1,386 research outputs found
Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation
Atherosclerotic cardiovascular disease is the leading cause of death worldwide. Intense research in vascular biology has advanced our knowledge of molecular mechanisms of its onset and progression until complications; however, several aspects of the patho-physiology of atherosclerosis remain to be further elucidated. Endothelial cell homeostasis is fundamental to prevent atherosclerosis as the appearance of endothelial cell dysfunction is considered the first pro-atherosclerotic vascular modification. Physiologically, high density lipoproteins (HDLs) exert protective actions for vessels and in particular for ECs. Indeed, HDLs promote endothelial-dependent vasorelaxation, contribute to the regulation of vascular lipid metabolism, and have immune-modulatory, anti-inflammatory and anti-oxidative properties. Sex- and gender-dependent differences are increasingly recognized as important, although not fully elucidated, factors in cardiovascular health and disease patho-physiology. In this review, we highlight the importance of sex hormones and sex-specific gene expression in the regulation of HDL and EC cross-talk and their contribution to cardiovascular disease
Chemical Abundances in AGN Environment: X-Ray/UV Campaign on the MRK 279 Outflow
We present the first reliable determination of chemical abundances in an AGN
outflow. The abundances are extracted from the deep and simultaneous FUSE and
HST/STIS observations of Mrk 279. This data set is exceptional for its high
signal-to-noise, unblended doublet troughs and little Galactic absorption
contamination. These attributes allow us to solve for the velocity-dependent
covering fraction, and therefore obtain reliable column densities for many
ionic species. For the first time we have enough such column densities to
simultaneously determine the ionization equilibrium and abundances in the flow.
Our analysis uses the full spectral information embedded in these
high-resolution data. Slicing a given trough into many independent outflow
elements yields the extra constraints needed for a physically meaningful
abundances determination. We find that relative to solar the abundances in the
Mrk 279 outflow are (linear scaling): carbon 2.2+/-0.7, nitrogen 3.5+/-1.1 and
oxygen 1.6+/-0.8. Our UV-based photoionization and abundances results are in
good agreement with the independent analysis of the simultaneous Mrk 279 X-ray
spectra. This is the best agreement between the UV and X-ray analyses of the
same outflow to date.Comment: 28 pages, 7 figures, accepted on 29 Nov 2006 for publication in the
ApJ (submission date: 27 Jul 2006
Metabolic reconstitution of germ-free mice by a gnotobiotic microbiota varies over the circadian cycle.
The capacity of the intestinal microbiota to degrade otherwise indigestible diet components is known to greatly improve the recovery of energy from food. This has led to the hypothesis that increased digestive efficiency may underlie the contribution of the microbiota to obesity. OligoMM12-colonized gnotobiotic mice have a consistently higher fat mass than germ-free (GF) or fully colonized counterparts. We therefore investigated their food intake, digestion efficiency, energy expenditure, and respiratory quotient using a novel isolator-housed metabolic cage system, which allows long-term measurements without contamination risk. This demonstrated that microbiota-released calories are perfectly balanced by decreased food intake in fully colonized versus gnotobiotic OligoMM12 and GF mice fed a standard chow diet, i.e., microbiota-released calories can in fact be well integrated into appetite control. We also observed no significant difference in energy expenditure after normalization by lean mass between the different microbiota groups, suggesting that cumulative small differences in energy balance, or altered energy storage, must underlie fat accumulation in OligoMM12 mice. Consistent with altered energy storage, major differences were observed in the type of respiratory substrates used in metabolism over the circadian cycle: In GF mice, the respiratory exchange ratio (RER) was consistently lower than that of fully colonized mice at all times of day, indicative of more reliance on fat and less on glucose metabolism. Intriguingly, the RER of OligoMM12-colonized gnotobiotic mice phenocopied fully colonized mice during the dark (active/eating) phase but phenocopied GF mice during the light (fasting/resting) phase. Further, OligoMM12-colonized mice showed a GF-like drop in liver glycogen storage during the light phase and both liver and plasma metabolomes of OligoMM12 mice clustered closely with GF mice. This implies the existence of microbiota functions that are required to maintain normal host metabolism during the resting/fasting phase of circadian cycle and which are absent in the OligoMM12 consortium
Comments and illustrations of the WFUMB CEUS liver guidelines: Rare benign focal liver lesion, part II.
It is important to be familiar with the typical imaging features of the uncommon or even extremely rare focal liver lesions (FLL). Current guidelines of the World Federation for Ultrasound in Medicine and Biology (WFUMB) is aimed at assessing the usefulness of contrast enhanced ultrasound (CEUS) in the management of various FLL. In this review, we aim to summarize the ultrasound and CEUS characteristics with literature review of some extremely rare benign FLL, which might be helpful for improving diagnostic efficiency clinically
Evidence for Type Ia Supernova Diversity from Ultraviolet Observations with the Hubble Space Telescope
We present ultraviolet (UV) spectroscopy and photometry of four Type Ia supernovae (SNe 2004dt, 2004ef, 2005M, and 2005cf) obtained with the UV prism of the Advanced Camera for Surveys on the Hubble Space Telescope, This dataset provides unique spectral time series down to 2000 A. Significant diversity is seen in the near-maximum-light spectra (approx.2000-3500 A) for this small sample. The corresponding photometric data, together with archival data from Swift Ultraviolet/Optical Telescope observations, provide further evidence of increased dispersion in the UV emission with respect to the optical. The peak luminosities measured in the uvw lIF250W filter are found to correlate with the B-band light-curve shape parameter .(Delta)m15(B), but with much larger scatter relative to the correlation in the broad-band B band (e.g., approx. 0.4 mag versus approx. 0.2 mag for those with 0.8 3(sigma), being brighter than normal SNe Ia such as SN 2005cf by approx. 0,9 mag and approx. 2.0 mag in the uvwl1F250W and uvm2/F220W filters, respectively. We show that different progenitor metallicity or line-expansion velocities alone cannot explain such a large discrepancy. Viewing-angle effects, such as due to an asymmetric explosion, may have a significant influence on the flux emitted in the UV region. Detailed modeling is needed to disentangle and quantify the above effect
Science with the Einstein Telescope: a comparison of different designs
The Einstein Telescope (ET), the European project for a third-generation
gravitational-wave detector, has a reference configuration based on a
triangular shape consisting of three nested detectors with 10 km arms, where in
each arm there is a `xylophone' configuration made of an interferometer tuned
toward high frequencies, and an interferometer tuned toward low frequencies and
working at cryogenic temperature. Here, we examine the scientific perspectives
under possible variations of this reference design. We perform a detailed
evaluation of the science case for a single triangular geometry observatory,
and we compare it with the results obtained for a network of two L-shaped
detectors (either parallel or misaligned) located in Europe, considering
different choices of arm-length for both the triangle and the 2L geometries. We
also study how the science output changes in the absence of the low-frequency
instrument, both for the triangle and the 2L configurations. We examine a broad
class of simple `metrics' that quantify the science output, related to compact
binary coalescences, multi-messenger astronomy and stochastic backgrounds, and
we then examine the impact of different detector designs on a more specific set
of scientific objectives.Comment: 197 pages, 72 figure
Evidence for Type Ia Supernova Diversity from Ultraviolet Observations with the Hubble Space Telescope
We present ultraviolet (UV) spectroscopy and photometry of four Type Ia
supernovae (SNe 2004dt, 2004ef, 2005M, and 2005cf) obtained with the UV prism
of the Advanced Camera for Surveys on the Hubble Space Telescope. This dataset
provides unique spectral time series down to 2000 Angstrom. Significant
diversity is seen in the near maximum-light spectra (~ 2000--3500 Angstrom) for
this small sample. The corresponding photometric data, together with archival
data from Swift Ultraviolet/Optical Telescope observations, provide further
evidence of increased dispersion in the UV emission with respect to the
optical. The peak luminosities measured in uvw1/F250W are found to correlate
with the B-band light-curve shape parameter dm15(B), but with much larger
scatter relative to the correlation in the broad-band B band (e.g., ~0.4 mag
versus ~0.2 mag for those with 0.8 < dm15 < 1.7 mag). SN 2004dt is found as an
outlier of this correlation (at > 3 sigma), being brighter than normal SNe Ia
such as SN 2005cf by ~0.9 mag and ~2.0 mag in the uvw1/F250W and uvm2/F220W
filters, respectively. We show that different progenitor metallicity or
line-expansion velocities alone cannot explain such a large discrepancy.
Viewing-angle effects, such as due to an asymmetric explosion, may have a
significant influence on the flux emitted in the UV region. Detailed modeling
is needed to disentangle and quantify the above effects.Comment: 17 pages, 13 figures, accepted by Ap
All-sky Medium Energy Gamma-ray Observatory: Exploring the Extreme Multimessenger Universe
The All-sky Medium Energy Gamma-ray Observatory (AMEGO) is a probe class
mission concept that will provide essential contributions to multimessenger
astrophysics in the late 2020s and beyond. AMEGO combines high sensitivity in
the 200 keV to 10 GeV energy range with a wide field of view, good spectral
resolution, and polarization sensitivity. Therefore, AMEGO is key in the study
of multimessenger astrophysical objects that have unique signatures in the
gamma-ray regime, such as neutron star mergers, supernovae, and flaring active
galactic nuclei. The order-of-magnitude improvement compared to previous MeV
missions also enables discoveries of a wide range of phenomena whose energy
output peaks in the relatively unexplored medium-energy gamma-ray band
Identification of heavy-flavour jets with the CMS detector in pp collisions at 13 TeV
Many measurements and searches for physics beyond the standard model at the LHC rely on the efficient identification of heavy-flavour jets, i.e. jets originating from bottom or charm quarks. In this paper, the discriminating variables and the algorithms used for heavy-flavour jet identification during the first years of operation of the CMS experiment in proton-proton collisions at a centre-of-mass energy of 13 TeV, are presented. Heavy-flavour jet identification algorithms have been improved compared to those used previously at centre-of-mass energies of 7 and 8 TeV. For jets with transverse momenta in the range expected in simulated events, these new developments result in an efficiency of 68% for the correct identification of a b jet for a probability of 1% of misidentifying a light-flavour jet. The improvement in relative efficiency at this misidentification probability is about 15%, compared to previous CMS algorithms. In addition, for the first time algorithms have been developed to identify jets containing two b hadrons in Lorentz-boosted event topologies, as well as to tag c jets. The large data sample recorded in 2016 at a centre-of-mass energy of 13 TeV has also allowed the development of new methods to measure the efficiency and misidentification probability of heavy-flavour jet identification algorithms. The heavy-flavour jet identification efficiency is measured with a precision of a few per cent at moderate jet transverse momenta (between 30 and 300 GeV) and about 5% at the highest jet transverse momenta (between 500 and 1000 GeV)
- âŠ