Examining the effect of ice dynamic changes on subglacial hydrology through modelling of a synthetic Antarctic glacier

Hydrologic pathways beneath ice sheets and glaciers play an important role in regulating ice flow. Antarctica has experienced, and will continue to experience, changes in ice dynamics and geometry, but the associated changes in subglacial hydrology have received less attention. Here, we use the GlaDS subglacial hydrology model to examine drainage evolution beneath an idealised Antarctic glacier in response to steepening ice surface slopes, accelerating ice velocities and subglacial lake drainages. Ice surface slope changes exerted a dominant influence, redirecting basal water to different outlet locations and substantially increasing channelised discharge crossing the grounding line. Faster ice velocities had comparatively negligible effects. Subglacial lake drainage results indicated that lake refilling times play a key role in drainage system evolution, with lake flux more readily accommodated following shorter refilling times. Our findings are significant for vulnerable Antarctic regions currently experiencing dynamic thinning since subglacial water re-routing could destabilise ice shelves through enhanced sub-shelf melting, potentially hastening irreversible retreat. These changes could also affect subglacial lake activity. We, therefore, emphasise that including a nuanced and complex representation of subglacial hydrology in ice-sheet models could provide critical information on the timing and magnitude of sea-level change contributions from Antarctica

The Effect of Firn-Aquifer Drainage on the Greenland Subglacial System or Subglacial Efficiency and Storage Modified by the Temporal Pattern of High-Elevation Meltwater Input

Ice flow in marginal region of the Greenland Ice Sheet dynamically responds to summer melting as surface meltwater is routed through the supraglacial hydrologic system to the bed of the ice sheet via crevasses and moulins. Given the expected increases in surface melt production and extent, and the potential for high elevation surface-to-bed connections, it is imperative to understand how meltwater delivered to the bed from different high-elevation supraglacial storage features affects the evolution of the subglacial hydrologic system and associated ice dynamics. Here, we use the two-dimensional subglacial hydrologic model, GLaDS, which includes distributed and channelized water flow, to test how the subglacial system of an idealized outlet glacier responds to cases of high-elevation firn-aquifer-type and supraglacial-lake-type englacial drainage over the course of 5 years. Model outputs driven by these high elevation drainage types are compared to steady-state model results, where the subglacial system only receives the 1980- 2016 mean MERRA-2 runoff via low-elevation moulins. Across all experiments, the subglacial hydrologic system displays inter-annual memory, resulting in multiyear declines in subglacial pressure during the onset of seasonal melting and growth of subglacial channels. The gradual addition of water in firn-aquifer-type drainage scenarios resulted in small increases in subglacial water storage but limited changes in subglacial efficiency and channelization. Rapid, supraglacial- lake-type drainage resulted in short-term local increases in subglacial water pressure and storage, which gave way to spatially extensive decreases in subglacial pressure and downstream channelization. These preliminary results suggest that the character of high-elevation englacial drainage can have a strong, and possibly outsized, control on subglacial efficiency throughout the ablation zone. Therefore, understanding both how high elevation meltwater is stored supraglacially and the probability of crevassing at high elevations will play an important role in how the subglacial system, proglacial discharge and ice motion will respond to future increases in surface melt production and runoff

Basal channels drive active surface hydrology and transverse ice shelf fracture

Ice shelves control sea-level rise through frictional resistance, which slows the seaward flow of grounded glacial ice. Evidence from around Antarctica indicates that ice shelves are thinning and weakening, primarily driven by warm ocean water entering into the shelf cavities. We have identified a mechanism for ice shelf destabilization where basal channels underneath the shelves cause ice thinning that drives fracture perpendicular to flow. These channels also result in ice surface deformation, which diverts supraglacial rivers into the transverse fractures. We report direct evidence that a major 2016 calving event at Nansen Ice Shelf in the Ross Sea was the result of fracture driven by such channelized thinning and demonstrate that similar basal channel–driven transverse fractures occur elsewhere in Greenland and Antarctica. In the event of increased basal and surface melt resulting from rising ocean and air temperatures, ice shelves will become increasingly vulnerable to these tandem effects of basal channel destabilization

Seismic evidence for complex sedimentary control of Greenland Ice Sheet flow

The land-terminating margin of the Greenland Ice Sheet has slowed down in recent decades, although the causes and implications for future ice flow are unclear. Explained originally by a self-regulating mechanism where basal slip reduces as drainage evolves from low to high efficiency, recent numerical modeling invokes a sedimentary control of ice sheet flow as an alternative hypothesis. Although both hypotheses can explain the recent slowdown, their respective forecasts of a long-term deceleration versus an acceleration of ice flow are contradictory. We present amplitude-versus-angle seismic data as the first observational test of the alternative hypothesis. We document transient modifications of basal sediment strengths by rapid subglacial drainages of supraglacial lakes, the primary current control on summer ice sheet flow according to our numerical model. Our observations agree with simulations of initial postdrainage sediment weakening and ice flow accelerations, and subsequent sediment restrengthening and ice flow decelerations, and thus confirm the alternative hypothesis. Although simulated melt season acceleration of ice flow due to weakening of subglacial sediments does not currently outweigh winter slowdown forced by self-regulation, they could dominate over the longer term. Subglacial sediments beneath the Greenland Ice Sheet must therefore be mapped and characterized, and a sedimentary control of ice flow must be evaluated against competing self-regulation mechanismspublishersversionPeer reviewe

Getz Ice Shelf melt enhanced by freshwater discharge from beneath the West Antarctic Ice Sheet

Antarctica's Getz Ice Shelf has been rapidly thinning in recent years, producing more meltwater than any other ice shelf in the world. The influx of fresh water is known to substantially influence ocean circulation and biological productivity, but relatively little is known about the factors controlling basal melt rate or how basal melt is spatially distributed beneath the ice shelf. Also unknown is the relative importance of subglacial discharge from the grounded ice sheet in contributing to the export of fresh water from the ice shelf cavity. Here we compare the observed spatial distribution of basal melt rate to a new sub-ice-shelf bathymetry map inferred from airborne gravity surveys and to locations of subglacial discharge from the grounded ice sheet. We find that melt rates are high where bathymetric troughs provide a pathway for warm Circumpolar Deep Water to enter the ice shelf cavity and that melting is enhanced where subglacial discharge fresh water flows across the grounding line. This is the first study to address the relative importance of meltwater production of the Getz Ice Shelf from both ocean and subglacial sources.publishedVersio

Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn2+ transporter

Zinc (Zn2+) is the second most abundant trace element, but is considered a micronutrient, as it is a cofactor for many enzymes and transcription factors. Whereas Zn2+ deficiency can cause cognitive immune or metabolic dysfunction and infertility, excess Zn2+ is nephrotoxic. As for other ions and solutes, Zn2+ is moved into and out of cells by specific membrane transporters: ZnT, Zip, and NRAMP/DMT proteins. ZIP10 is reported to be localized at the apical membrane of renal proximal tubules in rats, where it is believed to play a role in Zn2+ import. Renal regulation of Zn2+ is of particular interest in light of growing evidence that Zn2+ may play a role in kidney stone formation. The objective of this study was to show that ZIP10 homologs transport Zn2+, as well as ZIP10, kidney localization across species. We cloned ZIP10 from dog, human, and Drosophila (CG10006), tested clones for Zn2+ uptake in Xenopus oocytes and localized the protein in renal structures. CG10006, rather than foi (fear-of-intimacy, CG6817) is the primary ZIP10 homolog found in Drosophila Malpighian tubules. The ZIP10 antibody recognizes recombinant dog, human, and Drosophila ZIP10 proteins. Immunohistochemistry reveals that ZIP10 in higher mammals is found not only in the proximal tubule, but also in the collecting duct system. These ZIP10 proteins show Zn2+ transport. Together, these studies reveal ZIP10 kidney localization, a role in renal Zn2+ transport, and indicates that CG10006 is a Drosophila homolog of ZIP10

Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors

Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs). Objective To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients. Design 12-year prospective, observational study. Participants & Setting We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases. Interventions & Outcome AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310). Results Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650). Conclusions Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts