Lithium in the Upper Centaurus Lupus and Lower Centaurus Crux Subgroups of Scorpius-Centaurus

We utilize spectroscopically derived model atmosphere parameters and the \ion{Li}{1} $\lambda6104$ subordinate line and the $\lambda6708$ doublet to derive lithium abundances for 12 members of the Upper-Centaurus Lupus (UCL) and Lower-Centaurus Crux (LCC) subgroups of the Scorpius Centaurus OB Association. The results indicate any intrinsic Li scatter in our 0.9-1.4 $M_{\odot}$ stars is limited to ${\sim}0.15$ dex, consistent with the lack of dispersion in ${\ge}1.0$ $M_{\odot}$ stars in the 100 Myr Pleiades and 30-50 Myr IC 2391 and 2602 clusters. Both ab initio uncertainty estimates and the derived abundances themselves indicate that the $\lambda$6104 line yields abundances with equivalent or less scatter than is found from the $\lambda$6708 doublet as a result of lower uncertainties for the subordinate feature, a result of low sensitivity to broadening in the subordinate feature. Because NLTE corrections are less susceptible to changes in surface gravity and/or metallicity for the 6104 {\AA} line, the subordinate Li feature is preferred for deriving lithium abundances in young Li-rich stellar association stars with $T_{\rm eff}{\ge}5200$ K.Comment: Accepted for publication in Astronomical Journal (abstract shortened for astro-ph submission

V474 Car: A Rare Halo RS CVn Binary in Retrograde Galactic Orbit

We report the discovery that the star V474 Car is an extremely active, high velocity halo RS CVn system. The star was originally identified as a possible pre-main sequence star in Carina, given its enhanced stellar activity, rapid rotation (10.3 days), enhanced Li, and absolute magnitude that places it above the main sequence. However, its extreme radial velocity (264 km s$^{-1}$) suggested that this system was unlike any previously known pre-MS system. Our detailed spectroscopic analysis of echelle spectra taken with the CTIO 4-m finds that V474 Car is both a spectroscopic binary with orbital period similar to the photometric rotation period, and metal poor ([Fe/H] $\simeq -$0.99). The star's Galactic orbit is extremely eccentric (e $\simeq$ 0.93) with perigalacticon of only $\sim$0.3 kpc of the Galactic center - and its eccentricity and smallness of its perigalacticon are only surpassed by $\sim$0.05%, of local F/G-type field stars. The observed characteristics are consistent with V474 Car being a high velocity, metal poor, tidally-locked chromospherically active binary (CAB), i.e.\ a halo RS CVn binary, and one of only a few such specimens known.Comment: Accepted to Astronomical Journa

SARS-CoV-2 transmission and impacts of unvaccinated-only screening in populations of mixed vaccination status

Screening programs that test only the unvaccinated population have been proposed and implemented to mitigate SARS-CoV-2 spread, implicitly assuming that the unvaccinated population drives transmission. To evaluate this premise and quantify the impact of unvaccinated-only screening programs, we introduce a model for SARS-CoV-2 transmission through which we explore a range of transmission rates, vaccine effectiveness scenarios, rates of prior infection, and screening programs. We find that, as vaccination rates increase, the proportion of transmission driven by the unvaccinated population decreases, such that most community spread is driven by vaccine-breakthrough infections once vaccine coverage exceeds 55% (omicron) or 80% (delta), points which shift lower as vaccine effectiveness wanes. Thus, we show that as vaccination rates increase, the transmission reductions associated with unvaccinated-only screening decline, identifying three distinct categories of impact on infections and hospitalizations. More broadly, these results demonstrate that effective unvaccinated-only screening depends on population immunity, vaccination rates, and variant. &nbsp;</p

Estimating SARS-CoV-2 seroprevalence and epidemiological parameters with uncertainty from serological surveys

Establishing how many people have been infected by SARS-CoV-2 remains an urgent priority for controlling the COVID-19 pandemic. Serological tests that identify past infection can be used to estimate cumulative incidence, but the relative accuracy and robustness of various sampling strategies have been unclear. We developed a flexible framework that integrates uncertainty from test characteristics, sample size, and heterogeneity in seroprevalence across subpopulations to compare estimates from sampling schemes. Using the same framework and making the assumption that seropositivity indicates immune protection, we propagated estimates and uncertainty through dynamical models to assess uncertainty in the epidemiological parameters needed to evaluate public health interventions and found that sampling schemes informed by demographics and contact networks outperform uniform sampling. The framework can be adapted to optimize serosurvey design given test characteristics and capacity, population demography, sampling strategy, and modeling approach, and can be tailored to support decision-making around introducing or removing interventions. </div

A Revised Age for Upper Scorpius and The Star-Formation History Among the F-Type Members of the Scorpius-Centaurus OB Association

We present an analysis of the ages and star-formation history of the F-type stars in the Upper Scorpius (US), Upper Centaurus-Lupus (UCL) and Lower Centaurus-Crux (LCC) subgroups of Scorpius-Centaurus. We find that 1) our empirical isochrones are consistent with the previously published age-rank of the Sco-Cen subgroups, 2) LCC and UCL appear to reach the main sequence turn-on at spectral types ~F4 and ~F2, respectively. An analysis of the A-type stars shows US reaching the main sequence at about spectral type ~A3. 3) The median ages for the pre-main sequence members of UCL and LCC are 16 Myr and 17 Myr, respectively, in agreement with previous studies, however we find that 4) Upper Sco is much older than previously thought. The luminosities of the F-type stars in US are typically a factor of ~2.5 less luminous than predicted for a 5 Myr old population for four sets of evolutionary tracks. We reexamine the evolutionary state and isochronal ages for the B-, A-, and G-type Upper Sco members, and the evolved M supergiant Antares, and estimate a revised mean age for Upper Sco of 11+/-1+/-2 Myr (statistical, systematic). Using radial velocities and Hipparcos parallaxes we calculate a lower limit on the kinematic expansion age for Upper Sco of >10.5 Myr (99% confidence). However, the data are statistically consistent with no expansion. We reevaluate the inferred masses for the known substellar companions in Upper Sco using the revised age. Specifically, we estimate the mass of 1RXS J1609-2105b to be 14^{+2}_{-3} Mjup, suggesting that it is a brown dwarf rather than a planet. Finally, we find the fraction of F-type stars exhibiting Ha emission and/or a K-band excess consistent with accretion to be 0/17 (<19%; 95% C.L.) in US at ~11 Myr, while UCL has 1/41 (2^{+5}_{-1}%; 68% C.L.) accretors and LCC has 1/50 (2^{+4}_{-1}%; 68% C.L.) accretors at ~16 Myr and ~17 Myr, respectively. [Abridged]Comment: Accepted for publication in ApJ. Formatted with emulateapj, 28 pages, 16 figures, 14 table

Uniform Atmospheric Retrieval Analysis of Ultracool Dwarfs I : Characterizing Benchmarks, Gl570D and HD3651B

Michael Line, et al, 'UNIFORM ATMOSPHERIC RETRIEVAL ANALYSIS OF ULTRACOOL DWARFS. I. CHARACTERIZING BENCHMARKS, Gl 570D AND HD 3651B', The Astrophysical Journal, Vol. 802 (2), July 2015, doi: https://doi.org/10.1088/0004-637X/807/2/183, published by IOP.Interpreting the spectra of brown dwarfs is key to determining the fundamental physical and chemical processes occurring in their atmospheres. Powerful Bayesian atmospheric retrieval tools have recently been applied to both exoplanet and brown dwarf spectra to tease out the thermal structures and molecular abundances to understand those processes. In this manuscript we develop a significantly upgraded retrieval method and apply it to the SpeX spectral library data of two benchmark late T-dwarfs, Gl570D and HD3651B, to establish the validity of our upgraded forward model parameterization and Bayesian estimator. Our retrieved metallicities, gravities, and effective temperature are consistent with the metallicity and presumed ages of the systems. We add the carbon-to-oxygen ratio as a new dimension to benchmark systems and find good agreement between carbon-to-oxygens ratio derived in the brown dwarfs and the host stars. Furthermore, we have for the first time unambiguously determined the presence of ammonia in the low-resolution spectra of these two late T-dwarfs. We also show that the retrieved results are not significantly impacted by the possible presence of clouds, though some quantities are significantly impacted by uncertainties in photometry. This investigation represents a watershed study in establishing the utility of atmospheric retrieval approaches on brown dwarf spectra.Peer reviewedFinal Published versio

Nicotinic receptors

Regulation of normal or abnormal behaviour is critically controlled by the central serotonergic systems. Recent evidence has suggested that serotonin (5-HT) neurotransmission dysfunction contributes to a variety of pathological conditions, including depression, anxiety, schizophrenia and Parkinson’s disorders. There is also a great amount of evidence indicating that 5-HT signalling may affect the reinforcing properties of drugs of abuse by the interaction and modulation of dopamine (DA) function. This chapter is focused on one of the more addictive drugs, nicotine. It is widely recognised that the effects of nicotine are strongly associated with the stimulatory action it exhibits on mesolimbic DAergic function. We outline the role of 5-HT and its plethora of receptors, focusing on 5-HT2 subtypes with relation to their involvement in the neurobiology of nicotine addiction. We also explore the novel pharmacological approaches using 5-HT agents for the treatment of nicotine dependence. Compelling evidence shows that 5-HT2C receptor agonists may be possible therapeutic targets for smoking cessation, although further investigation is required.peer-reviewe

A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment

This paper is a personal account on the discovery and characterization of the 5-HT2C receptor (first known as the 5- HT1C receptor) over 30 years ago and how it translated into a number of unsuspected features for a G protein-coupled receptor (GPCR) and a diversity of clinical applications. The 5-HT2C receptor is one of the most intriguing members of the GPCR superfamily. Initially referred to as 5-HT1CR, the 5-HT2CR was discovered while studying the pharmacological features and the distribution of [3H]mesulergine-labelled sites, primarily in the brain using radioligand binding and slice autoradiography. Mesulergine (SDZ CU-085), was, at the time, best defined as a ligand with serotonergic and dopaminergic properties. Autoradiographic studies showed remarkably strong [3H]mesulergine-labelling to the rat choroid plexus. [3H]mesulergine-labelled sites had pharmacological properties different from, at the time, known or purported 5-HT receptors. In spite of similarities with 5-HT2 binding, the new binding site was called 5-HT1C because of its very high affinity for 5-HT itself. Within the following 10 years, the 5-HT1CR (later named 5- HT2C) was extensively characterised pharmacologically, anatomically and functionally: it was one of the first 5-HT receptors to be sequenced and cloned. The 5-HT2CR is a GPCR, with a very complex gene structure. It constitutes a rarity in theGPCR family: many 5-HT2CR variants exist, especially in humans, due to RNA editing, in addition to a few 5-HT2CR splice variants. Intense research led to therapeutically active 5-HT2C receptor ligands, both antagonists (or inverse agonists) and agonists: keeping in mind that a number of antidepressants and antipsychotics are 5- HT2CR antagonists/inverse agonists. Agomelatine, a 5-HT2CR antagonist is registered for the treatment of major depression. The agonist Lorcaserin is registered for the treatment of aspects of obesity and has further potential in addiction, especially nicotine/ smoking. There is good evidence that the 5-HT2CR is involved in spinal cord injury-induced spasms of the lower limbs, which can be treated with 5-HT2CR antagonists/inverse agonists such as cyproheptadine or SB206553. The 5-HT2CR may play a role in schizophrenia and epilepsy. Vabicaserin, a 5-HT2CR agonist has been in development for the treatment of schizophrenia and obesity, but was stopped. As is common, there is potential for further indications for 5-HT2CR ligands, as suggested by a number of preclinical and/or genome-wide association studies (GWAS) on depression, suicide, sexual dysfunction, addictions and obesity. The 5-HT2CR is clearly affected by a number of established antidepressants/antipsychotics and may be one of the culprits in antipsychotic-induced weight gain