Cerebrospinal fluid (CSF) biomarkers, although of established utility in the diagnostic evaluation of Alzheimer's disease (AD), are known to be sensitive to variation based on pre-analytical sample processing. We assessed whether gravity droplet collection versus syringe aspiration was another factor influencing CSF biomarker analyte concentrations and reproducibility.
Methods: Standardized lumbar puncture using small calibre atraumatic spinal needles and CSF collection using gravity fed collection followed by syringe aspirated extraction was performed in a sample of elderly individuals participating in a large long-term observational research trial. Analyte assay concentrations were compared.
Results: For the 44 total paired samples of gravity collection and aspiration, reproducibility was high for biomarker CSF analyte assay concentrations (concordance correlation [95%CI]: beta-amyloid1-42 (AÎČ42) 0.83 [0.71 - 0.90]), t-tau 0.99 [0.98 - 0.99], and phosphorylated tau (p-tau) 0.82 [95 % CI 0.71 - 0.89]) and Bonferroni corrected paired sample t-tests showed no significant differences (group means (SD): AÎČ42 366.5 (86.8) vs 354.3 (82.6), p = 0.10; t-tau 83.9 (46.6) vs 84.7 (47.4) p = 0.49; p-tau 43.5 (22.8) vs 40.0 (17.7), p = 0.05). The mean duration of collection was 10.9 minutes for gravity collection and <1 minute for aspiration.
Conclusions: Our results demonstrate that aspiration of CSF is comparable to gravity droplet collection for AD biomarker analyses but could considerably accelerate throughput and improve the procedural tolerability for assessment of CSF biomarkers
Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment
This paper describes an analysis of the angular distribution of W->enu and
W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with
the ATLAS detector at the LHC in 2010, corresponding to an integrated
luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and
the missing transverse energy, the W decay angular distribution projected onto
the transverse plane is obtained and analysed in terms of helicity fractions
f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV
and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw
> 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour,
are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017
+/- 0.030, where the first uncertainties are statistical, and the second
include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables,
revised author list, matches European Journal of Physics C versio
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