Propuesta de Supply Chain Management y logística para la empresa Foodbox S.AS.

Cuadro comparativo del LPISe realizará un análisis detallado sobre la compañía Foodbox sas, la cual es una compañía colombiana dedicada a la comercialización de pollo, ubicada en Bogotá D.C, como punto estratégico para la distribución nacional. Basados en la teoría vista del diplomado en Supply Chain Management y Logística, realizamos una serie de propuestas donde se puso en práctica el conocimiento adquirido buscando optimizar y mejorar los procesos de la compañía, donde se rediseño el espacio de almacenamiento para tener un mejor control de inventarios, rotación del producto y reducción de los tiempos por desplazamiento en cada uno de los procesos ya sea en la recepción del producto y en el despacho de este. Redistribución de las zonas de entrega al igual que la tipología de vehículos implementada para la misma, logrando así impactar significativamente en los gastos logísticos causados por el transporte, movilizando mayores volúmenes en vehículos de mayor capacidad reduciendo el número de viajes. Como otro de los puntos relevantes en el acompañamiento a la compañía es el de utilizar más la tecnología para su comercialización y publicidad, implementando las redes sociales para ser de más fácil acceso a los clientes finales.A detailed analysis will be carried out on the Foodbox sas company, which is a Colombian company dedicated to the commercialization of chicken, located in Bogotá D.C, as a strategic point for national distribution. Based on the theory seen in the Diploma in Supply Chain Management and Logistics, we made a series of proposals where the acquired knowledge was put into practice seeking to optimize and improve the company's processes, where the storage space was redesigned to have better control of inventories, product rotation and reduction of travel times in each of the processes, whether in the reception of the product and in its dispatch. Redistribution of delivery areas as well as the type of vehicles implemented for it, thus achieving a significant impact on logistics costs caused by transportation, mobilizing larger volumes in larger capacity vehicles, reducing the number of trips. As another of the relevant points in the accompaniment to the company is to use more technology for marketing and advertising, implementing social networks to be more easily accessible to end customers

TGFBR1 Intralocus Epistatic Interaction as a Risk Factor for Colorectal Cancer

In colorectal cancer (CRC), an inherited susceptibility risk affects about 35% of patients, whereas high-penetrance germline mutations account for <6% of cases. A considerable proportion of sporadic tumors could be explained by the coinheritance of multiple low-penetrance variants, some of which are common. We assessed the susceptibility to CRC conferred by genetic variants at the TGFBR1 locus. We analyzed 14 polymorphisms and the allele-specific expression (ASE) of TGFBR1 in 1025 individuals from the Spanish population. A case-control study was undertaken with 504 controls and 521 patients with sporadic CRC. Fourteen polymorphisms located at the TGFBR1 locus were genotyped with the iPLEX Gold (MassARRAY-Sequenom) technology. Descriptive analyses of the polymorphisms and haplotypes and association studies were performed with the SNPator workpackage. No relevant associations were detected between individual polymorphisms or haplotypes and the risk of CRC. The TGFBR1*9A/6A polymorphism was used for the ASE analysis. Heterozygous individuals were analyzed for ASE by fragment analysis using cDNA from normal tissue. The relative level of allelic expression was extrapolated from a standard curve. The cutoff value was calculated with Youden's index. ASE was found in 25.4% of patients and 16.4% of controls. Considering both bimodal and continuous types of distribution, no significant differences between the ASE values of patients and controls were identified. Interestingly, a combined analysis of the polymorphisms and ASE for the association with CRC occurrence revealed that ASE-positive individuals carrying one of the most common haplotypes (H2: 20.7%) showed remarkable susceptibility to CRC (RR: 5.25; 95% CI: 2.547–5.250; p<0.001) with a synergy factor of 3.7. In our study, 54.1% of sporadic CRC cases were attributable to the coinheritance of the H2 haplotype and TGFBR1 ASE. These results support the hypothesis that the allelic architecture of cancer genes, rather than individual polymorphisms, more accurately defines the CRC risk

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

GEL DE ALOE-VERA COMO POTENCIAL INHIBIDOR DE LA CORROSIÓN DEL ACERO DE REFUERZO ESTRUCTURAL

En el presente trabajo se estudiaelectroquímicamente un GELextracto de las hojas de ALOE VERAcomo un posible inhibidor de la corrosión del acero de refuerzo estructuraldel concreto.Los estudiosde corrosiónse llevaron a cabo en 1M de HCl y utilizando la técnica de espectroscopia de impedancia electroquímica (EIS)se evaluó la resistencia a la corrosión en presencia y ausencia del GEL.Los diagramas de impedancia mostraronque la adición en diferentes proporcionesdel GELinhibe notablemente el proceso de la corrosión del acero inmerso en la solución ácida. También se determinó que las moléculas del GEL obedecena un mecanismo de fisisorciónsobre la superficie del metal de acuerdo con el modelo de isoterma de Langmuircon unG°adsde alrededor de 14.17 kJ/mol. El GEL se clasificócomo un inhibidor orgánico del tipo mixto

Clinical and pathological characteristics of CRC patients.

<p>(UK: unknown).</p

Significant associations between <i>TGFBR1 locus</i> haplotype and CRC stratified by age at diagnosis and sex.

<p>(CRC: colorectal cancer; C: controls; OR: odds ratio; CI: confidence interval).</p

Relative expression of the <i>TGFBR1</i> rs11466445 allele calculated from a standard curve.

<p>The <i>TGFBR1</i> allele ratios in patients with sporadic CRC (panel A) and controls (panel B). The ASE-negative area is represented by the colored rectangle between the cutoff values (0.78 and 1.27). The mean and standard deviation are shown for each sample.</p

Association between <i>TGFBR1</i> H2 haplotype and <i>TGFBR1</i> ASE.

<p>(CRC: colorectal cancer; C: controls; RR: relative risk; CI: confidence interval).</p