BlogForever D5.1: Design and Specification of Case Studies

This document presents the specification and design of six case studies for testing the BlogForever platform implementation process. The report explains the data collection plan where users of the repository will provide usability feedback through questionnaires as well as details of scalability analysis through the creation of specific log files analytics. The case studies will investigate the sustainability of the platform, that it meets potential users’ needs and that is has an important long term impact

«La Metamorfosis de Narciso» o un reflejo objetivo del método paranoico-crítico de Salvador Dalí.

Sin resume

BlogForever D5.3: User Questionnaires and Reports

This report presents the feedback gathered from third party users during the BlogForever Case Studies. Therefore, the research framework is defined and the case studies results are presented, followed by a summary of conclusions and remarks

BlogForever: D3.1 Preservation Strategy Report

This report describes preservation planning approaches and strategies recommended by the BlogForever project as a core component of a weblog repository design. More specifically, we start by discussing why we would want to preserve weblogs in the first place and what it is exactly that we are trying to preserve. We further present a review of past and present work and highlight why current practices in web archiving do not address the needs of weblog preservation adequately. We make three distinctive contributions in this volume: a) we propose transferable practical workflows for applying a combination of established metadata and repository standards in developing a weblog repository, b) we provide an automated approach to identifying significant properties of weblog content that uses the notion of communities and how this affects previous strategies, c) we propose a sustainability plan that draws upon community knowledge through innovative repository design

BlogForever D5.2: Implementation of Case Studies

This document presents the internal and external testing results for the BlogForever case studies. The evaluation of the BlogForever implementation process is tabulated under the most relevant themes and aspects obtained within the testing processes. The case studies provide relevant feedback for the sustainability of the platform in terms of potential users’ needs and relevant information on the possible long term impact

Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs

peer-reviewedBackground: Carotid body (peripheral oxygen sensor) sensitisation is pivotal in the development of chronic intermittent hypoxia (CIH)-induced hypertension. We sought to determine if exposure to CIH, modelling human sleep apnoea, adversely affects cardiorespiratory control in guinea-pigs, a species with hypoxia-insensitive carotid bodies. We reasoned that CIH-induced disruption of gut microbiota would evoke cardiorespiratory morbidity. Methods: Adult male guinea-pigs were exposed to CIH (6.5% O2 at nadir, 6 cycles.hour−1) for 8 h.day−1 for 12 consecutive days. Findings: CIH-exposed animals established reduced faecal microbiota species richness, with increased relative abundance of Bacteroidetes and reduced relative abundance of Firmicutes bacteria. Urinary corticosterone and noradrenaline levels were unchanged in CIH-exposed animals, but brainstem noradrenaline concentrations were lower compared with sham. Baseline ventilation was equivalent in CIH-exposed and sham animals; however, respiratory timing variability, sigh frequency and ventilation during hypoxic breathing were all lower in CIH-exposed animals. Baseline arterial blood pressure was unaffected by exposure to CIH, but β-adrenoceptor-dependent tachycardia and blunted bradycardia during phenylephrine-induced pressor responses was evident compared with sham controls. Interpretation: Increased carotid body chemo-afferent signalling appears obligatory for the development of CIH-induced hypertension and elevated chemoreflex control of breathing commonly reported in mammals, with hypoxia-sensitive carotid bodies. However, we reveal that exposure to modest CIH alters gut microbiota richness and composition, brainstem neurochemistry, and autonomic control of heart rate, independent of carotid body sensitisation, suggesting modulation of breathing and autonomic homeostasis via the microbiota-gut-brainstem axis. The findings have relevance to human sleep-disordered breathing

Efectos inducidos por la hipoxia crónica intermitente en rata y cobaya como modelos animales de la apnea obstructiva del sueño

Desde un enfoque integrador, que combina estudios funcionales in vivo e in vitro, se ha probado la hipótesis de que el efecto hipertensivo arterial sistémico de la hipoxia crónica intermitente, producido en la enfermedad respiratoria de la apnea obstructiva del sueño, se atenuaría o eliminaría debido a una respuesta quimiorreceptora menor en las ratas viejas y por falta de capacidad de respuesta del cuerpo carotídeo en los cobayas. Los datos muestran que la hipoxia crónica intermitente produce sensibilización del cuerpo carotídeo en la rata vieja sin modificaciones cardiovasculares aparentes. Por el contrario, la hipoxia crónica intermitente en el cobaya modifica parámetros cardiovasculares y metabólicos sin cambios en la funcionalidad del cuerpo carotídeo.Departamento de Bioquímica y Biología Molecular y FisiologíaDoctorado en Investigación Biomédic

Análisis del entorno web, la e-logistic como elemento facilitador del e-commerce = Analysis of the environment, e-logistic as an enabler of e-commerce

A la hora de la puesta en marcha de cualquier organización conviene que ésta preste especial atención tanto al sistema logístico, como a las estrategias de distribución que sean más interesantes para el correcto funcionamiento de la misma. Es por este motivo por lo que, muchas empresas, teniendo en cuenta el contexto situacional en el que se enmarca la sociedad actual, deciden apostar por el comercio electrónico, para abrirse camino en mercados tanto nacionales, como internacionales, lo que les permite no sólo obtener un mayor rendimiento, sino también destacar sobre sus competidores. Por consiguiente, el objetivo del presente Trabajo Fin de Grado consiste, por un lado en la definición del sistema logístico y la posterior segmentación de los distintos tipos de comercio electrónico, desde una perspectiva teórica, y por otro lado, una parte práctica que toma como referencia el desarrollo teórico para analizar de forma exhaustiva las empresas más premiadas en “E-Commerce Awards España 2014”, para finalmente establecer un diagnóstico que nos permita identificar el estado de su logística empresarial