95 research outputs found

    The timing and duration of the Delamerian orogeny: Correlation with the Ross Orogen and implications for Gondwana assembly

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    Copyright © 2006 by the University of Chicago PressThe Antarctic Ross and the Australian Delamerian orogenies are the consequence of stress transfer to the outboard trailing edge of the newly assembled Gondwana supercontinent. This tectonic reorganization occurred in the Early to Middle Cambrian on completion of Pan-African deformation and subduction along the sutures between eastern and western Gondwanan continental fragments. Before this, Neoproterozoic to Early Cambrian rocks in eastern Australia were formed in a passive margin and record dispersion of Rodinia with consequent opening of the proto-Pacific. Our new U-Pb and Rb-Sr geochronology shows that in the South Australian (Adelaide Fold Belt) domain of the Delamerian Orogen, contractional orogenesis commenced at 514 ± 3 Ma and persisted for ∌24 m.yr. until 490 ± 3 Ma, terminated by rapid uplift, cooling, and extension in association with posttectonic magmatism. Integration of new and published U-Pb and 40Ar-39Ar geochronology from the entire Ross-Delamerian belt shows that although both the Delamerian and Ross have a synchronous late magmatic and terminal cooling history, the Ross commenced its convergent orogenic history at ∌540 Ma. This was 25 m.yr. before Delamerian deformation began. During the Early Cambrian, eastern Australia was still in a state of extension (or transtension), with opening of the Kanmantoo Basin and associated anorogenic, largely mafic magmatism. This basin received sediment from the already exposed Ross Orogen to the south. The simultaneous first occurrence of strain fabrics and subduction-related magmatism (including boninite, granite, and andesite lavas) at ∌514 Ma in New Zealand, Victoria, South Australia, New South Wales, and Tasmania implies that the Delamerian Orogeny was driven by ridge-push forces transmitted on the initiation of westward-dipping subduction. Subsequent eastward slab rollback at 490 Ma may have occurred when the new slab had reached the transition zone at 650-km depth, resulting in upper plate extension and anorogenic Basin and Range–style magmatism in South Australia and Tasmania (Mount Read belt). The delayed onset of subduction in the Australian sector of the margin implies that westward motion of the Australian portion of eastern Gondwana continued to be accommodated during the late Early Cambrian by subduction or deformation along either the Mozambique Suture or at the northern end of the South Prince Charles Mountains–Prydz Bay suture.John Foden, Marlina A. Elburg, Jon Dougherty-Page, and Andrew Burt

    Simcluster: clustering enumeration gene expression data on the simplex space

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    Transcript enumeration methods such as SAGE, MPSS, and sequencing-by-synthesis EST "digital northern", are important high-throughput techniques for digital gene expression measurement. As other counting or voting processes, these measurements constitute compositional data exhibiting properties particular to the simplex space where the summation of the components is constrained. These properties are not present on regular Euclidean spaces, on which hybridization-based microarray data is often modeled. Therefore, pattern recognition methods commonly used for microarray data analysis may be non-informative for the data generated by transcript enumeration techniques since they ignore certain fundamental properties of this space.

Here we present a software tool, Simcluster, designed to perform clustering analysis for data on the simplex space. We present Simcluster as a stand-alone command-line C package and as a user-friendly on-line tool. Both versions are available at: http://xerad.systemsbiology.net/simcluster.

Simcluster is designed in accordance with a well-established mathematical framework for compositional data analysis, which provides principled procedures for dealing with the simplex space, and is thus applicable in a number of contexts, including enumeration-based gene expression data

    Exploring Glucose Dysregulation in Migraine: Insights from Continuous Glucose Monitoring

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    Despite being associated with hypoglycemia for nearly a century, a definitive relationship between migraines and glucose dysregulation remains elusive. Accumulating evidence suggests that migraines are in part due to a metabolic mismatch between cerebral demand and available energy. Research analyzing plasma glucose levels and migraine activity may further elucidate this interface between metabolic dysregulation and migraine pathophysiology and may potentially open avenues for therapeutic interventions targeting holistic metabolism for migraine management

    What is behind a summary-evaluation decision?

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    Research in psychology has reported that, among the variety of possibilities for assessment methodologies, summary evaluation offers a particularly adequate context for inferring text comprehension and topic understanding. However, grades obtained in this methodology are hard to quantify objectively. Therefore, we carried out an empirical study to analyze the decisions underlying human summary-grading behavior. The task consisted of expert evaluation of summaries produced in critically relevant contexts of summarization development, and the resulting data were modeled by means of Bayesian networks using an application called Elvira, which allows for graphically observing the predictive power (if any) of the resultant variables. Thus, in this article, we analyzed summary-evaluation decision making in a computational framewor

    Genomic reconstruction of the SARS-CoV-2 epidemic in England.

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    The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021

    Therapeutic targeting of cathepsin C::from pathophysiology to treatment

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    Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl aminopeptidase. The best characterized physiological function of CatC is the activation of pro-inflammatory granule-associated serine proteases. These proteases are synthesized as inactive zymogens containing an N-terminal pro-dipeptide, which maintains the zymogen in its inactive conformation and prevents premature activation, which is potentially toxic to the cell. The activation of serine protease zymogens occurs through cleavage of the N-terminal dipeptide by CatC during cell maturation in the bone marrow. In vivo data suggest that pharmacological inhibition of pro-inflammatory serine proteases would suppress or attenuate deleterious effects of inflammatory/auto-immune disorders mediated by these proteases. The pathological deficiency in CatC is associated with Papillon-LefĂšvre syndrome. The patients however do not present marked immunodeficiency despite the absence of active serine proteases in immune defense cells. Hence, the transitory pharmacological blockade of CatC activity in the precursor cells of the bone marrow may represent an attractive therapeutic strategy to regulate activity of serine proteases in inflammatory and immunologic conditions. A variety of CatC inhibitors have been developed both by pharmaceutical companies and academic investigators, some of which are currently being employed and evaluated in preclinical/clinical trials

    Pb-Pb zircon evaporation date for the Charleston Granite, South Australia: Comparisons with other Zircon Geochronology techniques

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    In order to draw attention to the effectiveness of the single-grain evaporation technique of Pb-Pb zircon dating, this method has been applied to the Charleston Granite, a Mesoproterozoic granitoid from the South Australian Gawler Craton. The granite has previously been dated by both conventional and SHRIMP U-Pb techniques permitting comparison of the relative advantages of all three techniques. The date obtained by the evaporation technique for the crystallisation of the main magmatic phase of zircon was 1581 ± 4 Ma (2σ) which is the same within error as the SHRIMP result of 1585 ± 5 Ma (2σ)

    The Geochemistry and Geochronology of the Rathjen Gneiss: implications for the early tectonic evolution of the Delamerian Orogen.

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    The Rathjen Gneiss is the oldest and structurally most complex of the granitic intrusives in the southern Adelaide Fold-Thrust Belt and therefore provides an important constraint on the timing of the Delamerian Orogen. Zircons in the Rathjen Gneiss show a complex growth history, reflecting inheritance, magmatic crystallisation and metamorphism. Both single zircon evaporation ('Kober' technique) and SHRIMP analysis yield best estimates of igneous crystallisation of 514 ± 5 Ma, substantially older than other known felsic intrusive ages in the southern Adelaide Fold-Thrust Belt. This age places an older limit on the start of the Delamerian metamorphism and is compatible with known stratigraphic constraints suggesting the Early Cambrian Kanmantoo Group was deposited, buried and heated in less than 20 million years. High-U overgrowths on zircons were formed during subsequent metamorphism and yield a ÂČ⁰⁶Pb/ÂČ³⁞U age of 503 ± 7 Ma. The Delamerian Orogeny lasted no more than 35 million years. The emplacement of the Rathjen Gneiss as a pre- or early syntectonic granite is emphasised by its geochemical characteristics, which show affiliations with within-plate or anorogenic granites. In contrast, younger syntectonic granites in the southern Adelaide Fold-Thrust Belt have geochemical characteristics more typical of granites in convergent orogens. The Early Ordovician post-tectonic granites then mark a return to anorogenic compositions. The sensitivity of granite chemistry to changes in tectonic processes is remarkable and clearly reflects changes in the contribution of crust and mantle sources
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