Lupus Eritematoso Discoide do Couro Cabeludo em Doente com Lupus Eritematoso Sistémico: Um Caso com Repovoamento Capilar Completo

Scalp involvement with hair loss is common in systemic lupus erythematosus. Discoid lupus erythematosus may cause scarring alopecia, characterized by well-delimited erythematous plaques with scales, follicular hyperkeratosis and atrophy, which is considered a trichological emergency. Early diagnosis and treatment are necessary in order to prevent permanent hair loss. We describe a 44 years’ old female patient with systemic lupus erythematosus for 4 years, with multiple areas of occipitoparietal alopecia, erythematous plaques, atrophy, scales and some bloody crusts. Trichoscopy, histopathology and direct immunofluorescence led to the diagnosis of discoid lupus erythematosus. After 9 months treatment with thalidomide there was complete hair regrowth.O envolvimento do couro cabeludo no lúpus eritematoso sistémico é comum. O lúpus eritematoso discoide causa um tipo de alopecia cicatricial, caracterizada por placas eritematosas com descamação, hiperceratose folicular e atrofia, sendo considerada uma emergência tricológica. O diagnóstico e tratamento precoces são necessários a fim de evitar alopécia permanente. Descrevemos uma paciente de 44 anos com diagnóstico de lúpus eritematoso sistémico há 04 anos, evoluindo com múltiplas áreas de alopecia occiptoparietal, placas eritematosas, atrofia, descamação e algumas crostas hemáticas. A tricoscopia, histopatologia e imunofluorescência direta conduziram ao diagnóstico de lúpus eritematoso discoide. Após 9 meses de tratamento com talidomida houve repilação completa

Processo foto-fenton aplicado ao tratamento de águas produzidas em campos de petróleo

Na indústria do petróleo, as águas de produção representam 98% de todos os efluentes gerados.Este trabalho estuda a utilização do processo foto-Fenton para reduzir a toxicidade destes efluentesatravés da oxidação dos compostos orgânicos presentes. Este processo apresenta como grandesvantagens a baixa carga residual gerada e o baixo custo quando se utilizam reatores solares. Osresultados mostram a viabilidade de estudar a aplicação deste processo para o tratamento de águasde produção em campos de petróleo. A análise da água tratada revela que a mesma apresenta níveisaceitáveis para a utilização em agricultura (irrigação)

Processo foto-fenton aplicado ao tratamento de águas produzidas em campos de petróleo

Na indústria do petróleo, as águas de produção representam 98% de todos os efluentes gerados. Este trabalho estuda a utilização do processo foto-Fenton para reduzir a toxicidade destes efluentes através da oxidação dos compostos orgânicos presentes. Este processo apresenta como grandes vantagens a baixa carga residual gerada e o baixo custo quando se utilizam reatores solares. Os resultados mostram a viabilidade de estudar a aplicação deste processo para o tratamento de águas de produção em campos de petróleo. A análise da água tratada revela que a mesma apresenta níveis aceitáveis para a utilização em agricultura (irrigação)

Frequency and genetic diversity of the MAT1 locus of Histoplasma capsulatum isolates in Mexico and Brazil

The MAT1-1 and MAT1-2 idiomorphs associated with the MAT1 locus of Histoplasma capsulatum were identified by PCR. A total of 28 fungal isolates, 6 isolates from human clinical samples and 22 isolates from environmental (infected bat and contaminated soil) samples, were studied. Among the 14 isolates from Mexico, 71.4% (95% confidence interval [95% CI], 48.3% to 94.5%) were of the MAT1-2 genotype, whereas 100% of the isolates from Brazil were of the MAT1-1 genotype. Each MAT1 idiomorphic region was sequenced and aligned, using the sequences of the G-217B (+mating type) and G-186AR (-mating type) strains as references. BLASTn analyses of the MAT1-1 and MAT1-2 sequences studied correlated with their respective+ and-mating type genotypes. Trees were generated by the maximum likelihood (ML) method to search for similarity among isolates of each MAT1 idiomorph. All MAT1-1 isolates originated from Brazilian bats formed a well-defined group; three isolates from Mexico, the G-217B strain, and a subgroup encompassing all soil-derived isolates and two clinical isolates from Brazil formed a second group; last, one isolate (EH-696P) from a migratory bat captured in Mexico formed a third group of the MAT1-1 genotype. The MAT1-2 idiomorph formed two groups, one of which included two H. capsulatum isolates from infected bats that were closely related to the G-186AR strain. The other group was formed by two human isolates and six isolates from infected bats. Concatenated ML trees, with internal transcribed spacer 1 (ITS1) -5.8S-ITS2 and MAT1-1 or MAT1-2 sequences, support the relatedness of MAT1-1 or MAT1-2 isolates. H. capsulatum mating types were associated with the geographical origin of the isolates, and all isolates from Brazil correlated with their environmental sources. © 2013, American Society for Microbiology. All Rights Reserved

Direct antiviral therapy for treatment of hepatitis C: A real-world study from Brazil

Introduction and objectives: Direct antiviral agents (DAAs) including sofosbuvir (SOF), daclatasvir (DCV), simeprevir (SIM) and ombitasvir, paritaprevir and dasabuvir were introduced 2015 in Brazil for treatment of hepatitis C virus (HCV) infection. The aims of this study were to assess effectiveness and safety of HCV treatment with DAA in real-life world in a highly admixed population from Brazil. Materials and methods: All Brazilian reference centers for HCV treatment were invited to take part in a web-based registry, prospectively conducted by the Brazilian Society of Hepatology, to assess outcomes of HCV treatment in Brazil with DAAs. Data to be collected included demographics, disease severity and comorbidities, genotype (GT), viral load, DAA regimens, treatment side effects and sustained virological response (SVR). Results: 3939 patients (60% males, mean age 58 ± 10 years) throughout the country were evaluated. Most had advanced fibrosis or cirrhosis, GT1 and were treated with SOF/DCV or SOF/SIM. Overall SVR rates were higher than 95%. Subjects with decompensated cirrhosis, GT2 and GT3 have lower SVR rates of 85%, 90% and 91%, respectively. Cirrhosis and decompensated cirrhosis in GT1 and male sex and decompensated cirrhosis in GT3 were significantly associated with no SVR. Adverse events (AD) and serious AD occurred in 18% and 5% of those subjects, respectively, but less than 1% of patients required treatment discontinuation. Conclusion: SOF-based DAA regimens are effective and safe in the heterogeneous highly admixed Brazilian population and could remain an option for HCV treatment at least in low-income countries

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved