Municipal and Developer Success Rates at the Ontario Municipal Board: A London, Ontario Case Study

The Ontario Municipal Board (OMB) is a quasi-judicial tribunal with the authority to render decisions regarding land-use planning disputes. Using London, Ontario as a case study, this paper attempts to determine if municipalities or developers are generally more successful before the OMB when they are in direct opposition. The research seeks to highlight the underlying reasons why OMB makes its decisions, what it bases its decisions on, and any ramifications this may have for municipalities and developers. Through an extensive literature review, comparisons to other empirical studies of a similar nature, and a carefully selected research design, this paper provides evidence regarding the behaviour of the OMB. The findings reveal that it relies on two dominant factors to make its decisions: quality of planning designs and expert testimony

Contextualizing “Oriental” cults. New Lights on the Evidence between the Danube and the Adriatic

The Center for Interdisciplinary Research of Ancient History of the Institute of Croatian History at the Department of History, Faculty of Humanities and Social Sciences, University of Zagreb, initiated the international scientific symposium "Contextualizing 'Oriental' Cults. New Lights on the Evidence between the Danube and the Adriatic," held in Zagreb and Ptuj from September 15 to 17, 2022. The co-organizing institutions were the University of Toulouse Jean Jaurès, the Austrian Academy of Sciences, the Cultural Heritage Research Center "Cvetan Grozdanov" of the Macedonian Academy of Sciences and Arts, the Archaeological Museum in Zagreb, and the Regional Museum Ptuj – Ormož. The aims of the symposium were to explore and discuss how "Oriental" cults manifested in the Danubian and Balkan provinces, based on epigraphic and material evidence. Attention was given to the spread and development of these cults in various contexts – historical, political, topographical, civil, economic, and military. Presentations and discussions yielded valuable new insights and conclusions. The international character of the symposium, with participants from several countries (Croatia, Slovenia, Austria, France, Belgium, Luxembourg, Germany, North Macedonia, Greece, Hungary, and Romania), enabled an exceptionally cohesive and dynamic academic and cultural exchange. Two years after the symposium, we have gathered scientific contributions from most participants. The publication is intended for both the domestic and international scientific community, as it presents the latest findings and conclusions on the so-called "Oriental" cults.Centar za interdisciplinarno istraživanje stare povijesti Zavoda za hrvatsku povijest Odsjeka za povijest Filozofskog fakulteta Sveučilišta u Zagrebu pokrenuo je međunarodni znanstveni simpozij „Contextualizing 'Oriental' cults. New Lights on the Evidence between the Danube and the Adriatic”, održan u Zagrebu i Ptuju 15. – 17. rujna 2022. Institucije suorganizatori bile su Sveučilište u Toulouse Jean Jaurès, Austrijska akademija znanosti i umjetnosti, Istraživački centar za kulturnu baštinu “Cvetan Grozdanov” Makedonske akademije znanosti i umjetnosti, Arheološki muzej u Zagrebu i Pokrajinski muzej Ptuj – Ormož. Ciljevi simpozija bili su istražiti i raspraviti način na koji su se „orijentalni“ kultovi očitovali u podunavskim i balkanskim provincijama, na temelju epigrafskih i materijalnih izvora. Pozornost je posvećena širenju i razvoju spomenutih kultova u različitim kontekstima – povijesnom, političkom, topografskom, civilnom, gospodarskom i vojnom. Izlaganja i rasprave iznjedrili su dragocjene nove spoznaje i zaključke. Međunarodni karakter ovog skupa, čiji su sudionici bili iz više zemalja (Hrvatske, Slovenije, Austrije, Francuske, Belgije, Luksemburga, Njemačke, Sjeverne Makedonije, Grčke, Mađarske i Rumunjske), omogućio je izuzetno kohezivnu i dinamičnu akademsku i kulturnu razmjenu. Dvije godine nakon simpozija prikupili smo znanstvene priloge većine sudionika. Publikacija je namijenjena domaćoj i međunarodnoj znanstvenoj javnosti, jer predstavlja najnovija saznanja i zaključke o tzv. "orijentalnim" kultovima

The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross‐talk, and therapies

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/113753/1/odi12206.pd

Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1

To date, no immunization of humans or animals has elicited broadly neutralizing sera able to prevent HIV-1 transmission; however, elicitation of broad and potent heavy chain only antibodies (HCAb) has previously been reported in llamas. In this study, the anti-HIV immune responses in immunized llamas were studied via deep sequencing analysis using broadly neutralizing monoclonal HCAbs as a guides. Distinct neutralizing antibody lineages were identified in each animal, including two defined by novel antibodies (as variable regions called VHH) identified by robotic screening of over 6000 clones. The combined application of five VHH against viruses from clades A, B, C and CRF_AG resulted in neutralization as potent as any of the VHH individually and a predicted 100% coverage with a median IC50 of 0.17 µg/ml for the panel of 60 viruses tested. Molecular analysis of the VHH repertoires of two sets of immunized animals showed that each neutralizing lineage was only observed following immunization, demonstrating that they were elicited de novo. Our results show that immunization can induce potent and broadly neutralizing antibodies in llamas with features similar to human antibodies and provide a framework to analyze the effectiveness of immunization protocols

Alteration of AKT Activity Increases Chemotherapeutic Drug and Hormonal Resistance in Breast Cancer yet Confers an Achilles Heel by Sensitization to Targeted Therapy

The PI3K/PTEN/Akt/mTOR pathway plays critical roles in the regulation of cell growth. The effects of this pathway on drug resistance and cellular senescence of breast cancer cells has been a focus of our laboratory. Introduction of activated Akt or mutant PTEN constructs which lack lipid phosphatase [PTEN(G129E)] or lipid and protein phosphatase [PTEN(C124S)] activity increased the resistance of the cells to the chemotherapeutic drug doxorubicin, and the hormonal drug tamoxifen. Activated Akt and PTEN genes also inhibited the induction of senescence after doxorubicin treatment; a phenomenon associated with unrestrained proliferation and tumorigenesis. Interference with the lipid phosphatase domain of PTEN was sufficient to activate Akt/mTOR/p70S6K as MCF-7 cells transfected with the mutant PTEN gene lacking the lipid phosphatase activity [PTEN(G129E)] displayed elevated levels of activated Akt and p70S6K compared to empty vector transfected cells. Cells transfected with mutant PTEN or Akt constructs were hypersensitive to mTOR inhibitors when compared with the parental or empty vector transfected cells. Akt-transfected cells were cultured for over two months in tamoxifen from which tamoxifen and doxorubicin resistant cells were isolated that were >10-fold more resistant to tamoxifen and doxorubicin than the original Akt-transfected cells. These cells had a decreased induction of both activated p53 and total p21Cip1 upon doxorubicin treatment. Furthermore, these cells had an increased inactivation of GSK-3β and decreased expression of the estrogen receptor-α. In these drug resistant cells, there was an increased activation of ERK which is associated with proliferation. These drug resistant cells were hypersensitive to mTOR inhibitors and also sensitive to MEK inhibitors, indicating that the enhanced p70S6K and ERK expression was relevant to their drug and hormonal resistance. Given that Akt is overexpressed in greater than 50% of breast cancers, our results point to potential therapeutic targets, mTOR and MEK. These studies indicate that activation of the Akt kinase or disruption of the normal activity of the PTEN phosphatase can have dramatic effects on activity of p70S6K and other downstream substrates and thereby altering the therapeutic sensitivity of breast cancer cells. The effects of doxorubicin and tamoxifen on induction of the Raf/MEK/ERK and PI3K/Akt survival pathways were examined in unmodified MCF-7 breast cells. Doxorubicin was a potent inducer of activated ERK and to a lesser extent Akt. Tamoxifen also induced ERK. Thus a consequence of doxorubicin and tamoxifen therapy of breast cancer is the induction of a pro-survival pathway which may contribute to the development of drug resistance. Unmodified MCF-7 cells were also sensitive to MEK and mTOR inhibitors which synergized with both tamoxifen and doxorubicin to induce death. In summary, our results point to the key interactions between the PI3K/PTEN/Akt/mTOR and Raf/ MEK/ERK pathways in regulating chemotherapeutic drug resistance/sensitivity in breast cancer and indicate that targeting these pathways may prevent drug and hormonal resistance. Orignally published Advances in Enzyme Regulation, Vol. 48, No. 1, 2008

Panduan belajar DOS 5/ Scheid

xxv, 343 hal.: ill.; 24 cm

Teori dan soal-soal pengantar ilmu komputer/ Scheid

297 hal.: ill.; 28 cm

Teori dan soal-soal pengantar ilmu komputer/ Scheid

297 hal.: ill.; 28 cm

Teori dan soal-soal pengantar ilmu komputer/ Scheid

297 hal.: ill.; 28 cm