2,908 research outputs found
Economic drivers in the Amazon from the 19th century to the 1970s.
The objective of this chapter is to identify the main economic processes that occurred in the Brazilian, Andean, and Guyanese Amazon during the nineteenth and twentieth centuries until the 1970s. Specifically, the chapter describes the history of extractivism and the effects of geopolitical reconfiguration in the Amazon after the processes of emancipation or decolonization. It analyses the extractive history based on quina barks (species of the genus Chinchona, Rubiaceae) and rubber (Hevea brasiliensis, Euphorbiacae), as well as the characteristics and practices developed by social actors related to the local and regional economy that arose from these exploitations. It also includes a synthesis of the history of the emergence of the extractive economy based on the exploitation of oil, minerals (mainly gold), and the beginning of wildlife trafficking and the basis for the emergence of mechanized agriculture, intensive livestock herding, and mega-infrastructure, among others. Finally, it identifies the main lessons learned and key messages from the use of "historical commodities" in the Amazon and their implications in contemporary patterns of use of other resources in the Amazon, such as the Brazil nut (Bertholletia excelsa, Lecythidaceae)
FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells
Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream signalling. Here we investigated how FAK regulates signalling resulting from the overexpression of the RTKs RET and EGFR. FAK suppressed RTKs signalling in Drosophila melanogaster epithelia by impairing MAPK pathway. This regulation was also observed in MDA-MB-231 human breast cancer cells, suggesting it is a conserved phenomenon in humans. Mechanistically, FAK reduced receptor recycling into the plasma membrane, which resulted in lower MAPK activation. Conversely, increasing the membrane pool of the receptor increased MAPK pathway signalling. FAK is widely considered as a therapeutic target in cancer biology; however, it also has tumour suppressor properties in some contexts. Therefore, the FAK-mediated negative regulation of RTK/MAPK signalling described here may have potential implications in the designing of therapy strategies for RTK-driven tumours
Macroscopic superposition states of ultracold bosons in a double-well potential
We present a thorough description of the physical regimes for ultracold
bosons in double wells, with special attention paid to macroscopic
superpositions (MSs). We use a generalization of the Lipkin-Meshkov-Glick
Hamiltonian of up to eight single particle modes to study these MSs, solving
the Hamiltonian with a combination of numerical exact diagonalization and
high-order perturbation theory. The MS is between left and right potential
wells; the extreme case with all atoms simultaneously located in both wells and
in only two modes is the famous NOON state, but our approach encompasses much
more general MSs. Use of more single particle modes brings dimensionality into
the problem, allows us to set hard limits on the use of the original two-mode
LMG model commonly treated in the literature, and also introduces a new mixed
Josephson-Fock regime. Higher modes introduce angular degrees of freedom and MS
states with different angular properties.Comment: 15 pages, 8 figures, 1 table. Mini-review prepared for the special
issue of Frontiers of Physics "Recent Progresses on Quantum Dynamics of
Ultracold Atoms and Future Quantum Technologies", edited by Profs. Lee, Ueda,
and Drummon
A discrete firefly algorithm to solve a rich vehicle routing problem modelling a newspaper distribution system with recycling policy
A real-world newspaper distribution problem with recycling policy is tackled in this work. In order to meet all the complex restrictions contained in such a problem, it has been modeled as a rich vehicle routing problem, which can be more specifically considered as an asymmetric and clustered vehicle routing problem with simultaneous pickup and deliveries, variable costs and forbidden paths (AC-VRP-SPDVCFP). This is the first study of such a problem in the literature. For this reason, a benchmark composed by 15 instances has been also proposed. In the design of this benchmark, real geographical positions have been used, located in the province of Bizkaia, Spain. For the proper treatment of this AC-VRP-SPDVCFP, a discrete firefly algorithm (DFA) has been developed. This application is the first application of the firefly algorithm to any rich vehicle routing problem. To prove that the proposed DFA is a promising technique, its performance has been compared with two other well-known techniques: an evolutionary algorithm and an evolutionary simulated annealing. Our results have shown that the DFA has outperformed these two classic meta-heuristics
COVID-19 mental health care toolkit: an international collaborative effort by Early Career Psychiatrists section
The collaborative effort of an international research team from the Early Career Psychiatrists section of the World Psychiatry Association has brought about an easy-to-use, quick and stepwise mental health care toolkit for the identification and appropriate referral of those in need of mental health care during the pandemic. This simple guide can be applied in the general outpatient setting and is catered for all healthcare professionals, regardless of their expertise within the mental health field with minimal training. It is our hope that by incorporating this toolkit into our daily clinical care during the pandemic for high-risk patients and patients with non-specific complaints, we will be able to bridge the mental health gap present in our society
Observation of two new baryon resonances
Two structures are observed close to the kinematic threshold in the mass spectrum in a sample of proton-proton collision data, corresponding
to an integrated luminosity of 3.0 fb recorded by the LHCb experiment.
In the quark model, two baryonic resonances with quark content are
expected in this mass region: the spin-parity and
states, denoted and .
Interpreting the structures as these resonances, we measure the mass
differences and the width of the heavier state to be
MeV,
MeV,
MeV, where the first and second
uncertainties are statistical and systematic, respectively. The width of the
lighter state is consistent with zero, and we place an upper limit of
MeV at 95% confidence level. Relative
production rates of these states are also reported.Comment: 17 pages, 2 figure
Differential branching fraction and angular analysis of the decay B0âKâ0ÎŒ+ÎŒâ
The angular distribution and differential branching fraction of the decay B 0â K â0 ÎŒ + ÎŒ â are studied using a data sample, collected by the LHCb experiment in pp collisions at sâ=7 TeV, corresponding to an integrated luminosity of 1.0 fbâ1. Several angular observables are measured in bins of the dimuon invariant mass squared, q 2. A first measurement of the zero-crossing point of the forward-backward asymmetry of the dimuon system is also presented. The zero-crossing point is measured to be q20=4.9±0.9GeV2/c4 , where the uncertainty is the sum of statistical and systematic uncertainties. The results are consistent with the Standard Model predictions
Observation of an Excited Bc+ State
Using pp collision data corresponding to an integrated luminosity of 8.5 fb-1 recorded by the LHCb experiment at center-of-mass energies of s=7, 8, and 13 TeV, the observation of an excited Bc+ state in the Bc+Ï+Ï- invariant-mass spectrum is reported. The observed peak has a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(Bc+) MeV/c2, where the last uncertainty is due to the limited knowledge of the Bc+ mass. It is consistent with expectations of the Bcâ(2S31)+ state reconstructed without the low-energy photon from the Bcâ(1S31)+âBc+Îł decay following Bcâ(2S31)+âBcâ(1S31)+Ï+Ï-. A second state is seen with a global (local) statistical significance of 2.2Ï (3.2Ï) and a mass of 6872.1±1.3(stat)±0.1(syst)±0.8(Bc+) MeV/c2, and is consistent with the Bc(2S10)+ state. These mass measurements are the most precise to date
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