Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains

Journal ArticleDrosophila Enabled (Ena) was initially identified as a dominant genetic suppressor of mutations in the Abelson tyrosine kinase and, more recently, as a member of the Ena/human vasodilator-stimulated phosphoprotein (VASP) family of proteins. We have used genetic, biochemical, and cell biological approaches to demonstrate the functional relationship between Ena and human VASP

EKSPLORASI KONSEP DILATASI ETNOMATEMATIKA PADA BATIK TEMBAKAU JEMBER

Etnomatematika merupakan ragam cara yang berbeda dalam melakukan matematika yang memperhitungkan penggunaan konsep-konsep matematika dalam sistem akademik yang dikembangkan di berbagai lapisan masyarakat dengan tetap memperhatikan tujuan yang berbeda – beda, dimana perbedaan budaya akan menciptakan perbedaan dalam praktek matematikanya (cara berhitung, mengelompokkan, mengukur, merancang bangunan atau alat, bermain dan lainnya). Berdasarkan hal tesebut  penelitian ini bertujuan  mendeskripsikan hasil eksplorasi etnomatematika pada batik tembakau Jember. Metode analisis dalam penelitian ini dengan menggunakan metode kualitatif dengan pendekatan etnografi. Teknik pengumpulan data berupa observasi, dokumentasi dan wawancara. Penelitian ini dilakukan di Rumah Batik Rolla Jember dan Rezti’z Batik Tegalsari Ambulu Jember. Penelitian dilaksanakan selama satu minggu. Hasil dari penelitian ini menunjukkan bahwa Etnomatematika pada batik motif tembakau khas Jember mempunyai konsep matematis berupa konsep dilatasi

A late Pleistocene long pollen record from Lake Urmia, NW Iran

A palynological study based on two 100-m long cores from Lake Urmia in northwestern Iran provides a vegetation record spanning 200 ka, the longest pollen record for the continental interior of the Near East. During both penultimate and last glaciations, a steppe of Artemisia and Poaceae dominated the upland vegetation with a high proportion of Chenopodiaceae in both upland and lowland saline ecosystems. While Juniperus and deciduous Quercus trees were extremely rare and restricted to some refugia, Hippophaë rhamnoides constituted an important phanerophyte, particularly during the upper last glacial sediments. A pronounced expansion in Ephedra shrub-steppe occurred at the end of the penultimate late-glacial period but was followed by extreme aridity that favoured an Artemisia steppe. Very high lake levels, registered by both pollen and sedimentary markers, occurred during the middle of the last glaciation and upper part of the penultimate glaciation. The late-glacial to early Holocene transition is represented by a succession of Hippophaë, Ephedra, Betula, Pistacia and finally Juniperus and Quercus. The last interglacial period (Eemian), slightly warmer and moister than the Holocene, was followed by two interstadial phases similar in pattern to those recorded in the marine isotope record and southern European pollen sequences

PENGARUH MEDIA SOSIAL YOUTUBE TERHADAP PERKEMBANGAN MORAL SISWA KELAS VIII DI MTS NEGERI KALIBARU SEMESTER GENAP TAHUN PELAJARAN 2015 – 2016

Tujuan penelitian ini adalah untuk mengetahui pengaruh Media Sosial Youtube terhadap Perkembangan Moral Siswa Kelas VIII di MTs Negeri Kalibaru Semester Genap Tahun Pelajaran 2015-2016, peneliti menggunakan metode Purposive Sampling Area yaitu teknik penentuan daerah penelitian dengan pertimbangan tertentu (Sugiyono, 2015: 85). Adapun tempat penelitian yang ditentukan peneliti adalah MTs Negeri Kalibaru. Hasil penelitian ini dapat disimpulkan bahwa ada pengaruh positif yang signifikan media sosial youtube terhadap perkembangan moral siswa kelas VIII di MTs Negeri Kalibaru semester genap tahun pelajaran 2015/2016. Hal ini dapat dilihat pada hasil perhitungan angket yaitu dengan bantuan SPSS yang dapat dilihat pengaruh antara media sosial youtube dan perkembangan moral siswa kelas VIII MTs Negeri Kalibaru

New multi-proxy record shows potential impacts of precipitation on the rise and ebb of Bronze Age and imperial Persian societies in southeastern Iran

The Achaemenids and Sasanian ‘Persian’ Empires were significant political, economic, and social forces in the Late Bronze Age and Late Antiquity Eurasia, respectively, which have left marks on the heritage of the Mediterranean and Middle Eastern world. While attention is often focused on military and political conditions when discussing the prosperity and decline of these imperial powers, their realms, which crossed a variety of environmental settings, were highly dependent on the predictability of rainfall that drove agriculture and effective provisioning. Here, we present a multi-proxy sedimentological, geochemical, and palynological record from a 2.5-m long peat deposit near the excavation site in Konar Sandal near Jiroft in southeastern Iran, covering 4000-850 cal yr BP. Around 3950 cal yr BP a wet period prevailed based on elemental ratios, stable C isotope, pollen, and diagnostic lipids. Between 3900 and 3300 cal yr BP, wet/semi-wet conditions developed with the appearance of Cerealia-type pollen. Dry and windy conditions followed (ca. 3300-2900 cal yr BP), which coincided with the Siberian anticyclones and climatic shifts developing in the Eastern Mediterranean region. Consequently, the Bronze Age settlements around Jiroft, dependent on agriculture, underwent a steady decline. A prolonged wet period followed (ca. 2900-2300 cal yr BP) with the abundance of Sparganium-type pollen and the aquatic lipid proxy (Paq). This change coincided with intensive agricultural practices and the flourishing of the powerful Median and Achaemenid empires. The shift to high Ti/Al ratios coeval with the lowest δ13COM values suggests an increase in aeolian activity and dry conditions ca. 2100-1650 cal yr BP. The Jiroft valley again experienced wet conditions between 1550 and 1300 cal yr BP, which overlapped with the economic prosperity of the middle to late Sasanian empire. The paleoenvironmental reconstruction indicates that wet periods and intensive agriculture coincide with the Persian empires' zenith, political influence, and economic affluence. Therefore, contextualized and detailed paleoenvironmental records are desirable to explore the interplay of political and climatic factors in the development and fragmentation of the ancient settlements and imperial powers in Eurasian history.1. Introduction 2. Geographical setting 3. Materials and methods 3.1. Sampling, magnetic susceptibility, and grain size analysis 3.2. Radiocarbon analyses 3.3. Elemental and mineralogical analyses 3.4. C/N and stable isotope analyses 3.4.1. Lipid extraction 3.5. Pollen analysis 4. Results 4.1. Age-depth model and chronology 4.2. Units 4.2.1. Unit 1 (U 1; 250-189 cm; ca. 4000-3550 cal yr BP) 4.2.2. Unit 2 (U 2; 189-164 cm; ca. 3550-3300 cal yr BP) 4.2.3. Unit 3 (U 3; 164-134 cm; ca. 3300-2900 cal yr BP) 4.2.4. Unit 4 (U 4; 134-106 cm; ca. 2900-2300 cal yr BP) 4.2.5. Unit 5 (U 5; 106-61 cm; ca. 2300-1550 cal yr BP) 4.2.6. Unit 6 (U 6; 61-10 cm; ca. 1550-850 cal yr BP) 5. Discussion 5.1. Paleoclimate preceding the decline of the Jiroft civilization 5.2. The Late Bronze Age decline in Jiroft 5.3. Rise and fall of the Persian Empire 5.3.1. The pre-Islamic period and recent times 6. Conclusion

Late Little Ice Age palaeoenvironmental records from the Anzali and Amirkola Lagoons (south Caspian Sea): Vegetation and sea level changes

This is a postprint version of the article. The official published article can be found from the link below - Copyright @ 2011 Elsevier Ltd.Two internationally important Ramsar lagoons on the south coast of the Caspian Sea (CS) have been studied by palynology on short sediment cores for palaeoenvironmental and palaeoclimatic investigations. The sites lie within a small area of very high precipitation in a region that is otherwise dry. Vegetation surveys and geomorphological investigations have been used to provide a background to a multidisciplinary interpretation of the two sequences covering the last four centuries. In the small lagoon of Amirkola, the dense alder forested wetland has been briefly disturbed by fire, followed by the expansion of rice paddies from AD1720 to 1800. On the contrary, the terrestrial vegetation reflecting the diversity of the Hyrcanian vegetation around the lagoon of Anzali remained fairly complacent over time. The dinocyst and non-pollen palynomorph assemblages, revealing changes that have occurred in water salinity and water levels, indicate a high stand during the late Little Ice Age (LIA), from AD < 1620 to 1800–1830. In Amirkola, the lagoon spit remained intact over time, whereas in Anzali it broke into barrier islands during the late LIA, which merged into a spit during the subsequent sea level drop. A high population density and infrastructure prevented renewed breaking up of the spit when sea level reached its maximum (AD1995). Similar to other sites in the region around the southern CS, these two lagoonal investigations indicate that the LIA had a higher sea level as a result of more rainfall in the drainage basin of the CS.The coring and the sedimentological analyses were funded by the Iranian National Institute for Oceanography in the framework of a research project entitled “Investigation of the Holocene sediment along the Iranian coast of Caspian Sea: central Guilan”. The radiocarbon date of core HCGL02 was funded by V. Andrieu (Europôle Méditerranéen de l'Arbois, France) and that of core HCGA04 by Brunel University

Are morphological characteristics of Parrotia (Hamamelidaceae) pollen species diagnostic?

Parrotia persica is one of the most notable endemic relict tree species growing in the Hyrcanian forest at the southern Caspian Sea. The recent discovery of sibling species Parrotia subaequalis, occurring in the temperate for-ests of south-eastern China, offers the opportunity to compare their morphology and ecological preferences and to dig deeper into the paleophytogeographic history of the genus from a perspective. Since pollen morphology of these species would be essential to unravel the origin and evolution of these Arcto-Tertiary species, the present study aimed to investigate whether it is possible to segregate pollen from these two species. Therefore, a detailed combined light-and scanning electron microscopy-based pollen-analysis of each taxon was conducted, the pol-len was described, measured, and compared using statistical approaches and principal component analyses to es-tablish unbiased results. The correlation-based principal component analysis achieved for each species shows an overall good superposition of pollen grains measured in equatorial and polar views in the first principal plane, revealing that the P. persica pollen is morphometrically as homogeneous as that of P. subaequalis. Then, the sig-nificant difference, mainly driven by lumen density, has been highlighted between the two species. Ultimately, the cross-validation of the resulting two-species linear discriminants classifier shows that based upon this refer-ence dataset, (sub)fossil pollen grain can now be confidently assigned to either of the two species with an 85.8% correct-assignment rate. This opens new doors in the affiliation of fossil Parrotia pollen and suggests that previous pollen records need to be revised.(c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).Peer reviewe

Diagnosis and Management of Antibody‐Mediated Rejection: Current Status and Novel Approaches

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102649/1/ajt12589.pd

Human impact on the hydroenvironment of Lake Parishan, SW Iran, through the late Holocene

A multiproxy record from Lake Parishan, SW Iran, shows human impact on the lake and its catchment over the last 4000 years. The Parishan record provides evidence of changes in lake hydrology, from ostracod, diatom and isotope analyses, that are directly linked to human activity in the catchment; recorded by pollen and charcoal and supported by regional archaeological and historical data. The lake ostracod fauna is particularly sensitive to human induced catchment alterations and allow us to identify changes in catchment hydrology that are due to more than a simple change in precipitation: evaporation state. Oxygen isotope data from endogenic carbonates follow these faunal changes but also displays a longer trend to more positive values through the period, coincident with regional patterns of water balance for the late Holocene in the eastern Mediterranean

COVID-19-associated glomerulopathy and high-risk apol1 genotype; basis for a two-hit mechanism of injury? A narrative review on recent findings

Kidney is one of the most common organs affected by coronavirus disease 2019 (COVID-19) after the respiratory and immune systems. Among the renal parenchymal components, the tubulointerstitial compartment is presumed to be the prime target of injury in COVID-19. The main mechanism of renal tubular damage by COVID-19 is considered to be indirect, i.e., cytokine-mediated injury. A proportion of infected individuals mount a strong inflammatory response to the virus by an exaggerated immune response of the body, namely cytokine storm. Sudden and massive release of cytokines may lead to serious systemic hyper-inflammation and renal tubular injury and inflammation resulting in acute renal failure. In addition, a number of cases of glomerulopathies, particularly collapsing glomerulopathy (CG) have been reported, predominantly in people of African ancestry, as a rare form of kidney involvement by SARS-CoV-2 that may originate from the background genetic susceptibility in this population complicated by the second hit of SARS-CoV-2 infection, either directly or indirectly. It is noteworthy that renal injury in COVID-19 could be severe in individuals of African origin due to the aforementioned genetic susceptibility, especially the presence of high-risk apolipoprotein L1 (APOL1) genotypes. Although the exact mechanism of kidney injury by SARS-CoV-2 is as yet unknown, multiple mechanisms are likely involved in renal damage caused by this virus. This review was aimed to summarize the salient points of pathogenesis of kidney injury, particularly glomerular injury in COVID-19 disease in the light of published data. A clear understanding of these is imperative for the proper management of these cases. For this review, a search was made of Google Scholar, Web of Science, Scopus, EBSCO and PubMed for finding English language articles related to COVID-19, kidney injury and glomerulopathy. From the information given in finally selected papers, the key aspects regarding glomerular involvement in COVID-19 were drawn out and are presented in this descriptive review