Titanocene–gold complexes containing N-heterocyclic carbene ligands inhibit growth of prostate, renal, and colon cancers in vitro

We report on the synthesis, characterization, and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba = −OC(O)-p-C6H4-S−) bound to gold(I)−N-heterocyclic carbene fragments through the thiolate group: [(η5 -C5H5)2TiMe(μ-mba)Au(NHC)]. The cytotoxicities of the heterometallic compounds along with those of novel monometallic gold−N-heterocyclic carbene precursors [(NHC)Au(mbaH)] have been evaluated against renal, prostate, colon, and breast cancer cell lines. The highest activity and selectivity and a synergistic effect of the resulting heterometallic species was found for the prostate and colon cancer cell lines. The colocalization of both titanium and gold metals (1:1 ratio) in PC3 prostate cancer cells was demonstrated for the selected compound 5a, indicating the robustness of the heterometallic compound in vitro. We describe here preliminary mechanistic data involving studies on the interaction of selected mono- and bimetallic compounds with plasmid (pBR322) used as a model nucleic acid and the inhibition of thioredoxin reductase in PC3 prostate cancer cells. The heterometallic compounds, which are highly apoptotic, exhibit strong antimigratory effects on the prostate cancer cell line PC3

The Progress Test of the European Hematology Association: A New Tool for Continuous Learning.

info:eu-repo/semantics/publishedVersio

The impact of COVID-19 lockdown on soccer positional and physical demands in the Spanish La Liga

The present study aimed to analyse the playing surface area, dispersion and distance covered of professional football teams comparing the pre-lockdown and post-lockdown periods. Positional and match physical demands data were collected from all matches played in the First Spanish Division (n = 760) during season 2019/2020. Pre-lockdown (1st–27th matchday) and post-lockdown periods (28th–38th matchday) were compared. Variables related to team-level spatial (i.e., convex hull, team width and team length) and physical performance (i.e., total distance and high-speed running distance) were analysed using an optical tracking system (i.e., ChyronHego). In addition, these variables were concerned with respect to the match location contextual variable. Linear mixed models were used to examine the difference between the pre-lockdown and post-lockdown periods following a hierarchical structure considering players, matches and teams. The results revealed that the pandemic lockdown affected the teams’ performance when comparing the periods before and after lockdown, showing a general decrease in the average values of the spatial and physical variables measured. The current data could assist practitioners in making informed decisions in order to design and improve training plans for similar situations in which teams return to competition after an unusual period with no training

Development of photocatalytic coatings for building materials with Bi2O3-ZnO nanoparticles

The aim of this study was to develop versatile coatings that can protect the stone surfaces of Ar-chitectural Heritage. Two different 3D media, namely superhydrophobic (SPHB) and hydrooleophobic (OHB), were utilized as host matrices for nanostructured photocatalysts (Bi2O3-ZnO 8/92). These photocatalysts were sensitive to visible light to enhance their efficiency when exposed to sunlight. To prevent the nanophotocatalyst from clumping together in the 3D media, non-ionic dispersant additives (Tween20, TritonX-100, and Brij35) were incorporated. The optimized suspensions were then applied to various substrates such as sandstone, limestone, and granite. The effectiveness of the coatings was assessed by evaluating the hydrophobicity, oleo-phobicity, and photocatalytic activity of the coated substrates. The Bi2O3-ZnO photocatalyst exhib-ited higher activity in the SPHB medium compared to the OHB medium. To simulate real-life con-ditions, the coated substrates were subjected to accelerated weathering tests to predict their dura-bility. Despite a significant reduction in their thickness, the coatings demonstrated sustained hy-drophobic efficiency and self-cleaning capability after the accelerated ageing tests

The impact of COVID-19 lockdown on soccer positional and physical demands in the Spanish La Liga.

The present study aimed to analyse the playing surface area, dispersion and distance covered of professional football teams comparing the pre-lockdown and post-lockdown periods. Positional and match physical demands data were collected from all matches played in the First Spanish Division (n = 760) during season 2019/2020. Pre-lockdown (1st-27th matchday) and post-lockdown periods (28th-38th matchday) were compared. Variables related to team-level spatial (i.e., convex hull, team width and team length) and physical performance (i.e., total distance and high-speed running distance) were analysed using an optical tracking system (i.e., ChyronHego). In addition, these variables were concerned with respect to the match location contextual variable. Linear mixed models were used to examine the difference between the pre-lockdown and post-lockdown periods following a hierarchical structure considering players, matches and teams. The results revealed that the pandemic lockdown affected the teams' performance when comparing the periods before and after lockdown, showing a general decrease in the average values of the spatial and physical variables measured. The current data could assist practitioners in making informed decisions in order to design and improve training plans for similar situations in which teams return to competition after an unusual period with no training

Proximidad residencial a industrias y mortalidad por enfermedades cardiovasculares y cáncer en personas mayores: Estudio Seniors-ENRICA

XLI Reunión anual de la Sociedad Española de Epidemiología (SEE) y XVIII Congresso da Associação Portuguesa de Epidemiología (APE). Porto (Portugal), del 5 al 8 de septiembre de 2023.Antecedentes/Objetivos: Las enfermedades cardiovasculares (ECV) y el cáncer son las dos principales causas de muerte en el mundo. Su etiología no es única y, en el caso del cáncer, tiene una parte desconocida, por lo que se necesita seguir evaluando el papel de potenciales factores de riesgo asociados con estas enfermedades. El objetivo fue analizar la asociación entre proximidad residencial a industrias contaminantes y mortalidad por ECV y cáncer, teniendo en cuenta categorías de sectores industriales y contaminantes emitidos en el estudio Seniors-ENRICA. Métodos: Seniors-ENRICA es una cohorte representativa a nivel nacional de población mayor de 60 años no institucionalizada con un seguimiento de 10 años, cuyo objetivo es evaluar factores de riesgo ambientales que afectan a la salud de las personas mayores, incluyendo mortalidad por ECV y cáncer. La cohorte se estableció en 2008-2010 con 3289 individuos que contribuyeron con 8562 visitas bianuales. Se geocodificaron los domicilios de los individuos y las industrias y se calculó la distancia entre ellos. Como medida de efecto se estimó el hazard ratio (HR) y su intervalo de confianza al 95% (IC95%) asociado a la proximidad (distancias desde ≤ 2 km hasta ≤ 5 km) a industrias mediante modelos de regresión de Cox para riesgos competitivos, ajustando por variables sociodemográficas y de estilos de vida a nivel individual, y por índice de privación a nivel de sección censal. Resultados: Durante el seguimiento, se produjeron 136 muertes por ECV y 146 por cáncer. No se encontró asociación entre proximidad a industrias y mortalidad por ECV para ninguna de las distancias analizadas, con HRs oscilando entre 0,89 (≤ 4 km) y 0,99 (≤ 2 km). Para mortalidad por cáncer, se encontraron asociaciones (HR; IC95%) positivas para el conjunto de industrias en todas las distancias analizadas, desde ≤ 2 km (3,16; 1,60-6,26) hasta ≤ 5 km (2,57, 1,37-4,81). Por sectores industriales, destacan los excesos de riesgo (HR; IC95%) de morir por cáncer en el entorno (≤ 5 km) de astilleros (4,38; 1,67-11,48), cementeras (5,31; 1,31-21,49) e instalaciones de galvanizado (4,05; 1,59-10,33). Por contaminantes, los principales excesos de riesgo (HR; IC95%) se encontraron en el entorno (≤ 5 km) de industrias emisoras de antraceno (4,70; 1,71-12,93) antimonio (4,63; 2,01-10,64) y ftalatos (4,20; 1,58-11,14). Conclusiones/Recomendaciones: Los resultados sugieren que vivir cerca de industrias podría ser un factor de riesgo para la mortalidad por cáncer en población > 60 años, pero no para ECV.Financiación: CIBERESP-ESP21PI04.N

A highly-resolved food web for insect seed predators in a species-rich tropical forest

The top-down and indirect effects of insects on plant communities depend on patterns of host use, which are often poorly documented, particularly in species-rich tropical forests. At Barro Colorado Island, Panama, we compiled the first food web quantifying trophic interactions between the majority of co-occurring woody plant species and their internally-feeding insect seed predators. Our study is based on more than 200,000 fruits representing 478 plant species, associated with 369 insect species. Insect host-specificity was remarkably high: only 20% of seed predator species were associated with more than one plant species, while each tree species experienced seed predation from a median of two insect species. Phylogeny, but not plant traits, explained patterns of seed predator attack. These data suggest that seed predators are unlikely to mediate indirect interactions such as apparent competition between plant species, but are consistent with their proposed contribution to maintaining plant diversity via the Janzen-Connell mechanism

Search for Kaluza-Klein Graviton Emission in ppˉp\bar{p} Collisions at s=1.8\sqrt{s}=1.8 TeV using the Missing Energy Signature

We report on a search for direct Kaluza-Klein graviton production in a data sample of 84 ${pb}^{-1}$ of \ppb collisions at $\sqrt{s}$ = 1.8 TeV, recorded by the Collider Detector at Fermilab. We investigate the final state of large missing transverse energy and one or two high energy jets. We compare the data with the predictions from a $3+1+n$-dimensional Kaluza-Klein scenario in which gravity becomes strong at the TeV scale. At 95% confidence level (C.L.) for $n$=2, 4, and 6 we exclude an effective Planck scale below 1.0, 0.77, and 0.71 TeV, respectively.Comment: Submitted to PRL, 7 pages 4 figures/Revision includes 5 figure