Functional activation and connectivity of the left inferior frontal gyrus during lexical and phonological retrieval

Being language a paradigm of structural and functional asymmetry in cognitive processing, the left Inferior Frontal Gyrus has been consistently related to speech production. In fact, it has been considered a key node in cortical networks responsible for different components of naming. However, isolating these components (e.g., lexical, syntactic, and phonological retrieval) in neuroimaging studies is difficult due to the use of different baselines and tasks. In the present study, functional activation and connectivity of the left inferior frontal gyrus was explored using functional magnetic resonance imaging. Participants performed a covert naming task (pressing a button based on a phonological characteristic). Two conditions were compared: drawings of objects and single letters (baseline condition). Differences in activation and functional connectivity were obtained for objects and letters in different areas of the left Inferior Frontal Gyrus. The pars triangularis was involved in the retrieval of lexical-phonological information, showing a pattern of connectivity with temporal areas in the search for the name of objects and with perisylvanian areas for letters. Selection of phonological information seems to involve the pars opercularis both to letters and objects but recruiting supramarginal and superior temporal areas to letters, probably related to orthographicphonological conversion. The results support the notion of the left Inferior Frontal Gyrus as a buffer forwarding neural information across cortical networks responsible for different components of speech productionThis research was funded by the Spanish Ministerio de Economía y Competitividad (Grant number: PSI2013 43594-R), Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (Grant number: ED431C-2021/04, from the EDRF/FEDER) and by a post-doctoral fellowship from Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (Grant number: ED481B2016/078-0). The funding sources were not involved in any aspect of the research or the submission of this studyS

Factores de crecimiento plaquetarios en el tratamiento de la tendinitis del tendón flexor digital superficial de un caballo de carreras

La tendinitis es una patología frecuente en los caballos de carreras. Su resolución no quirúrgica se basa en la disminución de la intensidad del entrenamiento del animal y en un tratamiento médico adecuado, que consiste en la administración de antiinflamatorios tanto sistémicos como tópicos, así como diuréticos para disminuir el edema, acompañados de vendajes y duchas frías. Además de este tratamiento conservador, se esta utilizando en medicina deportiva equina la infiltración local de plasma autólogo rico en factores de crecimiento plaquetarios (PRP), con muy buenos resultados. Para explicar en qué consiste, cómo se lleva a cabo y qué efectos tiene este tratamiento, se parte del caso clínico de una yegua de carreras PSI (pura sangre inglés), que presenta una tendinitis aguda en el tendón flexor digital superficial. Se reduce el nivel de entrenamiento y se instaura el tratamiento médico conservador descrito, junto con la infiltración local de PRP, que se obtiene a partir de la sangre de la yegua mediante un protocolo de sucesivas centrifugaciones. La pauta de tratamiento es de una infiltración semanal durante tres semanas consecutivas, tras las cuales una reevaluación ecográfica muestra una aparente recuperación macroscópica del tendón, que se revela completa en el tercer control ecográfico realizado un mes más tarde. Se concluye que la infiltración local de PRP, como complemento de las medidas de manejo y terapéuticas adecuadas, parece mostrar muy buenos resultados, favoreciendo el proceso de cicatrización y recuperación tisular y posibilitando el retorno del animal a una vida deportiva de calidad.Tendonitis is a frequent disease in racehorses. Its not-surgery resolution is based on decrease of the training intensity and on correct medical treatment, which consists in systemic antiISSN: 1988-2688 RCCV VOL. 3 (2). 2009 253 inflammatory, diuretics to decrease swelling, topic treatment with dressings and cold showers. Furthermore, it has being already used autologous plateled riched plasma (PRP) in equine sports medicine, with very good outcome. To explain this treatment, we resort to case report of a Thoroughbred (TB) racehorse mare with an acute superficial digital flexor tendonitis. We reduce her training level and treat with the classical medical therapy combined with PRP injection, which is obtained by means of successively centrifugations of the mare’s blood. The guideline was a local infiltration each week during three weeks. After that, an ultrasonography reevaluation shows an apparent macroscopic tendon recuperation that is full one month later. As a conclusion, this is a good outcome example of local PRP infiltration as a complement of correct therapy and management, which improves the tissue recuperation and makes possible animal return to high quality sports live

Las dificultades que plantea el concepto de unidad económico administrativa en el impuesto al patrimonio agropecuario.

La tributación en el sector agropecuario ha sufrido modificaciones significativas desde la puesta en vigencia de la Ley 18.083 (Reforma tributaria) y la posterior Ley 19.088 del año 2013. La creación del concepto de Unidad Económico Administrativa en el Impuesto al Patrimonio Agropecuario despierta particular interés en cuanto a su aplicación práctica. Este trabajo consiste en identificar las dificultades de aplicación del concepto

Multilevel fast multipole algorithm for fields

An efficient implementation of the multilevel fast multipole algorithm is herein applied to accelerate the calculation of the electromagnetic near- and far-fields after the equivalent surface currents have been obtained. In spite of all the research efforts being drawn to the latter, the electric and/or magnetic fields (or other parameters derived from these) are ultimately the magnitudes of interest in most of the cases. Though straightforward, their calculation can be computationally demanding, and hence the importance of finding a sped-up accurate representation of the fields via a suitable setup of the method. A complete self-contained formulation for both near- and far-fields and for problems including multiple penetrable regions is shown in full detail. Through numerical examples we show that the efficiency and scalability of the implementation leads to a drastic reduction of the computation time.Ministerio de Economía y Competitividad | Ref. MAT2014-58201-C2-1-RMinisterio de Economía y Competitividad | Ref. MAT2014-58201-C2-2-RGobierno Regional de Extremadura | Ref. IB1318

Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years: A systemic review

Background Serum cotinine has become the most widely used biomarker of secondhand smoke exposure (SHS) over time in all ages. The aim of this study was to review the serum cotinine cutpoints used to classify children under 5 years as exposed to SHS. Methods A systematic review performed in the Pubmed (MEDLINE) and EMBASE databases up to April 2021 was conducted using as key words serum cotinine, tobacco smoke pollution (MeSH), secondhand smoke, environmental tobacco smoke and tobacco smoke exposure. Papers which assessed SHS exposure among children younger than 5 years old were included. The PRISMA 2020 guidelines were followed. Analysis was pre-registered in PROSPERO (registration number: CRD42021251263). Results 247 articles were identified and 51 fulfilled inclusion criteria. The selected studies were published between 1985-2020. Most of them included adolescents and adults. Only three assessed postnatal exposure exclusively among children under 5 years. None of the selected studies proposed age-specific cut-points for children < 5 years old. Cut-point values to assess SHS exposure ranged from 0.015 to 100 ng/ml. The most commonly used cut-point was 0.05 ng/ml, derived from the assay limit of detection used by the National Health and Nutrition Examination Survey (NHANES). Conclusions No studies have calculated serum cotinine age-specific cut-points to ascertained SHS exposure among children under 5 years old. Children's age-specific cut-points are warranted for health research and public health purposes aimed at accurately estimating the prevalence of SHS exposure and attributable burden of disease to such exposure, and at reinforcing 100% smoke-free policies worldwide, both in homes, private vehicles and public places

The Treatment With the SGLT2 Inhibitor Empagliflozin Modifies the Hepatic Metabolome of Male Zucker Diabetic Fatty Rats Towards a Protective Profile

[Abstract] The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in patients with Type 2 Diabetes Mellitus (T2DM)) trial evidenced the potential of sodium-glucose cotransporter 2 (SGLT2) inhibitors for the treatment of patients with diabetes and cardiovascular disease. Recent evidences have shown the benefits of the SGLT2 inhibitor empagliflozin on improving liver steatosis and fibrosis in patients with T2DM. Metabolomic studies have been shown to be very useful to improve the understanding of liver pathophysiology during the development and progression of metabolic hepatic diseases, and because the effects of empagliflozin and of other SGLT2 inhibitors on the complete metabolic profile of the liver has never been analysed before, we decided to study the impact on the liver of male Zucker diabetic fatty (ZDF) rats of a treatment for 6 weeks with empagliflozin using an untargeted metabolomics approach, with the purpose to help to clarify the benefits of the use of empagliflozin at hepatic level. We found that empagliflozin is able to change the hepatic lipidome towards a protective profile, through an increase of monounsaturated and polyunsaturated glycerides, phosphatidylcholines, phosphatidylethanolamines, lysophosphatidylinositols and lysophosphatidylcholines. Empagliflozin also induces a decrease in the levels of the markers of inflammation IL-6, chemerin and chemerin receptor in the liver. Our results provide new evidences regarding the molecular pathways through which empagliflozin could exert hepatoprotector beneficial effects in T2DM.This work was supported by Boehringer Ingelheim Pharma GmbH and Co., by the National Institute of Health “Fondo de Investigaciones Sanitarias del Instituto de Salud Carlos III” Madrid, Spain (PI15/00681, PI17/00409, PI18/00821, PI20/00902, RETICS Programme RD16/0012/0014 and CIBER de Enfermedades Cardiovasculares (CIBERCV)); European Regional Development Fund (FEDER) and European Union framework MSCA-RISE-H2020 Programme (Project number 734899). AH-A was funded by predoctoral research grants from Xunta de Galicia and FPU Program of the Spanish Ministry of Science, Innovation and Universities (Spain); MF-S was funded by the predoctoral research grants “Programa Científico do Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CiMUS) (Spain) and Xunta de Galicia; and AV-L was funded by the predoctoral research grant from the PFIS Program of the Spanish Ministry of Science and Instituto de Salud Carlos III (Spain

Evaluación curricular de una Escuela Normal Superior en el departamento del Atlántico

La presente investigación tiene como propósito evaluar el currículo de una Escuela Normal Superior del departamento del Atlántico, partiendo del análisis de los componentes curriculares, para determinar la existencia, la claridad, la coherencia y la pertinencia del horizonte institucional con respecto al Proyecto Educativo Institucional (PEI). Además, verificar la relación entre el currículo diseñado y el currículo enseñado para determinar la estrategia de intervención. El proyecto se sustenta desde la metodología estudio de caso, trabajado en dos momentos: En el primero aplicando la adaptación del modelo de evaluación de Stufflebeam y Shinkfield en términos de Contexto, Entrada o Insumo, Proceso, Producto (CIPP), utilizando técnicas e instrumentos de recolección de información como: Análisis documental, grupo focal, entrevista y observación no participante. Cabe anotar, que cada instrumento se ajustó a las condiciones de calidad que rigen a las Escuelas Normales Superiores en Colombia. En el segundo momento, se formuló un plan de mejoramiento de innovación curricular, dirigida a implementar la Pedagogía de géneros textuales como estrategia metodológica para fortalecer la enseñanza de la lectura y la escritura. El plan de mejoramiento, fue producto de los resultados de la evaluación curricular, encontrando como área de mejora el componente metodológico, específicamente en la implementación de las estrategias metodológicas en los microcurrículos. Por otro lado, existía el requerimiento institucional de transversalizar la enseñanza de la lectura y la escritura y mejorar los resultados de las Pruebas Saber en el área de lenguaje, para propender a la calidad educativa

ConCiencia Histórica: la arqueología comunitaria como medio para la coconstrucción de conocimiento en un entorno rural

En la última década la arqueología comunitaria ha experimentado un importante crecimiento en España. Este crecimiento se explica, en algunos casos, por la necesaria reinvención de los arqueólogos tras el colapso de la profesión ligada a la crisis económica que se inicia en el 2009; en otros casos está relacionado con la cada vez más demandada divulgación científica dentro del marco de la transferencia de conocimiento. Esto ha supuesto la realización de programas didácticos paralelos a los proyectos de investigación arqueológica. En este artículo presentamos la experiencia de arqueología comunitaria realizada por el grupo de investigación Llabor que lleva a cabo los trabajos arqueológicos en el yacimiento de Vigaña, el colegio público y el Ayuntamiento de Balmonte de Miranda. Un ensayo que puede ser un buen ejemplo para desarrollar experiencias similares en ámbitos rurales.Peer reviewe

Mortality Attributable to Environmental Tobacco Smoke Exposure in Spain in 2020

Introduction and objectives: Exposure to environmental tobacco smoke (ETS) is associated with increased mortality and morbidity. The objective of this study was to estimate the impact of ETS exposure in Spain on mortality in 2020 in the population aged 35 years and over. Methods: A method of estimating attributable mortality (AM) based on the prevalence of ETS exposure was applied. Prevalence data were obtained from a representative study conducted in Spain and the relative risks were derived from a meta-analysis. AM point estimates are presented along with 95% confidence intervals (95% CI), calculated using a bootstrap naive procedure. AM, both overall and by smoking habit, was estimated for each combination of sex, age group, and cause of death (lung cancer and ischemic heart disease). A sensitivity analysis was performed. Results: A total of 747 (95% CI 676–825) deaths were attributable to ETS exposure, of which 279 (95% CI 256–306) were caused by lung cancer, and 468 (95% CI 417–523) by ischemic heart disease. Three quarters (75.1%) of AM occurred in men and 60.9% in non-smokers. When chronic obstructive pulmonary disease and cerebrovascular disease are included, the burden of AM is estimated at 2242 deaths. Conclusions: ETS exposure is associated with 1.5% of all deaths from lung cancer and ischemic heart disease in the population aged 35 and over. These data underline the need for health authorities to focus on reducing exposure to ETS in all settings and environmentsInstituto de Salud Carlos III (ISCIII), reference: PI22/00727, co-funded by the European UnionS

ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer

The survival rate in lung cancer remains stubbornly low and there is an urgent need for the identification of new therapeutic targets. In the last decade, several members of the SWI/SNF chromatin remodeling complexes have been described altered in different tumor types. Nevertheless, the precise mechanisms of their impact on cancer progression, as well as the application of this knowledge to cancer patient management are largely unknown. In this study, we performed targeted sequencing of a cohort of lung cancer patients on genes involved in chromatin structure. In addition, we studied at the protein level the expression of these genes in cancer samples and performed functional experiments to identify the molecular mechanisms linking alterations of chromatin remodeling genes and tumor development. Remarkably, we found that 20% of lung cancer patients show ARID2 protein loss, partially explained by the presence of ARID2 mutations. In addition, we showed that ARID2 deficiency provokes profound chromatin structural changes altering cell transcriptional programs, which bolsters the proliferative and metastatic potential of the cells both in vitro and in vivo. Moreover, we demonstrated that ARID2 deficiency impairs DNA repair, enhancing the sensitivity of the cells to DNA-damaging agents. Our findings support that ARID2 is a bona fide tumor suppressor gene in lung cancer that may be exploited therapeutically.Financial Support: I. V. is supported by SAF2012-31627 and SAF2016-76758-R grants from the Spanish Ministerio de Economía y Competitividad (MINECO), by a Fundación Ramón Areces grant and by ERC2014-StG637904 grant from the European Research Council. I. V has been awardee of the Programa Ramón y Cajal (MINECO, Spain). T. M has been awardee of the Ayudas para la contratación de investigadores predoctorales (MINECO, Spain). B. M is awardee of the Ayudas para la formación de profesorado universitario (FPU, Ministerio de Educación y Formación Profesional, Spain). PC laboratory is supported by grant SAF-2015-63638R (MINECO/FEDER, UE); by Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) and by Asociación Española Contra el Cáncer (AECC), grant GCB141423113. BC has been supported by a Retos Jóvenes Investigadores grant SAF2015-73364-JIN (AEI/FEDER, UE) and a grant from Fundación Francisco Cobos. P. S. is supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001152), the UK Medical Research Council (FC001152). HUCA/IUOPA which is jointly financed by Servicio de Salud del Principado de Asturias, Instituto de Salud Carlos III and Fundación Bancaria Cajastur. This research was funded in part by the Wellcome Trust [FC001152]