58 research outputs found
Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.
BACKGROUND: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.
METHODS: We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis.
RESULTS: The overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P = 5.71 × 10(-7)). In addition, meta-analysis using the five cohorts with ≥3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P = 2.18 × 10(-8)) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively.
CONCLUSIONS: In this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function
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A Search for Dark Higgs Bosons
Recent astrophysical and terrestrial experiments have motivated the proposal
of a dark sector with GeV-scale gauge boson force carriers and new Higgs
bosons. We present a search for a dark Higgs boson using 516 fb-1 of data
collected with the BABAR detector. We do not observe a significant signal and
we set 90% confidence level upper limits on the product of the Standard
Model-dark sector mixing angle and the dark sector coupling constant.Comment: 7 pages, 5 postscript figures, published version with improved plots
for b/w printin
Minutes of Citi NY Capital Markets Approval Committee Regarding Meeting Approving Liquidity Put Option
B0 meson decays to rho0 K*0, f0 K*0, and rho-K*+, including higher K* resonances
We present branching fraction measurements for the decays B0 -> rho0 K*0, B0
-> f0 K*0, and B0 -> rho- K*+, where K* is an S-wave (K pi)_0* or a K*(892)
meson; we also measure B0 -> f0 K_2*(1430)^0. For the K*(892) channels, we
report measurements of longitudinal polarization fractions (for rho final
states) and direct CP-violation asymmetries. These results are obtained from a
sample of (471.0 +/- 2.8) x 10^6 BBbar pairs collected with the BaBar detector
at the PEP-II asymmetric-energy e+ e- collider at the SLAC National Accelerator
Laboratory. We observe rho0 K*(892)^0, rho0 (K pi)_0^{*0}, f0 K*(892)^0, and
rho- K*(892)+ with greater than 5 sigma significance, including systematics. We
report first evidence for f0 (K pi)_0^{*0} and f0 K_2*(1430)^0, and place an
upper limit on rho- (K pi)_0^{*+}. Our results in the K*(892) channels are
consistent with no direct CP-violation.Comment: 17 pages, 6 postscript figures, submitted to Phys. Rev.
Kuhn, Helmut: Die Struktur quantitativer Modelle. Zur wirtschaftstheoretischen Grundlegung der Ökonometrie
Kurt Eisner Collection circa 1892-1919
This collection contains correspondence with a publisher and with Strauss family (Bertha Badt-Strauss, Bruno Strauss, and Abraham Strauss), as well as signed checks from the Verein zur Abwehr des Antisemitismus (League for Defense against Anti-Semitism), a flyer printed shortly after Eisner's assassination calling for a speedy investigation and trial, and some photographs.R. WoelflerStargardtBruno StraussThe revolutionary socialist Kurt Eisner (1867-1919) was instrumental in the Bavarian November Revolution of 1918 and served as the Prime Minister of the short-lived Bavarian Soviet Republik from late 1918 until his assassination in 1919.The original German-language inventory is available in the folderCopies of police files (deaccessioned--originals in Library of Congress according to note)Processed for digitizationSent for digitizationReturned from digitizationLinked to online manifestationdigitize
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