Subject-ivity in the Classroom: Feminism Meets Academe

The literature of feminist pedagogy emphasizes the transformation of women from passive recipients of knowledge to active knowers who see themselves as agents of social change. This transformation is linked to consciousness-raising and experiential learning—as means to empower students. I here discuss prob- lems encountered as a white, heterosexual teacher developing such pedagogical practices in the university classroom, showing how these problems are related to the unexamined epistemological basis of these practices. I show how an over- emphasis on subjective, experiential learning can lead to epistemological relativ- ism as resistance to the hegemony of Eurocentric, academic feminism. Challenges to my authority as a white academic “expert” have led me to advocate a feminist pedagogy based on relational thinking that brings together subjective and objective dimensions of knowing. Ironically, this approach heightens rather than diminishes the contradictions we face as feminist teachers. Les écrits sur la pédagogie féministe mettent l’accent sur la transformation des femmes, de réceptrices passives des connaissances à connaisseures actives qui se voient comme des agentes des changements sociaux. Cette transformation est liée à la conscientisation et à l’apprentissage par l’expérience personnelle, deux moyens de responsabiliser les étudiants. L’auteure analyse des problèmes aux- quels elle a à faire face en tant que professeure hétérosexuelle de race blanche ayant recours à de telles méthodes pédagogiques à l’université; elle explique comment ces problèmes sont reliés au fait que le fondement épistémologique de ces méthodes n’a pas été approfondi. Elle montre comment la trop grande impor- tance accordée à l’apprentissage au moyen d’expériences subjectives peut mener à un relativisme épistémologique qui correspond à une forme de résistance à l’hégémonie du féminisme universitaire eurocentrique. La contestation de l’auto- rité de l’auteure en tant qu’“experte” universitaire de race blanche l’a amenée à prôner une pédagogie féministe reposant sur une pensée relationnelle qui con- jugue les dimensions subjectives et objectives de la connaissance. Ironiquement, cette approche intensifie les contraditions auxquelles font face les professeures féministes, plutôt que de les diminuer.

Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency

In obese humans, metabolism of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and A-ring reduction (by 5α- and 5β-reductases) is dysregulated in a tissue specific manner. These changes have been recapitulated in leptin resistant obese Zucker rats but were not observed in high-fat fed Wistar rats. Recent data from mouse models suggest that such discrepancies may reflect differences in leptin signalling. We therefore compared glucocorticoid metabolism in murine models of leptin deficiency and resistance. Male ob/ob and db/db mice and their respective littermate controls (n=10–12/group) were studied at the age of 12 weeks. Enzyme activities and mRNA expression were quantified in snap-frozen tissues. The patterns of altered pathways of steroid metabolism in obesity were similar in ob/ob and db/db mice. In liver, 5β-reductase activity and mRNA were increased and 11β-HSD1 decreased in obese mice, whereas 5α-reductase 1 (5αR1) mRNA was not altered. In visceral adipose depots, 5β-reductase was not expressed, 11β-HSD1 activity was increased and 5αR1 mRNA was not altered in obesity. By contrast, in subcutaneous adipose tissue 11β-HSD1 and 5αR1 mRNA were decreased. Systematic differences were not found between ob/ob and db/db murine models of obesity, suggesting that variations in leptin signalling through the short splice variant of the Ob receptor do not contribute to dysregulation of glucocorticoid metabolism

The Spitzer Survey of Interstellar Clouds in the Gould Belt. III. A Multi-Wavelength View of Corona Australis

We present Spitzer Space Telescope IRAC and MIPS observations of a 0.85 deg^2 field including the Corona Australis (CrA) star-forming region. At a distance of 130 pc, CrA is one of the closest regions known to be actively forming stars, particularly within its embedded association, the Coronet. Using the Spitzer data, we identify 51 young stellar objects (YSOs) in CrA which include sources in the well-studied Coronet cluster as well as distributed throughout the molecular cloud. Twelve of the YSOs discussed are new candidates, one of which is located in the Coronet. Known YSOs retrieved from the literature are also added to the list, and a total of 116 candidate YSOs in CrA are compiled. Based on these YSO candidates, the star formation rate is computed to be 12 M_o Myr^-1, similar to that of the Lupus clouds. A clustering analysis was also performed, finding that the main cluster core, consisting of 68 members, is elongated (having an aspect ratio of 2.36), with a circular radius of 0.59 pc and mean surface density of 150 pc^-2. In addition, we analyze outflows and jets in CrA by means of new CO and H_2 data. We present 1.3 mm interferometric continuum observations made with the Submillimeter Array (SMA) covering R CrA, IRS 5, IRS 7, and IRAS 18595-3712 (IRAS 32). We also present multi-epoch H_2 maps and detect jets and outflows, study their proper motions, and identify exciting sources. The Spitzer and ISAAC/VLT observations of IRAS 32 show a bipolar precessing jet, which drives a CO (2-1) outflow detected in the SMA observations. There is also clear evidence for a parsec-scale precessing outflow, E-W oriented, and originating in the SMA 2 region, likely driven by SMA 2 or IRS 7A.Comment: Accepted for publication in ApJS. 112 pages, 42 figures (quality reduced), 13 tables. Full resolution version can be found at http://www.cfa.harvard.edu/~dpeterson/CrA/CrA_highres.pd

Genome-scale resources for Thermoanaerobacterium saccharolyticum

Background Thermoanaerobacterium saccharolyticum is a hemicellulose-degrading thermophilic anaerobe that was previously engineered to produce ethanol at high yield. A major project was undertaken to develop this organism into an industrial biocatalyst, but the lack of genome information and resources were recognized early on as a key limitation. Results Here we present a set of genome-scale resources to enable the systems level investigation and development of this potentially important industrial organism. Resources include a complete genome sequence for strain JW/SL-YS485, a genome-scale reconstruction of metabolism, tiled microarray data showing transcription units, mRNA expression data from 71 different growth conditions or timepoints and GC/MS-based metabolite analysis data from 42 different conditions or timepoints. Growth conditions include hemicellulose hydrolysate, the inhibitors HMF, furfural, diamide, and ethanol, as well as high levels of cellulose, xylose, cellobiose or maltodextrin. The genome consists of a 2.7 Mbp chromosome and a 110 Kbp megaplasmid. An active prophage was also detected, and the expression levels of CRISPR genes were observed to increase in association with those of the phage. Hemicellulose hydrolysate elicited a response of carbohydrate transport and catabolism genes, as well as poorly characterized genes suggesting a redox challenge. In some conditions, a time series of combined transcription and metabolite measurements were made to allow careful study of microbial physiology under process conditions. As a demonstration of the potential utility of the metabolic reconstruction, the OptKnock algorithm was used to predict a set of gene knockouts that maximize growth-coupled ethanol production. The predictions validated intuitive strain designs and matched previous experimental results. Conclusion These data will be a useful asset for efforts to develop T. saccharolyticum for efficient industrial production of biofuels. The resources presented herein may also be useful on a comparative basis for development of other lignocellulose degrading microbes, such as Clostridium thermocellum. Electronic supplementary material The online version of this article (doi:10.1186/s12918-015-0159-x) contains supplementary material, which is available to authorized users

Young people’s orientations to the future: navigating the present and imagining the future

This article discusses the findings of the Imagine Sheppey project (2013-14) which studied how young people are ‘oriented’ towards the future. The aim and approach of the project was to explore future imaginaries in a participatory, experimental, and performative way. Working with young people in a series of arts-based workshops, we intervened in different environments to alter the space as an experience of change – temporal, material, symbolic. We documented this process visually and made use of the images produced as the basis for elicitation in focus groups with a wider group of young people. In this article we discuss young people’s future orientations through the themes of reach, resources, shape, and value. In so doing, we reflect on the paths that our young respondents traced to connect their presents to what is next, what we call their modes of present-future navigation. We explore the qualities and characteristics of their stances within a wider reflection about how young people approach, imagine and account for the future

The Spitzer Survey of Interstellar Clouds in the Gould Belt. IV. Lupus V and VI Observed with IRAC and MIPS

We present Gould's Belt (GB) Spitzer IRAC and MIPS observations of the Lupus V and VI clouds and discuss them in combination with near-infrared (2MASS) data. Our observations complement those obtained for other Lupus clouds within the frame of the Spitzer "Core to Disk" (c2d) Legacy Survey. We found 43 Young Stellar Object (YSO) candidates in Lupus V and 45 in Lupus VI, including 2 transition disks, using the standard c2d/GB selection method. None of these sources was classified as a pre-main sequence star from previous optical, near-IR and X-ray surveys. A large majority of these YSO candidates appear to be surrounded by thin disks (Class III; ~79% in Lupus V and ~87% in Lupus VI). These Class III abundances differ significantly from those observed for the other Lupus clouds and c2d/GB surveyed star-forming regions, where objects with optically thick disks (Class II) dominate the young population. We investigate various scenarios that can explain this discrepancy. In particular, we show that disk photo-evaporation due to nearby OB stars is not responsible for the high fraction of Class III objects. The gas surface densities measured for Lupus V and VI lies below the star-formation threshold (AV {\eqsim}8.6 mag), while this is not the case for other Lupus clouds. Thus, few Myrs older age for the YSOs in Lupus V and VI with respect to other Lupus clouds is the most likely explanation of the high fraction of Class III objects in these clouds, while a higher characteristic stellar mass might be a contributing factor. Better constraints on the age and binary fraction ofComment: 42 Pages, 19 Figures, Accepted for publication on Ap

Improving mental healthcare access and experience for people from minority ethnic groups : an England-wide multisite experience-based codesign (EBCD) study

Background Long-standing ethnic inequalities in access and mental healthcare were worsened by the COVID-19 pandemic. Objectives Stakeholders coproduced local and national implementation plans to improve mental healthcare for people from minority ethnic groups. Methods Experience-based codesign conducted in four areas covered by National Health Service (NHS) mental health trusts: Coventry and Warwickshire, Greater Manchester, East London and Sheffield. Data were analysed using an interpretivist–constructivist approach, seeking validation from participants on their priority actions and implementation plans. Service users (n=29), carers (n=9) and health professionals (n=33) took part in interviews; focus groups (service users, n=15; carers, n=8; health professionals, n=24); and codesign workshops (service users, n=15; carers, n=5; health professionals, n=21) from July 2021 to July 2022. Findings Each study site identified 2–3 local priority actions. Three were consistent across areas: (1) reaching out to communities and collaborating with third sector organisations; (2) diversifying the mental healthcare offer to provide culturally appropriate therapeutic approaches and (3) enabling open discussions about ethnicity, culture and racism. National priority actions included: (1) co-ordination of a national hub to bring about system level change and (2) recognition of the centrality of service users and communities in the design and provision of services. Conclusions Stakeholder-led implementation plans highlight that substantial change is needed to increase equity in mental healthcare in England

The impact of reduced routine community mental healthcare on people from minority ethnic groups during the COVID-19 pandemic : qualitative study of stakeholder perspectives

Background: Enduring ethnic inequalities exist in mental healthcare. The COVID-19 pandemic has widened these. Aims: To explore stakeholder perspectives on how the COVID-19 pandemic has increased ethnic inequalities in mental healthcare. Method: A qualitative interview study of four areas in England with 34 patients, 15 carers and 39 mental health professionals from National Health Service (NHS) and community organisations (July 2021 to July 2022). Framework analysis was used to develop a logic model of inter-relationships between pre-pandemic barriers and COVID-19 impacts. Results: Impacts were largely similar across sites, with some small variations (e.g. positive service impacts of higher ethnic diversity in area 2). Pre-pandemic barriers at individual level included mistrust and thus avoidance of services and at a service level included the dominance of a monocultural model, leading to poor communication, disengagement and alienation. During the pandemic remote service delivery, closure of community organisations and media scapegoating exacerbated existing barriers by worsening alienation and communication barriers, fuelling prejudice and division, and increasing mistrust in services. Some minority ethnic patients reported positive developments, experiencing empowerment through self-determination and creative activities. Conclusions: During the COVID-19 pandemic some patients showed resilience and developed adaptations that could be nurtured by services. However, there has been a reduction in the availability of group-specific NHS and third-sector services in the community, exacerbating pre-existing barriers. As these developments are likely to have long-term consequences for minority ethnic groups’ engagement with mental healthcare, they need to be addressed as a priority by the NHS and its partners