Unterdrückung von Bewegungsartefakten in PPG-Signalen mittels Adaptive-Noise-Canceling

In diesem Beitrag wird die Problematik der bewegungsbedingten Artefaktbehaftung von PPG-Siganlen im Kontext des Langzeitmonitorings untersucht. Dabei wird besonders das Potential einer Signalrekonstruktion basierend auf adaptiver Filterung mittels Beschleunigungssignalen anhand verschiedener Bewegungsmuster evaluiert und quantifiziert. Ziel ist es, die Anwendbarkeit für kontinuierliches Monitoring abzuschätze

Structure and non-essential function of glycerol kinase in <i>Plasmodium</i> <i>falciparum</i> blood stages

Malaria pathology is caused by multiplication of asexual parasites within erythrocytes, whereas mosquito transmission of malaria is mediated by sexual precursor cells (gametocytes). Microarray analysis identified glycerol kinase (GK) as the second most highly upregulated gene in Plasmodium falciparum gametocytes with no expression detectable in asexual blood stage parasites. Phosphorylation of glycerol by GK is the rate-limiting step in glycerol utilization. Deletion of this gene from P. falciparum had no effect on asexual parasite growth, but surprisingly also had no effect on gametocyte development or exflagellation, suggesting that these life cycle stages do not utilize host-derived glycerol as a carbon source. Kinetic studies of purified PfGK showed that the enzyme is not regulated by fructose 1,6 bisphosphate. The high-resolution crystal structure of P. falciparum GK, the first of a eukaryotic GK, reveals two domains embracing a capacious ligand-binding groove. In the complexes of PfGK with glycerol and ADP, we observed closed and open forms of the active site respectively. The 27° domain opening is larger than in orthologous systems and exposes an extensive surface with potential for exploitation in selective inhibitor design should the enzyme prove to be essential in vivo either in the human or in the mosquito

Assessment of Seismic Damage of Buildings and Related Environmental Impacts

Sustainable development has only recently started examining the existing infrastructure, and a key aspect of this is hazard mitigation. To examine buildings under a sustainable perspective requires an understanding of a building\u27s life-cycle environmental costs, including the consideration of associated environmental impacts induced by earthquake damage. Damage repair costs lead to additional material and energy consumption, leading to harmful environmental impacts. Merging results obtained from a seismic evaluation and life-cycle analysis for buildings will give a novel outlook on sustainable design decisions. To evaluate the environmental impacts caused by buildings, long-term impacts accrued throughout a building\u27s lifetime and impacts associated with damage repair need to be quantified. A method and literature review for completing this examination has been developed and is discussed. Using software Athena and HAZUS-MH, this study evaluated the performance of steel and concrete buildings considering their life-cycle assessments and earthquake resistance. It was determined that code design-level greatly effects a building repair and damage estimations. This study presented two case study buildings and found specific results that were obtained using several premade assumptions. Future research recommendations were provided to make this methodology more useful in real-world applications. Examining cost and environmental impacts that a building has through, a cradle-to-grave analysis and seismic damage assessment will help reduce material consumption and construction activities from taking place before and after an earthquake event happens

Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals

This is the peer-reviewed version of the following article: Anaya‐Plaza, E., van de Winckel, E., Mikkilä, J., Malho, J. M., Ikkala, O., Gulías, O., ... & Kostiainen, M. A. (2017). Photoantimicrobial biohybrids by supramolecular immobilization of cationic phthalocyanines onto cellulose nanocrystals. Chemistry–A European Journal, 23(18), 4320-4326., which has been published in final form at https://doi.org/10.1002/chem.201605285. This article may be used for non-commercial purposes in accordance with Wiley-VCH Terms and Conditions for Self-ArchivingThe development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surfaceA.d.l.E. acknowledges a Ramón y Cajal contract from the Spanish Ministry of Economy (MINECO). The work at Madrid was supported by the EU [SO2S (FP7‐PEOPLE‐2012‐ITN, 316975); and CosmoPHOS‐nano (FP7‐NMP‐2012‐6, 310337‐2)], the Spanish MINECO [CTQ‐2014‐52869‐P (T.T.) and CTQ‐2014‐53673‐P (A.d.l.E.)] and Comunidad de Madrid [FOTOCARBON (S2013/MIT‐2841)]. J.M., V.L., and M.A.K. acknowledge support through the Emil Aaltonen Foundation and the Academy of Finland (grants 267497, 273645 and 263504). This work was supported by the Academy of Finland through its Centers of Excellence Programme (2014–2019) and made use of the Aalto University Nanomicroscopy Centre (Aalto NMC). The work in Barcelona was supported by the Spanish MINECO (grant CTQ2013‐48767‐C3‐1‐R). R.B.‐O. thanks the European Social Funds and the SUR del DEC de la Generalitat de Catalunya for his predoctoral fellowship (2016 FI B1 00021)

I’ll have what she’s having: the impact of model characteristics on children’s food choices

This research investigates children’s use of social categories in their food selection. Across three studies, we presented preschoolers with sets of photographs that contrasted food‐eating models with different characteristics, including model gender, race (Black, White), age (child or adult), and/or expression (acceptance or rejection of the food). Children were asked to pick between the photographs to choose which food they would like for snack. Results demonstrated that preschoolers prefer foods being eaten by models with positive over negative expressions, foods being eaten by child over adult models, and foods being eaten by child models of the same gender as themselves over models of the other gender. This work connects with previous research on children’s understanding of social categories and also has important practical implications for how characteristics of a food‐eating model can affect children’s willingness to try new foods.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90408/1/j.1467-7687.2011.01106.x.pd

Capacitive Left Hand Finger and Bow Sensors for Synchronization and Rhythmical Regularity Analysis in String Ensembles

(Abstract to follow

Examples of Balancing Methods: Four-Run and Least-Squares Influence Coefficient

Case Stud

Examining Personality Factors of Consensually Non-monogamous and Monogamous Individuals

Consensual non-monogamy (CNM) is considered an umbrella term for romantic relationships that involve all partners agreeing to engage in sexual and/or emotional relationships with other people. The current study sought to address discrepancies in previous research regarding potential differences in personality traits between those who engage in CNM and those who engage in monogamy. The present study ( N = 255) examined personality and attitude differences between those who engaged in CNM and those who had not (i.e., monogamous or not in relationship). Big Five and Machiavellianism personality factors were measured through the use of the Big Five Inventory and MACH-IV, while attitudes towards engagement in CNM were measured through the use of the CNM Attitude Scale. Overall findings indicate that those who engaged in CNM had higher levels of Openness to experience, Extraversion, Agreeableness, and attitude towards engagement in CNM, and lower levels of Neuroticism and Machiavellianism, when compared to those who had not engaged in CNM. Additionally, these two groups did not differ in levels of Conscientiousness. These findings may help reduce the stigma surrounding CNM, as these individuals appeared to exhibit more positive personality factors when compared to those who engaged in monogamy or those who were not in a relationship. Future research should incorporate standardized measures and regression analyses in order to examine the predictive power of personality on future engagement in CNM

Field Investigation of Gearbox Vibration Due to Cracked Motor Rotor Bars

Case StudyApproximately one year after installing a new gearbox, vibration levels were gradually increasing. The tire plant requested that the gearbox manufacturer investigate under warranty. A field study was performed by an independent engineering company to measure the vibration of the motor, gearbox, and rubber mixer unit at the plant