69 research outputs found
Implementation and first results of the KM3NeT real-time core-collapse supernova neutrino search
The authors acknowledge the financial support of the funding agencies: Agence Nationale de la Recherche (contract ANR-15-CE31-0020), Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX-0001), Paris ile-de-France Region, France; Shota Rustaveli National Science Foundation of Georgia (SRNSFG, FR-18-1268), Georgia; Deutsche Forschungsgemeinschaft (DFG), Germany; The General Secretariat of Research and Technology (GSRT), Greece; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Universita e della Ricerca (MIUR), PRIN 2017 program (Grant NAT-NET 2017W4HA7S) Italy; Ministry of Higher Education Scientific Research and Professional Training, ICTP through Grant AF-13, Morocco; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; The National Science Centre, Poland (2015/18/E/ST2/00758); National Authority for Scientific Research (ANCS), Romania; Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento (refs. PGC2018-096663-B-C41, -A-C42, -B-C43, -B-C44) (MCIU/FEDER), Generalitat Valenciana: Prometeo (PROMETEO/2020/019), Grisolia (ref. GRISOLIA/2018/119) and GenT (refs. CIDEGENT/2018/034, /2019/043, /2020/049) programs, Junta de Andalucia (ref. A-FQM-053-UGR18), La Caixa Foundation (ref. LCF/BQ/IN17/11620019), EU: MSC program (ref. 101025085), Spain.The KM3NeT research infrastructure is unconstruction
in the Mediterranean Sea. KM3NeT will study
atmospheric and astrophysical neutrinos with two multipurpose
neutrino detectors, ARCA and ORCA, primarily
aimed at GeVâPeV neutrinos. Thanks to the multiphotomultiplier
tube design of the digital optical modules,
KM3NeT is capable of detecting the neutrino burst from
a Galactic or near-Galactic core-collapse supernova. This potential is already exploitable with the first detection units
deployed in the sea. This paper describes the real-time implementation
of the supernova neutrino search, operating on the
two KM3NeT detectors since the first months of 2019. A
quasi-online astronomy analysis is introduced to study the
time profile of the detected neutrinos for especially significant
events. Themechanism of generation and distribution of
alerts, aswell as the integration into theSNEWSandSNEWS
2.0 global alert systems, are described. The approach for the
follow-up of external alerts with a search for a neutrino excess
in the archival data is defined. Finally, an overviewof the current
detector capabilities and a report after the first two years
of operation are given.French National Research Agency (ANR)European Commission ANR-15-CE31-0020Centre National de la Recherche Scientifique (CNRS)Commission EuropeenneInstitut Universitaire de France (IUF)LabEx UnivEarthS ANR-10-LABX-0023
ANR-18-IDEX-0001Shota Rustaveli National Science Foundation of Georgia (SRNSFG), Georgia FR-18-1268German Research Foundation (DFG)Greek Ministry of Development-GSRTIstituto Nazionale di Fisica Nucleare (INFN)Ministry of Education, Universities and Research (MIUR)PRIN 2017 program, Italy NAT-NET 2017W4HA7SMinistry of Higher Education Scientific Research and Professional Training, ICTP, Morocco AF-13Netherlands Organization for Scientific Research (NWO)
Netherlands GovernmentNational Science Centre, Poland 2015/18/E/ST2/00758National Authority for Scientific Research (ANCS), RomaniaMinisterio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento PGC2018-096663-B-C41
PGC2018-096663-A-C42
PGC2018-096663-B-C43
PGC2018-096663-B-C44Generalitat Valenciana PROMETEO/2020/019Grisolia program GRISOLIA/2018/119
CIDEGENT/2018/034Junta de Andalucia A-FQM-053-UGR18La Caixa Foundation LCF/BQ/IN17/11620019EU: MSC program 101025085Paris Ile-de-France Region, FranceGenT program CIDEGENT/2018/034
CIDEGENT/2019/043
CIDEGENT/2020/04
Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization
Probing invisible neutrino decay with KM3NeT-ORCA
In the era of precision measurements of the neutrino oscillation parameters,
upcoming neutrino experiments will also be sensitive to physics beyond the
Standard Model. KM3NeT/ORCA is a neutrino detector optimised for measuring
atmospheric neutrinos from a few GeV to around 100 GeV. In this paper, the
sensitivity of the KM3NeT/ORCA detector to neutrino decay has been explored. A
three-flavour neutrino oscillation scenario, where the third neutrino mass
state decays into an invisible state, e.g. a sterile neutrino, is
considered. We find that KM3NeT/ORCA would be sensitive to invisible neutrino
decays with ~ at confidence
level, assuming true normal ordering. Finally, the impact of neutrino decay on
the precision of KM3NeT/ORCA measurements for ,
and mass ordering have been studied. No significant effect of neutrino decay on
the sensitivity to these measurements has been found.Comment: 27 pages, 14 figures, bibliography updated, typos correcte
Prospects for combined analyses of hadronic emission from -ray sources in the Milky Way with CTA and KM3NeT
The Cherenkov Telescope Array and the KM3NeT neutrino telescopes are major
upcoming facilities in the fields of -ray and neutrino astronomy,
respectively. Possible simultaneous production of rays and neutrinos
in astrophysical accelerators of cosmic-ray nuclei motivates a combination of
their data. We assess the potential of a combined analysis of CTA and KM3NeT
data to determine the contribution of hadronic emission processes in known
Galactic -ray emitters, comparing this result to the cases of two
separate analyses. In doing so, we demonstrate the capability of Gammapy, an
open-source software package for the analysis of -ray data, to also
process data from neutrino telescopes. For a selection of prototypical
-ray sources within our Galaxy, we obtain models for primary proton and
electron spectra in the hadronic and leptonic emission scenario, respectively,
by fitting published -ray spectra. Using these models and instrument
response functions for both detectors, we employ the Gammapy package to
generate pseudo data sets, where we assume 200 hours of CTA observations and 10
years of KM3NeT detector operation. We then apply a three-dimensional binned
likelihood analysis to these data sets, separately for each instrument and
jointly for both. We find that the largest benefit of the combined analysis
lies in the possibility of a consistent modelling of the -ray and
neutrino emission. Assuming a purely leptonic scenario as input, we obtain, for
the most favourable source, an average expected 68% credible interval that
constrains the contribution of hadronic processes to the observed -ray
emission to below 15%.Comment: 18 pages, 15 figures. Submitted to journa
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 Ă 10-5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 Ă 10-5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 Ă 10-10, odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression
Beneficial effects of renal sympathetic denervation on cardiovascular inflammation and remodeling in essential hypertension
Neuropeptide Y as an indicator of successful alterations in sympathetic nervous activity after renal sympathetic denervation
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