NG peptides: A novel family of neurophysin-associated neuropeptides

NOTICE: this is the author’s version of a work that was accepted for publication in GENE. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in GENE, [VOL 458, ISSUE 1-2, (2010)] DOI: 10.1016/j.gene.2010.03.00

A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers.

Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known. Here multiple Saccharomyces cerevisiae GCR assays and query mutations were crossed into arrays of mutants to identify progeny with increased GCR rates. One hundred eighty two GIS genes were identified that suppressed GCR formation. Another 438 cooperatively acting GIS genes were identified that were not GIS genes, but suppressed the increased genome instability caused by individual query mutations. Analysis of TCGA data using the human genes predicted to act in GIS pathways revealed that a minimum of 93% of ovarian and 66% of colorectal cancer cases had defects affecting one or more predicted GIS gene. These defects included loss-of-function mutations, copy-number changes associated with reduced expression, and silencing. In contrast, acute myeloid leukaemia cases did not appear to have defects affecting the predicted GIS genes

Psychiatric morbidity and social capital in rural communities of the Greek North Aegean islands

Which facets of social capital affect mental health in rural settings? This study explores the association between different aspects of social capital and psychiatric morbidity in rural communities of the Greek North Aegean islands. A large number of individual and community characteristics which may influence psychiatric morbidity are concurrently examined in multilevel models to account for the clustering of individuals within rural settings. The current findings indicate that psychiatric morbidity is to a large extent clustered within rural communities. Individuals’ perceived divisions in the community, i.e., political party preference, landholdings etc., low social support networks and lack of perceived solidarity are associated with psychiatric morbidity according to theoretical expectation. At the community level this risk is lower in villages with over 250 residents, where there are youth clubs or a common threat, for instance, property crime

How Good Is the Samaritan, and Why?

What is the extent and nature of religious prosociality? If religious prosociality exists, is it parochial and extended selectively to co-religionists, or is it generalized regardless of the recipient? Further, is it driven by preferences to help others or by expectations of reciprocity? We examined how much of a $0.30 bonus Mechanical Turk workers would share with the other player whose religion was prominently displayed during two online resource allocation games. In one game (but not the other), the recipient could choose to reciprocate. Results from both games showed that the more central religion was in participants’ lives, the more of the bonus they shared, regardless of whether they were giving to atheists or Christians. Furthermore, this effect was most clearly related to self-reported frequency of “thinking about religious ideas”, rather than belief in God or religious practice/experience. Our findings provide evidence of generalized religious prosociality and illuminate its basis

The Ties Allowed to Bind: Kinship Legalities and Migration Restriction in the Interwar Americas

AbstractNew immigration restrictions in the United States and elsewhere in the 1920s and 1930s made legal entry dependent on specific kinship formalities. This article explores the impact of the new system through a study of British Caribbean migrants. Because family patterns and the place of church and state sanction within them varied greatly by class—here, as in many parts of the world—the result was a curtailment of mobility that affected elites very little, and working-class would-be migrants enormously. In order to elucidate de facto patterns of exclusion, the author concludes, historians of transnational labor must begin paying more attention to the work “family” does.</jats:p

Isometric group actions on Banach spaces and representations vanishing at infinity

Our main result is that the simple Lie group $G=Sp(n,1)$ acts properly isometrically on $L^p(G)$ if $p>4n+2$. To prove this, we introduce property ({\BP}_0^V), for $V$ be a Banach space: a locally compact group $G$ has property ({\BP}_0^V) if every affine isometric action of $G$ on $V$, such that the linear part is a $C_0$-representation of $G$, either has a fixed point or is metrically proper. We prove that solvable groups, connected Lie groups, and linear algebraic groups over a local field of characteristic zero, have property ({\BP}_0^V). As a consequence for unitary representations, we characterize those groups in the latter classes for which the first cohomology with respect to the left regular representation on $L^2(G)$ is non-zero; and we characterize uniform lattices in those groups for which the first $L^2$-Betti number is non-zero.Comment: 28 page

Problems with Using Evolutionary Theory in Philosophy

Does science move toward truths? Are present scientific theories (approximately) true? Should we invoke truths to explain the success of science? Do our cognitive faculties track truths? Some philosophers say yes, while others say no, to these questions. Interestingly, both groups use the same scientific theory, viz., evolutionary theory, to defend their positions. I argue that it begs the question for the former group to do so because their positive answers imply that evolutionary theory is warranted, whereas it is self-defeating for the latter group to do so because their negative answers imply that evolutionary theory is unwarranted

A Novel Fluid Resuscitation Strategy Modulates Pulmonary Transcription Factor Activation in a Murine Model of Hemorrhagic Shock

INTRODUCTION: Combining the hemodynamic and immune benefits of hypertonic saline with the anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline (HSPTX) as a hemorrhagic shock resuscitation strategy reduces lung injury when compared with the effects of Ringer's lactate (RL). We hypothesized that HSPTX exerts its anti-inflammatory effects by interfering with nuclear factor kappa B/cAMP response element-binding protein (NF-&#954;B-CREB) competition for the coactivator CREB-binding protein (CBP) in lung tissue, thus affecting pro-inflammatory mediator production. METHODS: Male Sprague-Dawley rats underwent 60 minutes of hemorrhagic shock to reach a mean arterial blood pressure of 35 mmHg followed by resuscitation with either RL or HSPTX (7.5% HS + 25 mg/kg PTX). After four hours, lung samples were collected. NF-&#954;B activation was assessed by measuring the levels of phosphorylated cytoplasmic inhibitor of kappa B (I-&#954;B) and nuclear NF-&#954;B p65 by western blot. NF-&#954;B and CREB DNA-binding activity were measured by electrophoretic mobility shift assay (EMSA). Competition between NF-&#954;B and CREB for the coactivator CBP was determined by immunoprecipitation. Interleukin-8 (IL-8) levels in the lung were measured by ELISA. RESULTS: RL resuscitation produced significantly higher levels of lung IL-8 levels, I-&#954;B phosphorylation, p65 phosphorylation, and NF-&#954;B DNA binding compared with HSPTX. NF-&#954;B-CBP-binding activity was similar in both groups, whereas CREB-CBP-binding activity was significantly increased with HSPTX. CREB-DNA binding-activity increased to a greater level with HSPTX compared with RL. DISCUSSION: HSPTX decreases lung inflammation following hemorrhagic shock compared with conventional resuscitation using RL through attenuation of NF-&#954;B signaling and increased CREB-DNA binding activity. HSPTX may have therapeutic potential in the attenuation of ischemia-reperfusion injury observed after severe hemorrhagic shock

The Problem of Confirmation in the Everett Interpretation

I argue that the Oxford school Everett interpretation is internally incoherent, because we cannot claim that in an Everettian universe the kinds of reasoning we have used to arrive at our beliefs about quantum mechanics would lead us to form true beliefs. I show that in an Everettian context, the experimental evidence that we have available could not provide empirical confirmation for quantum mechanics, and moreover that we would not even be able to establish reference to the theoretical entities of quantum mechanics. I then consider a range of existing Everettian approaches to the probability problem and show that they do not succeed in overcoming this incoherence

American political affiliation, 2003–43: a cohort component projection

The recent rise and stability in American party identification has focused interest on the long-term dynamics of party bases. Liberal commentators cite immigration and youth as forces which will produce a natural Democratic advantage in the future while conservative writers highlight the importance of high Republican fertility in securing Republican growth. These concerns foreground the neglect of demography within political science. This paper addresses this omission by conducting the first ever cohort component projection of American partisan populations to 2043 based on survey and census data. A number of scenarios are modeled, but, on current trends, we predict that American partisanship will shift much less than the nation’s ethnic composition because the parties’ age structures are similar. Still, our projections find that the Democrats gain two to three percentage points from the Republicans by 2043, mainly through immigration, though Republican fertility may redress the balance in the very long term