ECommerce of the Spanish online pharmacies: web design and visibility on the Internet

En el trabajo presentado realizamos un estudio empírico que parte de la selección de las farmacias españolas online que venden por Internet mejor posicionadas en SEO. Mediante la utilización de una serie de herramientas online gratuitas hemos analizado sus diseños web, con especial mención al diseño web adaptativo, a la usabilidad y a la accesibilidad, así como su visibilidad en la Red y presencia en los medios sociales. Estas farmacias objeto del estudio presentan un nivel de SEO elevado, al igual que usabilidad y visibilidad, con presencia en las principales redes sociales Facebook y Twitter, mostrando carencias en la accesibilidad y adaptación de sus diseños web al comercio electrónico móvil.The work presented perform an empirical study of the Spanish selection of online pharmacies that sold in Internet with best SEO position in Google. We have analyzed, with free online tools, their web design, with special mention of the adaptative web design, usability and accessibility, and the visibility on the Web and social media presence. The sepharmacies under study exhibit a high level of SEO, usability and visibility, with presence in major social networks Facebook and Twitter, showing gaps in accessibility and adaptation of web designs for mobile commerce

La Farmacia española y el comercio electrónico

Objetivo: Analizar el comercio electrónico de las farmacias online españolas, teniendo en cuenta la normativa legal de la venta por Internet de medicamentos. Material y métodos: Selección de las diez farmacias que venden en Internet mejor posicionadas de forma natural en el motor de búsqueda Google y utilización de las mejores herramientas online gratuitas para el análisis de cada uno de los sitios web de las farmacias seleccionadas. Resultados y conclusiones: Las farmacias objeto del estudio presentan un nivel de SEO elevado, al igual que de seguridad, usabilidad y visibilidad, con diseños y arquitecturas web muy similares, mostrando carencias en la accesibilidad y adaptación de sus diseños web al comercio electrónico móvil.Aims: electronic commerce of selected Spanish pharmacies is analized taking into account the legal aspects of the Internet sales of medicines. Material and methods: selection of ten top natural ranked pharmacies that sell in Internet better positioned naturally in Internet search engine Google and use of the best free online tools for the analysis of each of the web sites selected pharmacies. Results and conclusions: The pharmacies under study exhibit a high level of SEO, security, usability and visibility, with very similar designs and web architectures but show gaps in accessibility and adaptation of web design for mobile commerce

Reconstructing the Crustal Section of the Intra-Oceanic Caribbean Island Arc: Constraints From the Cumulate Layered Gabbronorites and Pyroxenites of the Rio Boba Plutonic Sequence, Northern Dominican Republic

Located in northern Dominican Republic, the Early Cretaceous Rio Boba mafic-ultramafic plutonic sequence constitutes a lower crust section of the Caribbean island arc, made up by gabbroic rocks and subordinate pyroxenite. Modal compositions, mineral chemistry, whole-rock compositions and thermobarometric calculations indicate that pyroxenites and gabbronorites represent a cumulate sequence formed by fractionation of tholeiitic magmas with initially very low H2O content in the lower crust of the arc (0.6–0.8 GPa). Melts evolved along a simplified crystallization sequence of olivine → pyroxenes → plagioclase → Fe-Ti oxides. The magmatic evolution of the Rio Boba sequence and associated supra-crustal Puerca Gorda metavolcanic rocks is multi-stage and involves the generation of magmas from melting of different sources in a supra-subduction zone setting. The first stage included the formation of a highly depleted substrate as result of decompressional melting of a refractory mantle source, represented by a cumulate sequence of LREE-depleted island arc tholeiitic (IAT) and boninitic gabbronorites and pyroxenites. The second stage involved volumetrically subordinate cumulate troctolites and gabbros, which are not penetratively deformed. The mantle source was refractory and enriched by a LILE-rich hydrous fluid derived from a subducting slab and/or overlying sediments, and possibly by a LREE-rich melt. The third stage is recorded in the upper crust of the arc by the Puerca Gorda “normal” IAT protoliths, which are derived from an N-MORB mantle source enriched with a strong subduction component. This magmatic evolution has implications for unraveling the processes responsible for subduction initiation and subsequent building of the Caribbean island arc.This research was funded through CGL2012-33669/BTE and PID2019-105625RB-C22 of the MCIN/AEI/10.13039/501100011033 projects and PRX18/00055 stay grant to the J. Escuder-Viruete of the Ministerio de Ciencia e Innovación of the Spanish Government

Steppes, savannahs, forests and phytodiversity reservoirs during the Pleistocene in the Iberian Peninsula

A palaeobotanical analysis of the Pleistocene floras and vegetation in the Iberian Peninsula shows the existence of patched landscapes with Pinus woodlands, deciduous and mixed forests, parklands (savannah-like), shrublands, steppes and grasslands. Extinctions of Arctotertiary woody taxa are recorded during the Early and Middle Pleistocene, but glacial refugia facilitated the survival of a number of temperate, Mediterranean and Ibero-North African woody angiosperms. The responses of Iberian vegetation to climatic changes during the Pleistocene have been spatially and temporarily complex, including rapid changes of vegetation in parallel to orbital and suborbital variability, and situations of multi-centennial resilience or accommodation to climatic changes. Regional characteristics emerged as soon as for the Middle Pleistocene, if not earlier: Ericaceae in the Atlantic coast indicating wetter climate, thermo-mediterranean elements in the south as currently, and broad-leaf trees in the northeastern. Overall, steppe landscapes and open Pinus woodlands prevailed over many continental regions during the cold spells of the Late Pleistocene. The maintenance of a high phytodiversity during the glacials was linked to several refuge zones in the coastal shelves of the Mediterranean and intramountainous valleys. Northern Iberia, especially on coastal areas, was also patched with populations of tree species, and this is not only documented by palaeobotanical data (pollen, charcoal) but also postulated by phylogeographical models

Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast‐derived ADAMTS‐7 and ‐12

Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the inhibition of metalloproteinases, might be because of their constitutive expres‐ sion in homeostasis, together with their network complexity. The knowledge of this network would contribute to selective target pathological conditions. In this sense, blockade of mediators produced by neighbouring joint cells, such as synovial fibro‐ blasts (SF), would prevent cartilage damage. Thus, we studied the contribution of ADAMTS‐7 and ‐12 from SF to cartilage oligomeric matrix protein (COMP) degrada‐ tion, and the signalling pathways involved in their expression. We report for the first time in SF, the involvement of ERK‐Runx2 axis and Wnt/β‐catenin signalling in ADAMTS‐12 and ADAMTS‐7 expressions, respectively, with the subsequent conse‐ quences in COMP degradation from cartilage extracellular matrix. After stimulation with IL‐1β or fibronectin fragments, we showed that ERK inhibition decreased Runx2 activation and ADAMTS‐12 expression in OA‐SF, also reducing Fn‐fs‐induced COMP degradation. Blockage of Wnt signalling by DKK1 reduced ADAMTS‐7 and COMP degradation in OA‐SF as well. In addition, Wnt7B expression was induced by IL‐1β and by itself, also increasing ADAMTS‐7. Our results could contribute to the develop‐ ment of disease‐modifying OA drugs targeting ADAMTS‐7 and ‐12 for the prevention of extracellular matrix components degradation like COMP

High efficacy of Sofosbuvir plus Simeprevir in a large cohort of Spanish cirrhotic patients infected with genotypes 1 and 4

[Abstract] Background and Aims. Hepatitis C (HCV) therapy with Sofosbuvir (SOF)/Simeprevir (SMV) in clinical trials and real‐world clinical practice, showed high rates of sustained virological response (SVR) in non‐cirrhotic genotype (GT)‐1 and GT‐4 patients. These results were slightly lower in cirrhotic patients. We investigated real‐life effectiveness and safety of SOF/SMV with or without ribavirin (RBV) in a large cohort of cirrhotic patients. Methods. This collaborative multicentre study included data from 968 patients with cirrhosis infected with HCV‐GT1 or 4, treated with SOF/SMV±RBV in 30 centres across Spain between January‐2014 and December‐2015. Demographic, clinical, virological and safety data were analysed. Results. Overall SVR was 92.3%; the majority of patients were treated with RBV (62%) for 12 weeks (92.4%). No significant differences in SVR were observed between genotypes (GT1a:94.3%; GT1b:91.7%; GT4:91.1%). Those patients with more advanced liver disease (Child B/C, MELD≥10) or portal hypertension (platelet count≤100×109/L, transient elastography≥21 Kpa) showed significantly lower SVR rates (84.4%‐91.9%) than patients with less advanced liver disease (93.8%‐95.9%, P<.01 in all cases). In the multivariate analysis, the use of RBV, female gender, baseline albumin≥35 g/L, MELD<10 and lack of exposure to a triple therapy regimen were independent predictors of SVR (P<.05). Serious adverse events (SAEs) and SAE‐associated discontinuation events occurred in 5.9% and 2.6%. Conclusions. In this large cohort of cirrhotic patients managed in the real‐world setting in Spain, SOF/SMV±RBV yielded to excellent SVR rates, especially in patients with compensated liver cirrhosis. In addition, this combination showed to be safe, with low rates of SAEs and early discontinuations.Instituto de Salud Carlos III; PI15/0015

pilotSTRATEGY project 2021-2026: “CO2 Geological Pilots in Strategic Territories”

[EN] The pilotSTRATEGY (2021-2026) is investigating geological CO2 storage sites in industrial regions to support development of large-scale carbon capture and storage (CCS). It is focused on deep saline aquifers–porous rock formations filled with brine several kilometres below ground – which promise a large capacity for storing captured CO2. The goal of the characterisation is to assess the site’s containment, injectivity, capacity, integrity, hydrodynamics, and monitorability in order to ensure safe and permanent storage of CO2. PilotSTRATEGY covers the initial stages of project development up to the pre-final investment decision (pre-FID), regulatory approval and permitting of storage, and applied on selected structures of Paris Basin in France, the Lusitanian Basin in Portugal and the Ebro Basin in Spain, and in lower detail, in West Macedonia in Greece and Upper Silesia in Poland.The project has received funding from the European Union’s Horizon 2020 programme (10.1 million Euros, No. 101022664).Peer reviewe

Socialización escolar : procesos, experiencias y trayectos

En los artículos que forman parte de este libro se despliega un conjunto de temas, problemas y debates que, en un primer momento, se hicieron presentes entre el equipo coordinador del libro y que luego fueron compartidos con los investigadores miembros del Grupo de Trabajo "Juventudes, Infancias: Políticas, Culturas e Instituciones Sociales" (GT) del Consejo Latinoamericano de Ciencias Sociales (CLACSO). En tal sentido, el propósito de la compilación consiste en aportar a la actualización de un área o campo que, desde sus inicios, fue y es pensado por las ciencias sociales: la escuela y los sistemas educativos. Sin embargo, en los últimos años, el campo de estudios sobre la escuela se ha diversificado y especializado, encontrando nuevos objetos de estudio y ampliando los ya existentes, al tiempo que los temas y problemas educativos se hablan y debaten por toda la sociedad

INNOVASONORA: gestión de archivos sonoros, sonido inmersivo y realidad virtual en plataformas LMS

Memoria del proyecto de innovación docente "Innovasonora" (Curso 2021-2022