7 research outputs found
A new strategy to dissolve long-chain surfactants in water at low temperatures
- Author
- Publication venue
- ROYAL SOC CHEMISTRY
- Publication date
- 01/01/2022
- Field of study
Surfactants find widespread use in daily life for cleaning purposes and form a vital part of many industrial formulations. So far, their application has been limited to amphiphilic structures with relatively short alkyl chains (typically up to C14 or C16) due to the poor solubility of longer-chain homologues under relevant conditions. Here we introduce a concept that eventually allows octadecyl sulfates and carboxylates to be effectively solubilised in water at room temperature. Through synthesis of alkoxylated derivatives of choline - an abundant molecule of natural origin - we have designed a new class of counterions preventing the precipitation of long-chain surfactants, as commonly observed with alkali ions or unmodified choline. The resulting amphiphilic systems show superior properties with respect to surface activity, which directly translates into enhanced cleaning performance in lab-based washing tests. Studies on the cytotoxicity and biodegradability of the alkoxylated choline derivatives highlight their potential for sustainable surfactant development. In the end, our approach could pave the way towards the use of hitherto unleveraged raw material resources in tailoured surfactant formulations for cleaning applications and beyond
Combination chemotherapy with adriamycin, cyclophosphamide, vincristine, methotrexate, etoposide and dexamethasone (ACOMED) followed by involved field radiotherapy induces high remission rates and durable long-term survival in patients with aggressive malignant non-Hodgkin's lymphomas: long-term follow-up of a pilot study
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
- Author
- Absher Devin
- Aherrahrou Zouhair
- Alings Marco
- Allaart Cor F
- Allayee Hooman
- Altshuler David
- Aly Anette
- Anand Sonia
- Andersen Karl
- Anderson Jeffrey L
- Anner Karolina
- Ardissino Diego
- Assimes Themistocles L
- Assmann Gerd
- Attwood Tony
- AWells George
- Azhar Muhammad
- Ball Stephen G
- Balmforth Anthony J
- Barbalic Maja
- Barlera Simona
- Barnes Timothy
- Basart Hanneke
- Baumert Jens
- Becker Diane M
- Becker Lewis C
- Belz Stephanie
- Benham J
- Berger Klaus
- Bezzina Connie R
- Bis Joshua C
- Björklund Karin
- Blankenberg Stefan
- Blomgren Gun
- Boehm Bernhard O
- Boekholdt S Matthijs
- Boer Jolanda M A
- Boerwinkle Eric
- Braund Peter
- Brocheton Jessy
- Brown Morris J
- Bruinsma Nienke
- Bugert Peter
- Burnett Mary Susan
- Butterworth Adam S
- Buysschaert Ian
- Cambien Francois
- Cambien François
- Carlquist John F
- Cederschiöld Barbro
- Chambers John C
- Chen Li
- Clark S
- Clarke Robert
- Cobb L
- Cobb M
- Codd Veryan
- Collins Rory
- Cooper Jason
- Couper David
- Crisp-Hihn Abi
- Crowther J
- Cupples L Adrienne
- Danell-Toverud Karin
- Danesh John
- Davies C
- Davies Robert W
- de Bakker Paul I W
- de Boer Anthonius
- de Faire Ulf
- de Jong Jonas S
- de Winter Robbert J
- Dedoussis George
- Dehghan Abbas
- Dekker Lukas R
- Deloukas Panos
- Demissie Serkalem
- DerOhannessian Stephanie
- Devaney Joseph
- Diemert Patrick
- Do Ron
- Doering Angela
- Edwards C
- Ejebe Kenechi
- El Mokhtari Nour Eddine
- Elbers Clara C
- Elliott Paul
- Ellis Stephen G
- Elosua Roberto
- Engert James C
- Epstein Stephen
- Erdmann Jeanette
- Eriksson Per
- Farrall Martin
- Ferguson Jane
- Fischer Marcus
- Foad Nicola
- Folsom Aaron R
- Fornage Myriam
- Franzosi Maria-Grazia
- Freyer Jennifer
- Frossard Philippe
- Garner Stephen
- Gieger Christian
- Gigante Bruna
- Girelli Domenico
- Goel Anuj
- Gonzalez H
- Goodall Alison H
- Goodwin N
- Gorgels Anton P
- Gracey Jay
- Gray Emma
- Green Fiona
- Gretarsdottir Solveig
- Grobbee Diederick E
- Grundstedt Ulla
- Gudnason Vilmundur
- Gulcher Jeffrey R
- Gunter R
- Gut Ivo
- Gwilliams Rhian
- Hakonarson Hakon
- Hall Alistair S
- Halperin Eran
- Hammond Naomi
- Hamsten Anders
- Hardwick Robert J
- Hazen Stanley L
- Heath Simon
- Heimerl Susanne
- Heinonen Merja
- Hellénius Mai-Lis
- Hengstenberg Christian
- Henriques José P
- Hofker Marten H
- Hofman Albert
- Holm Hilma
- Hopewell J C
- Horne Benjamin D
- Hunt Sarah E
- Husman Karin
- Illig Thomas
- Iribarren Carlos
- Ishaq Mohammad
- Jolley Jennifer
- Jones Gregory T
- Jukema J Wouter
- Kaiser Michael A
- Kaplan Lee M
- Kastelein John J P
- Kathiresan Sekar
- Keating Brendan
- Khaw Kay-Tee
- Kleber Marcus E
- Klopp Norman
- Klungel Olaf H
- Klüter Harald
- Knowles Joshua W
- Koch Karel T
- Koch Kerstin
- Koenig Wolfgang
- Kolovou Genovefa
- Kong Augustine
- Kooner Angad S
- Kooner Jaspal S
- Kourellias K
- Krishnan Unni
- König Inke R
- Laaksonen Reijo
- Lagercrantz Jacob
- Lambrechts Diether
- Larsson Anita
- Larsson Malin
- Lathrop Mark
- Leander Karin
- Lettre Guillaume
- Li Mingyao
- Lieb Wolfgang
- Linksted P
- Liu Kiang
- Lloyd-Jones Heather
- Loley Christina
- Lotery Andrew J
- Lugauer Ingrid
- Lundmark Per
- Maitland-van der Zee Anke-Hilse
- Mallick Nadeem Hayat
- Mannucci Pier M
- Maouche Seraya
- Martinelli Nicola
- Mathews C
- Matthai William
- McKeown Pascale P
- McPherson Ruth
- Mehta Nehal N
- Meisinger Christa
- Meitinger Thomas
- Melander Olle
- Merlini Pier Angelica
- Moore Jasbir S
- Mooser Vincent
- Morgan Thomas
- Mossfeldt Magnus
- Mozley S
- Mueller Martina
- Muhlestein Joseph B
- Muir David
- Munday A
- Murray Elizabeth
- Musameh Muntaser D
- Musani Solomon
- Musunuru Kiran
- Mälarstig Anders
- März Winfried
- Mätz Winfried
- Mühleisen Thomas W
- Nahrstaedt Janja
- Nelson Chris P
- Nelson Christopher P
- Neudert Jessica
- Niblett David
- Notman J
- Nöthen Markus M
- O'Donnell Christopher J
- O'Leary Karen
- Olivieri Oliviero
- Olsson Gunnar
- Olsson Per
- Ongen Halit
- Onland-Moret N Charlotte
- Ostley T
- Ouwehand Willem H
- Papanicolaou George
- Parish S
- Patel Riyaz S
- Patterson Chris C
- Peden John
- Peters Annette
- Peters Bas J M
- Peyvandi Flora
- Pollard Helen
- Potter Simon
- Preuss Michael
- Psaty Bruce M
- Qasim Atif
- Qu Liming
- Quertermous Thomas
- Quyyumi Arshed A
- Rader Daniel J
- Radley M
- Rafelt Suzanne
- Rallidis Loukianos S
- Rankin Angela
- Rasheed Asif
- Reilly Muredach
- Rice Catherine
- Rice Catherine M
- Richards A
- Roberts Robert
- Rosendaal Frits R
- Rubin Diana
- Rust Stephan
- Sabater-Lleal Maria
- Sager Hendrik
- Saleheen Danish
- Salomaa Veikko
- Samad Abdus
- Samani Nilesh J
- Sambrook Jennifer
- Sampietro M Lourdes
- Samuel Maria
- Sandhu Manj S
- Schadt Eric
- Schillert Arne
- Schmitz Gerd
- Scholz Michael
- Schreiber Stefan
- Schrezenmeir Jürgen
- Schroeder Laura
- Schunkert Heribert
- Schwartz Stephen M
- Schäfer Arne
- Scott James
- Seedorf Udo
- Sehmi Joban S
- Sennblad Bengt
- Shah Nabi
- Shah S
- Silveira Angela
- Silver M
- Siscovick David S
- Sivananthan Mohan
- Sivapalaratnam Suthesh
- Smith Albert V
- Smith Tamara B
- Snoep Jaapjan D
- Soranzo Nicole
- Sotoodehnia Nona
- Spertus John A
- Stark Klaus
- Stefansson Kari
- Stephens Jonathan
- Stewart Alexandre F R
- Stirrups Kathy
- Stoll Monika
- Strawbridge Rona
- Syvannen Ann-Christine
- Söderholm Birgitta
- Tang W H Wilson
- Tennstedt Stephanie
- Thompson John R
- Thompson Simon G
- Thorgeirsson Gudmundur
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tochlin S
- Tognoni Gianni
- Tomaszewski Maciej
- Trip Mieke D
- Uitterlinden Andre G
- van der Harst Pim
- van der Schoot C Ellen
- van der Schouw Yvonne T
- van Rij Andre M
- van Setten Jessica
- van't Hooft Ferdinand
- Vasan Ramachandran S
- Verdon V
- Verheugt Freek W
- Verschuren W M Monique
- Voight Benjamin F
- Wallace Chris
- Wareham Nick J
- Watkins Hugh
- Wichmann H-Erich
- Wijmenga Cisca
- Wilde Arthur A M
- Wilensky Robert
- Willenborg Christina
- Winkelmann Bernhard R
- Witteman Jaqueline C M
- Wright Benjamin J
- Ye Shu
- Young A
- Zaidi Moazzam
- Zaman Khan Shah
- Zelenika Diana
- Zhang Weihua
- Ziegler Andreas
- Öhrvik John
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/09/2011
- Field of study
Defining the role of common variation in the genomic and biological architecture of adult human height
- Author
- Abecasis Goncalo R
- Absher Devin
- Afzal Uzma
- Albrecht Eva
- Alizadeh B
- Altshuler D
- Altshuler D
- Ambite JL
- Amin Najaf
- Amouyel Philippe
- Anand S
- Anand S
- Anderson G
- Anderson Denise
- Ardissino D
- Ardissino D
- Ardissino D
- Arnold A
- Arscott Gillian M
- Arveiler Dominique
- Asselbergs Folkert W
- Asselta R
- Assimes Themistocles L
- Avery C
- Avila PC
- Bakker Stephan J. L
- Ball SG
- Balmforth AJ
- Bandinelli Stefania
- Baron Jeffrey
- Barrett Amy
- Barroso Inês
- Basford M
- Beckmann Jacques S
- Beekman Marian
- Beilby John
- Bellis Claire
- Bennett Amanda J
- Berg R
- Berger K
- Berglund G
- Bergman Richard N
- Bergmann Sven
- Bernardi F
- BERNARDINELLI LUISA
- Berndt Sonja I
- Berne Christian
- Berzuini C
- Bielinski S
- Biffar Reiner
- Blangero John
- Blüher Matthias
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle E
- Boerwinkle Eric
- Boezen HM
- Bolton Jennifer L
- Boomsma Dorret I
- Borecki Ingrid B
- Bornstein Stefan R
- Boston J
- Bottinger Erwin P
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Brambilla Paolo
- Braund PS
- Brown Gentry K
- Brown Morris J
- Bruinenberg M
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Burke W
- Burnett MS
- Burtt N
- Bush WS
- Buyske S
- Buyske Steven
- Buzkova P
- Böttcher Yvonne
- Cambien F
- Campbell Harry
- Carlson C
- Carlson C
- Carrell D
- Carty C
- Casari G
- Caspersen Ida H
- Cauchi Stéphane
- Caulfield Mark J
- Celli P
- Chakravarti Aravinda
- Chambers John C
- Chanock Stephen J
- Chasman Daniel I
- Chen L
- Chen Z
- Cheng I
- Chines Peter S
- Chisholm RL
- Choudary V
- Chu Audrey Y
- Churchill LR
- Chute C
- Clarke Robert
- Claudi Boehm Simone
- Clayton E
- Cochran B
- Cole S
- Collins Francis S
- Collins Rory
- Cooper Matthew
- Cooper Richard S
- Cornfield D
- Corrocher R
- Crane P
- Crawford D
- Crawford D
- Crawford Dana C
- Croteau Chonka Damien C
- Cupples L. Adrienne
- Daly MJ
- Danesh John
- Darbar D
- Daw E. Warwick
- Day Felix R
- de Andrade M
- De Bakker Paul I. W
- de Boer RA
- De Faire Ulf
- De Groot Lisette C. P. G. M.
- De Jong Pim A
- Dedoussis George
- Deelen Joris
- Deelman E
- Delgado Graciela
- Deloukas P
- Deloukas Panos
- Demirkan Ayse
- Den Ruijter Hester M
- Denny JC
- Denny Josh C
- Devaney J
- Dhonukshe Rutten Rosalie
- Dimitriou Maria
- Ding K
- Do R
- Doney Alex S. F
- Duan Yanan
- Duga S
- Duggan D
- Dumitrescu L
- Durda P
- Dörr Marcus
- Ehret Georg B
- Eklund Niina
- Elosua R
- Elosua R
- Elosua R
- Elosua R
- Engert JC
- Engert JC
- Epstein SE
- Erbel Raimund
- Erdmann J
- Erdmann J
- Erdmann J
- Erdmann J
- Erdmann Jeanette
- Eriksson Johan G
- Esko Tonu
- Estrada Karol
- Eury Elodie
- Fall Tove
- Farrall Martin
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary F
- Ferrannini Ele
- Ferrario M
- Ferreira Teresa
- Ferrières Jean
- Ferrucci Luigi
- Fetiveau R
- Fischer M
- Fischer M
- Fischer Krista
- Folkersen Lasse
- Ford Ian
- Fornage M
- Forouhi Nita G
- Forrester Terrence
- Fost N
- Fowke J
- Fox Caroline S
- Franceschini N
- Franke L
- Franke Lude
- Franks Paul W
- Fraser Ross M
- Frayling Timothy M
- Friedlander Y
- Froguel Philippe
- Fullerton SM
- Gabriel SB
- Galli M
- Gansevoort Ron T
- Garcia Melissa E
- Gejman Pablo V
- Geller Frank
- Gianniny L
- Giedraitis Vilmantas
- Gieger Christian
- Girelli D
- Girelli D
- Glenn K
- Go Alan S
- Goddard Michael E
- Goel Anuj
- Golay Alain
- Gong J
- Gong Jian
- Goodall A
- Goodloe R
- Gottesman Omri
- Graff M
- Grallert Harald
- Grammer Tanja B
- Greenland P
- Groop Leif C
- Gross M
- Grosshennig A
- Grosshennig A
- Groves Christopher J
- Gräßler Jürgen
- Grönberg Henrik
- Gudnason Vilmundur
- Guiducci C
- Gustafsson Stefan
- Gyllensten Ulf
- Haas David W
- Haessler J
- Haessler Jeffrey
- Haiman C
- Haiman Christopher A
- Haines J
- Haines JL
- Hakonarson HH
- Hall AS
- Hall Alistair S
- Hall Per
- Haller Toomas
- Hallmans Goran
- Hamsten Anders
- Hannemann Anke
- Harris Tamara B
- Hart G
- Hart L
- Hartman Catharina A
- Hassinen Maija
- Hattersley Andrew T
- Havulinna AS
- Hayes M
- Hayes M. Geoffrey
- Hayward Caroline
- Heard Costa Nancy L
- Heath Andrew C
- Heid Iris M
- Heiss G
- Helmer Quinta
- Hemani Gibran
- Henders Anjali K
- Henderson B
- Hengstenberg C
- Hengstenberg C
- Hengstenberg C
- Hengstenberg Christian
- Henriksen J
- Hicks Andrew A
- Higashio J
- Hillege HL
- Hillege Hans L
- Hindorff L
- Hindorff Lucia A
- Hingorani Aroon D
- Hirschhorn JN
- Hirschhorn Joel N
- Hlatky Mark A
- Hoffmann Per
- Hoffmann Wolfgang
- Hofman Albert
- Holmen Oddgeir
- Houwing Duistermaat Jeanine J
- Hovingh G. Kees
- Huge A
- Hui Jennie
- Humowiecki J
- Humphries Steve E
- Hunt Steven C
- Hunter David J
- Hutchinson F
- Hveem Kristian
- Hypponen Elina
- Hólm H
- Illig Thomas
- Ingelsson Erik
- Isaacs Aaron
- Jackson R
- Jackson Anne U
- Jacobs Kevin B
- James Alan L
- Jarvelin Marjo Riitta
- Jarvik G
- Jeff J
- Jeff Janina
- Jenny N
- Johansen Berit
- Johansson Åsa
- Jolley Jennifer
- Jousilahti Pekka
- Jukema J. Wouter
- Jula Antti M
- Juliusdottir Thorhildur
- Junttila Juhani
- Justice Anne E
- Kanoni Stavroula
- Kao L
- Kaplan Robert C
- Kaprio Jaakko
- Karjalainen Juha
- Kastelein John J. P
- Kathiresan S
- Kathiresan S
- Kathiresan S
- Kathiresan S
- Kathiresan S
- Kayser Manfred
- Kee Frank
- Keinanen Kiukaanniemi Sirkka M
- Kent KM
- Kho A
- Kho Abel N
- Kibbe WA
- Kiemeney Lambertus A
- Kinnunen Leena
- Kitchner T
- Kivimaki Mika
- Kleber Marcus E
- Klopp Norman
- Knouff CW
- Kocarnik J
- Kocher Thomas
- Koenig B
- Kolonel L
- Kooner Jaspal S
- Kooperberg C
- Kooperberg Charles
- Korn JM
- Koskinen Seppo
- Kovacs Peter
- Kraja Aldi T
- Kratzer Wolfgang
- Kristiansson Kati
- Kuh Diana
- Kuller L.
- Kullo I
- Kumari Meena
- Kutalik Zoltán
- Kuusisto Johanna
- König I
- König IR
- Laakso Markku
- LaCroix A
- Lakka Timo A
- Langenberg Claudia
- Larson EB
- Law M
- Le Marchand L
- Le Marchand Loic
- Leach Irene Mateo
- Lehtimäki Terho
- Lemke AA
- Lettre Guillaume
- Li M
- Lichtner Peter
- Lieb W
- Lieb W
- Lim U
- Lim Unhee
- Lin D
- Lin Y
- Lind Lars
- Lindgren Cecilia M
- Lindsay JM
- Lindström Jaana
- Linneman J
- Linsel Nitschke P
- Linsel Nitschke P
- Liu Yongmei
- Lo Ken Sin
- Lobbens Stéphane
- Locke Adam E
- Loos Ruth J. F
- Lorentzon Mattias
- Lotay Vaneet
- Lowe WL
- Lu Yingchang
- Luan Jian'An
- Lucas G
- Lucas G
- Ludman E
- Lui Julian C
- Lupoli Sara
- Lyssenko Valeriya
- MacCluer J
- MacRae CA
- Madden Pamela A. F
- Magnusson Patrik K. E
- Mahajan Anubha
- Maillard Marc
- Malin BA
- Malinowski J
- Mangino Massimo
- Mannucci PM
- Mannucci PM
- Mannucci PM
- Manolio T
- Manunta Paolo
- Marette André
- Marrugat J
- Martin Nicholas G
- Martinelli N
- Marziliano N
- Masys DR
- Matise T
- Matise Tara C
- Matthai W
- Mcardle Wendy L
- McCarroll SA
- Mccarthy Mark I
- McCarty CA
- McDavid A
- Mckenzie Colin A
- McKeown PP
- McKeown PP
- Mcknight Barbara
- Mclachlan Stela
- Mclaren Paul J
- Medina Gomez Carolina
- Meigs JB
- Meitinger Thomas
- Melander O
- Melander O
- Melander O
- Melbye Mads
- Menni Cristina
- Merger Sigrun
- Merlini PA
- Metspalu Andres
- Mihailov Evelin
- Milani Lili
- Miller A
- Mirel D
- Mitchell SL
- Moayyeri Alireza
- Moebus Susanne
- Mohlke Karen L
- Moll Frans L
- Monda Keri L
- Monroe K
- Montgomery Grant W
- Mooser V
- Morgan T
- Morgan T
- Morken Mario A
- Morris Andrew D
- Morris Andrew P
- Munroe Patricia B
- Murdock D
- Murray Jeffrey C
- Musk Arthur W
- Musunuru K
- Musunuru K
- Mägi Reedik
- Männistö Satu
- März Winfried
- Müller Nurasyid Martina
- Müller Gabriele
- Nalls Michael A
- Narisu Narisu
- Nathan DM
- Nato A
- Nauck Matthias
- Navis G
- Nelis Mari
- Nemesh J
- Newton K
- Njølstad Inger
- Nolte Ilja M
- North KE
- North Kari E
- Nyholt Dale R
- Nöthen Markus M
- O'Connell Jeffrey R
- O'Donnell CJ
- O'Donnell CJ
- O'Donnell CJ
- Oetjens M
- Ohlsson Claes
- Oldehinkel Albertine J
- Olivieri O
- Ong Ken K
- Oostra Ben A
- Oozageer Laticia
- Ormel J
- Ouwehand W
- Ouwehand Willem H
- Pacheco JA
- Palbicki J
- Palmer Cameron D
- Palmer Colin N. A
- Pankow J
- Park L
- Parkin M
- Pasko Dorota
- Pasterkamp Gerard
- Pathak J
- Patsy B
- Patterson CC
- Patterson CC
- Pechlivanis Sonali
- Pedersen Nancy L
- Peissig P
- Peltonen L
- Peltonen L
- Peltonen L
- Pendergrass S
- Perola Markus
- Pers Tune H
- Person S
- Peters U
- Peters Annette
- Peters Ulrike
- Peyvandi F
- Piazza A
- Pichard AD
- Pilz Stefan
- Porcu Eleonora
- Postma DS
- Powell Joseph E
- Power Chris
- Pramstaller Peter P
- Prentice R
- Preuss M
- Preuss M
- Price Alkes L
- Price Jackie F
- Prokopenko Inga
- Pulley J
- Purcell S
- Purcell S
- Purcell S
- Pérusse Louis
- Qasim A
- Qi Lu
- Quertermous Thomas
- Quibrera M
- Rader DJ
- Rader DJ
- Raitakari Olli T
- Ramirez AH
- Ramos R
- Randall Joshua C
- Rankinen Tuomo
- Rao D. C.
- Rasmussen L
- Rauramaa Rainer
- Rayner Nigel W
- Reeser J
- Reilly MP
- Reilly MP
- Reinmaa Eva
- Renstrom Frida
- Restrepo N
- Ribichini F
- Rice Treva K
- Ridker Paul M
- Ried Janina S
- Ripke Stephan
- Ritchie M
- Ritchie M
- Ritchie MD
- Ritchie Marylyn
- Rivadeneira Fernando
- Robertson Neil R
- Roden DM
- Rose Lynda M
- Rosmalen JG
- Rosse S
- Rossi M
- Rotter Jerome I
- Roussel Ronan
- Rudan Igor
- Saaristo Timo E
- Sala J
- Saleheen Danish
- Salomaa V
- Salomaa V
- Salomaa V
- Salomaa Veikko
- Samani NJ
- Samani NJ
- Samani NJ
- Samani NJ
- Samani Nilesh J
- Sanna Serena
- Saramies Jouko
- Sarzynski Mark A
- Satler L
- Savova G
- Scharnagl Hubert
- Scheffold T
- Scherag André
- Schildcrout JS
- Schlessinger David
- Scholtens Salome
- Scholz M
- Schreiber S
- Schreiber S
- Schumacher F
- Schumacher Fredrick R
- Schunkert H
- Schunkert H
- Schunkert H
- Schunkert I
- Schunkert Heribert
- Schwartz SM
- Schwartz SM
- Schwartz SM
- Schwartz SM
- Schwarz Peter E. H
- Scott Robert A
- Sebert Sylvain
- Sehmi Joban
- Seufferlein Thomas
- Sever Peter
- Shi Jianxin
- Shohet R
- Shuldiner Alan R
- Shungin Dmitry
- Silventoinen Karri
- Sinisalo Juha
- Siscovick D
- Siscovick DS
- Siscovick DS
- Slaets JP
- Slagboom P. Eline
- Smit Johannes H
- Smith ME
- Smith Albert Vernon
- Smolonska Joanna
- Snieder H
- Snieder Harold
- Spangler L
- Spector Tim D
- Speliotes Elizabeth K
- Spencer K
- Spertus JA
- Spertus JA
- Spreafico M
- Stancáková Alena
- Stanton Alice V
- Stark K
- Stark K
- Starren J
- Stefansson K
- Stefansson Kari
- Steinthorsdottir Valgerdur
- Stirrups Kathleen
- Stolk RP
- Stolk Ronald P
- Stoll M
- Stoll M
- Stott David J
- Strachan David P
- Stram D
- Strauch Konstantin
- Strawbridge Rona J
- Stringham Heather M
- Stumvoll Michael
- Subirana I
- Subirana I
- Sundström Johan
- Sung Yun Ju
- Surti A
- Swertz Morris A
- Syvänen Ann Christine
- Tanaka Toshiko
- Tardif Jean Claude
- Taylor K
- Tayo Bamidele O
- Teumer Alexander
- Thompson JR
- Thompson WK
- Thorleifsson G
- Thorleifsson Gudmar
- Thornton Wells T
- Thorsteinsdottir U
- Thorsteinsdottir Unnur
- Tiirikainen M
- Tremblay Angelo
- Tremoli Elena
- Trinidad SB
- Trompet Stella
- Tubaro M
- Tuomilehto Jaakko
- Tyrer Jonathan P
- Tönjes Anke
- Uitterlinden André G
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- Uusitupa Matti
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- Völzke Henry
- Waite Lindsay L
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- Wang Zhaoming
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- Westra Harm Jan
- Wichmann HE
- Wichmann HE
- Wichmann H. Erich
- Wijmenga C
- Wilensky R
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- Wilkens Lynne R
- Willenborg Christina
- Willer Cristen J
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- Wilsgaard Tom
- Wilson S
- Wilson James F
- Winkler Thomas W
- Wojczynski Mary K
- Wolf WA
- Wolffenbuttel BH
- Wong Andrew
- Wood Andrew R
- Workalemahu Tsegaselassie
- Wright BJ
- Wright Alan F
- Wu C
- Wu J
- Xie C
- Xu H
- Yang Jian
- Yee J
- Yee J
- Yengo Loïc
- Young A
- Zanen Pieter
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zheng W
- Ziegler A
- Ziegler A
- Zonzin P
- Ärnlöv Johan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants
Genetic studies of body mass index yield new insights for obesity biology
- Author
- Aasarød K
- Abecasis G
- Abecasis GR
- Abecasis GR
- Abecasis Gonçalo R.
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- Österholm AM
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Note: A full list of authors and affiliations appears at the end of the article.
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
- Author
- Aalfs C M
- Aalfs Cora M
- Aben Katja K H
- Adenis Claude
- Adlard Julian
- Agata Simona
- Aghajanian Carol A
- Aghmesheh Morteza
- Agnarsson Bjarni A
- Aittomäki Kristiina
- Akloul Linda
- Alducci Elisa
- Allavena Anna
- Amor David
- Andersen Mette K
- Andrews Lesley
- Andrulis Irene L
- Antill Yoland
- Anton-Culver Hoda
- Antonenkova Natalia
- Antoniou Antonis C
- Apostolou Paraskevi
- Arason Adalgeir
- Ardern-Jones Audrey
- Ardnor Christina Edwinsdotter
- Aretini Paolo
- Armitage Shane
- Arnold Leanne
- Arnold Norbert
- Arun Banu K
- Arver Brita
- Attard Virginia
- Ausems M G E M
- Ausems Margreet G E M
- Azmi Mat Adenan Noor
- Azodi Masoud
- Bae-Jump Victoria L
- Baker Helen
- Balleine Rosemary
- Balmana Judith
- Bancroft Elizabeth
- Bandera Elisa V
- Bankier Agnes
- Bardsley Cathryn
- Barile Monica
- Barjhoux Laure
- Barkardottir Rosa B
- Barouk-Simonet Emmanuelle
- Barrowdale Daniel
- Barton David
- Barwell Julian
- Basil Jack B
- Bastick Patti
- Baumgärtner Anne
- Bean Yukie
- Becker Alexandra
- Beckmann Matthias W
- Beesley Jonathan
- Beilby John
- Belotti Muriel
- Benitez Javier
- Bennett Barbara
- Bennett Ian
- Berchuck Andrew
- Berger Andreas
- Berger Raanan
- Berlin Cheryl
- Bernard Loris
- Berry Geoffrey
- Berthet Pascaline
- Bignon Yves-Jean
- Birot Anne-Marie
- Bisogna Maria
- Bjorge Line
- Blackburn Anneke
- Blanco Ignacio
- Blank Stephanie V
- Blok M J
- Blok Marinus J
- Blom Marie-Jose
- bniak Tadeusz D
- Bogdanova Natalia
- Boggess John F
- Bogwitz Michael
- Bojesen Anders
- Bonadona Valérie
- Bonanni Bernardo
- Bonnet Françoise
- Borg Ake
- Bosch Nina
- Bourdon Violaine
- Boutry-Kryza Nadia
- Bove Betsy
- Bowtell D
- Bradshaw Nicola
- Brennan Meagan
- Bressac-de Paillerets Brigitte
- Bressac-de-Paillerets Brigitte
- Brewer Carole
- Brice Glen
- Brinton Louise A
- Bronner Myriam
- Brooks-Wilson Angela
- Brown Melissa
- Bruinsma Fiona
- Brunet Joan
- Bubien Virginie
- Buckley Michael
- Buecher Bruno
- Burgess Matthew
- Burke Jo
- Bustinza Gisela Barbany
- Butow Phyllis
- Butzow Ralf
- Buys Saundra S
- Byron John W
- Byron Keith
- Byrski Tomasz
- Caldes Trinidad
- Calender Alain
- Caligo Maria A
- Callen David
- Campbell Ian
- Capella Gabriel
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- Cattaneo Elisa
- Catts Zohra Ali-Kahn
- Caux-Moncoutier Virginie
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- Chauhan Deepa
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- Chen Xiaoqing
- Chen Zhihua
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- Christian Alice
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- Chung Wendy K
- Claber Oonagh
- Claes Kathleen
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- Coetzee Gerry
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- Eeles Ros
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- Miedzybrodzka Zosia
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- Scott Elizabeth
- Scott Rodney
- Scuvera Giulietta
- Searle Anne
- Segura Pedro Perez
- Seldon Joyce
- Selkirk Christina
- Sellers Thomas A
- Senter Leigha
- Serra-Feliu Gemma
- Seshadri Ram
- Sevenet Nicolas
- Sexton Adrienne
- Seynaeve C
- Shah Sohela
- Shapira Iuliana
- Sharma Priyanka
- Sharma Raghwa
- Shelling Andrew
- Shen Howard C
- Sherman Mark E
- Shu Xiao-Ou
- Shvetsov Yurii B
- Siddiqui Nadeem
- Side Lucy
- Side Lucy E
- Sieh Weiva
- Siesling S
- Sighoko Dominique
- Simard Jacques
- Simpson Peter
- Singer Christian F
- Sinilnikova Olga
- Skytte Anne-Bine
- Slager Susan
- Small Laurie
- Smalley Sarah
- Snadden Lesley
- Snyder Carrie L
- Sobol Hagay
- Sokolenko Anna P
- Sokolowska Johanna
- Solanes Ares
- Soller Maria
- Song Honglin
- Soubrier Florent
- Soucy Penny
- Southey Melissa
- Spindler Tassja J
- Spurdle Amanda
- Stayner Barbara
- Steele Linda
- Steinemann Doris
- Stenmark-Askmalm Marie
- Stevens Kristen
- Stoppa-Lyonnet Dominique
- Sucheston Lara
- Sukiennicki Grzegorz
- Sunde Lone
- Suthers Graeme
- Sutter Christian
- Sykes Pamela
- Szabo Csilla I
- Tancredi Mariella
- Tangen Ingvild L
- Tassell Margaret
- Taylor Amy
- Taylor Donna
- Taylor Jane
- Taylor Jessica
- Taylor Natalie
- Tchatchou Sandrine
- Tea Muy-Kheng
- Teixeira Manuel R
- Tejada Maria-Isabel
- Teo Soo-Hwang
- Terry Kathryn L
- Terry Mary Beth
- Teule Alex
- Thames N E
- Thierry Benjamin
- Thomas Susan
- Thomassen Mads
- Thompson Ella
- Thompson Pamela J
- Thorne Heather
- Tibiletti Maria Grazia
- Tihomirova Laima
- Tilanus-Linthorst Madeleine A
- Timorek Agnieszka
- Tirapo Carole
- Tischkowitz Marc
- Tizzoni Laura
- Tobias Ed
- Tognazzo Silvia
- Toland Amanda Ewart
- Tollenaar R A E M
- Toloczko-Grabarek Aleksandra
- Tommasi Stefania
- Tornero Eva
- Torres Diana
- Toulas Christine
- Townshend Sharron
- Trainer Alison
- Tran Lan
- Tripathi Vishakha
- Tsai Ya-Yu
- Tucker Kathy
- Tung Nadine
- Tworoger Shelley S
- Tyler Janet
- Tyrer Jonathan
- Uhrhammer Nancy
- van Altena Anne M
- van Asperen C J
- van Asperen Christi J
- van Cronenburg T C T E F
- van den Ouweland A M W
- van den Ouweland Ans M W
- van der Baan Frederieke H
- van der Hout A H
- van der Hout Annemarie H
- van der Luijt R B
- van der Luijt Rob B
- van der Pol C C
- van Deurzen C H M
- van Deurzen Carolien H M
- van Dooren Marieke F
- Van Le Linda
- van Leeuwen F E
- van Leeuwen Flora E
- Van Nieuwenhuysen Els
- van Os T A M
- van Os Theo A M
- van Rensburg Elizabeth J
- van Roozendaal K E P
- Varesco Liliana
- Varon-Mateeva Raymonda
- Vasen H F
- Vasen Hans F A
- Vaszko Tibor
- Vaur Dominique
- Vega Ana
- Velasco Angela
- Venat-Bouvet Laurence
- Vennin Philippe
- Vergote Ignace
- Verhoef S
- Verhoef Senno
- Verloop J
- Verny-Pierre Carole
- Verp Marion
- Viel Alessandra
- Vierkant Robert A
- Vignolo-Lutati Francesca
- Vijai Joseph
- Visvader Jane
- Volorio Sara
- von Wachenfeldt Anna
- Vratimos Athanassios
- Væth Signe
- Vénat-Bouvet Laurence
- Waisfisz Q
- Waisfisz Quinten
- Wakeley Katie
- Walker Lisa
- Walker Logan
- Walpole Ian
- Walsh Christine
- Wang Chen
- Wang Xianshu
- Wang-Gohrke Shan
- Wappenschmidt Barbara
- Warcoin Mathilde
- Ward Robin
- Waring Paul
- Warner Bev
- Warren Graham
- Watt Catherine
- Weaver JoEllen
- Webb P
- Weber Bernhard H F
- Weber Rachel Palmieri
- Weitzel Jeffrey N
- Wentzensen Nicolas
- Whiteman David C
- Whittemore Alice S
- Wicklund Kristine G
- Wiggins Jennifer
- Wijnands R
- Wijnen J T
- Wijnen Juul T
- Wilkens Lynne R
- Williams Rachael
- Wilson Judy
- Winchester Lizzie
- Winship Ingrid
- Woo Yin-Ling
- Wu Anna H
- Wu Kathy
- Wu Xifeng
- Yang Hannah
- Young Mary Ann
- Zaffaroni Daniela
- Zhang Jing
- Zheng Wei
- Zheng Yonglan
- Zidan Jamal
- Zikan Michal
- Ziogas Argyrios
- Złowocka-Perłowska Elżbieta
- Öfverholm Anna
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2015
- Field of study