Leeds Edible Schools Sustainability Network

There is a growing interest in both urban agriculture and the issue of sustainability, as framed in terms of climate change, landscape, economic uncertainty and resource shortages, while issues around child health and wellbeing are increasingly causing concern. Education, especially in terms of sustainability teaching and the production of food by schools on school premises is key. The Leeds Edible Schools Sustainability Network is, at this date, an un-constituted, informal group of organisations and academics, all based or active within the Leeds district, who share core values around the wellbeing and sustainability agenda and who are all, in various ways, involved in supporting educational establishments and related organisations in the growing (often on school premises) and consumption of local food, the promotion of resilient and healthy practices, including outdoor work and teaching about healthy school food, and the development of effective education around the topic of sustainability

Virtual Site as an aid to first-year learning

Courses run by the School of the Built Environment have a range of entry requirements that enable diverse students and those with lower academic qualifications to gain entry. This results in a particular challenge for the Documentation & Estimating module, which is a very practical, skillsand competence-based module. It is delivered to large tutorial cohorts of mixed courses, abilities, ages and experience. Many students need one-toone guidance to understand what, practically, they have to do. They are given the theory first in a lecture and then have practical tutorials to carry out assessed exercises with limited tutor contact time. The module includes some basic surveying techniques and a levelling exercise which involves the transfer of a level from an assumed benchmark to establish a temporary benchmark some distance away. Many students have problems with computation of results. In spite of a careful introduction and explanation of the use of the instruments and techniques, many students find it difficult to visualise what is happening

Releasing an Educational Android App

This paper explores the process and challenges of creating an educational app for android devices. The Heat Loss Calculator app was initially conceived to allow researchers to quickly calculate building heat loss by entering the U-values of different building element fabrics. Selecting lower U-values equates to the various insulation improvements which can potentially reduce heat loss and improve energy efficiency. During early development it became clear that the app would also be a useful learning tool for students. Therefore, it was designed with this wider audience in mind, with the intention of publishing it in the public domain. Issues encountered during development and some that became apparent after release on the Google Play Store will be discussed. The user experience will be evaluated by means of an online survey of students and by using the app in a group session in the classroom. The feedback will be examined to inform how the app can be improved

Genetic Architecture of Gene Expression Traits Across Diverse Populations

For many complex traits, gene regulation is likely to play a crucial mechanistic role. How the genetic architectures of complex traits vary between populations and subsequent effects on genetic prediction are not well understood, in part due to the historical paucity of GWAS in populations of non-European ancestry. We used data from the MESA (Multi-Ethnic Study of Atherosclerosis) cohort to characterize the genetic architecture of gene expression within and between diverse populations. Genotype and monocyte gene expression were available in individuals with African American (AFA, n = 233), Hispanic (HIS, n = 352), and European (CAU, n = 578) ancestry. We performed expression quantitative trait loci (eQTL) mapping in each population and show genetic correlation of gene expression depends on shared ancestry proportions. Using elastic net modeling with cross validation to optimize genotypic predictors of gene expression in each population, we show the genetic architecture of gene expression for most predictable genes is sparse. We found the best predicted gene in each population, TACSTD2 in AFA and CHURC1 in CAU and HIS, had similar prediction performance across populations with R2 \u3e 0.8 in each population. However, we identified a subset of genes that are well-predicted in one population, but poorly predicted in another. We show these differences in predictive performance are due to allele frequency differences between populations. Using genotype weights trained in MESA to predict gene expression in independent populations showed that a training set with ancestry similar to the test set is better at predicting gene expression in test populations, demonstrating an urgent need for diverse population sampling in genomics. Our predictive models and performance statistics in diverse cohorts are made publicly available for use in transcriptome mapping methods at https://github.com/WheelerLab/DivPop

Cosmic Star Formation: Constraints on the Galaxy Formation Models

We study the evolution of the cosmic star formation by computing the luminosity density (LD) in the UV, B, J, and K bands, and the stellar mass density (MD) of galaxies in two reference models of galaxy evolution: the pure luminosity evolution (PLE) model developed by Calura & Matteucci (2003) and the semi-analytical model (SAM) of hierarchical galaxy formation by Menci et al. (2002). The former includes a detailed description of the chemical evolution of galaxies of different morphological types with no density evolution; the latter includes the merging histories of the galactic DM haloes, as predicted by the hierarchical clustering scenario, but it does not contain morphological classification nor chemical evolution. We find that at z< 1.5 both models are consistent with the available data on the LD of galaxies in all the considered bands. At high z, the LDs predicted in the PLE model show a peak due to the formation of ellipticals, whereas the SAM predicts a gradual decrease of the star formation and of the LD for z> 2.5. At such redshifts the PLE predictions tend to overestimate the present data in the B band whereas the SAM tends to underestimate the observed UV LD. As for the stellar MD, the PLE picture predicts that nearly 50% and 85% of the present stellar mass are in place at z=4 and z=1, respectively. According to the SAM, 50% and 60% of the present stellar mass are in place at z=1.2 and z=1, respectively. Both predictions fit the observed MD up to z=1. At z>1, the PLE model and the SAM tend to overestimate and underestimate the observed values, respectively. We discuss the origin of the above model results, and the role of observational uncertainties (such as dust extinction) in comparing models with observations.Comment: 14 pages, accepted for publication in MNRA

Immobile indices and CQ-free optimality criteria for linear copositive programming problems

We consider problems of linear copositive programming where feasible sets consist of vectors for which the quadratic forms induced by the corresponding linear matrix combinations are nonnegative over the nonnegative orthant. Given a linear copositive problem, we define immobile indices of its constraints and a normalized immobile index set. We prove that the normalized immobile index set is either empty or can be represented as a union of a finite number of convex closed bounded polyhedra. We show that the study of the structure of this set and the connected properties of the feasible set permits to obtain new optimality criteria for copositive problems. These criteria do not require the fulfillment of any additional conditions (constraint qualifications or other). An illustrative example shows that the optimality conditions formulated in the paper permit to detect the optimality of feasible solutions for which the known sufficient optimality conditions are not able to do this. We apply the approach based on the notion of immobile indices to obtain new formulations of regularized primal and dual problems which are explicit and guarantee strong duality.publishe

The Rise of Massive Red Galaxies: the color-magnitude and color-stellar mass diagrams for z < ~2 from the MUltiwavelength Survey by Yale-Chile (MUSYC)

We present the color-magnitude and color-stellar mass diagrams for galaxies with z_phot < ~2, based on a K < 22 (AB) catalog of the Extended Chandra Deep Field South (ECDFS) from the MUltiwavelength Survey by Yale-Chile (MUSYC). Our main sample of 7840 galaxies contains 1297 M_* > 10^11 M_Sol galaxies in the range 0.2 < z_phot < 1.8. We show empirically that this catalog is approximately complete for M_* > 10^11 M_Sol galaxies for z_phot < 1.8. For this mass-limited sample, we show that the locus of the red sequence color-stellar mass relation evolves as Del(u-r) ~ (-0.44+/-0.02) z_phot for z_phot ~1.3, however, we are no longer able to reliably distinguish red and blue subpopulations from the observed color distribution; we show that this would require much deeper near infrared data. At 1.5 < z_phot 10^11 M_Sol galaxies is ~50% of the local value, with a red fraction of ~33%. Making a parametric fit to the observed evolution, we find n_tot(z) ~ (1+z_phot)^(-0.52+/-0.12(+/-0.20)). We find stronger evolution in the red fraction: f_red(z) ~ (1+z_phot)^(-1.17+/-0.18(+/-0.21)). Through a series of sensitivity analyses, we show that the most important sources of systematic error are: 1. systematic differences in the analysis of the z~0 and z>>0 samples; 2. systematic effects associated with details of the photometric redshift calculation; and 3. uncertainties in the photometric calibration. With this in mind, we show that our results based on photometric redshifts are consistent with a completely independent analysis which does not require redshift information for individual galaxies. Our results suggest that, at most, 1/5 of local red sequence galaxies with M_* >10^11 M_Sol were already in place at z ~ 2.Comment: Accepted for publication in ApJ. 31 pages in emulateapj format; 18 figues (14 in main text). Additional online data available through http://www.strw.leidenuniv.nl/~ent

Nonradioactive heteroduplex tracking assay for the detection of minority-variant chloroquine-resistant Plasmodium falciparum in Madagascar

<p>Abstract</p> <p>Background</p> <p>Strains of <it>Plasmodium falciparum </it>genetically resistant to chloroquine (CQ) due to the presence of <it>pfcrt </it>76T appear to have been recently introduced to the island of Madagascar. The prevalence of such resistant genotypes is reported to be low (< 3%) when evaluated by conventional PCR. However, these methods are insensitive to low levels of mutant parasites present in patients with polyclonal infections. Thus, the current estimates may be an under representation of the prevalence of the CQ-resistant <it>P. falciparum </it>isolates on the island. Previously, minority variant chloroquine resistant parasites were described in Malawian patients using an isotopic heteroduplex tracking assay (HTA), which can detect <it>pfcrt </it>76T-bearing <it>P. falciparum </it>minority variants in individual patients that were undetectable by conventional PCR. However, as this assay required a radiolabeled probe, it could not be used in many resource-limited settings.</p> <p>Methods</p> <p>This study describes a digoxigenin (DIG)-labeled chemiluminescent heteroduplex tracking assay (DIG-HTA) to detect <it>pfcrt </it>76T-bearing minority variant <it>P. falciparum</it>. This assay was compared to restriction fragment length polymorphism (RFLP) analysis and to the isotopic HTA for detection of genetically CQ-resistant parasites in clinical samples.</p> <p>Results</p> <p>Thirty one clinical <it>P. falciparum </it>isolates (15 primary isolates and 16 recurrent isolates) from 17 Malagasy children treated with CQ for uncomplicated malaria were genotyped for the <it>pfcrt </it>K76T mutation. Two (11.7%) of 17 patients harboured genetically CQ-resistant <it>P. falciparum </it>strains after therapy as detected by HTA. RFLP analysis failed to detect any <it>pfcrt </it>K76T-bearing isolates.</p> <p>Conclusion</p> <p>These findings indicate that genetically CQ-resistant <it>P. falciparum </it>are more common than previously thought in Madagascar even though the fitness of the minority variant <it>pfcrt </it>76T parasites remains unclear. In addition, HTAs for malaria drug resistance alleles are promising tools for the surveillance of anti-malarial resistance. The use of a non-radioactive label allows for the use of HTAs in malaria endemic countries.</p

Gene expression and matrix turnover in overused and damaged tendons

Chronic, painful conditions affecting tendons, frequently known as tendinopathy, are very common types of sporting injury. The tendon extracellular matrix is substantially altered in tendinopathy, and these changes are thought to precede and underlie the clinical condition. The tendon cell response to repeated minor injuries or “overuse” is thought to be a major factor in the development of tendinopathy. Changes in matrix turnover may also be effected by the cellular response to physical load, altering the balance of matrix turnover and changing the structure and composition of the tendon. Matrix turnover is relatively high in tendons exposed to high mechanical demands, such as the supraspinatus and Achilles, and this is thought to represent either a repair or tissue maintenance function. Metalloproteinases are a large family of enzymes capable of degrading all of the tendon matrix components, and these are thought to play a major role in the degradation of matrix during development, adaptation and repair. It is proposed that some metalloproteinase enzymes are required for the health of the tendon, and others may be damaging, leading to degeneration of the tissue. Further research is required to investigate how these enzyme activities are regulated in tendon and altered in tendinopathy. A profile of all the metalloproteinases expressed and active in healthy and degenerate tendon is required and may lead to the development of new drug therapies for these common and debilitating sports injuries