Here Today, Gone Tomorrow: The Temporal Stability of Crime Hot Spots and the Criminology of Place

It is widely recognized that the distribution of crime in urban areas is not randomly distributed, but is highly concentrated in small pockets of space known as crime “hot spots”. While the empirical evidence supporting the law of crime concentration is strong, most studies that have examined the stability of crime hot spots over time have aggregated crime across years. This dissertation seeks to expand our understanding of the temporal stability of micro-geographic crime hot spots by addressing three research questions: (1) How are high-crime micro-places distributed at the monthly level? How much variation exists in the distribution of crime across micro-places when crimes are aggregated on a monthly rather than an annual basis?; (2) Do structural characteristics associated with micro-geographic crime hot spots differ compared to low-crime and crime-free places?; and (3) Are structural characteristics of micro-geographic hot spots associated with hot spot periodicity? Can the likelihood that a place will experience multiple high-crime months be determined by its structural characteristics? To address these questions, the dissertation examines data from the St. Louis Metropolitan Police Department (SLMPD), the American Communities Survey (ACS), the decennial Census of the United States, and the St. Louis Open Data Portal. In response to the first question, this dissertation explores monthly crime concentrations at the micro-geographic level using street segments in St. Louis, Missouri. Logistic and negative binomial regression models are estimated to address the second research question regarding the structural attributes of violent and property crime hot spots. Finally, the structural characteristics of temporary and violent crime hot spots are compared using a Cox regression model commonly used in survival analyses. Results from these analyses produced several substantively interesting findings, including: (1) there is significant within-year variation in the distribution of crime hot spots, including differences in the temporal stability of high-crime street segments depending on the type of crime studied; (2) violent and property crime hot spots can be distinguished based on their specific sets of structural attributes, with some characteristics of place exhibit inverse relationships between crime types; and (3) the attributes of micro-geographic places may influence the temporal stability of crime hot spots. Implications of these findings for criminal justice policy and directions for future research are discussed

From Russia with Love: Understanding the Russian Cyber Threat to U.S. Critical Infrastructure and What to Do about It

I. Introduction II. A Short History of Russian Hacking of U.S. Government Networks and Critical Infrastructure III. Unpacking the Ukraine Grid Hacks and Their Aftermath IV. Analyzing Policy Options to Help Promote the Resilience of U.S. Government Systems and Critical Infrastructure ... A. Contextualizing and Introducing Draft Version 1.1 of the NIST Cybersecurity Framework ... B. Operationalizing International Cybersecurity Norms on Critical Infrastructure ... C. Deterrence and a Path Forward ... 1. Publicize Benefits as Applied … 2. Publicize Exercise Results ... 3. Publicize Updates V. Conclusio

Displacement and Resettlement: Understanding the Role of Climate Change in Contemporary Migration

How do we understand displacement and resettlement in the context of climate change? This chapter outlines challenges and debates in the literature connecting climate change to the growing global flow of people. We begin with an outline of the literature on environmental migration, specifically the definitions, measurements, and forms of environmental migration. The discussion then moves to challenges in the reception of migrants, treating the current scholarship on migrant resettlement. We detail a selection of cases in which the environment plays a role in the displacement of a population, including sea level rise in Pacific Island States, cyclonic storms in Bangladesh, and desertification in West Africa, as well as the role of deforestation in South America’s Southern Cone as a driver of both climate change and migration. We outline examples of each, highlighting the complex set of losses and damages incurred by populations in each case

From Russia with Love: Understanding the Russian Cyber Threat to U.S. Critical Infrastructure and What to Do about It

I. Introduction II. A Short History of Russian Hacking of U.S. Government Networks and Critical Infrastructure III. Unpacking the Ukraine Grid Hacks and Their Aftermath IV. Analyzing Policy Options to Help Promote the Resilience of U.S. Government Systems and Critical Infrastructure ... A. Contextualizing and Introducing Draft Version 1.1 of the NIST Cybersecurity Framework ... B. Operationalizing International Cybersecurity Norms on Critical Infrastructure ... C. Deterrence and a Path Forward ... 1. Publicize Benefits as Applied … 2. Publicize Exercise Results ... 3. Publicize Updates V. Conclusio

Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR‐124 and reduced AMPA receptors

ObjectiveHippocampal demyelination, a common feature of postmortem multiple sclerosis (MS) brains, reduces neuronal gene expression and is a likely contributor to the memory impairment that is found in >40% of individuals with MS. How demyelination alters neuronal gene expression is unknown.MethodsTo explore whether loss of hippocampal myelin alters expression of neuronal microRNAs (miRNAs), we compared miRNA profiles from myelinated and demyelinated hippocampi from postmortem MS brains and performed validation studies.ResultsA network-based interaction analysis depicts a correlation between increased neuronal miRNAs and decreased neuronal genes identified in our previous study. The neuronal miRNA miR-124 was increased in demyelinated MS hippocampi and targets mRNAs encoding 26 neuronal proteins that were decreased in demyelinated hippocampus, including the ionotrophic glutamate receptors AMPA2 and AMPA3. Hippocampal demyelination in mice also increased miR-124, reduced expression of AMPA receptors, and decreased memory performance in water maze tests. Remyelination of the mouse hippocampus reversed these changes.InterpretationWe establish here that myelin alters neuronal gene expression and function by modulating the levels of the neuronal miRNA miR-124. Inhibition of miR-124 in hippocampal neurons may provide a therapeutic approach to improve memory performance in MS patients

Test selection, adaptation, and evaluation:a systematic approach to assess nutritional influences on child development in developing countries

Background: Evaluating the impact of nutrition interventions on developmental outcomes in developing countries can be challenging since most assessment tests have been produced in and for developed country settings. Such tests may not be valid measures of children's abilities when used in a new context. Aims: We present several principles for the selection, adaptation, and evaluation of tests assessing the developmental outcomes of nutrition interventions in developing countries where standard assessment tests do not exist. We then report the application of these principles for a nutrition trial on the Indonesian island of Lombok. Sample: Three hundred children age 22-55 months in Lombok participated in a series of pilot tests for the purpose of test adaptation and evaluation. Four hundred and eighty-seven 42-month-old children in Lombok were tested on the finalized test battery. Methods: The developmental assessment tests were adapted to the local context and evaluated for a number of psychometric properties, including convergent and discriminant validity, which were measured based on multiple regression models with maternal education, depression, and age predicting each test score. Results: The adapted tests demonstrated satisfactory psychometric properties and the expected pattern of relationships with the three maternal variables. Maternal education significantly predicted all scores but one, maternal depression predicted socio-emotional competence, socio-emotional problems, and vocabulary, while maternal age predicted socio-emotional competence only. Conclusion: Following the methodological principles we present resulted in tests that were appropriate for children in Lombok and informative for evaluating the developmental outcomes of nutritional supplementation in the research context. Following this approach in future studies will help to determine which interventions most effectively improve child development in developing countries