Dynamiques géographiques d'émergence et de coconstruction des destinations touristiques gourmandes : de la baie de Naples à la riviera d'Athènes (NADETOURGO): NADETOURGO

Projet de recherche Études touristiquesIn Naples and its bay, beyond the tourist promotion of pizza and the so-called “volcanic taste” (Boutain et Etcheverria, 2026), socio-professional actors in tourism and gastronomy offer culinary tourism experiences that highlight a wide range of agricultural food products as well as culinary and pastry preparations. These offerings take the form of food tours and cooking classes, visits to sites of production and commercialization, and tasting experiences.At the same time, "gourmand tourists"—through their practices, discourses and imaginaries, and through the ways they observe and experience places—directly contribute to these visible dynamics, from Naples to Sorrento and across the slopes of Mount Vesuvius.Adopting a comparative perspective, the case of the Bay of Naples will be placed in relation to that of the Athenian Riviera, where similar dynamics of gastronomization, touristification, heritagization, and eventification can also be observed.À Naples et sa baie, au-delà de la valorisation touristique des pizzas et du goût "volcanique" (Boutain et Etcheverria, 2026), les acteurs socioprofessionnels du tourisme et du gourmand proposent des offres touristiques gourmandes qui valorisent l'ensemble des produits agricoles alimentaires et des préparations culinaires et pâtissières se traduisant par des food tours et des cooking classes, des visites de lieux de production et de commercialisation et des dégustations. Concomitamment, les touristes gourmands, par leurs pratiques, par leurs discours et imaginaires, par leurs regards, participent directement à ces dynamiques visibles de Naples à Sorrento en passant par les pentes du Vésuve. Dans une démarche comparative, l'exemple de la baie de Naples sera mis en perspective avec celui de la riviera d'Athènes, où les dynamiques de gastronomisation, de touristification, de patrimonialisation et d'événementialisation sont également observables

Let’s not make things worse in the management of tacrolimus overdoses due to nirmatrelvir/ritonavir

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Discrete numerical analysis of cohesive granular flow in a thin rotating drum: Flow regimes and cohesion estimation

International audienceIn this study, we investigate the rheological behavior of cohesive granular flows within a rotating drum geometry using discrete element method (DEM) simulations. By systematically varying particle size, cohesion, and stiffness, we identify the emergence of distinct flow regimes-consistent with prior experimental observations. While the transitions between these regimes are primarily governed by cohesion, particle stiffness is also shown to significantly influence flow dynamics.To interpret the numerical results, we employ a dimensional analysis rooted in the physics of adhesive particle collisions. This analysis provides a conceptual framework for the remainder of the paper, which explores how "upscaled" discrete simulations can replicate experimental findings and help infer interparticle contact properties such as the adhesive surface energy. Notably, we use it to examine rotating drum experiments involving a unique class of granular materials, ice powders, which holds particular relevance in planetary science applications, and which flowability was shown to be strongly temperature-dependent.</div

GATE 10 Monte Carlo particle transport simulation: II. Architecture and innovations

International audienceOver the past years, we have developed GATE version 10, a major re-implementation of the long-standing Geant4-based Monte Carlo application for particle and radiation transport simulation in medical physics. This release introduces many new features and significant improvements, most notably a Python-based user interface replacing the legacy static input files. The new functionality of GATE version 10 is described in the part 1 companion paper (Sarrutet al2025 arXiv:2507.09842). The development brought significant challenges. In this paper, we present the solutions that we have developed to overcome these challenges. In particular, we present a modular design that robustly manages the core components of a simulation: particle sources, geometry, physics processes, and data acquisition. The architecture consists of integrated C++ and Python codes. This framework allows for the precise, time-aware generation of primary particles, a critical requirement for accurately modeling positron emission tomography, radionuclide therapies, or prompt-gamma timing systems. We present how GATE 10 handles complex Geant4 physics settings while exposing a simple interface to the user. Furthermore, we describe the methodological solutions that facilitate the seamless integration of advanced physics models and variance reduction techniques. The architecture supports sophisticated scoring of physical quantities (such as Linear Energy Transfer and Relative Biological Effectiveness) and is designed for multithreaded execution. The new user interface allows researchers to script complex simulation workflows and directly couple external tools, such as artificial intelligence models for source generation or detector response. By detailing these architectural innovations, we demonstrate how GATE 10 provides a more powerful and flexible tool for research and innovation in medical physics. This paper is not intended to be a developer guide. Its purpose is to share with the research community in-depth explanations of our development effort that made the new GATE 10 possible

Who are the healthcare professionals involved in interprofessional team meetings in French multidisciplinary primary care centres? A quantitative analysis of eight centres

International audienceBACKGROUND: Interprofessional collaboration is crucial for providing high-quality care to patients with complex conditions in primary care. In France, multidisciplinary primary care centres (MPCC) receive funding if they organise at least 6 interprofessional team meetings (ITM) per year to discuss complex patient situations and collectively define care strategies. It remains unclear how ITM have been implemented in France. This study analyses healthcare professionals’ involvement in ITMs within MPCCs.METHOD: A multicenter retrospective quantitative study in 8 French MPCCs based on the analysis of ITM reports for the period from 2018 to 2019 was conducted. RESULTS: 1733 patients’situations (n = 1733 cases) discussed during ITMs were analysed. The 8 MPCCs were heterogeneous in terms of geographical location, creation date, and size (3 MPCCs with &gt; 20,000 patients followed by more than 60 professionals and 3 MPCCs with &lt; 20 professionals). On average, five healthcare professionals attended each ITM, with huge variations among MPCCs. The nurse-general practitioner (GP) pair was central. At least one GP was present at 89% (n = 1469) and nurses at 38.15% (n = 630) of ITMs. Participation of other professionals was less frequent and varied according to the MPCC. Physiotherapists were present at 7.8% of ITMs, and other healthcare professionals were present at &lt; 6% of ITMs, including pharmacists (3% of ITMs). In some cases, healthcare professionals external to MPCC, particularly those related to mental health, were also involved in ITMs.CONCLUSIONS: Depending on the MPCC, the professionals involved in ITM vary widely, with the nurse-GP pair at the centre. The relative absence of certain professionals needs to be analysed in order to encourage interprofessional working

Lactuchelins represent lipopeptide siderophores produced by <i>Pseudomonas lactucae</i> that inhibit <i>Xanthomonas campestris</i>

International audienceThe seed is a habitat with limited resources and space. Although it is widely accepted that microbial competition is a key driver of the assembly of seed-associated microbial communities, the underlying mechanisms of this competition are not well understood. The initial objective of this work was to assess the importance of contact-independent microbial competition between the phytopathogenic bacterium Xanthomonas campestris pv. campestris 8004 (Xcc8004) and 30 strains representative of the bacterial populations most commonly associated with radish (Raphanus sativus) seeds. We identified Pseudomonas lactucae CFBP 13502 as a potent inhibitor of Xcc8004, mediated by exometabolites, specifically induced by certain seed-borne strains. Transcriptomic analysis linked this inducible activity to the upregulation of a gene cluster encoding a lipopeptide siderophore. Targeted gene deletion in P. lactucae CFBP 13502 confirmed that this cluster is essential for antagonism against Xcc8004. Furthermore, iron supplementation abolished this inhibitory effect, strongly supporting iron chelation as the underlying mechanism. Through comparative metabolomics, we elucidated the structure of a family of lipopeptide siderophores, produced by P. lactucae CFBP 13502, which we named lactuchelins. Our findings provide molecular evidence of competitive exclusion mechanisms at the seed microbiome interface, highlighting lactuchelins as a promising avenue for the development of seedbased biocontrol strategies against seed-borne phytopathogens

Impact of Long-Term Cumulative Exposure to Wildfire Smoke PM2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States

International audienceBackground: As wildfires intensify in a warming climate, prolonged exposure to smoke-derived fine particulate matter (PM2.5) poses significant health risks. However, the cardiovascular impacts of long-term cumulative exposure to smoke PM2.5 remain understudied.Objectives: This study sought to investigate associations between long-term cumulative exposure to wildfire smoke PM2.5 and first cardiovascular disease (CVD) hospitalizations among U.S. Medicare beneficiaries and to assess potential effect modification by sociodemographic factors.Methods: This population-based cohort study analyzed 65.2 million Medicare beneficiaries (aged ≥65 years) across the contiguous United States from 2017 to 2022. Wildfire smoke PM2.5 was estimated with the use of a spatiotemporal model at 10 × 10 km resolution and assigned to beneficiaries' residential ZIP codes. We applied quasi-Poisson regressions to estimate relative risks (RRs) and 95% CIs of CVD hospitalizations for each decile of wildfire smoke PM2.5 concentrations, using exposures below the 1st percentile (0.08 μg/m3) as reference.Results: Three-year average wildfire smoke PM2.5 was significantly associated with increased CVD hospitalization risk. We observed a nonlinear pattern peaking at moderate exposure levels (wildfire smoke PM2.5 concentrations between 0.26 and 0.32 μg/m3) for overall CVD (RR: 1.04; 95% CI: 1.03-1.05), ischemic heart disease (RR: 1.07; 95% CI: 1.06-1.09), and arrhythmias (RR: 1.06; 95% CI: 1.04-1.07). Cerebrovascular hospitalizations showed an increasing trend across exposure levels. Beneficiaries of lower socioeconomic status were potentially more vulnerable.Conclusions: Long-term cumulative wildfire smoke PM2.5 exposure is associated with elevated CVD hospitalization risk, varying by exposure levels and individual characteristics. These findings underscore the need for targeted public health strategies to mitigate cardiovascular risks among older adults with the occurrence of wildfires

Benzo[a]pyrene induces an adaptive mitochondrial-dynamics response in endothelial cells, at human relevant concentration

International audienceAlthough polycyclic aromatic hydrocarbons (PAHs) are a public health concern in many countries, the cellular response at concentrations representative of human exposure remains poorly defined. At the cellular level, because of their function and composition, mitochondria are privileged targets of these contaminants. PAHs such as benzo[a]pyrene (B[a]P) can compromise mitochondrial functions. Using an integrated approach, we examined how low-dose B[a]P disrupts the three determinants of mitochondrial homeostasis (biogenesis, mitophagy, and dynamics) and triggers apoptosis. We assessed the cellular response to a low-dose of B[a]P (100 nM) in the human microvascular endothelial cell line HMEC-1. Endothelial cells are sensitive to PAHs and display marked reactivity to effectors of B[a]P toxicity, such as oxidative stress. We show that B[a]P doesn’t modify mRNA expression of mitochondrial biogenesis markers but causes a blockage of autophagic flux. In parallel, we observe early and transient mitochondrial elongation accompanied by decreased expression of the fission factors DRP1 and MFF, and increased intracellular concentration of ATP. These events constitute cellular signatures of stress-induced mitochondrial hyperfusion (SIMH), a mechanism of resistance to apoptosis. B[a]P eventually causes apoptosis of HMEC-1 cells, which is mitochondria-dependent, caspase-independent, requires B[a]P bioactivation by CYP1 family enzymes, and is only detectable after 24 h of exposure when SIMH markers decline. Our results show that endothelial cells can mobilize SIMH to delay and limit B[a]P-induced apoptosis. We confirm that mitochondria, at human-relevant doses, are early sensitive targets of B[a]P and show that changes in mitochondrial dynamics constitute an early readout of cellular responses to B[a]P

Offline Reinforcement Learning Of High-Quality Behaviors Under Robust Style Alignment

We study offline reinforcement learning of style-conditioned policies using explicit style supervision via subtrajectory labeling functions. In this setting, aligning style with high task performance is particularly challenging due to distribution shift and inherent conflicts between style and reward. Existing methods, despite introducing numerous definitions of style, often fail to reconcile these objectives effectively. To address these challenges, we propose a unified definition of behavior style and instantiate it into a practical framework. Building on this, we introduce Style-Conditioned Implicit Q-Learning (SCIQL), which leverages offline goal-conditioned RL techniques, such as hindsight relabeling and value learning, and combine it with a new Gated Advantage Weighted Regression mechanism to efficiently optimize task performance while preserving style alignment. Experiments demonstrate that SCIQL achieves superior performance on both objectives compared to prior offline methods

Del animal colonial al animal mestizo: a propósito de las metamorfosis de la fábula en el Río de la Plata

International audienceAbstract: This article focuses on the evolution of animal stories and fables in the literature of the Río de la Plata between the colonial period and the 20th century. It does not examine the literary theme of transformation, or metamorphosis, as explored by Ovid and Kafka, because in the examples discussed, the animals already appear humanized and/or personified. The anthropomorphic ingredients in the protagonists of these stories take on different degrees of importance, but what is interesting is the mixed presence of elements of European or Latin American reality in the representation of these animal beings assimilated to humans. The motif is explored through two writers from the colonial era (Ruy Díaz de Guzmán and Juan Cruz Varela) and two writers from the 20th century (Juana de Ibarbourou and María Elena Walsh). The hybridity of these characters is imbued with a distinct and gradual vision of reality: Europeanizing or indigenous.Resumen: Este artículo se interesa por la evolución del relato animal y de la fábula en la literatura del Río de la Plata entre la época colonial y el siglo XX. No se estudia el tópico literario de la transformación que Ovidio y Kafka inscribieron en la literatura, la metamorfosis, porque en los ejemplos tratados los animales ya aparecen humanizados y/o personificados. Los ingredientes antropomorfos en los protagonistas de estos relatos cobran diferentes grados de importancia, pero lo que interesa es la presencia mixta de elementos de la realidad europea o latinoamericana en la representación de estos seres animales asimiladosal ser humano. El motivo es explorado a través de dos escritores de la época colonial (Ruy Díaz de Guzmán y Juan Cruz Varela) y dos escritoras del siglo XX(Juana de Ibarbourou y María Elena Walsh). La hibridez de estos personajes está impregnada por una visión distinta y graduada de la realidad: europeizante o autóctona