Lifetime suicidal-related behaviour among patients in treatment forsubstance use disorder: a cross-sectional study

Suicidal-related behaviours are an important concern in individuals who present with substance use disorders (SUDs). The distinction among the specific characteristics of the different patients might help to improve prevention strategies. We describe and compare the sociodemographic characteristics, severity of addiction, and psychopathology of the participants depending on the severity of their lifetime suicidal behaviour. In addition, we examine whether the number of suicide attempts can be estimated based on the variables that differentiate the groups. A sample of 318 men and 86 women who sought treatment for addiction were assessed. The sample was divided into: no ideation or attempts, suicidal ideation, one suicide attempt, and two or more suicide attempts. The group with two or more suicide attempts exhibited a greater severity in the addiction profile. The group with one suicide attempt presented a higher psychopathological symptomatology at the time of the assessment. The severity of the Psychiatric area was related to the group with two or more attempts and to the number of suicide attempts. The presence of any number of attempts is associated with greater severity of addiction. Providing specific intervention strategies for SUD patients depending on their suicidal behaviours is promising for clinical application.The first author was supported by a grant from the European UnionNext Generation EU by Ministerio de Universidades (Gobierno de España) and Universidad del País Vasco (UPV/EHU). The second author was supported by a grant (589/2021) from Universidad Pública de Navarra and Fundación Bancaria Caja Navarra. Open access funding provided by Universidad Pública de Navarr

Diferencias en variables de personalidad en sujetos adictos a drogas con y sin conductas violentas contra la pareja

This study explores the differences in personality characteristics of patients in treatment for drug addiction, comparing those who have committed intimate partner violent with those who do not. 125 subjects on treatment in the programs of the Proyecto Hombre Navarra Foundation were assessed. Sociodemographic and substance use variables (EuropASI), violent behaviours against intimate partners (CTS-2), interpersonal response (IRI), the anger expression (STAXI), impulsivity (BIS) and the degree of bad adaptation to daily life due to the drug consumption (Maladjustment Scale) were evaluated. The results showed that 33.6% of the patients had committed abusive behaviors against a partner in the past. The group with violent behaviours showed significantly higher scores in state-anger and anger-trait, as well as higher levels of impulsivity (motor and global). This group had a higher prevalence of women than men. There were no differences in other variables.ResumenEste estudio explora las diferencias en características de personalidad de pacientes en tratamiento por adicción a drogas, comparando aquellos que han presentado conductas violentas contra la pareja con aquellos que no. Participaron 125 sujetos en tratamiento en los programas de la Fundación Proyecto Hombre Navarra. Fueron evaluadas variables sociodemográficas y de consumo de sustancias (EuropASI), las conductas violentas contra la pareja (CTS-2), la respuesta interpersonal (IRI), la manifestación de la ira (STAXI), la impulsividad (BIS) y el grado de afectación por el consumo (Escala de Inadaptación). El 33.6% de los sujetos presentó conductas violentas contra su pareja en el pasado. El grupo con conductas violentas contra la pareja presentó puntuaciones significativamente más altas en los niveles de ira-estado y de ira-rasgo, así como en los niveles de impulsividad (motora y global). Dicho grupo tuvo una mayor prevalencia de mujeres que de hombres. No existieron diferencias en el resto de variables.AbstractThis study explores the differences in personality characteristics of patients in treatment for drug addiction, comparing those who have committed intimate partner violent with those who do not. 125 subjects on treatment in the programs of the Proyecto Hombre Navarra Foundation were assessed. Sociodemographic and substance use variables (EuropASI), violent behaviours against intimate partners (CTS-2), interpersonal response (IRI), the anger expression (STAXI), impulsivity (BIS) and the degree of bad adaptation to daily life due to the drug consumption (Maladjustment Scale) were evaluated. The results showed that 33.6% of the patients had committed abusive behaviors against a partner in the past. The group with violent behaviours showed significantly higher scores in state-anger and anger-trait, as well as higher levels of impulsivity (motor and global). This group had a higher prevalence of women than men. There were no differences in other variables.

Metastatic benign pleomorphic adenoma : report of a case and review of the literature

Pleomorphic adenoma (PA), originally called mixed tumour, is the most common neoplasm of the salivary glands and is generally accepted as benign biologically. Occasionally PA may give rise to metastasis. The metastasis may develop in a PA in which a malignant transformation occurs, either arising a carcinoma in the PA (carcinoma ex-mixed tumour) or as a carcinosarcoma (so?called true malignant mixed tumour). However, very rare benign PA eventually metastasise, usually after having a previous recurrence, displaying benign histological features as well in the primary tumour as in the metastasis. These tumours have been termed metastatic PA or metastatic mixed tumours. The aim of this paper is to report one case of metastatic histological benign pleomorphic adenoma, and to consider the clinical, pathological and therapeutic consequences of these rare tumours as well as its possible causes and mechanisms for its behaviour

Empty Urbanism: the bursting of the Spanish housing bubble

The depth of the Spanish housing crisis manifests itself in the collapse of construction activity and in the amount of housing and land stocks. The geography of the crisis shows its widespread nature, and the intensity of the previous bubble explains spatial differences. Resulting from this collapse are some problematic areas of 'empty urbanism'. An enormous land bubble, emerging from the peculiar Spanish urban development model, was a key factor in the impacts - caused by the crisis - on the territory and land-use plans. The crisis has demonstrated the unsustainability of this and the urgency of change in the existing land-use plans

Characterization of Photochromic Dye Solar Cells Using Small-Signal Perturbation Techniques

Photochromic dye-sensitized solar cells (DSSCs) are novel semi-transparent photovoltaic devices that self-adjust their optical properties to the irradiation conditions, a feature that makes them especially suitable for building integrated photovoltaics. These novel solar cells have already achieved efficiencies above 4%, and there are multiple pathways to improve the performance. In this work, we conduct a full characterization of DSSCs with the photochromic dye NPI, combining electrical impedance spectroscopy (EIS) and intensity-modulated photocurrent spectroscopy (IMPS). We argue that the inherent properties of the photochromic dye, which result in a modification of the functioning of the solar cell by the optical excitation that also acts as a probe, pose unique challenges to the interpretation of the results using conventional models. Absorption of light in the visible range significantly increases when the NPI dye is in the activated state; however, the recombination rate also increases, thus limiting the efficiency. We identify and quantify the mechanism of enhanced recombination when the photochromic dye is activated using a combination of EIS and IMPS. From the comparison to a state-of-the-art reference dye (RK1), we were able to detect a new feature in the IMPS spectrum that is associated with the optical activation of the photochromic dye, providing a useful tool for assessing the electronic behavior of the device under different conditions of light excitation. This study provides guidelines to adequate characterization protocols of photochromic solar cells and essential insights on the interfacial electronic processes.Universidad Pablo de Olavide / CEA Grenobl

Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer

[Background]: The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and outcomes of patients with early-onset CRC (EOCRC). [Methods]: We included all of the patients with pathologically confirmed diagnosis of CRC at Hospital Universitario La Paz from October 2016 to September 2020. EOCRC age cut-off was 50 years. All statistical analyses were carried out using SPSS v.25. [Results]: A total of 1152 patients were diagnosed with CRC, fifty-nine (5,1%) of them were After a median follow-up of 24 months, 279 patients have died. Median overall survival (OS) was not reached in either group (p = 0,06). Three-year OS was 80% (95%CI: 73-87) and 67 (95%CI: 65-69) in the younger and older group, respectively. In patients with localized disease that underwent surgery or other antineoplastic treatment ( n = 856), 159 events for disease-free survival (DFS) were observed. Median DFS was [Conclusions]: Patients with EOCRC are diagnosed at a more advanced stage and display distinct biological features (more prevalence of dMMR and WT tumors among others). Studies focusing on screening in this population and deeper molecular profiling are needed

Clinico-pathological characteristics and outcomes of patients with early-onset colorectal cancer

[Background]: The rising incidence of colorectal cancer (CRC) among young patients is alarming. We aim to characterize the clinico-pathological features and outcomes of patients with early-onset CRC (EOCRC).[Methods]: We included all of the patients with pathologically confirmed diagnosis of CRC at Hospital Universitario La Paz from October 2016 to September 2020. EOCRC age cut-off was 50 years. All statistical analyses were carried out using SPSS v.25. [Results]: A total of 1152 patients were diagnosed with CRC, fifty-nine (5,1%) of them were After a median follow-up of 24 months, 279 patients have died. Median overall survival (OS) was not reached in either group (p ¼ 0,06). Three-year OS was 80% (95% CI: 73-87) and 67 (95%CI: 65-69) in the younger and older group, respectively. In patients with localized disease that underwent surgery or other antineoplastic treatment ( n ¼ 856), 159 events for disease-free survival (DFS) were observed. Median DFS was not reached in either group (p ¼0,144). Three-year DFS was 86% (95%CI: 79-93) and 73% (95%CI: 71-75, respectively). In patients with metastatic disease (n ¼ 332; synchronous or metachronic), median OS was not reach in the EOCRC group vs 18,1 (95%CI: 13,8-22,4), p ¼ 0,05). In those patients with metastatic EOCRC with mutational status assessed (n ¼23), no difference in OS according to RAS was observed (p ¼ 0,55).[Conclusions]: Patients with EOCRC are diagnosed at a more advanced stage and display distinct biological features (more prevalence of dMMR and WT tumors among others). Studies focusing on screening in this population and deeper molecular profiling are needed.Peer reviewe

Actualistic taphonomic study of the rodents digested by the Achala culpeo fox (Lycalopex culpaeus smithersi) in the highlands of central Argentina

We present the first actualistic study of the rodents consumed by the South American foxLycalopex culpaeus smithersi (Achala culpeo fox), a subspecies of the culpeo fox that is endemicto the highlands of central Argentina. We provide a taphonomic characterization of this canidbased on digested micromammal bones, and compare it to other carnivores. We studied over 1000bones derived from 83 scats collected in Quebrada del Condorito National Park, Córdobaprovince, Argentina, corresponding to caviomorph and myomorph rodents. Galea leucoblepharawas the main prey (59.8% MNI, 93.1% biomass). Average relative abundance for the totalassemblage was 26.7. Cranial and, to a lesser extent, proximal limb bones were the most abundantelements. A high degree of breakage was observed in cranial elements and, to a lesser extent, inlimb bones. A high proportion of heavy and extreme digestion was inferred, while some elementsbear light or no digestion traces at all. Overall, the Achala culpeo fox fits best with othermammalian carnivores in the category of extreme modification, and shows types and proportionsof taphonomic attributes similar to other South American mammalian predators. These resultscontribute to the understanding of regional taphonomic processes and of digestivemodifications by Lycalopex foxes generally, and are thus relevant to interpreting the presence of micromammal remains in the archaeological and palaeontological recordsand the impact of these foxes in their formation.Fil: Coll, Daiana Geraldine. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Montalvo, Claudia Inés. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Fernández, Fernando Julián. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pia, Monica Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; ArgentinaFil: Mondini, Nora Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Antropología de Córdoba. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Instituto de Antropología de Córdoba; Argentin

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE