Purex Plant gaseous iodine-129 control capability and process development requirements

This report describes the ability of the Purex Plant to effectively control iodine-129 emissions. Based on historical evidence, the current Purex Plant iodine control system appears capable of meeting the goal of limiting gaseous iodine-129 emissions at the point of discharge to levels stipulated by the Department of Energy (DOE) for an uncontrolled area. Expected decontamination factors (DF`s) with the current system will average about 100 and will be above the calculated DF`s of 2.2 and 87 required to meet DOE yearly average concentration limits for controlled and uncontrolled areas respectively, but below the calculated DF of 352 required for meeting the proposed Environmental Protection Agency (EPA) mass emission limit. Chemical costs for maintaining compliance with the DOE limits will be approximately $166 per metric ton of fuel processed (based on a silver nitrate price of$12.38/oz). Costs will increase in proportion to increases in silver prices

Report from the Participation in the Current System Workgroup

OSI2016 Workgroup Question: Do researchers and scientists participate in the current system of scholarly publishing because they like it, they need it, they don’t have a choice in the matter, or they don’t really care one way or another? What perceptions, considerations and incentives do academicians have for staying the course (like impact factors and tenure points), and what are their pressures and incentives for changing direction (like lowering publishing charges)? The authors of scholarly works play a critical role in the scholarly communications system: authors are the original content creators, and in many or most cases are the original rightsholders and the ultimate decisionmakers when it comes to how, when, and where to publish their work. Although there are other significant participants in the current system (including publishers, librarians, information consumers, etc.), understanding and respecting the range of influences that shape author publication decisions are crucial to effecting change in the system. While recognizing the highly individual and diverse nature of author interests, we identified several priorities that stand out as driving decisions in the publication process. Career advancement concerns are primary, and the perceived currency of a publication mode or venue with promotion and tenure committees is a significant factor in decision making. A related, but distinct, factor is a publication venue’s perceived prestige among the authors’ peers. Both of these considerations have significant interplay with, and often serve as proxies for, scholarly authors’ overarching motivation to advance knowledge and make an impact in their fields. External factors may also direct author choice. Funder requirements and, in the case of works made for hire, employer requirements, can narrow the range of options available to authors. Survey evidence suggests that authors increasingly see open publication models as being consistent with, or in furtherance of, their goals as scholars.1 For instance, authors increasingly see open access (OA) publication as leading to wider circulation, greater visibility, and possibly more citations. Our task was to consider how we might accelerate these trends to facilitate openness in scholarship

Report from the Participation in the Current System Workgroup

OSI2016 Workgroup Question: Do researchers and scientists participate in the current system of scholarly publishing because they like it, they need it, they don’t have a choice in the matter, or they don’t really care one way or another? What perceptions, considerations and incentives do academicians have for staying the course (like impact factors and tenure points), and what are their pressures and incentives for changing direction (like lowering publishing charges)? The authors of scholarly works play a critical role in the scholarly communications system: authors are the original content creators, and in many or most cases are the original rightsholders and the ultimate decisionmakers when it comes to how, when, and where to publish their work. Although there are other significant participants in the current system (including publishers, librarians, information consumers, etc.), understanding and respecting the range of influences that shape author publication decisions are crucial to effecting change in the system. While recognizing the highly individual and diverse nature of author interests, we identified several priorities that stand out as driving decisions in the publication process. Career advancement concerns are primary, and the perceived currency of a publication mode or venue with promotion and tenure committees is a significant factor in decision making. A related, but distinct, factor is a publication venue’s perceived prestige among the authors’ peers. Both of these considerations have significant interplay with, and often serve as proxies for, scholarly authors’ overarching motivation to advance knowledge and make an impact in their fields. External factors may also direct author choice. Funder requirements and, in the case of works made for hire, employer requirements, can narrow the range of options available to authors. Survey evidence suggests that authors increasingly see open publication models as being consistent with, or in furtherance of, their goals as scholars.1 For instance, authors increasingly see open access (OA) publication as leading to wider circulation, greater visibility, and possibly more citations. Our task was to consider how we might accelerate these trends to facilitate openness in scholarship

The Human Endogenous Circadian System Causes Greatest Platelet Activation during the Biological Morning Independent of Behaviors

Platelets are involved in the thromboses that are central to myocardial infarctions and ischemic strokes. Such adverse cardiovascular events have day/night patterns with peaks in the morning (~9 AM), potentially related to endogenous circadian clock control of platelet activation. The objective was to test if the human endogenous circadian system influences (1) platelet function and (2) platelet response to standardized behavioral stressors. We also aimed to compare the magnitude of any effects on platelet function caused by the circadian system with that caused by varied standardized behavioral stressors, including mental arithmetic, passive postural tilt and mild cycling exercise.We studied 12 healthy adults (6 female) who lived in individual laboratory suites in dim light for 240 h, with all behaviors scheduled on a 20-h recurring cycle to permit assessment of endogenous circadian function independent from environmental and behavioral effects including the sleep/wake cycle. Circadian phase was assessed from core body temperature. There were highly significant endogenous circadian rhythms in platelet surface activated glycoprotein (GP) IIb-IIIa, GPIb and P-selectin (6-17% peak-trough amplitudes; p ≤ 0.01). These circadian peaks occurred at a circadian phase corresponding to 8-9 AM. Platelet count, ATP release, aggregability, and plasma epinephrine also had significant circadian rhythms but with later peaks (corresponding to 3-8 PM). The circadian effects on the platelet activation markers were always larger than that of any of the three behavioral stressors.These data demonstrate robust effects of the endogenous circadian system on platelet activation in humans--independent of the sleep/wake cycle, other behavioral influences and the environment. The 9 AM timing of the circadian peaks of the three platelet surface markers, including platelet surface activated GPIIb-IIIa, the final common pathway of platelet aggregation, suggests that endogenous circadian influences on platelet function could contribute to the morning peak in adverse cardiovascular events as seen in many epidemiological studies

Cloning and characterization of a pharmacologically distinct A1 adenosine receptor from guinea pig brain

Three full-length cDNA clones encoding the guinea pig A1 adenosine receptor have been isolated by polymerase chain reaction (PCR) and low-stringency hybridization screening of a guinea pig brain cDNA library. These three cDNAs, though differing in their 5' untranslated regions, contain the same open reading frame encoding a 326 amino acid residue protein with seven hydrophobic [alpha]-helices long enough to form the transmembrane domains, suggesting that it belongs to the G protein-coupled receptor superfamily. This protein is highly homologous to the A1 adenosine receptors previously cloned from other species. Pharmacological characterization of this receptor transiently expressed in mammalian cells demonstrates that, despite its high homology to A1 adenosine receptors of other species, the guinea pig A1 adenosine receptor displays a unique pharmacological profile: high affinity for the A1-selective antagonist CPX, yet very low affinity for some A1-selective agonists such as CCPA, CHA and R-PIA. Northern blotting for different guinea pig tissues and in situ hybridization for guinea pig brain sections reveal an abundant and broad distribution of mRNA of this A1 subtype receptor in the brain.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31281/1/0000187.pd

Primary Human mDC1, mDC2, and pDC Dendritic Cells Are Differentially Infected and Activated by Respiratory Syncytial Virus

Respiratory syncytial virus (RSV) causes recurrent infections throughout life. Vaccine development may depend upon understanding the molecular basis for induction of ineffective immunity. Because dendritic cells (DCs) are critically involved in early responses to infection, their interaction with RSV may determine the immunological outcome of RSV infection. Therefore, we investigated the ability of RSV to infect and activate primary mDCs and pDCs using recombinant RSV expressing green fluorescent protein (GFP). At a multiplicity of infection of 5, initial studies demonstrated ∼6.8% of mDC1 and ∼0.9% pDCs were infected. We extended these studies to include CD1c−CD141+ mDC2, finding mDC2 infected at similar frequencies as mDC1. Both infected and uninfected cells upregulated phenotypic markers of maturation. Divalent cations were required for infection and maturation, but maturation did not require viral replication. There is evidence that attachment and entry/replication processes exert distinct effects on DC activation. Cell-specific patterns of RSV-induced maturation and cytokine production were detected in mDC1, mDC2, and pDC. We also demonstrate for the first time that RSV induces significant TIMP-2 production in all DC subsets. Defining the influence of RSV on the function of selected DC subsets may improve the likelihood of achieving protective vaccine-induced immunity

Natural parenting : back to basics in infant care

Peer reviewe

Iron-Based Imidazolium Salts as Versatile Catalysts for the Synthesis of Quinolines and 2- and 4-Allylanilines by Allylic Substitution of Alcohols

Readily available iron(III)-based imidazolium salts have proven to be very versatile catalysts for the allylic substitution reaction of alcohols with anilines, allowing the synthesis of quinolines, 2-allylanilines and 4-allylanilines just by modulating the reaction conditions. Noteworthy, the formation of quinoline derivatives proceeds by ortho-allylation of the corresponding aniline and subsequent oxidative cyclization mediated by atmospheric oxygen. The reaction using anilines as nucleophiles is selective to the C-alkylation versus the N-alkylation, under any reaction conditions studied.This work was financially supported by the University of Alicante