823 research outputs found

    The Academy for Student Ministry: a study in youth ministry

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    https://place.asburyseminary.edu/ecommonsatsdissertations/1330/thumbnail.jp

    Love at First Sight? Jane Austen and the Transformative Male Gaze

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    In this thesis, I claim that the gaze is central to the courtship process in Austen’s novels. I also propose that an analysis of the gaze is crucial to understanding the gendered power dynamics that are central to these relationships. We tend to think of male gazers as having all the power, but one of Austen’s subversive arguments is that women can also be subjects of the gaze and transform through it. However, limits exist to their power. As I will argue, while men are able to simply project their transformative gaze, women must first use their gaze to perceive their societal position before successfully having a transformative effect

    Role REVersal: understanding how RRE RNA binds its peptide ligand

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    AbstractThe structure of a complex between the HIV Revresponsive element (RRE) RNA and a fragment of the Rev protein has recently been determined by NMR. Together with previous studies of the Tat–TAR complex, these results show how RNA elements with considerable tertiary structure are able to play a more active role in directing binding to elements of protein secondary structure

    Many accurate small-discriminatory feature subsets exist in microarray transcript data: biomarker discovery

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    BACKGROUND: Molecular profiling generates abundance measurements for thousands of gene transcripts in biological samples such as normal and tumor tissues (data points). Given such two-class high-dimensional data, many methods have been proposed for classifying data points into one of the two classes. However, finding very small sets of features able to correctly classify the data is problematic as the fundamental mathematical proposition is hard. Existing methods can find "small" feature sets, but give no hint how close this is to the true minimum size. Without fundamental mathematical advances, finding true minimum-size sets will remain elusive, and more importantly for the microarray community there will be no methods for finding them. RESULTS: We use the brute force approach of exhaustive search through all genes, gene pairs (and for some data sets gene triples). Each unique gene combination is analyzed with a few-parameter linear-hyperplane classification method looking for those combinations that form training error-free classifiers. All 10 published data sets studied are found to contain predictive small feature sets. Four contain thousands of gene pairs and 6 have single genes that perfectly discriminate. CONCLUSION: This technique discovered small sets of genes (3 or less) in published data that form accurate classifiers, yet were not reported in the prior publications. This could be a common characteristic of microarray data, thus making looking for them worth the computational cost. Such small gene sets could indicate biomarkers and portend simple medical diagnostic tests. We recommend checking for small gene sets routinely. We find 4 gene pairs and many gene triples in the large hepatocellular carcinoma (HCC, Liver cancer) data set of Chen et al. The key component of these is the "placental gene of unknown function", PLAC8. Our HMM modeling indicates PLAC8 might have a domain like part of lP59's crystal structure (a Non-Covalent Endonuclease lii-Dna Complex). The previously identified HCC biomarker gene, glypican 3 (GPC3), is part of an accurate gene triple involving MT1E and ARHE. We also find small gene sets that distinguish leukemia subtypes in the large pediatric acute lymphoblastic leukemia cancer set of Yeoh et al

    Evaluating Factors That Influence MVP Voting in the NBA

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    We develop and test an empirical model to study the factors that affect variation in the proportion of MVP votes received by NBA players over the years 2007 to 2017. Our explanatory variables fall into two categories: player performance and team performance. The empirical results suggest that player performance variables, such as points per game, steals per game, offensive rebounds per game, and fouls per game, help to explain the proportion of MVP votes received by players. We found that team characteristics did not have a statistically significant influence on the proportion of MVP votes received by players

    Betti tables forcing failure of the Weak Lefschetz Property

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    We study the Artinian reduction AA of a configuration of points X⊂PnX \subset {\mathbb P}^n , and the relation of the geometry of XX to Lefschetz properties of AA. Migliore initiated the study of this connection, with a particular focus on the Hilbert function of AA, and further results appear in work of Migliore--Mir\'o-Roig--Nagel. Our specific focus is on Betti tables rather than Hilbert functions, and we prove that a certain type of Betti table forces the failure of the Weak Lefschetz Property (WLP). The corresponding Artinian algebras are typically not level, and the failure of WLP in these cases is not detected in terms of the Hilbert function

    ENHANCED ERYTHROPOIESIS WITH CONCOMITANT DIMINISHED GRANULOPOIESIS IN PREIRRADIATED RECIPIENT MICE : EVIDENCE FOR A COMMON STEM CELL

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    Three different methods of measuring the proliferative capacity of transplanted mouse bone marrow were used to study the effects of preirradiation of the recipient. Recipient mice were exposed to 700 R and given graded numbers of syngeneic bone marrow. 7 days were allowed for proliferation of these cells, and then the granulocytic or erythrocytic progeny was measured. The former was determined by the response to endotoxin, and the latter by the incorporation of radioactive iron into newly formed red blood cells. Erythropoiesis, therefore, could be measured independently from granulopoiesis by these techniques. The third method used was the spleen colony method of Till and McCulloch (5). Recipient animals exposed to 150 R preirradiation, 7 days before 700 R and bone marrow transplantation, demonstrated an increase in erythropoiesis with a concommittant decrease in granulopoiesis compared to similar recipients not preirradiated. The spleen colony technique showed that while the number of colonies were the same in both groups, the colonies themselves were significantly larger in the preirradiated animals. Since such colonies are primarily erythropoietic, this finding is consistent with the other methods. The results can be explained by assuming the presence of a hematopoietic stem cell which, in these preirradiated recipients, is directed towards erythropoiesis at the expense of granulopoiesis

    Exploring the Accounting Teaching Practices of Lecturers in a Higher Education Institution: A Case at a South African University

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    This paper aimed to determine the accounting lecturers’ teaching practices at a South African university. Teaching practices are a complex set of ways that lecturers use for instruction. When compromisingly crafted/implemented, they impact on success. In accounting education, teaching practices were found cognitively driven to determine success. Cognitivism learning theory guided the study. It emphasises mental processes, thinking, solving complex problems, and focusing on tasks requiring increased information processing, and procedural rules. The related elements enhance accounting teaching practices. This paper used a qualitative exploratory research methodology, enabling the researcher’s engagement with participants in their natural settings. Participants were purposefully selected for this study. Data was generated through individual semi-structured interviews to determine accounting lecturers’ practices. Issues including participants’ teaching practices and challenges experienced were explored. Data was thematically analysed. Findings suggest that current accounting teaching practices are detriment to performance. Hence this paper suggests that teaching practices require intervention

    If I Were to Meet You Again

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