82 research outputs found
Hydrodebridement of wounds: effectiveness in reducing wound bacterial contamination and potential for air bacterial contamination
<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to assess the level of air contamination with bacteria after surgical hydrodebridement and to determine the effectiveness of hydro surgery on bacterial reduction of a simulated infected wound.</p> <p>Methods</p> <p>Four porcine samples were scored then infected with a broth culture containing a variety of organisms and incubated at 37°C for 24 hours. The infected samples were then debrided with the hydro surgery tool (Versajet, Smith and Nephew, Largo, Florida, USA). Samples were taken for microbiology, histology and scanning electron microscopy pre-infection, post infection and post debridement. Air bacterial contamination was evaluated before, during and after debridement by using active and passive methods; for active sampling the SAS-Super 90 air sampler was used, for passive sampling settle plates were located at set distances around the clinic room.</p> <p>Results</p> <p>There was no statistically significant reduction in bacterial contamination of the porcine samples post hydrodebridement. Analysis of the passive sampling showed a significant (<it>p </it>< 0.001) increase in microbial counts post hydrodebridement. Levels ranging from 950 colony forming units per meter cubed (CFUs/m<sup>3</sup>) to 16780 CFUs/m<sup>3 </sup>were observed with active sampling of the air whilst using hydro surgery equipment compared with a basal count of 582 CFUs/m<sup>3</sup>. During removal of the wound dressing, a significant increase was observed relative to basal counts (<it>p </it>< 0.05). Microbial load of the air samples was still significantly raised 1 hour post-therapy.</p> <p>Conclusion</p> <p>The results suggest a significant increase in bacterial air contamination both by active sampling and passive sampling. We believe that action might be taken to mitigate fallout in the settings in which this technique is used.</p
Wound dressings for a proteolytic-rich environment
Wound dressings have experienced continuous and significant changes over the years based on the knowledge of the biochemical events associated with chronic wounds. The development goes from natural
materials used to just cover and conceal the wound to interactive materials that can facilitate the healing process, addressing specific issues in non-healing wounds. These
new types of dressings often relate with the proteolytic wound environment and the bacteria load to enhance the healing. Recently, the wound dressing research is focusing on the replacement of synthetic polymers by natural protein materials to delivery bioactive agents to the wounds. This
article provides an overview on the novel protein-based wound dressings such as silk fibroin keratin and elastin.
The improved properties of these dressings, like the release of antibiotics and growth factors, are discussed. The different types of wounds and the effective parameters of
healing process will be reviewed
Observation of Two New Excited Ξb0 States Decaying to Λb0 K-π+
Two narrow resonant states are observed in the Λb0K-π+ mass spectrum using a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV, collected by the LHCb experiment and corresponding to an integrated luminosity of 6 fb-1. The minimal quark content of the Λb0K-π+ system indicates that these are excited Ξb0 baryons. The masses of the Ξb(6327)0 and Ξb(6333)0 states are m[Ξb(6327)0]=6327.28-0.21+0.23±0.12±0.24 and m[Ξb(6333)0]=6332.69-0.18+0.17±0.03±0.22 MeV, respectively, with a mass splitting of Δm=5.41-0.27+0.26±0.12 MeV, where the uncertainties are statistical, systematic, and due to the Λb0 mass measurement. The measured natural widths of these states are consistent with zero, with upper limits of Γ[Ξb(6327)0]<2.20(2.56) and Γ[Ξb(6333)0]<1.60(1.92) MeV at a 90% (95%) credibility level. The significance of the two-peak hypothesis is larger than nine (five) Gaussian standard deviations compared to the no-peak (one-peak) hypothesis. The masses, widths, and resonant structure of the new states are in good agreement with the expectations for a doublet of 1D Ξb0 resonances
Measurement of the CKM angle using with decays
A model-dependent amplitude analysis of the decay is performed using proton-proton collision data
corresponding to an integrated luminosity of 3.0fb, recorded at
and by the LHCb experiment. The CP violation observables
and , sensitive to the CKM angle , are measured to
be \begin{eqnarray*} x_- &=& -0.15 \pm 0.14 \pm 0.03 \pm 0.01, y_- &=& 0.25 \pm
0.15 \pm 0.06 \pm 0.01, x_+ &=& 0.05 \pm 0.24 \pm 0.04 \pm 0.01, y_+ &=&
-0.65^{+0.24}_{-0.23} \pm 0.08 \pm 0.01, \end{eqnarray*} where the first
uncertainties are statistical, the second systematic and the third arise from
the uncertainty on the amplitude model. These
are the most precise measurements of these observables. They correspond to
and , where is
the magnitude of the ratio of the suppressed and favoured decay amplitudes, in a mass region of around the
mass and for an absolute value of the cosine of the decay
angle larger than .Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-007.htm
Search for dark photons produced in 13 TeV collisions
Searches are performed for both promptlike and long-lived dark photons,
A
0
, produced in proton-proton
collisions at a center-of-mass energy of 13 TeV, using
A
0
→
μ
þ
μ
−
decays and a data sample corresponding
to an integrated luminosity of
1
.
6
fb
−
1
collected with the LHCb detector. The promptlike
A
0
search covers
the mass range from near the dimuon threshold up to 70 GeV, while the long-lived
A
0
search is restricted to
the low-mass region
214
<m
ð
A
0
Þ
<
350
MeV. No evidence for a signal is found, and 90% confidence
level exclusion limits are placed on the
γ
–
A
0
kinetic-mixing strength. The constraints placed on promptlike
dark photons are the most stringent to date for the mass range
10
.
6
<m
ð
A
0
Þ
<
70
GeV, and are
comparable to the best existing limits for
m
ð
A
0
Þ
<
0
.
5
GeV. The search for long-lived dark photons is the
first to achieve sensitivity using a displaced-vertex signature
Recommended from our members
Study of the and states in decays
The decays are studied using a data
set corresponding to an integrated luminosity of 9fb collected with the
LHCb detector in proton-proton collisions between 2011 and 2018. Precise
measurements of the ratios of branching fractions with the intermediate
, and states are reported. The decay
of with is observed for the first time with a significance of 5.1
standard deviations. The mass differences between the ,
and states are measured to be resulting in the
most precise determination of the mass. The width of the
state is found to be below 5.2MeV at 90\% confidence level. The
Breit-Wigner width of the state is measured to be which is inconsistent with zero by 5.5 standard deviations
Precise determination of the B-s(0)-B-s(-0) oscillation frequency
Mesons comprising a beauty quark and a strange quark can oscillate between
particle (B0s) and antiparticle (B0s) flavour eigenstates, with a frequency
given by the mass difference between heavy and light mass eigenstates, deltams.
Here we present ameasurement of deltams using B0s2DsPi decays produced in
proton-proton collisions collected with the LHCb detector at the Large Hadron
Collider. The oscillation frequency is found to be deltams = 17.7683 +- 0.0051
+- 0.0032 ps-1, where the first uncertainty is statistical and the second
systematic. This measurement improves upon the current deltams precision by a
factor of two. We combine this result with previous LHCb measurements to
determine deltams = 17.7656 +- 0.0057 ps-1, which is the legacy measurement of
the original LHCb detector.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2021-005.html (LHCb
public pages
Angular Analysis of the B+ -> K*(+)mu(+) mu(-) Decay
We present an angular analysis of the
B
+
→
K
*
+
(
→
K
0
S
π
+
)
μ
+
μ
−
decay using
9
fb
−
1
of
p
p
collision data collected with the LHCb experiment. For the first time, the full set of
C
P
-averaged angular observables is measured in intervals of the dimuon invariant mass squared. Local deviations from standard model predictions are observed, similar to those in previous LHCb analyses of the isospin-partner
B
0
→
K
*
0
μ
+
μ
−
decay. The global tension is dependent on which effective couplings are considered and on the choice of theory nuisance parameters
Search for the doubly heavy baryons Omega(0)(bc) and Xi(0)(bc) decaying to Lambda(+)(c)pi(-) and Xi(+)(c)pi-
Abstract available from publisher's website
Search for time-dependent violation in and decays
A search for time-dependent violation of the charge-parity symmetry in and decays is performed at the LHCb experiment using proton-proton collision data recorded from 2015 to 2018 at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 6 fb. The meson is required to originate from a decay, such that its flavour at production is identified by the charge of the accompanying pion. The slope of the time-dependent asymmetry of the decay rates of and mesons into the final states under consideration is measured to be , , where the first uncertainties are statistical and the second are systematic. These results are compatible with the conservation of the charge-parity symmetry at the level of 2 standard deviations and improve the precision by nearly a factor of two
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