Conicoid Mirrors

The first order equation relating object and image location for a mirror of arbitrary conic-sectional shape is derived. It is also shown that the parabolic reflecting surface is the only one free of aberration and only in the limiting case of distant sources.Comment: 9 page

Measures of fine tuning

Fine-tuning criteria are frequently used to place upper limits on the masses of superpartners in supersymmetric extensions of the standard model. However, commonly used prescriptions for quantifying naturalness have some important shortcomings. Motivated by this, we propose new criteria for quantifying fine tuning that can be used to place upper limits on superpartner masses with greater fidelity. In addition, our analysis attempts to make explicit the assumptions implicit in quantifications of naturalness. We apply our criteria to the minimal supersymmetric extension of the standard model, and we find that the scale of supersymmetry breaking can be larger than previous methods indicate.Comment: 15 pages, LaTex, 5 figures uuencoded, gz-compressed file. Minor revisions bring the archived manuscript into agreement with published versio

Discrete symmetries and isosinglet quarks in low-energy supersymmetry

Many extensions of the minimal supersymmetric standard model contain superfields for quarks which are singlets under weak isospin with electric charge -1/3. We explore the possibility that such isosinglet quarks have low or intermediate scale masses, but do not mediate rapid proton decay because of a discrete symmetry. By imposing the discrete gauge anomaly cancellation conditions, we show that the simplest way to achieve this is to extend the Z_3 "baryon parity" of Ibanez and Ross to the isosinglet quark superfields. This can be done in three distinct ways. This strategy is not consistent with grand unification with a simple gauge group, but may find a natural place in superstring-inspired models, for example. An interesting feature of this scenario is that proton decay is absolutely forbidden.Comment: 13 pages, MIT-CTP-2345, NUB-3097-94T

Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis

OBJECTIVES: We used a screening strategy of global serum microRNA (miRNA) profiling, followed by a second stage of independent replication and exploration of liver expression of selected miRNAs to study: (1) the circulating miRNA signature associated with non-alcoholic fatty liver disease (NAFLD) progression and predictive power, (2) the role of miRNAs in disease biology and (3) the association between circulating miRNAs and features of the metabolic syndrome. METHODS: The study used a case-control design and included patients with NAFLD proven through biopsy and healthy controls. RESULTS: Among 84 circulating miRNAs analysed, miR-122, miR-192, miR-19a and miR-19b, miR-125b, and miR-375 were upregulated >2-fold (p<0.05) either in simple steatosis (SS) or non-alcoholic steatohepatitis (NASH). The most dramatic and significant fold changes were observed in the serum levels of miR-122 (7.2-fold change in NASH vs controls and 3.1-fold change in NASH vs SS) and miR-192 (4.4-fold change in NASH vs controls); these results were replicated in the validation set. The majority of serum miR-122 circulate in argonaute2-free forms. Circulating miR-19a/b and miR-125b were correlated with biomarkers of atherosclerosis. Liver miR-122 expression was 10-fold (p<0.03) downregulated in NASH compared with SS and was preferentially expressed at the edge of lipid-laden hepatocytes. In vitro exploration showed that overexpression of miR-122 enhances alanine aminotransferase activity. CONCLUSIONS: miR-122 plays a role of physiological significance in the biology of NAFLD; circulating miRNAs mirror the histological and molecular events occurring in the liver. NAFLD has a distinguishing circulating miRNA profile associated with a global dysmetabolic disease state and cardiovascular risk.Fil: Pirola, Carlos Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Fernandez Gianotti, Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Castaño, Gustavo Osvaldo. Gobierno de la Ciudad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mallardi, Pablo. Hospital Diego Thompson; ArgentinaFil: San Martino, Julio. Hospital Diego Thompson; ArgentinaFil: González López Ledesma, María Mora. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Flichman, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; ArgentinaFil: Mirshahi, Faridodin. Virginia Commonwealth University; Estados UnidosFil: Sanyal, Arun J.. Virginia Commonwealth University; ArgentinaFil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentin

eIMRT: a web platform for the verification and optimization of radiation treatment plans

The eIMRT platform is a remote distributed computing tool that provides users with Internet access to three different services: Monte Carlo optimization of treatment plans, CRT & IMRT treatment optimization, and a database of relevant radiation treatments/clinical cases. These services are accessible through a user-friendly and platform independent web page. Its flexible and scalable design focuses on providing the final users with services rather than a collection of software pieces. All input and output data (CT, contours, treatment plans and dose distributions) are handled using the DICOM format. The design, implementation, and support of the verification and optimization algorithms are hidden to the user. This allows a unified, robust handling of the software and hardware that enables these computation-intensive services. The eIMRT platform is currently hosted by the Galician Supercomputing Center (CESGA) and may be accessible upon request (there is a demo version at http://eimrt.cesga.es:8080/ eIMRT2/demo; request access in http://eimrt.cesga.es/signup.html). This paper describes all aspects of the eIMRT algorithms in depth, its user interface, and its services. Due to the flexible design of the platform, it has numerous applications including the intercenter comparison of treatment planning, the quality assurance of radiation treatments, the design and implementation of new approaches to certain types of treatments, and the sharing of information on radiation treatment techniques. In addition, the web platform and software tools developed for treatment verification and optimization have a modular design that allows the user to extend them with new algorithms. This software is not a commercial product. It is the result of the collaborative effort of different public research institutions and is planned to be distributed as an open source project. In this way, it will be available to any user; new releases will be generated with the new implemented codes or upgradesThis work was financed by Xunta de Galicia of Spain through grant PGIDT05SIN00101CT and by the European Community through the BeInGrid projectS

b→sγb\to s\gamma Constraints on the Minimal Supergravity Model with Large tan⁡β\tan\beta

In the minimal supergravity model (mSUGRA), as the parameter $\tan\beta$ increases, the charged Higgs boson and light bottom squark masses decrease, which can potentially increase contributions from $tH^\pm$, \tg\tb_j and \tz_i\tb_j loops in the decay $b\to s\gamma$. We update a previous QCD improved $b\to s\gamma$ decay calculation to include in addition the effects of gluino and neutralino loops. We find that in the mSUGRA model, loops involving charginos also increase, and dominate over $tW$, $tH^\pm$, \tg\tq and \tz_i\tq contributions for \tan\beta\agt 5-10. We find for large values of $\tan\beta \sim 35$ that most of the parameter space of the mSUGRA model for $\mu <0$ is ruled out due to too large a value of branching ratio $B(b\to s\gamma)$. For $\mu >0$ and large $\tan\beta$, most of parameter space is allowed, although the regions with the least fine-tuning (low $m_0$ and $m_{1/2}$) are ruled out due to too low a value of $B(b\to s\gamma)$. We compare the constraints from $b\to s\gamma$ to constraints from the neutralino relic density, and to expectations for sparticle discovery at LEP2 and the Fermilab Tevatron $p\bar p$ colliders. Finally, we show that non-universal GUT scale soft breaking squark mass terms can enhance gluino loop contributions to $b\to s\gamma$ decay rate even if these are diagonal.Comment: 14 page REVTEX file plus 6 PS figure

Naturalness Lowers the Upper Bound on the Lightest Higgs Boson Mass in Supersymmetry

We quantify the extent to which naturalness is lost as experimental lower bounds on the Higgs boson mass increase, and we compute the natural upper bound on the lightest supersymmetric Higgs boson mass. We find that it would be unnatural for the mass of the lightest supersymmetric Higgs boson to saturate it's maximal upper bound. In the absence of significant fine-tuning, the lightest Higgs boson mass should lie below $120$ GeV, and in the most natural cases it should be lighter than $108$ GeV. For modest $tan \beta$, these bounds are significantly lower. Our results imply that a failure to observe a light Higgs boson in pre-LHC experiments could provide a serious challenge to the principal motivation for weak-scale supersymmetry.Comment: 11 pages, LaTex, 3 ps.figure

An 8-mm diameter fibre robot positioner for massive spectroscopy surveys

This article has been accepted for publication in Monthly Notices of Royal Astronomical Society © 2015 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reservedMassive spectroscopic survey are becoming trendy in astrophysics and cosmology, as they can address new fundamental knowledge such as understanding the formation of the Milky Way and probing the nature of the mysterious dark energy. To enable massive spectroscopic surveys, new technology has been developed to place thousands of optical fibres at a given position on a focal plane. This technology needs to be: (1) accurate, with micrometer positional accuracy; (2) fast to minimize overhead; (3) robust to minimize failure; and (4) low cost. In this paper, we present the development, properties, and performance of a new single 8-mm in diameter fibre positioner robot, using two 4-mm DC-brushless gearmotors, that allows us to achieve accuracies up to 0.07 arcsec (5 μm). This device has been developed in the context of the Dark Energy Spectroscopic InstrumentWe acknowledge support from the Spanish MICINNs Consolider-Ingenio 2010 Program me under grant MultiDark CSD2009-00064, HEPHACOS S2009/ESP-1473, and MINECO Centro de Excelencia Severo Ochoa Programme under grant SEV-2012-0249. We also thank the support from a CSIC-AVS contract through MICINN grant AYA2010-21231-C02- 01, and CDTI grant IDC-20101033; and support from the Spanish MINECO research grants AYA2012-31101 and FPA2012-34694. JPK, PH and LM acknowledge support from the ERC advanced grant LIDA and from an SNF Interdisciplinary grant

Naturalness and superpartner masses or when to give up on weak scale supersymmetry

Superpartner masses cannot be arbitrarily heavy if supersymmetric extensions of the standard model explain the stability of the gauge hierarchy. This ancient and hallowed motivation for weak scale supersymmetry is often quoted, yet no reliable determination of this upper limit on superpartner masses exists. In this paper we compute upper bounds on superpartner masses in the minimal supersymmetric model, and we identify which values of the superpartner masses correspond to the most natural explanation of the hierarchy stability. We compare the most natural value of these masses and their upper limits to the physics reach of current and future colliders. As a result, we find that supersymmetry could explain weak scale stability naturally even if no superpartners are discovered at LEP II or the Tevatron (even with the Main Injector upgrade). However, we find that supersymmetry cannot provide a complete explanation of weak scale stability, if squarks and gluinos have masses beyond the physics reach of the LHC. Moreover, in the most natural scenarios, many sparticles, for example, charginos, squarks, and gluinos, lie within the physics reach of either LEP II or the Tevatron. Our analysis determines the most natural value of the chargino (squark) ((gluino)) mass consistent with current experimental constraints is $\sim$ 50 (250) ((250)) GeV and the corresponding theoretical upper bound is $\sim$ 250 (700) ((800)) GeV.Comment: 14 pages, LaTex, 17 figures uuencoded, gz-compressed file. Minor revisions bring archived manuscript in line with the published versio