600 research outputs found
Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity
- Author
- Agostinho Carvalho
- Arjan van Laarhoven
- Boris Novakovic
- Caspi
- Charles A. Dinarello
- Chen
- Cheng
- Cheng
- Clary Clish
- Colin Logie
- Cristina Cunha
- David L. Williams
- Donohoe
- Ehsan Habibi
- Ekta Lachmandas
- Fernando Rodrigues
- Frank L. van de Veerdonk
- Fu
- Hendrik G. Stunnenberg
- Hirschey
- Inês Mesquita
- Jiang
- Jos W.M. van der Meer
- Ke
- Keating
- King
- Kleinnijenhuis
- Koivunen
- Kurtz
- Leo A.B. Joosten
- Li
- Lu
- Luke A. O'Neill
- Luís G. Gonçalves
- Mihai G. Netea
- Mills
- Muthamilarasan
- Netea
- Netea
- Niels P. Riksen
- O’Sullivan
- Pearce
- Quintin
- Ramnik J. Xavier
- Reinout van Crevel
- Repnik
- Ricardo Silvestre
- Richard A. Notebaart
- Rob J.W. Arts
- Rob ter Horst
- Robey
- Roth
- Saeed
- Schreiber
- Secombe
- Serra-Pérez
- Shah
- Shih-Chin Cheng
- Shuang-Yin Wang
- Sikalidis
- Singh
- Singhal
- Siroon Bekkering
- Sun
- Tan
- Tannahill
- Van den Bossche
- Xia
- Xiao
- Yang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and the cholesterol synthesis pathway as indispensable for the induction of trained immunity by ß-glucan in monocytes. Accumulation of fumarate, due to glutamine replenishment of the TCA cycle, integrates immune and metabolic circuits to induce monocyte epigenetic reprogramming by inhibiting KDM5 histone demethylases. Furthermore, fumarate itself induced an epigenetic program similar to ß-glucan-induced trained immunity. In line with this, inhibition of glutaminolysis and cholesterol synthesis in mice reduced the induction of trained immunity by ß-glucan. Identification of the metabolic pathways leading to induction of trained immunity contributes to our understanding of innate immune memory and opens new therapeutic avenues.Netherlands Organization for Scientific Research (NWO). B.N. is supported by an NHMRC (Australia) CJ Martin Early Career Fellowship. N.P.R. Netherlands Heart Foundation (2012T051). N.P.R. and M.G.N. received a H2020 grant (H2020-PHC-2015-667873-2) from the European Union (grant agreement 667837). Fundação para a Ciência e Tecnologia, FCT (IF/00735/2014 to A.C., IF/00021/2014 to R.S., RECI/BBB-BQB/0230/2012 to L.G.G., and SFRH/BPD/96176/2013 to C. Cunha). The NMR spectrometers are part of the National NMR Facility supported by FCT (RECI/BBB-BQB/0230/2012). The research leading to these results received funding from the Fundação para a Ciência e Tecnologia (FCT), cofunded by Programa Operacional Regional do Norte (ON.2—O Novo Norte); from the Quadro de Referência Estratégico Nacional (QREN) through the Fundo Europeu de Desenvolvimento Regional (FEDER) and from the Projeto Estratégico – LA 26 – 2013–2014 (PEst-C/SAU/LA0026/2013). NIH (DK43351 and DK097485) and Helmsley Trust. D.L.W. is supported, in part, by the NIH (GM53522, GM083016, GM119197, and C06RR0306551
Four top quark production searches and cross section measurements at the LHC
- Author
- Publication venue
- Publication date
- 16/11/2023
- Field of study
Four top quark production is a rare standard model that has been observed for the first time in proton-proton collisions at s=13\,TeV at the CERN LHC by both the ATLAS and CMS Collaborations. Both observations were made in the same-sign dilepton and multilepton final states of the process and are presented in this contribution. In addition, another measurement of four top production by the CMS Collaboration using the all hadronic, one lepton and opposite-sign dilepton final states is presented. This is the first result to take a direct look at the all hadronic final state.Four top quark production is a rare standard model process that has been observed for the first time in proton-proton collisions at \sqrts at the CERN LHC by both the ATLAS and CMS Collaborations. Both observations were made in the same-sign dilepton and multilepton final states of the process and are presented in this contribution. In addition, another measurement of four top production by the CMS Collaboration using the all hadronic, one lepton and opposite-sign dilepton final states is presented. This is the first result to take a direct look at the all hadronic final state
Aberglauben, Krankheit und das Böse. Exorzismus und Teufelsglaube im 18. und 19. Jahrhundert
- Publication venue
- Publication date
- 01/01/1999
- Field of study
peer reviewe
Prevalence and associated risk factors of HIV infections in a representative transgender and non-binary population in Flanders and Brussels (Belgium) : protocol for a community-based, cross-sectional study using time-location sampling
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2022
- Field of study
IntroductionHIV prevalence and sexual risk have been estimated very high for transgender people. However, the limited sampling and data collection methods used in current research on transgender people potentially led to overrepresentation and generalisation of people at risk for HIV. Current HIV prevalence estimates in transgender populations are generalised from studies mainly focusing on transgender women engaging in sex work. Moreover, studies focusing on non-binary people, who identify with a broad range of identities beyond the traditional male and female gender identities, are scarce. ObjectivesTo estimate the HIV prevalence rate in the Flemish and Brussels (Belgium) transgender population, including transgender women, transgender men and non-binary people, and to identify the associated risk factors. MethodsIn this community-based cross-sectional study, self-identified transgender and non-binary (TGNB) people will be recruited through a two-stage time-location sampling approach. First, community settings in which TGNB people gather will be mapped to develop an accurate sampling frame. Secondly, a multistage sampling design is applied involving a stratification based on setting type (healthcare facilities vs outreach events), a selection of clusters by systematic sampling and a simple random selection of TGNB people within each cluster. Participants will complete an electronic self-reported survey to measure sociological, sexual and drug-using behaviors (risk factors) and oral fluid aliquots will be collected and tested for HIV antibodies. Logistic regression models will be used to evaluate risk factors independently associated with HIV infection. The presented study is registered at ClinicalTrials.gov (NCT04930614). DiscussionThis study will be the first to investigate the HIV prevalence rates and associated risk behaviors in an accurate representation of the TGNB population in a Western European country. The findings will globally serve as a knowledge base for identifying subgroups at risk for becoming infected with HIV within TGNB people and to set up targeted prevention programs.
Discussion
This study will be the first to investigate the HIV prevalence rates and associated risk behaviors in an accurate representation of the TGNB population in a Western European country. The findings will globally serve as a knowledge base for identifying subgroups at risk for becoming infected with HIV within TGNB people and to set up targeted prevention programs
Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans
- Author
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2016
- Field of study
Elevated lipoprotein(a) [Lp(a)] is a prevalent, independent cardiovascular risk factor, but the underlying mechanisms responsible for its pathogenicity are poorly defined. Because Lp(a) is the prominent carrier of proinflammatory oxidized phospholipids (OxPLs), part of its atherothrombosis might be mediated through this pathway. In vivo imaging techniques including magnetic resonance imaging, (18)F-fluorodeoxyglucose uptake positron emission tomography/computed tomography and single-photon emission computed tomography/computed tomography were used to measure subsequently atherosclerotic burden, arterial wall inflammation, and monocyte trafficking to the arterial wall. Ex vivo analysis of monocytes was performed with fluorescence-activated cell sorter analysis, inflammatory stimulation assays, and transendothelial migration assays. In vitro studies of the pathophysiology of Lp(a) on monocytes were performed with an in vitro model for trained immunity. We show that subjects with elevated Lp(a) (108 mg/dL [50-195 mg/dL]; n=30) have increased arterial inflammation and enhanced peripheral blood mononuclear cells trafficking to the arterial wall compared with subjects with normal Lp(a) (7 mg/dL [2-28 mg/dL]; n=30). In addition, monocytes isolated from subjects with elevated Lp(a) remain in a long-lasting primed state, as evidenced by an increased capacity to transmigrate and produce proinflammatory cytokines on stimulation (n=15). In vitro studies show that Lp(a) contains OxPL and augments the proinflammatory response in monocytes derived from healthy control subjects (n=6). This effect was markedly attenuated by inactivating OxPL on Lp(a) or removing OxPL on apolipoprotein(a). These findings demonstrate that Lp(a) induces monocyte trafficking to the arterial wall and mediates proinflammatory responses through its OxPL content. These findings provide a novel mechanism by which Lp(a) mediates cardiovascular disease. URL: http://www.trialregister.nl. Unique identifier: NTR5006 (VIPER Study
NLRP3 gain-of-function in CD4+ T lymphocytes ameliorates experimental autoimmune encephalomyelitis
- Author
- Alhallaf
- Amanda Campelo L. Melo
- Andalib
- Arbore
- Balkwill
- Barclay
- Bauer
- Bettelli
- Blanchfield
- Bruchard
- Bruchard
- Buck
- Cameron
- Carecchio
- Chang
- Christy
- Chu
- Codarri
- Cua
- Felipe Valença Pereira
- Feriotti
- Fernanda Fernandes Terra
- Gris
- Gurung
- Hatylas Azevedo
- Heppner
- Inoue
- Inoue
- Ivanov
- Jean Pierre S. Peron
- Jha
- Kang
- Kanneganti
- Lukens
- Mariathasan
- Mascanfroni
- McCandless
- Mehta
- Meire Ioshie Hiyane
- Miller
- Molgora
- Moore
- Neumann
- Niels Olsen Saraiva Camara
- Paré
- Peng
- Petrilli
- Pierson
- Poppensieker
- Provoost
- Qiao
- Reboldi
- Renkl
- Ritter
- Rostami
- Rothhammer
- Sallusto
- Sato
- Shaw
- Singh
- Siveke
- Ting
- Tárcio Teodoro Braga
- Van den Bossche
- Vinicius Andrade-Oliveira
- Wang
- Wesley Nogueira Brandao
- Zhang
- Zhou
- Publication venue
- 'Portland Press Ltd.'
- Publication date
- Field of study
Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases
- Author
- Alberico L Catapano
- Alwan
- Andersson
- Angelovich
- Arts
- Arts
- Assmus
- Baghdadi
- Barreto
- Baylin
- Bekkering
- Bekkering
- Bekkering
- Bekkering
- Bekkering
- Bernelot Moens
- Bernelot Moens
- Bernelot Moens
- Bochem
- Boring
- Brown
- Børge G Nordestgaard
- Cao
- Chang
- Cheng
- Choi
- Christ
- Courties
- Cremers
- Davies
- Duenas-Gonzalez
- Dutta
- Edfeldt
- Emami
- Erik S G Stroes
- Esther Lutgens
- Everett
- Fayad
- Figueroa
- Fredman
- Fuster
- Gilham
- Giugliano
- Hanahan
- Hansson
- Hasegawa
- Heidenreich
- Heinz
- Hermansson
- Hoeksema
- Hoeksema
- Huang
- Huang
- Ifrim
- Jahagirdar
- Jaiswal
- Jaiswal
- Karouzakis
- Kastelein
- Keating
- Kelly
- Klein
- Kleinnijenhuis
- Kleinnijenhuis
- Kokkola
- Kurtz
- Lahoute
- Lehrer-Graiwer
- Leuschner
- Libby
- Libby
- Libby
- Madjid
- Magnoni
- Mann
- Marnane
- Masteling
- Matthias Nahrendorf
- Medzhitov
- Menno P J de Winther
- Michel Neidhart
- Mihai G Netea
- Miller
- Montgomery
- Moore
- Nahrendorf
- Neele
- Netea
- Netea
- Niels P Riksen
- Olivares
- Ouimet
- Paulmier
- Pisetsky
- Quintin
- Rahman
- Renate M Hoogeveen
- Ridker
- Ridker
- Ridker
- Robbins
- Rodriguez
- Rossol
- Rudd
- Schoors
- Senolt
- Shirai
- Singh
- Siroon Bekkering
- Sommerer
- Sriranjan
- Stienstra
- Subramanian
- Swirski
- Tabas
- Tabas
- Tall
- Tall
- Taqueti
- Tarkin
- Tawakol
- Tawakol
- Tawakol
- Valk
- Valk
- Van den Bossche
- van der Valk
- van Wijk
- Wang
- Wollenweber
- Woollard
- Wyss
- Yonekawa
- Zimmer
- Zimmer
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
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- Wissing Christoph
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- Wolf Roger
- Wong Kak
- Wong Wing Yan
- Wood Darien
- Wozniak Kinga Anna
- Wozniewski Sebastian
- Wright Douglas
- Wu Hsin-Yeh
- Wu Zhenbin
- Wuchterl Sebastian
- Wulansatiti Meutia
- Wulz Claudia-Elisabeth
- Wunsch Stefan
- Würthwein Frank
- Wyslouch Bolek
- Xiang Yifan
- Xiao Jie
- Xiao Meng
- Xiao Rui
- Xie Si
- Xie Wei
- Yagil Avraham
- Yalvac Metin
- Yan Furong
- Yan Xuli
- Yang Heng
- Yang Seungjin
- Yang Shuai
- Yang Tianyu
- Yang Unki
- Yang Yewon
- Yang Yu Chul
- Yao Yao
- Yarar Hevjin
- Yates Brent
- Yazgan Efe
- Ye Zhenyu
- Yi Kai
- Yigitbasi Efe
- Yockey Henry
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoo Jieun
- Yoon Inseok
- You Zhengyun
- Yu David
- Yu Intae
- Yu Shin-Shan
- Yuan Li
- Yuan Siqi
- Yuldashev Bekhzod S.
- Yumiceva Francisco
- Yusuff Imran
- Zabi Alexandre
- Zacharopoulou Anna
- Zaleski Shawn
- Zalewski Piotr
- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zecchinelli Angelo Giacomo
- Zeinali Maryam
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Wenyu
- Zhang Yousen
- Zhang Yu
- Zhao Jingzhou
- Zhizhin Ilia
- Zhokin Alexander
- Zhu Ren-Yuan
- Ziemons Tim
- Zilizi Gyula
- Zimermmane Castro Santos André
- Zipper Noah
- Zisopoulos Ilias
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zotto Pierluigi
- Zotz Alexander
- Zou Rui
- Zucchetta Alberto
- Zumerle Gianni
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Publication venue
- arXiv
- Publication date
- 01/01/2023
- Field of study
Two-particle Bose-Einstein momentum correlation functions are studied for charged-hadron pairs in lead-lead collisions at a center-of-mass energy per nucleon pair of sNN = 5.02 TeV. The data sample, containing 4.27×109 minimum bias events corresponding to an integrated luminosity of 0.607 nb−1, was collected by the CMS experiment in 2018. The experimental results are discussed in terms of a L\'evy-type source distribution. The parameters of this distribution are extracted as functions of particle pair average transverse mass and collision centrality. These parameters include the L\'evy index or shape parameter (α), the L\'evy scale parameter (R), and the correlation strength parameter (λ). The source shape, characterized by α, is found to be neither Cauchy nor Gaussian, implying the need for a full L\'evy analysis. Similarly to what was previously found for systems characterized by Gaussian source radii, a hydrodynamical scaling is observed for the L\'evy R parameter. The λ parameter is studied in terms of the core-halo model.Comment: Submitted to Physical Review C. All figures and tables can be found at http://cms-results.web.cern.ch/cms-results/public-results/publications/HIN-21-011 (CMS Public Pages
First evidence for off-shell production of the Higgs boson and measurement of its width
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdalla Hassan
- Abdullin Salavat
- Abercrombie Daniel
- Abreu Andrés
- Acharya Himal
- Acosta Darin
- Adam Wolfgang
- Adamidis Kosmas
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Addesa Francesca Maria
- Adloff Catherine
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Aggleton Robin
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Ahuja Sudha
- Aimè Chiara
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Albergo Sebastiano
- Albert Andreas
- Albrecht Steffen
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Almond John
- Alpana Alpana
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gallo Pereira Miguel
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrozas Marijus
- Amendola Chiara
- Amin Nick
- Amram Oz
- Amsler Claude
- An Sitong
- An Ying
- Anagnostou Georgios
- Andrea Jeremy
- Andreassi Guido
- Andreev Vladimir
- Andreev Yuri
- Andrejkovic Janik Walter
- Andrews Michael Benjamin
- Androsov Konstantin
- Anguiano Justin
- Antchev Georgy
- Anthony David
- Antunovic Zeljko
- Apollinari Giorgio
- Apparu Dylan
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Araujo Mariana
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Aruta Caterina
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asenov Patrick
- Asghar Muhammad Irfan
- Asilar Ece
- Askew Andrew
- Asmuss Paul
- Atakisi Ismail Okan
- Attikis Alexandros
- Auffray Etiennette
- Aushev Tagir
- Auzinger Georg
- Avati Valentina
- Avery Paul
- Avila Carlos
- Awais Ali
- Awan Muhammad Imran Malik
- Ayala Edy
- Ayala Gabriel
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzurri Paolo
- Baarmand Marc M
- Babaev Anton
- Bacchetta Nicola
- Bachiller Irene
- Bachtis Michail
- Backhaus Malte
- Baden Drew
- Baechler Joachim
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakas Georgios
- Bakhshiansohi Hamed
- Bakshi Amandeep Singh
- Baldenegro Barrera Cristian
- Ban Yong
- Band Reyer
- Bandyopadhyay Hirak
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Bargassa Pedrame
- Baringer Philip
- Barnes Virgil E
- Barney David
- Baron Owen
- Barria Patrizia
- Barrio Luna Mar
- Barroso Ferreira Filho Mapse
- Bartek Rachel
- Bartosik Nazar
- Bartók Márton
- Bastos Diogo
- Battilana Carlo
- Baty Austin
- Bauer Gerry
- Bauerdick Lothar At
- Baxter Samuel
- Bayatmakou Maryam
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Becerril Gonzalez Hugo
- Bechtel Janek
- Beghin Diego
- Behera Prafulla Kumar
- Behera Subash Chandra
- Behnke Olaf
- Bein Samuel
- Belforte Stefano
- Bell Ken W
- Bellan Riccardo
- Belloni Alberto
- Bellora Andrea
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benecke Anna
- Benelli Gabriele
- Benitez Jose F
- Benussi Luigi
- Berenguer Antequera Jorge
- Bergauer Thomas
- Berger Pirmin
- Beri Suman Bala
- Bermúdez Martínez Armando
- Bernardes Cesar Augusto
- Bernet Colin
- Berry Douglas
- Berryhill Jeffrey
- Bertacchi Valerio
- Besancon Marc
- Bestintzanos Ioannis
- Bethani Agni
- Beyrouthy Taha
- Bhal Eshwen
- Bhardwaj Ashutosh
- Bharthuar Shudhashil
- Bharti Monika
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhattacharya Soham
- Bhowmik Debabrata
- Bhowmik Sandeep
- Bhyun Ji Hwan
- Bi Ran
- Bialkowska Helena
- Bianchini Lorenzo
- Bianco Michele
- Bianco Stefano
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bin Anuar Afiq Aizuddin
- Bin Norjoharuddeen Nurfikri
- Bisello Dario
- Black Kevin
- Blekman Freya
- Blinov Vladimir
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Boccali Tommaso
- Bocci Andrea
- Bodek Arie
- Boimska Bozena
- Boldrini Giacomo
- Boletti Alessio
- Bologna Simone
- Bols Emil Sørensen
- Bonacorsi Daniele
- Bonanomi Matteo
- Bonham Brandon
- Bonilla Johan
- Bonomally Shameena
- Boos Edouard
- Boran Fatma
- Borg Johan
- Borgonovi Lisa
- Bornheim Adolf
- Borras Kerstin
- Borshch Vladislav
- Bortignon Pierluigi
- Bose Tulika
- Bossini Edoardo
- Botta Cristina
- Botta Valeria
- Boudoul Gaelle
- Bouhali Othmane
- Bourgatte Guillaume
- Bourilkov Dimitri
- Bozzo Marco
- Bragagnolo Alberto
- Braghieri Alessandro
- Brainerd Christopher
- Brandao Malbouisson Helena
- Branson James G
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- Hatakeyama Kenichi
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- Hoorani Hafeez R
- Horisberger Roland
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- Zipper Noah
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zotz Alexander
- Zou David
- Zou Rui
- Zucchetta Alberto
- Zumerle Gianni
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Álvarez Fernández Adrian
- Özçelik Özlem
- Publication venue
- HAL CCSD
- Publication date
- 28/02/2022
- Field of study
The first evidence for off-shell Higgs production is reported in the final state with two Z bosons decaying into either four charged leptons (muons or electrons), or two charged leptons and two neutrinos, and a measurement of the Higgs boson width is performed. Results are based on data from the CMS experiment at the LHC at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of up to 140 fb−1. The total rate of off-shell Higgs boson production beyond the Z boson pair production threshold, relative to its standard model expectation, is constrained to the interval [0.0061, 2.0] at 95% confidence level. The scenario with no off-shell production is excluded at 99.97% confidence level (3.6 standard deviations). The width of the Higgs boson is extracted as ΓH = 3.2−1.7+2.4 MeV, in agreement with the standard model expectation of 4.1 MeV. The data are also used to set new constraints on anomalous Higgs boson couplings to W and Z boson pairs
Search for Z' bosons decaying to pairs of heavy Majorana neutrinos in proton-proton collisions at s = 13 TeV
- Author
- Aarrestad Thea Klaeboe
- Aarup Petersen Henriette
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abercrombie Daniel
- Abreu Andrés
- Abu Zeid Shimaa
- Acharya Himal
- Acosta Darin
- Adam Wolfgang
- Adamidis Kosmas
- Adams Eric
- Adams Mark Raymond
- Adams Todd
- Addesa Francesca Maria
- Adloff Catherine
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Agarwal Garvita
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Agyel Doruk
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Asar
- Aimè Chiara
- Akchurin Nural
- Akgun Bora
- Akpinar Alp
- Albert Andreas
- Albrecht Anna
- Albrecht Steffen
- Albrow Michael
- Alcaraz Maestre Juan
- Alcerro Alcerro Luis Fernando
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alhusseini Mohammad
- Alimena Juliette
- Alison John
- Allmond Braden
- Almond John
- Alpana Alpana
- Alvarez Gonzalez Barbara
- Alverson George
- Alves Gallo Pereira Miguel
- Alves Gilvan
- Aly Reham
- Alyari Maral
- Amapane Nicola
- Ambrozas Marijus
- Amendola Chiara
- Amin Nick
- Amram Oz
- Amsler Claude
- An Sitong
- An Ying
- Anagnostou Georgios
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrejkovic Janik Walter
- Andrews Michael Benjamin
- Androsov Konstantin
- Anguiano Justin
- Antchev Georgy
- Anthony David
- Antonello Massimiliano
- Antunovic Zeljko
- Apollinari Giorgio
- Apparu Dylan
- Appelt Eric
- Apresyan Artur
- Araujo Mariana
- Arcaro Daniel
- Arcidiacono Roberta
- Argiro Stefano
- Arneodo Michele
- Aruta Caterina
- Asawatangtrakuldee Chayanit
- Asenov Patrick
- Asghar Muhammad Irfan
- Asilar Ece
- Askew Andrew
- Asmuss Paul
- Assiouras Panagiotis
- Atakisi Ismail Okan
- Attikis Alexandros
- Auffray Etiennette
- Aushev Tagir
- Auzinger Georg
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- Avery Paul
- Avila Carlos
- Awais Ali
- Awan Muhammad Imran Malik
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- Ayala Gabriel
- Aydilek Orhan
- Azarkin Maksim
- Aziz Tariq
- Azzi Patrizia
- Azzurri Paolo
- Baarmand Marc M
- Babaev Anton
- Babbar Jyoti
- Bacchetta Nicola
- Bachtis Michail
- Backhaus Malte
- Baden Drew
- Baechler Joachim
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakas Georgios
- Bakhshiansohi Hamed
- Bakshi Amandeep Singh
- Baldenegro Barrera Cristian
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- Baxter Samuel
- Bayatmakou Maryam
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- Bechtel Janek
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- Behera Subash Chandra
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- Bein Samuel
- Belforte Stefano
- Bell Ken W
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- Bendavid Joshua
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- Benitez Jose F
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- Christoforou Konstantinos
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- de Barbaro Pawel
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- de Trocóniz Jorge F
- de Wit Adinda
- Decaro Matthew
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- Delannoy Andrés G
- Delcourt Martin
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- Xiang Yifan
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- Yang Yu Chul
- Yao Yao
- Yarar Hevjin
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- Yazgan Efe
- Ye Zhenyu
- Yi Kai
- Yigitbasi Efe
- Yockey Henry
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoo Jieun
- Yoon Inseok
- You Zhengyun
- Yu David
- Yu Intae
- Yu Pei-Rong
- Yu Shin-Shan
- Yuan Li
- Yuan Siqi
- Yuldashev Bekhzod S
- Yumiceva Francisco
- Yusuff Imran
- Zabi Alexandre
- Zacharopoulou Anna
- Zaleski Shawn
- Zalewski Piotr
- Zanetti Marco
- Zarubin Anatoli
- Zarucki Mateusz
- Zecchinelli Angelo Giacomo
- Zeinali Maryam
- Zeuner Wolfram Dietrich
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhang Liuyao
- Zhang Wenyu
- Zhang Yousen
- Zhang Yu
- Zhao Jingzhou
- Zhizhin Ilia
- Zhokin Alexander
- Zhu Ren-Yuan
- Ziemons Tim
- Zimermmane Castro Santos André
- Zipper Noah
- Zisopoulos Ilias
- Zoi Irene
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zotto Pierluigi
- Zotz Alexander
- Zou Rui
- Zucchetta Alberto
- Zuo Xunwu
- Zuolo Davide
- Zygala Lara
- Álvarez Fernández Adrian
- Özçelik Özlem
- Publication venue
- HAL CCSD
- Publication date
- 25/07/2023
- Field of study
International audienceA search for the production of pairs of heavy Majorana neutrinos (Nℓ) from the decays of Z' bosons is performed using the CMS detector at the LHC. The data were collected in proton-proton collisions at a center-of-mass energy of s = 13 TeV, with an integrated luminosity of 138 fb−1. The signature for the search is an excess in the invariant mass distribution of the final-state objects, two same-flavor leptons (e or μ) and at least two jets. No significant excess of events beyond the expected background is observed. Upper limits at 95% confidence level are set on the product of the Z' production cross section and its branching fraction to a pair of Nℓ, as functions of Nℓ and Z' boson masses (mNℓ and mZ′, respectively) for mZ′ from 0.4 to 4.6 TeV and mNℓ from 0.1 TeV to mZ′/2. In the theoretical framework of a left-right symmetric model, exclusion bounds in the mNℓ-mZ′ plane are presented in both the electron and muon channels. The observed upper limit on mZ′ reaches up to 4.42 TeV. These are the most restrictive limits to date on the mass of Nℓ as a function of the Z' boson mass
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