Aggarwal

Amit

Anders

Andrade

Banaei-Bouchareb

Boris Calderon

Buxadé

Calderon

Carrero

Castellino

Chee

Chen

Chevrier

Christen

del Rey

Diana

Dinarello

Dobin

Droop

Dror

Dufour

Emil R. Unanue

Ewald

Ferris

Foster

Fridovich

García

Gautier

Gilchrist

Greeley

Griffith

Haldar

Harrow

Heng

Javier A. Carrero

Johnson

Kaikkonen

Kanehisa

Kawai

Koblansky

Kotas

Kurth

Kägi

Lavin

Litvak

Love

Mandrup-Poulsen

Markle

Matloubian

Maxim N. Artyomov

Melli

Miller

Mootha

Moratz

Oldenburg

Pakala

Park

Pasparakis

Pavel N. Zakharov

Reddy

Reif

Ritchie

Rütti

Schott

Smyth

Stephen T. Ferris

Subramanian

Suri

Terauchi

Thomas

Vomund

Wood

Xiaoxiao Wan

Yamada

Yang

Yosef

Yurkovetskiy

Zhao

English

Ferris, Stephen T

Zakharov, Pavel N

Wan, Xiaoxiao

Calderon, Boris

Artyomov, Maxim N

Unanue, Emil R

Carrero, Javier A

Digital Commons@Becker

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

We examined the transcriptional profiles of macrophages that reside in the islets of Langerhans of 3-wk-old non-obese diabetic (NOD), NOD.Rag1−/−, and B6.g7 mice. Islet macrophages expressed an activation signature with high expression of Tnf, Il1b, and MHC-II at both the transcript and protein levels. These features are common with barrier macrophages of the lung and gastrointestinal tract. Moreover, injection of lipopolysaccharide induced rapid inflammatory gene expression, indicating that blood stimulants are accessible to the macrophages and that these macrophages can sense them. In NOD mice, the autoimmune process imparted an increased inflammatory signature, including elevated expression of chemokines and chemokine receptors and an oxidative response. The elevated inflammatory signature indicates that the autoimmune program was active at the time of weaning. Thus, the macrophages of the islets of Langerhans are poised to mount an immune response even at steady state, while the presence of the adaptive immune system elevates their activation state.</jats:p

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The Journal of Experimental Medicine

https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=7131&amp;context=open_access_pubs

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

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