Alien Registration- Emack, Malvina (Washburn, Aroostook County)

https://digitalmaine.com/alien_docs/23647/thumbnail.jp

Alien Registration- Emack, Aabram M. (Washburn, Aroostook County)

https://digitalmaine.com/alien_docs/23646/thumbnail.jp

Alien Registration- Emack, Winslow S. (Presque Isle, Aroostook County)

https://digitalmaine.com/alien_docs/33817/thumbnail.jp

Stress Responses of Neonates Related to Maternal Characteristics

∙ The authors have no financial conflicts of interest. Purpose: To investigate the pre- and post-heelstick stress response patterns of infants and to identify related maternal factors. Materials and Methods: Fifty-two mothers and their 57 infants were studied. Stress response patterns in neonates were collected by measurements of pulse rate, oxygen saturation, and salivary cortisol. Maternal demographic factors and awakening saliva were collected. Results: Median level of pulse rate of infant increased from 132.1 to 140.4 beats per minute and salivary cortisol was elevated from 0.41 µg/dL to 0.70 µg/dL during the periods of discomfort, while oxygen saturation decreased from 97 % to 95%. Infant’s pulse rate change was negatively correlated with gestational age (GA) (r =- 0.37, p < 0.05), whereas the change of infants ’ salivary cortisol was correlated positively with maternal age (r = 0.29, p < 0.05). GA was the only independently significant predictor of pulse rate responses (R 2 = 0.15, p < 0.05). Influence of maternal age on infants ’ salivary cortisol changes (R 2 = 0.09, p < 0.05) was observed in a stepwis

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual\u27s risk of non-communicable disease in later life: the developmental origins of health and disease (DOHaD) hypothesis. During the 1990s the validity of the DOHaD hypothesis was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in the in utero development between humans and guinea pigs, the strengths and limitations of the guinea pig as an experimental model of DOHaD and the guinea pig\u27s potential to enhance clinical therapeutic innovation to improve human health. (Figure presented.)

Alien Registration- Emack, Rachel (Bar Harbor, Hancock County)

https://digitalmaine.com/alien_docs/17578/thumbnail.jp

Alien Registration- Emack, Fred A. (Houlton, Aroostook County)

https://digitalmaine.com/alien_docs/36203/thumbnail.jp

Alien Registration- Emack, Donald A. (Bar Harbor, Hancock County)

https://digitalmaine.com/alien_docs/19388/thumbnail.jp

Alien Registration- Emack, Rachel (Bar Harbor, Hancock County)

https://digitalmaine.com/alien_docs/17578/thumbnail.jp

Alien Registration- Emack, Malvina (Washburn, Aroostook County)

https://digitalmaine.com/alien_docs/23647/thumbnail.jp