Public and Private Enforcement of Title VII of the Civil Rights Act of 1964—A Ten-Year Perspective

The purpose of this Article is to describe the enforcement provisions of the Act and to outline the litigative activities by government agencies and private parties in the three types of cases that have characterized court action under Title VII during the ten-year period since the Act\u27s adoption. The record of enforcement compels the conclusion that effective enforcement of the Act has barely commenced. A much larger volume of litigation probably will be filed before the country approaches widespread compliance with the law against discrimination in employment

Ledoux-Convection in Protoneutron Stars --- a Clue to Supernova Nucleosynthesis?

Two-dimensional hydrodynamical simulations of the deleptonization of a newly formed neutron star were performed. Driven by negative lepton fraction and entropy gradients, convection starts near the neutrinosphere about 20-30 ms after core bounce, but moves deeper into the protoneutron star, and after about one second the whole protoneutron star is convective. The deleptonization of the star proceeds much faster than in the corresponding spherically symmetrical model because the lepton flux and the neutrino luminosities increase by up to a factor of two. The convection below the neutrinosphere raises the neutrinospheric temperatures and mean energies of the emitted neutrinos by 10-20%. This can have important implications for the supernova explosion mechanism and changes the detectable neutrino signal from the Kelvin-Helmholtz cooling of the protoneutron star. In particular, the enhanced electron neutrino flux relative to the electron antineutrino flux during the early post-bounce evolution might solve the overproduction problem of certain elements in the neutrino-heated ejecta in models of type-II supernova explosions.Comment: 17 pages, LaTeX, 8 postscript figures, uses epsf.sty. To appear in ApJ 473 (Letters), 1996 December 1

The Circuit Ideal of a Vector Configuration

The circuit ideal, \ica, of a configuration \A = \{\a_1, ..., \a_n\} \subset \Z^d is the ideal generated by the binomials {\x}^{\cc^+} - {\x}^{\cc^-} \in \k[x_1, ..., x_n] as \cc = \cc^+ - \cc^- \in \Z^n varies over the circuits of \A. This ideal is contained in the toric ideal, \ia, of \A which has numerous applications and is nontrivial to compute. Since circuits can be computed using linear algebra and the two ideals often coincide, it is worthwhile to understand when equality occurs. In this paper we study \ica in relation to \ia from various algebraic and combinatorial perspectives. We prove that the obstruction to equality of the ideals is the existence of certain polytopes. This result is based on a complete characterization of the standard pairs/associated primes of a monomial initial ideal of \ica and their differences from those for the corresponding toric initial ideal. Eisenbud and Sturmfels proved that \ia is the unique minimal prime of \ica and that the embedded primes of \ica are indexed by certain faces of the cone spanned by \A. We provide a necessary condition for a particular face to index an embedded prime and a partial converse. Finally, we compare various polyhedral fans associated to \ia and \ica. The Gr\"obner fan of \ica is shown to refine that of \ia when the codimension of the ideals is at most two.Comment: 25 page

Towards Gravitational Wave Signals from Realistic Core Collapse Supernova Models

We have computed the gravitational wave signal from supernova core collapse using the presently most realistic input physics available. We start from state-of-the-art progenitor models of rotating and non-rotating massive stars, and simulate the dynamics of their core collapse by integrating the equations of axisymmetric hydrodynamics together with the Boltzmann equation for the neutrino transport including an elaborate description of neutrino interactions, and a realistic equation of state. We compute the quadrupole wave amplitudes, the Fourier wave spectra, the amount of energy radiated in form of gravitational waves, and the S/N ratios for the LIGO and the tuned Advanced LIGO interferometers resulting both from non-radial mass motion and anisotropic neutrino emission. The simulations demonstrate that the dominant contribution to the gravitational wave signal is produced by neutrino-driven convection behind the supernova shock. For stellar cores rotating at the extreme of current stellar evolution predictions, the core-bounce signal is detectable with advanced LIGO up to a distance of 5kpc, whereas the signal from post-shock convection is observable up to a distance of about 100kpc. If the core is non-rotating its gravitational wave emission can be measured up to a distance of 15kpc, while the signal from the Ledoux convection in the deleptonizing, nascent neutron star can be detected up to a distance of 10kpc. Both kinds of signals are generically produced by convection in any core collapse supernova.Comment: 9 pages, 13 figures, Latex, submitted to ApJ, error in ps-file fixed; figures in full resolution are available upon reques

Topological String Amplitudes, Complete Intersection Calabi-Yau Spaces and Threshold Corrections

We present the most complete list of mirror pairs of Calabi-Yau complete intersections in toric ambient varieties and develop the methods to solve the topological string and to calculate higher genus amplitudes on these compact Calabi-Yau spaces. These symplectic invariants are used to remove redundancies in examples. The construction of the B-model propagators leads to compatibility conditions, which constrain multi-parameter mirror maps. For K3 fibered Calabi-Yau spaces without reducible fibers we find closed formulas for all genus contributions in the fiber direction from the geometry of the fibration. If the heterotic dual to this geometry is known, the higher genus invariants can be identified with the degeneracies of BPS states contributing to gravitational threshold corrections and all genus checks on string duality in the perturbative regime are accomplished. We find, however, that the BPS degeneracies do not uniquely fix the non-perturbative completion of the heterotic string. For these geometries we can write the topological partition function in terms of the Donaldson-Thomas invariants and we perform a non-trivial check of S-duality in topological strings. We further investigate transitions via collapsing D5 del Pezzo surfaces and the occurrence of free Z2 quotients that lead to a new class of heterotic duals.Comment: 117 pages, 1 Postscript figur

Dihydropyrimidine Dehydrogenase Testing prior to Treatment with 5-Fluorouracil, Capecitabine, and Tegafur: A Consensus Paper

Background: 5-Fluorouracil (FU) is one of the most commonly used cytostatic drugs in the systemic treatment of cancer. Treatment with FU may cause severe or life-threatening side effects and the treatment-related mortality rate is 0.2–1.0%. Summary: Among other risk factors associated with increased toxicity, a genetic deficiency in dihydropyrimidine dehydrogenase (DPD), an enzyme responsible for the metabolism of FU, is well known. This is due to variants in the DPD gene (DPYD). Up to 9% of European patients carry a DPD gene variant that decreases enzyme activity, and DPD is completely lacking in approximately 0.5% of patients. Here we describe the clinical and genetic background and summarize recommendations for the genetic testing and tailoring of treatment with 5-FU derivatives. The statement was developed as a consensus statement organized by the German Society for Hematology and Medical Oncology in cooperation with 13 medical associations from Austria, Germany, and Switzerland. Key Messages: (i) Patients should be tested for the 4 most common genetic DPYD variants before treatment with drugs containing FU. (ii) Testing forms the basis for a differentiated, risk-adapted algorithm with recommendations for treatment with FU-containing drugs. (iii) Testing may optionally be supplemented by therapeutic drug monitorin

Identifying key questions in the ecology and evolution of cancer

The application of evolutionary and ecological principles to cancer prevention and treatment, as well as recognizing cancer as a selection force in nature, has gained impetus over the last 50 years. Following the initial theoretical approaches that combined knowledge from interdisciplinary fields, it became clear that using the eco‐evolutionary framework is of key importance to understand cancer. We are now at a pivotal point where accumulating evidence starts to steer the future directions of the discipline and allows us to underpin the key challenges that remain to be addressed. Here, we aim to assess current advancements in the field and to suggest future directions for research. First, we summarize cancer research areas that, so far, have assimilated ecological and evolutionary principles into their approaches and illustrate their key importance. Then, we assembled 33 experts and identified 84 key questions, organized around nine major themes, to pave the foundations for research to come. We highlight the urgent need for broadening the portfolio of research directions to stimulate novel approaches at the interface of oncology and ecological and evolutionary sciences. We conclude that progressive and efficient cross‐disciplinary collaborations that draw on the expertise of the fields of ecology, evolution and cancer are essential in order to efficiently address current and future questions about cancer