Dynamics of the water circulations in the southern South China Sea and its seasonal transports

A three-dimensional Regional Ocean Modeling System is used to study the seasonal water circulations and transports of the Southern South China Sea. The simulated seasonal water circulations and estimated transports show consistency with observations, e.g., satellite altimeter data set and re-analysis data of the Simple Ocean Data Assimilation. It is found that the seasonal water circulations are mainly driven by the monsoonal wind stress and influenced by the water outflow/inflow and associated currents of the entire South China Sea. The intrusion of the strong current along the East Coast of Peninsular Malaysia and the eddies at different depths in all seasons are due to the conservation of the potential vorticity as the depth increases. Results show that the water circulation patterns in the northern part of the East Coast of Peninsular Malaysia are generally dominated by the geostrophic currents while those in the southern areas are due solely to the wind stress because of negligible Coriolis force there. This study clearly shows that individual surface freshwater flux (evaporation minus precipitation) controls the sea salinity balance in the Southern South China Sea thermohaline circulations. Analysis of climatological data from a high resolution Regional Ocean Modeling System reveals that the complex bathymetry is important not only for water exchange through the Southern South China Sea but also in regulating various transports across the main passages in the Southern South China Sea, namely the Sunda Shelf and the Strait of Malacca. Apart from the above, in comparision with the dynamics of the Sunda Shelf, the Strait of Malacca reflects an equally significant role in the annual transports into the Andaman Sea

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM). The field of immunometabolism implies a bidirectional link between the immune system and metabolism, in which inflammation plays an essential role in the promotion of metabolic abnormalities (e.g., obesity and T2DM), and metabolic factors, in turn, regulate immune cell functions. Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM. Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. Hyperglycemia and the subsequent inflammation are the main causes of micro- and macroangiopathies in the circulatory system. They also promote the gut microbiota dysbiosis, increased intestinal permeability, and fatty liver disease. The impaired immune system together with metabolic imbalance also increases the susceptibility of patients to several pathogenic agents such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, the need for a proper immunization protocol among such patients is granted. The focus of the current review is to explore metabolic and immunological abnormalities affecting several organs of T2DM patients and explain the mechanisms, whereby diabetic patients become more susceptible to infectious diseases.Peer reviewe

The effects on functional balance in hemiplegic stroke individuals wearing an ankle foot orthosis with rocker bottom shoes

Background: One of the disorders in stroke patients is asymmetrical posture, which leads to decreased movement and balance control. An ankle-foot orthosis (AFO) is the most common orthopedic device used in patients with post-stroke hemiplegia, and are often utilized with shoes. The purpose of this study was to investigate the effect, in stroke patients, of rocker bottom shoes on an AFO in the clinical assessments of balance compared to standard shoes on an AFO.    Methods: This quasi-experimental study involved 10 chronic stroke patients. The evaluated individuals were under four conditions using rocker bottom shoes and standard shoes coupled with a rigid AFO immediately, and after a 3-week adaptation. The walking speed was assessed using a 10-m walk test (10 MWT), and the clinical assessments of balance were evaluated using the Timed-Up and Go test (TUG) and the Functional Reach Test (FRT).   Results: The findings revealed that wearing rocker bottom shoes on the AFO significantly increased walking speed, the distance on the FRT, and reduced the TUG compared to wearing standard shoes on the AFO (p < 0.05). Conclusion: The study indicated that stroke patients showed an improvement in walking speed and functional balance when utilizing the AFOs with rocker bottom shoes. This outcome could be a possibility in application by doctors to prescribe this type of footwear for individuals who have had a stroke

Efficacy of Corrective Surgery for Gait and Energy Expenditure in Patients with Scoliosis: A Literature Review

The aim of this literature review was to evaluate selected original papers that measured gait parameters and energy expenditure in idiopathic scoliosis (IS) treated with surgical intervention. IS is a progressive growth disease that affects spinal anatomy, mobility, and left–right trunk symmetry. Consequently, IS can modify human gait. Spinal fusions remain the primary approach to correcting scoliosis deformities, thereby halting progression. Using the population intervention comparison outcome measure framework and selected keywords, 15 studies that met the inclusion criteria were selected. Alteration of spatial and temporal variables in patients with IS was contradictory among the selected studies. Ankle and foot kinematics did not change after surgery; however, pelvic and hip frontal motions increased and pelvic rotation decreased following surgery. Patients with IS continued to show excessive energy expenditure following surgery in the absence of a physical rehabilitation protocol. Spinal surgery may be considered for gait improvement and IS treatment. There were inadequate data regarding the effect of corrective surgery on the kinetics, energy expenditure, and muscle activity parameters

The role of T helper 9(Th9) against Infectious Diseases

Background and aims: Infectious diseases are disorders caused by organisms such as bacteria, viruses, fungi or parasites .The Th9 subset develops in response to combined signals from TGF-b and IL-4 among a cacophony of other cytokines in an extracellular milieu. T helper 9 (Th9) cells, as a novel CD4 T cell subset, seem to play a complex role in the outcome of specific immune responses. In this article, we aimed to review the role of these cells in infectious disease. Methods: In this mini-review study, we study 25 novel articles since 2009 to 2014 about the role of T helper 9 in some Infectious Diseases. Results: Pleural mesothelial cells promoted Th9 cell differentiation by presenting antigen. It significantly differentiated Th17, but not Th9 cells in the development of CVB3-induced VMC. The microenvironment of VMC seemed to contribute to the differentiation and proliferation of Th17 rather than to differentiation of Th9 cells. Having reviewed the limited number of articles considering this relevance, we came to this result that Lymphatic Filariasis and mycobacterium tuberculosis infections confirmed the existence of such relationship. In addition, Rapamycin resistant murine Th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity but concerning Viral Myocarditis, Th9 cells could not protect against it. Conclusion: The accurate molecular mechanisms underlying the generation and differentiation of human Th9 cells are not elucidated completely. Th9 cells exhibit Ag specific expansion in a chronic helminth infection (lymphatic filariasis), but in relevance to viral myocarditis, Th9 cells did not play an efficient role against it. However; knowing that whether Th9 cells participate in the protection against infections needs further research

Comparison of Psychometric Properties of the Original and Brief Version of the Tampa Scale for Kinesiophobia

Introduction: Some accurate tools exist to assess fear-avoidance behavior, such as the Tampa scale for kinesiophobia (TSK) in individuals with musculoskeletal problems. The current research aims to compare the psychometric characteristics of the original 17-items TSK questionnaire and its 11-item brief version in chronic non-specific low-back pain (CNSLBP). Materials and Methods: In this test development study, 295 patients with CNSLBP referred to the physiotherapy clinic of Milad Hospital in Tehran city, Iran were evaluated. Confirmatory factor analysis (CFA) and α Cronbach was conducted to assess the validity and reliability of the original and brief version of the TSK, respectively. For goodness-of-fit, the Χ2/df, root mean square error of approximation (RMSEA), goodness-of-fit index (GFI), and comparative fit index (CFI) indices were used. Results: Internal consistency specified by Cronbach’s α was 0.949 for the original version of the questionnaire and 0.927 for the brief one. Based on the CFA findings, the goodness-of-fit indices for the brief version were GFI=0.921, RMSEA=0.078 (90% confidence interval (CI), 0.062%-0.094%), comparative fit index (CFI)=0.981, and Χ2/df=2.791. These indices for the original one were 0.882, 0.066 (90% CI, 0.055%-0.076%), 0.983, and 2.270, respectively. A significant correlation was found between these two versions (P<0.001). These findings confirm the adequacy of the brief version of the TSK. Conclusion: The brief version of TSK can be considered a reliable and valid tool to evaluate somatic focus and activity avoidance in patients with CNSLBP

第1090回千葉医学会例会・第7回環境生命医学研究会

A three-dimensional Regional Ocean Modelling System is used to study the tidal characteristics and their dynamics in the Sunda Shelf of the southern South China Sea. In this model, the outer domain is set with a 25 km resolution and the inner one, with a 9 km resolution. Calculations are performed on the inner domain. The model is forced at the sea surface by climatological monthly mean wind stress, freshwater (evaporation minus precipitation), and heat fluxes. Momentum and tracers (such as temperature and salinity) are prescribed in addition to the tidal heights and currents extracted from the Oregon State University TOPEX/Poseidon Global Inverse Solution (TPXO7.2) at the open boundaries. The results are validated against observed tidal amplitudes and phases at 19 locations. Results show that the mean average power energy spectrum (in unit m2/s/cph) for diurnal tides at the southern end of the East Coast of Peninsular Malaysia is approximately 43% greater than that in the East Malaysia region located in northern Borneo. In contrast, for the region of northern Borneo the semidiurnal power energy spectrum is approximately 25% greater than that in the East Coast of Peninsular Malaysia. This implies that diurnal tides are dominant along the East Coast of Peninsular Malaysia while both diurnal and semidiurnal tides dominate almost equally in coastal East Malaysia. Furthermore, the diurnal tidal energy flux is found to be 60% greater than that of the semidiurnal tides in the southern South China Sea. Based on these model analyses, the significant tidal mixing frontal areas are located primarily off Sarawak coast as indicated by high chlorophyll-a concentrations in the area

The Evaluation of Electromyography Biofeedback on Proprioception and Balance in Healthy Young Athletes

Introduction: We evaluated the effect of electromyography biofeedback on proprioception and functional balance in healthy young athletes. Materials and Methods: In this clinical trial, 24 athletes were randomly divided into two study (n=12) and control (n=12) groups. The study group received rehabilitation exercises, including one-foot standing, squatted standing, and isometric contraction of quadriceps muscle at different knee angles, including 30, 45, and 90 degrees of knee flexion along with electromyography biofeedback. The control group received only rehabilitation exercises without electromyography biofeedback. Exercises were performed by both groups for a 4-week period in three sessions per week. Functional balance and proprioception before and after exercises were measured using the star excursion balance test and a system consisting of digital photography non-reflective markers, respectively. The data of the center of pressure and time of vertical ground reaction force using a force plate was also collected to evaluate static balance and dynamic balance, respectively. Results: The absolute error in knee joint reconstruction for 30° (P=0.005), 45° (P=0.001), and 90° (P=0.033) angles significantly decreased after the intervention in the study group compared to the control group. Star excursion balance test scores in all directions did not show any significant differences between the two groups (P>0.05), except for the anterior-lateral direction (P=0.03). Moreover, all variables related to static and dynamic balance did not show a significant difference between two the groups after the interventions (P>0.05). Conclusion: The electromyography biofeedback intervention can probably be used as a rehabilitation protocol in recovering and healing proprioception injuries resulting from sports injuries

Ankylosing Spondylitis and Mesenchymal Stromal/Stem Cell Therapy: A New Therapeutic Approach

Ankylosing spondylitis (AS) is an inflammatory rheumatoid disease categorized within spondyloarthropathies (SpA) and manifested by chronic spinal arthritis. Several innate and adaptive immune cells and secreted-mediators have been indicated to play a role in AS pathogenesis. Considering the limitations of current therapeutic approaches (NSAIDs, glucocorticoids, DMARDs and biologic drugs), finding new treatments with fewer side effects and high therapeutic potentials are required in AS. Mesenchymal stem cells (MSCs) with considerable immunomodulatory and regenerative properties could be able to attenuate the inflammatory responses and help tissue repair by cell-to-cell contact and secretion of soluble factors. Moreover, MSCs do not express HLA-DR, which renders them a favorable therapeutic choice for transplantation in immune-mediated disorders. In the present review, we describe immunopathogenesis and current treatments restrictions of AS. Afterwards, immunomodulatory properties and applications of MSCs in immune-mediated disorders, as well as recent findings of clinical trials involving mesenchymal stem cell therapy (MSCT) in ankylosing spondylitis, will be discussed in detail. Additional studies are required to investigate several features of MSCT such as cell origin, dosage, administration route and, specifically, the most suitable stage of disease for ideal intervention