546 research outputs found
A quasitopos containing CONV and MET as full subcategories
We show that convergence spaces with continuous maps and metric spaces with
contractions, can be viewed as entities of the same kind. Both can be characterized by a limit function λ which with each filter ℱ associates a map λℱ from the underlying set to the extended positive real line. Continuous maps and contractions can both be characterized as limit function preserving maps
Self-Organized Criticality model for Brain Plasticity
Networks of living neurons exhibit an avalanche mode of activity,
experimentally found in organotypic cultures. Here we present a model based on
self-organized criticality and taking into account brain plasticity, which is
able to reproduce the spectrum of electroencephalograms (EEG). The model
consists in an electrical network with threshold firing and activity-dependent
synapse strenghts. The system exhibits an avalanche activity power law
distributed. The analysis of the power spectra of the electrical signal
reproduces very robustly the power law behaviour with the exponent 0.8,
experimentally measured in EEG spectra. The same value of the exponent is found
on small-world lattices and for leaky neurons, indicating that universality
holds for a wide class of brain models.Comment: 4 pages, 3 figure
Statistical Signatures of Structural Organization: The case of long memory in renewal processes
Identifying and quantifying memory are often critical steps in developing a
mechanistic understanding of stochastic processes. These are particularly
challenging and necessary when exploring processes that exhibit long-range
correlations. The most common signatures employed rely on second-order temporal
statistics and lead, for example, to identifying long memory in processes with
power-law autocorrelation function and Hurst exponent greater than .
However, most stochastic processes hide their memory in higher-order temporal
correlations. Information measures---specifically, divergences in the mutual
information between a process' past and future (excess entropy) and minimal
predictive memory stored in a process' causal states (statistical
complexity)---provide a different way to identify long memory in processes with
higher-order temporal correlations. However, there are no ergodic stationary
processes with infinite excess entropy for which information measures have been
compared to autocorrelation functions and Hurst exponents. Here, we show that
fractal renewal processes---those with interevent distribution tails ---exhibit long memory via a phase transition at .
Excess entropy diverges only there and statistical complexity diverges there
and for all . When these processes do have power-law
autocorrelation function and Hurst exponent greater than , they do not
have divergent excess entropy. This analysis breaks the intuitive association
between these different quantifications of memory. We hope that the methods
used here, based on causal states, provide some guide as to how to construct
and analyze other long memory processes.Comment: 13 pages, 2 figures, 3 appendixes;
http://csc.ucdavis.edu/~cmg/compmech/pubs/lrmrp.ht
Liquid-liquid equilibrium for monodisperse spherical particles
A system of identical particles interacting through an isotropic potential
that allows for two preferred interparticle distances is numerically studied.
When the parameters of the interaction potential are adequately chosen, the
system exhibits coexistence between two different liquid phases (in addition to
the usual liquid-gas coexistence). It is shown that this coexistence can occur
at equilibrium, namely, in the region where the liquid is thermodynamically
stable.Comment: 6 pages, 8 figures. Published versio
Spatiotemporal complexity of the universe at subhorizon scales
This is a short note on the spatiotemporal complexity of the dynamical
state(s) of the universe at subhorizon scales (up to 300 Mpc). There are
reasons, based mainly on infrared radiative divergences, to believe that one
can encounter a flicker noise in the time domain, while in the space domain,
the scaling laws are reflected in the (multi)fractal distribution of galaxies
and their clusters. There exist recent suggestions on a unifying treatment of
these two aspects within the concept of spatiotemporal complexity of dynamical
systems driven out of equilibrium. Spatiotemporal complexity of the subhorizon
dynamical state(s) of the universe is a conceptually nice idea and may lead to
progress in our understanding of the material structures at large scalesComment: references update
Non-equilibrium dynamics of stochastic point processes with refractoriness
Stochastic point processes with refractoriness appear frequently in the
quantitative analysis of physical and biological systems, such as the
generation of action potentials by nerve cells, the release and reuptake of
vesicles at a synapse, and the counting of particles by detector devices. Here
we present an extension of renewal theory to describe ensembles of point
processes with time varying input. This is made possible by a representation in
terms of occupation numbers of two states: Active and refractory. The dynamics
of these occupation numbers follows a distributed delay differential equation.
In particular, our theory enables us to uncover the effect of refractoriness on
the time-dependent rate of an ensemble of encoding point processes in response
to modulation of the input. We present exact solutions that demonstrate generic
features, such as stochastic transients and oscillations in the step response
as well as resonances, phase jumps and frequency doubling in the transfer of
periodic signals. We show that a large class of renewal processes can indeed be
regarded as special cases of the model we analyze. Hence our approach
represents a widely applicable framework to define and analyze non-stationary
renewal processes.Comment: 8 pages, 4 figure
Correlation studies of open and closed states fluctuations in an ion channel: Analysis of ion current through a large conductance locust potassium channel
Ion current fluctuations occurring within open and closed states of large
conductance locust potassium channel (BK channel) were investigated for the
existence of correlation. Both time series, extracted from the ion current
signal, were studied by the autocorrelation function (AFA) and the detrended
fluctuation analysis (DFA) methods. The persistent character of the short- and
middle-range correlations of time series is shown by the slow decay of the
autocorrelation function. The DFA exponent is significantly larger
than 0.5. The existence of strongly-persistent long-range correlations was
detected only for closed-states fluctuations, with . The
long-range correlation of the BK channel action is therefore determined by the
character of closed states. The main outcome of this study is that the memory
effect is present not only between successive conducting states of the channel
but also independently within the open and closed states themselves. As the ion
current fluctuations give information about the dynamics of the channel
protein, our results point to the correlated character of the protein movement
regardless whether the channel is in its open or closed state.Comment: 12 pages, 5 figures; to be published in Phys. Rev.
Gaugino condensation scale of one family hidden SU(5)', dilaton stabilization and gravitino mass
The hidden SU(5)' with one family, 10 and 5-bar, breaks supersymmetry
dynamically. From the effective Lagrangian approach, we estimate the hidden
sector gaugino candensation scale, the dilaton stabilization and the resulting
gravitino mass. In some models, this gravitino mass can be smaller than the
previous naive estimate. Then, it is possible to raise the SU(5)' confining
scale above 10^{13} GeV.Comment: 8 pages, 4 figure
Integrated random processes exhibiting long tails, finite moments and 1/f spectra
A dynamical model based on a continuous addition of colored shot noises is
presented. The resulting process is colored and non-Gaussian. A general
expression for the characteristic function of the process is obtained, which,
after a scaling assumption, takes on a form that is the basis of the results
derived in the rest of the paper. One of these is an expansion for the
cumulants, which are all finite, subject to mild conditions on the functions
defining the process. This is in contrast with the Levy distribution -which can
be obtained from our model in certain limits- which has no finite moments. The
evaluation of the power spectrum and the form of the probability density
function in the tails of the distribution shows that the model exhibits a 1/f
spectrum and long tails in a natural way. A careful analysis of the
characteristic function shows that it may be separated into a part representing
a Levy processes together with another part representing the deviation of our
model from the Levy process. This allows our process to be viewed as a
generalization of the Levy process which has finite moments.Comment: Revtex (aps), 15 pages, no figures. Submitted to Phys. Rev.
A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen
NY-ESO-1 has been a major target of many immunotherapy trials because it is expressed by various cancers and is highly immunogenic. In this study, we have identified a novel HLA-B*1801-restricted CD8<sup>+</sup>T cell epitope, NY-ESO-1<sub>88–96</sub> (LEFYLAMPF) and compared its direct- and cross-presentation to that of the reported NY-ESO-1<sub>157–165</sub> epitope restricted to HLA-A*0201. Although both epitopes were readily cross-presented by DCs exposed to various forms of full-length NY-ESO-1 antigen, remarkably NY-ESO-1<sub>88–96</sub> is much more efficiently cross-presented from the soluble form, than NY-ESO-1<sub>157–165</sub>. On the other hand, NY-ESO-1<sub>157–165</sub> is efficiently presented by NY-ESO-1-expressing tumor cells and its presentation was not enhanced by IFN-γ treatment, which induced immunoproteasome as demonstrated by Western blots and functionally a decreased presentation of Melan A<sub>26–35</sub>; whereas NY-ESO-1<sub>88–96</sub> was very inefficiently presented by the same tumor cell lines, except for one that expressed high level of immunoproteasome. It was only presented when the tumor cells were first IFN-γ treated, followed by infection with recombinant vaccinia virus encoding NY-ESO-1, which dramatically increased NY-ESO-1 expression. These data indicate that the presentation of NY-ESO-1<sub>88–96</sub> is immunoproteasome dependent. Furthermore, a survey was conducted on multiple samples collected from HLA-B18+ melanoma patients. Surprisingly, all the detectable responses to NY-ESO-1<sub>88–96</sub> from patients, including those who received NY-ESO-1 ISCOMATRIX™ vaccine were induced spontaneously. Taken together, these results imply that some epitopes can be inefficiently presented by tumor cells although the corresponding CD8<sup>+</sup>T cell responses are efficiently primed in vivo by DCs cross-presenting these epitopes. The potential implications for cancer vaccine strategies are further discussed
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