8 research outputs found
The C-type lectin receptor SIGNR3 binds to fungi present in commensal microbiota and influences immune regulation in experimental colitis
Inflammatory bowel disease is a condition of acute and chronic inflammation of
the gut. An important factor contributing to pathogenesis is a dysregulated
mucosal immunity against commensal bacteria and fungi. Host pattern-
recognition receptors (PRRs) sense commensals in the gut and are involved in
maintaining the balance between controlled responses to pathogens and
overwhelming innate immune activation. C-type lectin receptors (CLRs) are PRRs
recognizing glycan structures on pathogens and self-antigens. Here we examined
the role of the murine CLR specific intracellular adhesion molecule-3 grabbing
non-integrin homolog-related 3 (SIGNR3) in the recognition of commensals and
its involvement in intestinal immunity. SIGNR3 is the closest murine homolog
of the human dendritic cell-specific intercellular adhesion
molecule-3-grabbing non-integrin (DC-SIGN) receptor recognizing similar
carbohydrate ligands such as terminal fucose or high-mannose glycans. We
discovered that SIGNR3 recognizes fungi present in the commensal microbiota.
To analyze whether this interaction impacts the intestinal immunity against
microbiota, the dextran sulfate sodium-induced colitis model was employed.
SIGNR3(-/-) mice exhibited an increased weight loss associated with more
severe colitis symptoms compared to wild-type control mice. The increased
inflammation in SIGNR3(-/-) mice was accompanied by a higher level of TNF-α in
colon. Our findings demonstrate for the first time that SIGNR3 recognizes
intestinal fungi and has an immune regulatory role in colitis
Car-2-Car Communication Consortium - Manifesto
This document summarizes and describes the main building blocks of the Car2X Communication System as it is pursued by the Car2Car Communication Consortium (C2C-CC). “Car2X” means interactions among cars, between cars and infrastructures, and viceversa. It provides interested readers with an introduction to Car2X communications. It is intended to be a living document which will be complemented according to the progress of the work of the C2C-CC. One main objective of this document is to give insight into ongoing and upcoming activities, such as public funded projects which target to contribute to the C2C-CC specifications, an overview on ongoing work and results achieved so far. In addition, this document provides concepts and technologies that have been developed or identified by the C2C-CC and assessed as necessary building blocks to be proposed for a standard