Update of the Devonian lithostratigraphic subdivision in the subsurface of the Campine Basin (northern Belgium)

The continental and mainly conglomeratic Booischot Formation is formally introduced for the strata intersected close to the base of the Booischot borehole from the Campine Basin. It is nearly 400 m thick and its upper part is Upper Givetian to Upper Frasnian in age whereas its lower part has not been dated so far. The Booischot borehole is overlain by the Upper Devonian marine Aisemont and Falisolle Formations which are capped by Famennian sandstones assigned to the Evieux Formation. These latter three lithostratigraphic units are also present in the Heibaart borehole, above a few metres of the Middle Frasnian Huccorgne Formation which rest directly on the Caledonian basement of the Brabant Massif, without any trace of the Booischot Formation. It appears that in the Campine Basin, the Devonian transgression arrived very late during the Frasnian. The Devonian succession at the northern margin of the Brabant Massif is very different from that of the north side of the Namur Basin and the Vis area characterized more particularly by the occurrence of Givetian marine deposits. Some rugose corals of this stage are figured for the first time from the Vis area. The conglomerates of the Booischot Formation are also compared to similar thick strata from the Givetian of NW Germany

Remote sensing and GIS-based analysis of cave development in the Suoimuoi Catchment (Son La - NW Vietnam)

Integration of remotely sensed imagery with ground surveys is a promising method in cave development studies. In this research a methodology was set up in which a variety of remote sensing and GIS techniques support cave analysis in the tropical karst area of the Suoimuoi catchment, NW Vietnam. In order to extract the maximum information from different remotely sensed data, the hue invariant IHS transformation was applied to integrate Landsat multispectral channels with the high resolution Landsat 7 ETM panchromatic channel. The resulting fused image was used, after enhancement, to visually and digitally extract lineaments. Aerial photos evaluated the extracted lineaments. Based on lineament density indices a fracture zone favorable for cave development is defined. The distance between caves and faults was investigated as well as the correspondence between the cave occurrence and the fracture zone

Characterization of Deep Geothermal Energy Resources in Low enthalpy sedimentary basins in Belgium using Electro-Magnetic Methods – CSEM and MT results

International audienceSedimentary basins in Northwest Europe have significant potential for low to medium enthalpy, deep geothermal energy resources. These resources are generally assessed using standard seismic exploration techniques to resolve geological structures. The ElectroMagnetic campaign carried-out in Mol area (Belgium) has shown that despite the presence of high level of industrialization, the resistivity of deep formations (>3km) can be recovered from MT and CSEM methods and hence provide very valuable information for the assessment of geothermal resources. 1. INTRODUCTION Sedimentary basins in Northwest Europe have significant potential for low to medium enthalpy, deep geothermal energy resources. These resources are generally assessed using standard seismic exploration techniques to resolve geological structures. However, the electrical resistivity parameter, which can be directly impacted by the presence of a geothermal reservoir is rarely investigated in such context. Therefore, the development of alternative and complementary exploration techniques such as Electromagnetic (EM) techniques may have an important role in reducing the cost and uncertainty associated with geothermal resource assessment

Serious fungal infections in Portugal

There is a lack of knowledge on the epidemiology of fungal infections worldwide because there are no reporting obligations. The aim of this study was to estimate the burden of fungal disease in Portugal as part of a global fungal burden project. Most published epidemiology papers reporting fungal infection rates from Portugal were identified. Where no data existed, specific populations at risk and fungal infection frequencies in those populations were used in order to estimate national incidence or prevalence, depending on the condition. An estimated 1,510,391 persons develop a skin or nail fungal infection each year. The second most common fungal infection in Portugal is recurrent vulvovaginal candidiasis, with an estimated 150,700 women (15-50 years of age) suffering from it every year. In human immunodeficiency virus (HIV)-infected people, oral or oesophageal candidiasis rates were estimated to be 19.5 and 16.8/100,000, respectively. Candidaemia affects 2.19/100,000 patients, in a total of 231 cases nationally. Invasive aspergillosis is less common than in other countries as chronic obstructive pulmonary disease (COPD) is uncommon in Portugal, a total of 240 cases annually. The estimated prevalence of chronic pulmonary aspergillosis after tuberculosis (TB) is 194 cases, whereas its prevalence for all underlying pulmonary conditions was 776 patients. Asthma is common (10% in adults) and we estimate 16,614 and 12,600 people with severe asthma with fungal sensitisation and allergic bronchopulmonary aspergillosis, respectively. Sixty-five patients develop Pneumocystis pneumonia in acquired immune deficiency syndrome (AIDS) and 13 develop cryptococcosis. Overall, we estimate a total number of 1,695,514 fungal infections starting each year in Portugal.info:eu-repo/semantics/publishedVersio

Diagnosis of Breakthrough Fungal Infections in the Clinical Mycology Laboratory: An ECMM Consensus Statement.

Breakthrough invasive fungal infections (bIFI) cause significant morbidity and mortality. Their diagnosis can be challenging due to reduced sensitivity to conventional culture techniques, serologic tests, and PCR-based assays in patients undergoing antifungal therapy, and their diagnosis can be delayed contributing to poor patient outcomes. In this review, we provide consensus recommendations on behalf of the European Confederation for Medical Mycology (ECMM) for the diagnosis of bIFI caused by invasive yeasts, molds, and endemic mycoses, to guide diagnostic efforts in patients receiving antifungals and support the design of future clinical trials in the field of clinical mycology. The cornerstone of lab-based diagnosis of breakthrough infections for yeast and endemic mycoses remain conventional culture, to accurately identify the causative pathogen and allow for antifungal susceptibility testing. The impact of non-culture-based methods are not well-studied for the definite diagnosis of breakthrough invasive yeast infections. Non-culture-based methods have an important role for the diagnosis of breakthrough invasive mold infections, in particular invasive aspergillosis, and a combination of testing involving conventional culture, antigen-based assays, and PCR-based assays should be considered. Multiple diagnostic modalities, including histopathology, culture, antibody, and/or antigen tests and occasionally PCR-based assays may be required to diagnose breakthrough endemic mycoses. A need exists for diagnostic tests that are effective, simple, cheap, and rapid to enable the diagnosis of bIFI in patients taking antifungals.S

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

© The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Serum amyloid P component (SAP, also known as Pentraxin 2; APCS gene) is a component of the humoral arm of innate immunity involved in resistance to bacterial infection and regulation of tissue remodeling. Here we investigate the role of SAP in antifungal resistance. Apcs-/- mice show enhanced susceptibility to A. fumigatus infection. Murine and human SAP bound conidia, activate the complement cascade and enhance phagocytosis by neutrophils. Apcs-/- mice are defective in vivo in terms of recruitment of neutrophils and phagocytosis in the lungs. Opsonic activity of SAP is dependent on the classical pathway of complement activation. In immunosuppressed mice, SAP administration protects hosts against A. fumigatus infection and death. In the context of a study of hematopoietic stem-cell transplantation, genetic variation in the human APCS gene is associated with susceptibility to invasive pulmonary aspergillosis. Thus, SAP is a fluid phase pattern recognition molecule essential for resistance against A. fumigatus.The contribution of the European Commission (ERC project PHII-669415; FP7 project 281608 TIMER; ESA/ITN, H2020-MSCA-ITN-2015-676129), Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR) (project FIRB RBAP11H2R9), Associazione Italiana Ricerca sul Cancro (AIRC IG-19014 and IG-21714, AIRC 5 × 1000 −9962 and −21147), the Italian Ministry of Health, the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) (NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023), the Fundação para a Ciência e Tecnologia (FCT) (UIDB/50026/2020, UIDP/50026/2020, PTDC/SAU-SER/29635/2017, PTDC/MED-GEN/28778/2017, CEECIND/04058/2018 and CEECIND/03628/2017), the European Union’s Horizon 2020 research and innovation program under grant agreement no. 847507 and the “la Caixa” Foundation (ID 100010434) and FCT under the agreement LCF/PR/HR17/52190003 is gratefully acknowledged.info:eu-repo/semantics/publishedVersio

The one health problem of azole resistance in Aspergillus fumigatus: current insights and future research agenda

Azole resistance is a concern for the management of diseases caused by Aspergillus fumigatus in humans. Azole fungicide use in the environment has been identified as a possible cause for development of resistance, which increases the complexity and number of stakeholders involved in this emerging problem. A workshop was held in Amsterdam early 2019 in which stakeholders, including medical and agricultural researchers, representatives from the government, public health, fungicide producers and end-users, reviewed the current evidence supporting environmental selection for resistance and to discuss which research and measures are needed to retain the effectiveness of the azole class for environmental and medical applications. This paper provides an overview of the latest insights and understanding of azole resistance development in the clinical setting and the wider environment. A One Health problem approach was undertaken to list and prioritize which research will be needed to provide missing evidence and to enable preventive intervention

Visualization and Movement as Configurations of Human-Nonhuman Engagements : Precolonial Geometric Earthwork Landscapes of the Upper Purus, Brazil

Producing geometric designs and images on materials, such as pottery, basketry, and bead artwork, as well as the human body, is elemental and widespread among Amazonian Indigenous peoples. In this article, we examine the different geometric forms identified in the precolonial geoglyph architecture of southwestern Amazonia in the context of geometric design making and relational ontologies. Our aim is to explore earthwork iconography through the lens of Amerindian visual arts and movement. Combining ethnographic and archaeological data from the Upper Purus, Brazil, the article shows how ancient history and socio-cosmology are deeply "written" onto the landscape in the form of geometric earthworks carved out of the soil, which materialize interactions between nonhuman and human actors. We underline skills in visualization, imaginative practices, and movement as ways to promote well-balanced engagements with animated life forms. Here, iconography inserted in the landscape is both a form of writing and also emerges as an agent, affecting people through visual and corporal practices.Peer reviewe