SN 2003du: 480 days in the life of a normal type Ia supernova

Peer reviewe

Genistein supplementation and cardiac function in postmenopausal women with metabolic syndrome: Results from a pilot strain-echo study

Genistein, a soy-derived isoflavone,may improve cardiovascular risk profile in postmenopausal women with metabolic syndrome (MetS), but few literature data on its cardiac effects in humans are available. The aim of this sub-study of a randomized double-blind case-control study was to analyze the effect on cardiac function of one-year genistein dietary supplementation in 22 post-menopausal patients with MetS. Participants received 54 mg/day of genistein (n = 11) or placebo (n = 11) in combination with a Mediterranean-style diet and regular exercise. Left ventricular (LV) systolic function was assessed as the primary endpoint, according to conventional and strain-echocardiography measurements. Also, left atrial (LA) morphofunctional indices were investigated at baseline and at the final visit. Results were expressed as median with interquartile range (IQ). A significant improvement of LV ejection fraction (20.3 (IQ 12.5) vs. -1.67 (IQ 24.8); p = 0.040)), and LA area fractional change (11.1 (IQ 22.6) vs. 2.8 (9.5); p = 0.034)) were observed in genistein patients compared to the controls, following 12 months of treatment. In addition, body surface area indexed LA systolic volume and peak LA longitudinal strain significantly changed from basal to the end of the study in genistein-treated patients. One-year supplementation with 54 mg/day of pure genistein improved both LV ejection fraction and LA remodeling and function in postmenopausal women with MetS

Optimization clustering techniques on register unemployment data

An important strategy for data classification consists in organising data points in clusters. The k-means is a traditional optimisation method applied to cluster data points. Using a labour market database, aiming the segmentation of this market taking into account the heterogeneity resulting from different unemployment characteristics observed along the Portuguese geographical space, we suggest the application of an alternative method based on the computation of the dominant eigenvalue of a matrix related with the distance among data points. This approach presents results consistent with the results obtained by the k-means.info:eu-repo/semantics/publishedVersio

SN 1999ga: a low-luminosity linear type II supernova?

Type II-linear supernovae are thought to arise from progenitors that have lost most of their H envelope by the time of the explosion, and they are poorly understood because they are only occasionally discovered. It is possible that they are intrinsically rare, but selection effects due to their rapid luminosity evolution may also play an important role in limiting the number of detections. In this context, the discovery of a subluminous type II-linear event is even more interesting. We investigate the physical properties and characterise the explosion site of the type II SN 1999ga, which exploded in the nearby spiral galaxy NGC 2442. Spectroscopic and photometric observations of SN 1999ga allow us to constrain the energetics of the explosion and to estimate the mass of the ejected material, shedding light on the nature of the progenitor star in the final stages of its life. The study of the environment in the vicinity of the explosion site provides information on a possible relation between these unusual supernovae and the properties of the galaxies hosting them. Despite the lack of early-time observations, we provide reasonable evidence that SN 1999ga was probably a type II-linear supernova that ejected a few solar masses of material, with a very small amount of radioactive elements of the order of 0.01 solar masses.Comment: 11 pages, 9 figures. Accepted for publication in A&A (March 28, 2009

Gaia data release 1: Principles of the photometric calibration of the G band

Context. Gaia is an ESA cornerstone mission launched on 19 December 2013 aiming to obtain the most complete and precise 3D map of our Galaxy by observing more than one billion sources. This paper is part of a series of documents explaining the data processing and its results for Gaia Data Release 1, focussing on the G band photometry. Aims. This paper describes the calibration model of the Gaia photometric passband for Gaia Data Release 1. Methods. The overall principle of splitting the process into internal and external calibrations is outlined. In the internal calibration, a self-consistent photometric system is generated. Then, the external calibration provides the link to the absolute photometric flux scales. Results. The Gaia photometric calibration pipeline explained here was applied to the first data release with good results. Details are given of the various calibration elements including the mathematical formulation of the models used and of the extraction and preparation of the required input parameters (e.g. colour terms). The external calibration in this first release provides the absolute zero point and photometric transformations from the Gaia G passband to other common photometric systems. Conclusions. This paper describes the photometric calibration implemented for the first Gaia data release and the instrumental effects taken into account. For this first release no aperture losses, radiation damage, and other second-order effects have not yet been implemented in the calibration.Comment: 15 pages, 16 figures, Gaia data release 1 documentation special volum

An asymmetric explosion as the origin of spectral evolution diversity in type Ia supernovae

Type Ia Supernovae (SNe Ia) form an observationally uniform class of stellar explosions, in that more luminous objects have smaller decline-rates. This one-parameter behavior allows SNe Ia to be calibrated as cosmological `standard candles', and led to the discovery of an accelerating Universe. Recent investigations, however, have revealed that the true nature of SNe Ia is more complicated. Theoretically, it has been suggested that the initial thermonuclear sparks are ignited at an offset from the centre of the white-dwarf (WD) progenitor, possibly as a result of convection before the explosion. Observationally, the diversity seen in the spectral evolution of SNe Ia beyond the luminosity decline-rate relation is an unresolved issue. Here we report that the spectral diversity is a consequence of random directions from which an asymmetric explosion is viewed. Our findings suggest that the spectral evolution diversity is no longer a concern in using SNe Ia as cosmological standard candles. Furthermore, this indicates that ignition at an offset from the centre of is a generic feature of SNe Ia.Comment: To appear in Nature, 1st July 2010 issue. 36 pages including supplementary materials. 4 figures, 3 supplementary figures, 1 supplementary tabl

NTT and NOT spectroscopy of SDSS-II supernovae

Context. The SDSS-II Supernova Survey, conducted between 2005 and 2007, was designed to detect a large number of Type Ia supernovae (SNe Ia) around z~0.2, the redshift "gap" between low-z and high-z SN searches. The survey has provided multi-band photometric lightcurves for variable targets, and SN candidates were scheduled for spectroscopic observations, primarily to provide SN classification and accurate redshifts. We present SN spectra obtained in 2006 and 2007 using the NTT and the NOT. Aims. We provide an atlas of SN spectra in the range z =0.03-0.32 that complements the well-sampled lightcurves from SDSS-II in the forthcoming three-year SDSS SN cosmology analysis. The sample can, for example, be used for spectral studies of SNe Ia, which are critical for understanding potential systematic effects when SNe are used to determine cosmological distances. Methods. The spectra were reduced in a uniform manner, and special care was taken in estimating the uncertainties for the different processing steps. Host-galaxy light was subtracted when possible and the SN type fitted using the SuperNova IDentification code (SNID). We also present comparisons between spectral and photometric dating using SALT lightcurve fits to the photometry from SDSS-II, as well as the global distribution of our sample in terms of the lightcurve parameters: stretch and colour. Results. We report new spectroscopic data from 141 SNe Ia, mainly between -9 and +15 days from lightcurve maximum, including a few cases of multi-epoch observations. This homogeneous, host-galaxy subtracted, SN Ia spectroscopic sample is among the largest such data sets and unique in its redshift interval. The sample includes two potential SN 1991T-like SNe (SN 2006on and SN 2007ni) and one potential SN 2002cx-like SN (SN 2007ie). In addition, the new compilation includes spectra from 23 confirmed Type II and 8 Type Ib/c SNe.Comment: Accepted for publication in A&

Significance of P16INK4A hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study

BACKGROUND: Methylation of the p16 promoter is one of the most frequent mechanisms of gene inactivation; its incidence is extremely variable according to the type of tumor involved. Our purpose was to analyze the hypermethylation of the p16 promoter in laryngeal squamous cell carcinomas (LSCC), salivary gland (SG) tumors and in colorectal cancer (CRC), to detect any possible association with the clinicopathological features and to determine the prognostic significance of the p16 gene in the tumors analyzed. PATIENTS AND METHODS: The hypermethylation of the p16 promoter was prospectively analyzed, by MSP, in a consecutive series of 64 locally advanced LSCC patients, in a consecutive series of 33 SG tumor patients and in a consecutive series of 66 sporadic CRC patients. RESULTS: Hypermethylation was observed in 9% of the LSCC cases, in all cases of SG cancer and in 21% of the CRC cases. No significant association was observed between p16 hypermethylation and clinicopathological variables in all the tissue samples analyzed. Moreover at univariate analysis p16 mutations were not independently related at disease relapse and death in LSCC and CRC. CONCLUSIONS: The results of this study suggest that the lack of p16 function could happen in advanced stage of SG tumors

A Study of the Type II-P Supernova 2003gd in M74

We present photometric and spectroscopic data of the type II-P supernova 2003gd, which was discovered in M74 close to the end of its plateau phase. SN 2003gd is the first type II supernova to have a directly confirmed red supergiant progenitor. We compare SN 2003gd with SN 1999em, a similar type II-P supernova, and estimate an explosion date of 18th March 2003. We determine a reddening towards the supernova of E(B-V) = 0.14+/-0.06, using three different methods. We also calculate three new distances to M74 of 9.6+/-2.8 Mpc, 7.7+/-1.7 Mpc and 9.6+/-2.2 Mpc. The former was estimated using the Standardised Candle Method (SCM), for type II supernovae, and the latter two using the Brightest Supergiants Method (BSM). When combined with existing kinematic and BSM distance estimates, we derive a mean value of 9.3+/-1.8 Mpc. SN 2003gd was found to have a lower tail luminosity compared to other ``normal'' type II-P SNe bringing into question the nature of this supernova. We present a discussion concluding that this is a ``normal'' type II-P supernova which is consistent with the observed progenitor mass of 8(+4/-2) Mo.Comment: 23 pages, 24 figures to appear in MNRA

Il bilancio idrico nel malato di terapia intensiva

Aim. In the critically ill patient the hemodynamic management is essential. Usually the hemodynamic status is estimated by the measurement of the intravascular pressure or volume and by computing the fluid balance, while the change in body weight estimates the total body water. The fluid balance is computed by subtracting the fluid output to the input. Although the input (fluids, drugs, infusion....) are well known, the output are difficult to correctly compute, because they depend on several factors such as the body-room temperature, amount of humidity and may change with time. Aim of this study was to prospectively evaluate the accuracy of the fluid balance compared to the body weight measured by a dedicated mattress (Hill-Rom®). Methods. Fifteen critically ill patients were enrolled (mean age of 63.2±19.7 years, body mass index of 24.9±3.5 kg/m2) and the measurements were computed every 8 hours. The data were analyzed by the Bland-Altman test. Results. Four-hundred and seventy-two measurements for a mean intensive care stay of 12.3.±7.3 days were computed. The Bland-Altamn showed a great inaccuracy, because the agreement (the difference between the 2 methods) was poor with a standard deviation of 1 840 L. Conclusion. Although the fluid balance was not accurate, the only body weight without any intravascular measurement is not helpful for a correct clinical hemodynamic management of the patient