Improving Amazon Pipelines efficiency for Web Applications

The web applications we use in our day to day are supported by an infrastucture to makethem avaliable for our use. In this project we will analyse and improve upon the infrastucture thatsupports some of the web applications used in Idneo. In this project the applications are hostedusing Amazon Web Services. AWS will be the main source of infrastucture used to support ourapplications. We will explain and compare the various services from AWS used to support ourapplications and find out ways to improve the currently used systems to reduce costs and improvethe quality of the infrastucure.Las aplicaciones web que usamos en nuestro d ́ıa a d ́ıa funcionan gracias a toda unainfraestructura que permite que las podamos usar. En este proyecto analizaremos y mejoraremosla infraestructura que usamos en algunas de las aplicaciones web que usamos en Idneo. Estasaplicaciones usan Amazon Web Services para mantenerse. Explicaremos los varios servicios deAWS usados para dar soporte a las aplicaciones web y encontraremos formas de mejorarlos parareducir costes y mejorar la calidad de esta infraestructura.Les aplicacions web que fem servir en el nostre dia a dia compten amb una infraestructura per fer-les disponibles per al nostre ús. En aquest projecte analitzarem i millorarem la infraestructura que admet algunes de les aplicacions web utilitzades a Idneo. En aquest projecte, les aplicacions s'allotgen mitjançant Amazon Web Services. AWS serà la principal font d'infraestructura que s'utilitza per donar suport a les aplicacions. Explicarem i compararem els diversos serveis d'AWS que s'utilitzen per donar suport a les aplicacions i trobarem maneres de millorar els sistemes que s'utilitzen actualment per reduir els costos i millorar la qualitat de la infraestructura

Field dependence of the electronic phase separation in Pr0.67Ca0.33MnO3 by small angle magnetic neutron scattering

We have studied by small angle neutron scattering the evolution induced by the application of magnetic field of the coexistence of ferromagnetism (F) and antiferromagnetism (AF) in a crystal of Pr$_{0.67}$Ca$_{0.33}$MnO$_3$. The results are compared to magnetic measurements which provide the evolution of the ferromagnetic fraction. These results show that the growth of the ferromagnetic phase corresponds to an increase of the thickness of the ferromagnetic ''cabbage'' sheets

Trophic transfer of pesticides : The fine line between predator–prey regulation and pesticide–pest regulation

Acknowledgments JF benefited from a Marie Skłodowska-Curie fellowship (European Commission, project "VOLES", 660718). VB was employed with this project funds. We are very grateful to Deon Roos for reviewing drafts. We thank Alessandro Massolo, Thibault Moulin and Francis Raoul for helpful suggestions. This work benefited from long-term data collected at Zone atelier (ILTER) Arc jurassien (http://zaaj.univ-fcomte.fr) and its financial support. DATA availability statement All code and data used for this manuscript are available on Github https://zenodo.org/badge/latestdoi/233555669 (Baudrot et al., 2020).Peer reviewedPostprin

Evaluation of live forensic techniques, towards Salsa20-Based cryptographic ransomware mitigation

Ransomware has been established as one of the largest current threats to organisations, small businesses, governments, and individuals alike. The appearance of cryptocurrencies and the enhancement of encryption key management schemes increased the capacity of this malicious software to compromise the victim's data and demand ransom payments. The variety of ransomware families and their continued evolution make the task of detecting and mitigating these attacks extremely difficult. Current ransomware typically uses complex multi-layer hybrid encryption methods, which cannot be mitigated using conventional methods such as attacking the encryption keys directly. Recent studies have shown that when using live forensic techniques, it is possible to find the ransomware data encryption keys in the volatile memory of an infected machine while the ransomware is being executed, in a form of a side-channel attack. However, the related work in the field does not address the most recent cryptography typically now used by ransomware, including stream ciphers such as Salsa20. Related work has also not fully explored the typical use of unique keys per victim's file which is now common with current ransomware. The work described in this paper reproduces these latest cryptographic management techniques being used and explores methods for both, Salsa20 key extraction from memory, and one key per file ransomware encryption key recovery. The methods have been evaluated against recent real-world ransomware samples with various victim file data sets. The method has been shown in some cases to successfully recover over 90% of Salsa20 key and nonce pairs from volatile memory, which in turn have been used to decrypt victim files to validate the extracted pairs. This method could facilitate the recovery of victims' files without the need for paying a ransom and bypasses the complex hybrid encryption methods typically used by current ransomware. The findings from the experiments show that it is possible to use live memory forensics to extract multiple ransomware symmetric encryption keys during execution, and then use these to successfully decrypt a large percentage of the victim's encrypted files without requiring the master key. The developed method could be used to help recover from the most advanced current ransomware attack and can prove useful when developing new cryptographic ransomware mitigation techniques

Correlations equalities and some upper bounds for the critical temperature for spin one systems

Starting from correlation identities for the Blume-Capel spin 1 systems and using correlation inequalities, we obtain rigorous upper bounds for the critical temperature.The obtained results improve over effective field type results.Comment: 13 page

Theory of hot electrons: general discussion

Sylwester Gawinkowski opened discussion of the paper by Javier Aizpurua: How many electrons are transferred by one ultrashort pulse? If you are thinking about applications in electronics, then it seems that this number may be too small. Is simply increasing the pulse energy and therefore significantly increasing the number of such emitted electrons possible

Photometric determination of the mass accretion rates of pre-main sequence stars. II. NGC346 in the Small Magellanic Cloud

[Abridged] We have studied the properties of the stellar populations in the field of the NGC346 cluster in the Small Magellanic Cloud, using a novel self-consistent method that allows us to reliably identify pre-main sequence (PMS) objects actively undergoing mass accretion, regardless of their age. The method does not require spectroscopy and combines broad-band V and I photometry with narrow-band Halpha imaging to identify all stars with excess Halpha emission and derive the accretion luminosity Lacc and mass accretion rate Macc for all of them. The application of this method to existing HST/ACS photometry of the NGC346 field has allowed us to identify and study 680 bona-fide PMS stars with masses from ~0.4 to ~4 Msolar and ages in the range from ~1 to ~30 Myr. This is the first study to reveal that, besides a young population of PMS stars (~ 1 Myr old), in this field there is also an older population of PMS objects with a median age of ~20 Myr. We provide for all of them accurate physical parameters. We study the evolution of the mass accretion rate as a function of stellar parameters and find that logMacc ~ -0.6 Log t + Log m + c, where t is the age of the star, m its mass and c a quantity that is higher at lower metallicity. The high mass accretion rates that we find suggest that a considerable fraction of the stellar mass is accreted during the PMS phase and that PMS evolutionary models that do not account for this effect will systematically underestimate the true age when compared with the observations.Comment: Accepted for publication in the ApJ. 14 pages, 11 figures. Corrected typos and reference

Abcg2 transporter affects plasma, milk and tissue levels of meloxicam

33 p.ATP-binding cassette (ABCG2) is an efflux transporter that extrudes xenotoxins from cells in liver, intestine, mammary gland, brain and other organs, affecting the pharmacokinetics, brain accumulation and secretion into milk of several compounds, including antitumoral, antimicrobial and anti-inflammatory drugs. The aim of this study was to investigate whether the widely used anti-inflammatory drug meloxicam is an Abcg2 sustrate, and how this transporter affects its systemic distribution. Using polarized ABCG2-transduced cell lines, we found that meloxicam is efficiently transported by murine Abcg2 and human ABCG2. After oral administration of meloxicam, the area under the plasma concentration-time curve in Abcg2-/- mice was 2-fold higher than in wild type mice (146.06 ± 10.57 μg·h/ml versus 73.80 ± 10.00 μg·h/ml). Differences in meloxicam distribution were reported for several tissues, with a 20-fold higher concentration in the brain of Abcg2-/- compared to wild-type mice. Meloxicam secretion into milk was also affected by the transporter, with a 2.5-fold higher milk-to-plasma ratio in wild-type compared with Abcg2-/- lactating female mice (0.58 ± 0.08 versus 0.23 ± 0.06). We conclude that Abcg2 is an important determinant of the plasma and brain distribution of meloxicam and is clearly involved in its secretion into milk. This study was supported by the research projects AGL2015-65626-R (MINECO/FEDER, UE) and RTI2018-100903-B-I00 (AEI/FEDER, UE); and by the predoctoral grants from the Ministry of Economy, Industry and Competitiveness (BES-2016-077235 grant to AMGL), and from Spanish Ministry of Education, Culture and Sport (FPU14/05131 grant to DGM AND FPU18/01559 grant to EBP); and the Junta de Castilla y Leon and European Regional Development Fund (Post-Doctoral Fellowship LE011P17 grant to IAF)

Abcg2 transporter affects plasma, milk and tissue levels of meloxicam

https://doi.org/10.1016/j.bcp.2020.113924ATP-binding cassette (ABCG2) is an efflux transporter that extrudes xenotoxins from cells in liver, intestine, mammary gland, brain and other organs, affecting the pharmacokinetics, brain accumulation and secretion into milk of several compounds, including antitumoral, antimicrobial and anti-inflammatory drugs. The aim of this study was to investigate whether the widely used anti-inflammatory drug meloxicam is an Abcg2 sustrate, and how this transporter affects its systemic distribution. Using polarized ABCG2-transduced cell lines, we found that meloxicam is efficiently transported by murine Abcg2 and human ABCG2. After oral administration of meloxicam, the area under the plasma concentration-time curve in Abcg2-/- mice was 2-fold higher than in wild type mice (146.06 ± 10.57 μg·h/ml versus 73.80 ± 10.00 μg·h/ml). Differences in meloxicam distribution were reported for several tissues after oral and intravenous administration, with a 20-fold higher concentration in the brain of Abcg2-/- after oral administration. Meloxicam secretion into milk was also affected by the transporter, with a 2-fold higher milk-to-plasma ratio in wild-type compared with Abcg2-/- lactating female mice after oral and intravenous administration. We conclude that Abcg2 is an important determinant of the plasma and brain distribution of meloxicam and is clearly involved in its secretion into milk.S

Dynamics of enhancer chromatin signatures mark the transition from pluripotency to cell specification during embryogenesis

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date; after six months, it is available under a Creative Commons License.-- et al.The generation of distinctive cell types that form different tissues and organs requires precise, temporal and spatial control of gene expression. This depends on specific cis-regulatory elements distributed in the noncoding DNA surrounding their target genes. Studies performed on mammalian embryonic stem cells and Drosophila embryos suggest that active enhancers form part of a defined chromatin landscape marked by histone H3 lysine 4 mono-methylation (H3K4me1) and histone H3 lysine 27 acetylation (H3K27ac). Nevertheless, little is known about the dynamics and the potential roles of these marks during vertebrate embryogenesis. Here, we provide genomic maps of H3K4me1/me3 and H3K27ac at four developmental time-points of zebrafish embryogenesis and analyze embryonic enhancer activity. We find that (1) changes in H3K27ac enrichment at enhancers accompany the shift from pluripotency to tissue-specific gene expression, (2) in early embryos, the peaks of H3K27ac enrichment are bound by pluripotent factors such as Nanog, and (3) the degree of evolutionary conservation is higher for enhancers that become marked by H3K27ac at the end of gastrulation, suggesting their implication in the establishment of the most conserved (phylotypic) transcriptome that is known to occur later at the pharyngula stage.We thank the Spanish and Andalusian Governments for grants (BFU2010-14839, CSD2007-00008, and Proyecto de Excelencia CVI-3488) for funding this study.Peer reviewe